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Extremozyme
An extremozyme is an enzyme, often created by archaea, which are known prokaryotic extremophiles that can function under extreme environments. Examples of such are those in highly acidic/basic conditions, high/low temperatures, high salinity, or other factors, that would otherwise denature typical enzymes (e.g. catalase, rubisco, carbonic anhydrase). This feature makes these enzymes of interest in a variety of biotechnical applications in the energy, pharmaceutical, agricultural, environmental, food, health, and textile industries. History Since the 1960s, scientists have known that most enzymes have a range of functionality under different conditions. Due to their unique properties that allow catalytic reactions to occur in a more efficient nature, enzymes were sought after for use in harsh industrial chemical processes in the interest of profits and environmental protection. As time passed and demand called for higher product output, the harshness of the chemical processes cont ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecules known as product (chemistry), products. Almost all metabolism, metabolic processes in the cell (biology), cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called ''enzymology'' and the field of pseudoenzyme, pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Other biocatalysts include Ribozyme, catalytic RNA molecules, also called ribozymes. They are sometimes descr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Catalysis
Catalysis () is the increase in rate of a chemical reaction due to an added substance known as a catalyst (). Catalysts are not consumed by the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recycles quickly, very small amounts of catalyst often suffice; mixing, surface area, and temperature are important factors in reaction rate. Catalysts generally react with one or more reactants to form intermediates that subsequently give the final reaction product, in the process of regenerating the catalyst. The rate increase occurs because the catalyst allows the reaction to occur by an alternative mechanism which may be much faster than the noncatalyzed mechanism. However the noncatalyzed mechanism does remain possible, so that the total rate (catalyzed plus noncatalyzed) can only increase in the presence of the catalyst and never decrease. Catalysis may be classified as either homogeneous, whose components are dispersed in the same phase (usual ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allostery
In the fields of biochemistry and pharmacology an allosteric regulator (or allosteric modulator) is a substance that binds to a site on an enzyme or Receptor (biochemistry), receptor distinct from the active site, resulting in a conformational change that alters the protein's activity, either enhancing or inhibiting its function. In contrast, substances that bind directly to an enzyme's active site or the binding site of the endogenous ligand of a receptor are called orthosteric regulators or modulators. The site to which the effector binds is termed the ''allosteric site'' or ''regulatory site''. Allosteric sites allow effectors to bind to the protein, often resulting in a conformational change and/or a change in protein dynamics. Effectors that enhance the protein's activity are referred to as ''allosteric activators'', whereas those that decrease the protein's activity are called ''allosteric inhibitors''. Allosteric regulations are a natural example of control loops, such ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metabolic reactions, DNA replication, Cell signaling, responding to stimuli, providing Cytoskeleton, structure to cells and Fibrous protein, organisms, and Intracellular transport, transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the Nucleic acid sequence, nucleotide sequence of their genes, and which usually results in protein folding into a specific Protein structure, 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called pep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polypeptide
Peptides are short chains of amino acids linked by peptide bonds. A polypeptide is a longer, continuous, unbranched peptide chain. Polypeptides that have a molecular mass of 10,000 Da or more are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. Peptides fall under the broad chemical classes of biological polymers and oligomers, alongside nucleic acids, oligosaccharides, polysaccharides, and others. Proteins consist of one or more polypeptides arranged in a biologically functional way, often bound to ligands such as coenzymes and cofactors, to another protein or other macromolecule such as DNA or RNA, or to complex macromolecular assemblies. Amino acids that have been incorporated into peptides are termed residues. A water molecule is released during formation of each amide bond.. All peptides except cyclic peptides have an N-terminal (amine group) and C-terminal (ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Berkeley Pit
The Berkeley Pit is a former open pit copper mine in the western United States, located in Butte, Montana. It is long by wide, with an approximate maximum depth of . It is filled to a depth of about with water that is acidic (4.1 - 4.5 pH level), about the acidity of beer or tomatoes. As a result, the pit's water is laden with heavy metals and dissolved metals that leach from the rock in a natural process known as acid rock drainage. The dissolved metals include but are not limited to copper, arsenic, cadmium, zinc, and sulfuric acid. The mine was opened in 1955 and operated by the Anaconda Copper Mining Company, and later by the Atlantic Richfield Company (ARCO), until its closure on April 22, 1982. When the pit was closed, the water pumps in the nearby Kelley Mine, below the surface, were turned off, and groundwater began to slowly fill the Berkeley Pit, rising at about the rate of per month. Since its closure, the water level in the pit has risen to within of the "prote ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ACS Publications
The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all degree levels and in all fields of chemistry, chemical engineering, and related fields. It is one of the world's largest scientific societies by membership. The ACS is a 501(c)(3) non-profit organization and holds a congressional charter under Title 36 of the United States Code. Its headquarters are located in Washington, D.C., and it has a large concentration of staff in Columbus, Ohio. The ACS is a leading source of scientific information through its peer-reviewed scientific journals, national conferences, and the Chemical Abstracts Service. Its publications division produces over 80 scholarly journals including the prestigious '' Journal of the American Chemical Society'', as well as the weekly trade magazine ''Chemical & Engineeri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aquifex
''Aquifex'' is a bacterial genus, belonging to phylum Aquificota. There is one species of ''Aquifex'' with a validly published name – '' A. pyrophilus'' – but "'' A. aeolicus''" is sometimes considered as species though it has no standing as a name given it has not been validly or effectively published. ''Aquifex'' spp. are extreme thermophiles, growing best at temperature of 85 °C to 95 °C. They are members of the ''Bacteria'' as opposed to the other inhabitants of extreme environments, the Archaea. ''Aquifex'' spp. are rod-shaped bacteria with a length of 2 to 6 μm, have a diameter of around 0.5 μm and are motile. They are non-sporeforming, Gram negative autotrophs. ''Aquifex'' means ''water-maker'' in Latin, and refers to the fact that its method of respiration creates water. ''Aquifex'' tend to form cell aggregates composed of up to 100 individual cells. ''Aquifex'' spp. are thermophilic and often grow near underwater volcanoes or hot springs. ''A. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thermotoga
''Thermotoga'' is a genus of the phylum '' Thermotogota''. Members of ''Thermotoga'' are hyperthermophilic bacteria whose cell is wrapped in a unique sheath-like outer membrane, called a "toga". The members of the phylum stain Gram-negative as they possess a thin peptidoglycan in between two lipid bilayers, albeit both peculiar. The peptidoglycan is unusual as the crosslink is not only meso-diaminopimelate as occurs in Pseudomonadota, but D-lysine.All proteinogenic amino acids have the L- configuration; in peptidoglycan some amino acids with the D- configuration are present. Lysine is synthesised from meso-diaminopimelate by Diaminopimelate decarboxylase The species are anaerobes with varying degrees of oxygen tolerance. They are capable of reducing elemental sulphur (S0) to hydrogen sulphide. Whether thermophily is an innovation of the lineage or an ancestral trait is unclear and cannot be determined. The genome of '' Thermotoga maritima'' was sequenced in 1999, revealing se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Regensburg
The University of Regensburg () is a public research university located in the city of Regensburg, Germany. The university was founded on 18 July 1962 by the Landtag of Bavaria as the fourth full-fledged university in Bavaria. Following groundbreaking in 1965, the university officially opened to students during the 1967–1968 winter semester, initially housing faculties in Law and Business Sciences and Philosophy. During the summer semester of 1968 the faculty of Theology was created. Currently, the University of Regensburg houses eleven faculties. The university actively participates in the European Union's SOCRATES programme as well as part of the Compostela-Group. Its most famous academic, Pope Benedict XVI, served as a professor there until 1977 and formally retained his chair in theology. History Attempts to establish a university in Regensburg had been advocated since the late 15th century. In 1487, Duke Albrecht IV of Bavaria and the Regensburg city council sent a pe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Karl Stetter
Karl Otto Stetter (born 16 July 1941) is a German microbiologist and authority on astrobiology. Stetter is an expert on microbial life at high temperatures. Career Stetter was born in Munich and studied biology at the Technical University of Munich. Stetter wrote Stetter's doctoral dissertation on lactobacilli. From 1980 to 2002 Stetter was professor at, and head of, the department of microbiology and of the Archaea center of the University of Regensburg. The majority of Stetter's research has focused on sampling, isolating and characterizing archaeal organisms which comprise the third domain of life, particularly undiscovered extremely heat-loving ('' hyperthermophilic'') bacteria and Archaea, also called extremophiles, growing optimally between 80 and 113 °C. Major discovery In 1992, Stetter, along with Robert Huber, discovered a new species of thermophilic bacteria near Kolbeinsey Ridge and named the species '' Aquifex pyrophilous''. '' Nanoarchaeum equitans'', a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elsevier
Elsevier ( ) is a Dutch academic publishing company specializing in scientific, technical, and medical content. Its products include journals such as ''The Lancet'', ''Cell (journal), Cell'', the ScienceDirect collection of electronic journals, ''Trends (journals), Trends'', the ''Current Opinion (Elsevier), Current Opinion'' series, the online citation database Scopus, the SciVal tool for measuring research performance, the ClinicalKey search engine for clinicians, and the ClinicalPath evidence-based cancer care service. Elsevier's products and services include digital tools for Data management platform, data management, instruction, research analytics, and assessment. Elsevier is part of the RELX Group, known until 2015 as Reed Elsevier, a publicly traded company. According to RELX reports, in 2022 Elsevier published more than 600,000 articles annually in over 2,800 journals. As of 2018, its archives contained over 17 million documents and 40,000 Ebook, e-books, with over one b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
