Dibenzoxazepine
   HOME





Dibenzoxazepine
CR gas or dibenzoxazepine (chemical name dibenz 'b'',''f''1,4]oxazepine, is an incapacitating agent and a lachrymatory agent. CR was developed by the British Ministry of Defence as a riot control agent in the late 1950s and early 1960s. A report from the Porton Down laboratories described exposure as "like being thrown blindfolded into a bed of stinging nettles", and it earned the nickname "firegas". In its effects, CR gas is very similar to CS gas (''o''-chlorobenzylidene malononitrile), but twice as potent, even though there is little structural resemblance between the two. For example, 2 mg of dry CR causes skin redness in 10 min, 5 mg causes burning and erythremia, and strong pain. Water usually amplifies the pain effect of CR on skin. CR aerosols cause irritation at concentrations of 0.2 mcg/L, becoming intolerable at 3 mcg/L. The of CR through air inhalation 350 mg·min/L. Physical properties and deployment CR is a pale yellow crystalline solid wi ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   [Amazon]


picture info

Loxapine
Loxapine, sold under the brand names Loxitane and Adasuve (''inhalation'' only) among others, is a tricyclic antipsychotic medication used primarily in the treatment of schizophrenia. The medicine is a member of the dibenzoxazepine class and structurally very similar to clozapine. Several researchers have argued that loxapine, initially classified as a typical antipsychotic, behaves as an atypical antipsychotic. Loxapine may be metabolized by ''N''-demethylation to amoxapine, a tricyclic antidepressant. Medical uses The US Food and Drug Administration (FDA) has approved loxapine inhalation powder for the acute treatment of agitation associated with schizophrenia or bipolar I disorder in adults. A brief review of loxapine found no conclusive evidence that it was particularly effective in patients with schizophrenia. A subsequent systematic review considered that the limited evidence did not indicate a clear difference in its effects from other antipsychotics. Available ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   [Amazon]


picture info

Riot Control Agent
Riot control is a form of public order policing used by law enforcement, military, paramilitary or security forces to social control, control, disperse, and arrest people who are involved in a riot, unlawful Demonstration (people), demonstration or unlawful protest. If a riot is spontaneous, then actions which cause people to stop and think (e.g. loud noises or issuing instructions in a calm tone) can be enough to stop it. However, these methods usually fail when there is severe anger, or the riot was planned or organized. Riot control personnel have long used less lethal weapons such as Baton (law enforcement), batons and whips to disperse crowds and detain rioters. Since the 1980s, riot control officers have also used tear gas, pepper spray, rubber bullets, stun grenades, and electric tasers. In some cases, riot squads may also use Long Range Acoustic Devices, water cannons, armoured fighting vehicles, aerial surveillance, police dogs or mounted police on horses. Persons perform ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   [Amazon]


TRPA1
Transient receptor potential cation channel, subfamily A, member 1, also known as transient receptor potential ankyrin 1, TRPA1, or The Mustard and Wasabi Receptor, is a protein that in humans is encoded by the ''TRPA1'' (and in mice and rats by the ''Trpa1'') gene. TRPA1 is an ion channel located on the plasma membrane of many human and animal cells. This ion channel is best known as a sensor for pain, cold and itch in humans and other mammals, as well as a sensor for environmental irritants giving rise to other protective responses (tears, airway resistance, and cough). Function TRPA1 is a member of the transient receptor potential channel family. TRPA1 contains 14 N-terminal ankyrin repeats and is believed to function as a mechanical and chemical stress sensor. One of the specific functions of this protein involves a role in the detection, integration, and initiation of pain signals in the peripheral nervous system. It can be activated at sites of tissue injury or sites ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   [Amazon]


picture info

Incapacitating Agent
Incapacitating agent is a chemical or biological agent which renders a person unable to harm themselves or others, regardless of consciousness. Lethal agents are primarily intended to kill, but incapacitating agents can also kill if administered in a potent enough dose, or in certain scenarios. The term "incapacitation," when used in a general sense, is not equivalent to the term "disability" as used in occupational medicine and denotes the inability to perform a task because of a quantifiable physical or mental impairment. In this sense, any of the chemical warfare agents may incapacitate a victim; however, by the military definition of this type of agent, incapacitation refers to impairments that are temporary and nonlethal. Thus, riot-control agents are incapacitating because they cause temporary loss of vision due to blepharospasm, but they are not considered military incapacitants because the loss of vision does not last long. Although incapacitation may result from physio ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   [Amazon]


picture info

Nerve Agent
Nerve agents, sometimes also called nerve gases, are a class of organic chemistry, organic chemicals that disrupt the mechanisms by which nerves transfer messages to organs. The disruption is caused by the blocking of acetylcholinesterase (AChE), an enzyme that catalyzes the breakdown of acetylcholine, a neurotransmitter. Nerve agents are irreversible acetylcholinesterase inhibitors used as poison. Poisoning by a nerve agent leads to constriction of pupils, profuse salivation, convulsions, and involuntary urination and defecation, with the first symptoms appearing in seconds after exposure. Death by asphyxiation or cardiac arrest may follow in minutes due to the loss of the body's control over Respiration (physiology), respiratory and other muscles. Some nerve agents are readily vaporized or aerosolized, and the primary portal of entry into the body is the respiratory system. Nervous agents can also be absorbed through the skin, requiring that those likely to be subjected to su ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   [Amazon]


Palliative
Palliative care (from Latin root "to cloak") is an interdisciplinary medical care-giving approach aimed at optimizing quality of life and mitigating or reducing suffering among people with serious, complex, and often terminal illnesses. Many definitions of palliative care exist. The World Health Organization (WHO) describes palliative care as:"an approach that improves the quality of life of patients and their families facing the problem associated with life-threatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems, physical, psychosocial, and spiritual". Since the 1990s, many palliative care programs involved a disease-specific approach. However, as the field developed throughout the 2000s, the WHO began to take a broader patient-centered approach that suggests that the principles of palliative care should be applied as early as possible to any chronic and ultimatel ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   [Amazon]


picture info

2011 Egyptian Revolution
The 2011 Egyptian revolution, also known as the 25 January Revolution (;), began on 25 January 2011 and spread across Egypt. The date was set by various youth groups to coincide with the annual Egyptian "Police holiday" as a statement against increasing police brutality during the last few years of Hosni Mubarak's presidency. It consisted of demonstrations, marches, occupations of plazas, non-violent civil resistance, acts of civil disobedience and strikes. Millions of protesters from a range of socio-economic and religious backgrounds demanded the overthrow of Egyptian President Hosni Mubarak. Violent clashes between security forces and protesters resulted in at least 846 people killed and over 6,000 injured. Protesters retaliated by burning over 90 police stations across the country. The Egyptian protesters' grievances focused on legal and political issues, including police brutality, state-of-emergency laws, lack of political freedom, civil liberty, freedom of speech, cor ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   [Amazon]


picture info

Mohammed ElBaradei
Mohamed Mostafa ElBaradei (, ; born 17 June 1942) is an Egyptian law scholar and diplomat who served as the vice president of Egypt on an interim basis from 14 July 2013 until his resignation on 14 August 2013. He was the Director General of the International Atomic Energy Agency (IAEA), an intergovernmental organization under the auspices of the United Nations (UN), from 1997 to 2009. At the end of his tenure he was appointed “Director General Emeritus of the International Atomic Energy Agency”. He and the IAEA were jointly awarded the Nobel Peace Prize in 2005 "for their efforts to prevent nuclear energy from being used for military purposes and to ensure that nuclear energy for peaceful purposes is used in the safest possible way". ElBaradei was also featured in the Western press regarding politics in Egypt, particularly the 2011 revolution which ousted President Hosni Mubarak and the 2013 Egyptian coup d'état. ElBaradei was born and raised in Giza Governorate, Greater ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   [Amazon]


picture info

Human Rights Watch
Human Rights Watch (HRW) is an international non-governmental organization that conducts research and advocacy on human rights. Headquartered in New York City, the group investigates and reports on issues including War crime, war crimes, crimes against humanity, Child labour, child labor, torture, human trafficking, and Women's rights, women's and LGBTQ rights. It pressures governments, policymakers, companies, and individual abusers to respect human rights, and frequently works on behalf of refugees, children, migrants, and political prisoners. The organization was founded in 1978 as Helsinki Watch, whose purpose was to monitor the Soviet Union's compliance with the 1975 Helsinki Accords. Its separate global divisions merged into Human Rights Watch in 1988. The group publishes annual reports on about 100 countries with the goal of providing an overview of the worldwide state of human rights. In 1997, HRW shared the Nobel Peace Prize as a founding member of the International C ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   [Amazon]


picture info

Tahrir Square
Tahrir Square (, ; ), also known as Martyr Square, is a public town square in downtown Cairo, Egypt. The square has been the location and focus for political demonstrations. The 2011 Egyptian revolution and the resignation of President of Egypt, President Hosni Mubarak occurred at the Tahrir Square. History The square was originally called "Ismailia Square", after the 19th-century ruler of Egypt, Khedive Ismail, who commissioned the new downtown district's 'Paris on the Nile River, Nile'. After the Egyptian Revolution of 1919, the square became widely known as Tahrir (Liberation) Square. In 1933 Fuad I of Egypt, King Fuad I (r. 1922–1936), the son of Khedive Ismail, renamed the square officially to Khedive Ismail Square (). Before the end of his reign in 1936, a roundabout with a garden was created at the center of the square. Under his successor, Farouk of Egypt, King Farouk (r. 1936–1952), a pedestal was installed in the center of square which was intended to support a ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   [Amazon]


Asphyxiation
Asphyxia or asphyxiation is a condition of deficient supply of oxygen to the body which arises from abnormal breathing. Asphyxia causes generalized hypoxia, which affects all the tissues and organs, some more rapidly than others. There are many circumstances that can induce asphyxia, all of which are characterized by the inability of a person to acquire sufficient oxygen through breathing for an extended period of time. Asphyxia can cause coma or death. In 2015, about 9.8 million cases of unintentional suffocation occurred which resulted in 35,600 deaths. The word asphyxia is from Ancient Greek "without" and , "squeeze" (throb of heart). Causes Situations that can cause asphyxia include but are not limited to: airway obstruction (such as from asthma, laryngospasm, or simple blockage from the presence of foreign materials); from being in environments where oxygen is not readily accessible: such as underwater, in a low oxygen atmosphere, or in a vacuum; environments where ...
[...More Info...]      
[...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   [Amazon]