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Dibenzothiazepine
Dibenzothiazepines are chemical compounds which are derivatives of thiazepine with two benzene rings. Examples include quetiapine Quetiapine ( ), sold under the brand name Seroquel among others, is an atypical antipsychotic medication used in the treatment of schizophrenia, bipolar disorder, bipolar depression, and major depressive disorder. Despite being widely prescri ... and metiapine. References Dibenzothiazepines {{heterocyclic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metiapine
Metiapine is a typical antipsychotic medication of the dibenzothiazepine group. There is scarce research on the safety and efficacy of metiapine in humans, though limited human trials exist. Medical uses Metiapine has been investigated for the treatment of schizophrenia. Side effects Like other typical antipsychotics, it has a high rate of extrapyramidal side effects. Pharmacology Metiapine has strong antidopaminergic effects and is classified as a typical (i.e., first-generation) antipsychotic. Chemistry Metiapine is a dibenzothiazepine derivative. Like clothiapine, metiapine has a sulfur atom replacing the nitrogen atom found in dibenzodiazepine derivative antipsychotics like clozapine. Synthesis Metiapine can be synthesized through the following mechanism: History Metiapine was first discovered in the 1970s by Marion Merrell Dow (now a part of Sanofi). Research A 2017 Cochrane Review provided guidance for a double-blind, randomized controlled trial of metiapine versus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quetiapine
Quetiapine ( ), sold under the brand name Seroquel among others, is an atypical antipsychotic medication used in the treatment of schizophrenia, bipolar disorder, bipolar depression, and major depressive disorder. Despite being widely prescribed as a sleep aid due to its tranquillizing effects, the benefits of such use may not outweigh the risk of undesirable side effects. It is taken orally. Common side effects include sedation, fatigue, weight gain, constipation, and dry mouth. Other side effects include low blood pressure with standing, seizures, high blood sugar, tardive dyskinesia, and neuroleptic malignant syndrome. In older people with dementia, its use increases the risk of death. Use in the third trimester of pregnancy may result in a movement disorder in the baby for some time after birth. Quetiapine is believed to work by blocking a number of receptors, including those for serotonin and dopamine. Quetiapine was developed in 1985 and was approved for medical u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thiazepine
Thiazepines are substituted thiepins, with a nitrogen replacing a carbon in the seven-membered heterocyclic compound. Depending on the location of the nitrogen, one distinguishes 1,3-thiazepine and 1,4-thiazepine. Benzothiazepines have a single benzene attached to the ring, while dibenzothiazepines have two. Diltiazem, a benzothiazepine, is a calcium channel blocker intermediate in properties between verapamil and the dihydropyridines. It is used to treat variant angina (Prinzmetal's angina Variant angina, also known as Prinzmetal angina, vasospastic angina, angina inversa, coronary vessel spasm, or coronary artery vasospasm, is a syndrome typically consisting of angina (cardiac chest pain). Variant angina differs from stable angin ...), either naturally occurring or drug-induced and stable angina. References External links * {{heterocyclic-stub Thiazepines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quetiapine
Quetiapine ( ), sold under the brand name Seroquel among others, is an atypical antipsychotic medication used in the treatment of schizophrenia, bipolar disorder, bipolar depression, and major depressive disorder. Despite being widely prescribed as a sleep aid due to its tranquillizing effects, the benefits of such use may not outweigh the risk of undesirable side effects. It is taken orally. Common side effects include sedation, fatigue, weight gain, constipation, and dry mouth. Other side effects include low blood pressure with standing, seizures, high blood sugar, tardive dyskinesia, and neuroleptic malignant syndrome. In older people with dementia, its use increases the risk of death. Use in the third trimester of pregnancy may result in a movement disorder in the baby for some time after birth. Quetiapine is believed to work by blocking a number of receptors, including those for serotonin and dopamine. Quetiapine was developed in 1985 and was approved for medical u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benzene
Benzene is an Organic compound, organic chemical compound with the Chemical formula#Molecular formula, molecular formula C6H6. The benzene molecule is composed of six carbon atoms joined in a planar hexagonal Ring (chemistry), ring with one hydrogen atom attached to each. Because it contains only carbon and hydrogen atoms, benzene is classed as a hydrocarbon. Benzene is a natural constituent of petroleum and is one of the elementary petrochemicals. Due to the cyclic continuous pi bonds between the carbon atoms, benzene is classed as an aromatic hydrocarbon. Benzene is a colorless and highly Combustibility and flammability, flammable liquid with a sweet smell, and is partially responsible for the aroma of gasoline. It is used primarily as a Precursor (chemistry), precursor to the manufacture of chemicals with more complex structures, such as ethylbenzene and cumene, of which billions of kilograms are produced annually. Although benzene is a major Chemical industry, industrial che ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
