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Dibenzoxazepine
CR gas or dibenzoxazepine (chemical name dibenz 'b'',''f''1,4]oxazepine, is an incapacitating agent and a lachrymatory agent. CR was developed by the British Ministry of Defence as a riot control agent in the late 1950s and early 1960s. A report from the Porton Down laboratories described exposure as "like being thrown blindfolded into a bed of stinging nettles", and it earned the nickname "firegas". In its effects, CR gas is very similar to CS gas (''o''-chlorobenzylidene malononitrile), but twice as potent, even though there is little structural resemblance between the two. For example, 2 mg of dry CR causes skin redness in 10 min, 5 mg causes burning and erythremia, and strong pain. Water usually amplifies the pain effect of CR on skin. CR aerosols cause irritation at concentrations of 0.2 mcg/L, becoming intolerable at 3 mcg/L. The of CR through air inhalation 350 mg·min/L. Physical properties and deployment CR is a pale yellow crystalline solid wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
Loxapine
Loxapine, sold under the brand names Loxitane and Adasuve (''inhalation'' only) among others, is a tricyclic antipsychotic medication used primarily in the treatment of schizophrenia. The medicine is a member of the dibenzoxazepine class and structurally very similar to clozapine. Several researchers have argued that loxapine, initially classified as a typical antipsychotic, behaves as an atypical antipsychotic. Loxapine may be metabolized by ''N''-demethylation to amoxapine, a tricyclic antidepressant. Medical uses The US Food and Drug Administration (FDA) has approved loxapine inhalation powder for the acute treatment of agitation associated with schizophrenia or bipolar I disorder in adults. A brief review of loxapine found no conclusive evidence that it was particularly effective in patients with schizophrenia. A subsequent systematic review considered that the limited evidence did not indicate a clear difference in its effects from other antipsychotics. Available ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
