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Desmoid Tumor
Aggressive fibromatosis or desmoid tumor is a Rare disease, rare condition. Desmoid tumors are a type of fibromatosis and related to sarcoma, though without the ability to spread throughout the body (Metastasis, metastasize). The tumors arise from cells called fibroblasts, which are found throughout the body and provide structural support, protection to the vital organs, and play a critical role in wound healing. These tumors tend to occur in women in their thirties, but can occur in anyone at any age. They can be either relatively slow-growing or malignant. However, aggressive fibromatosis is locally aggressive and invasive, with spindle-like growths. The tumors can lead to pain, life-threatening problems, or, rarely, death when they invade other soft tissue or compress vital organs such as intestines, kidneys, lungs, blood vessels, or nerves. Most cases are sporadic, but some are associated with familial adenomatous polyposis (FAP). Approximately 10% of individuals with Gardner ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
National Institutes Of Health
The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Services (HHS). Many NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its scientific research through the NIH Intramural Research Program (IRP) and provides significant biomedical research funding to non-NIH research facilities through its Extramural Research Program. , the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research institution in the world, while, as of 2003, the extramural arm provided 28% of biomedical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
Fibroblasts
A fibroblast is a type of biological cell typically with a spindle shape that synthesizes the extracellular matrix and collagen, produces the structural framework ( stroma) for animal tissues, and plays a critical role in wound healing. Fibroblasts are the most common cells of connective tissue in animals. Structure Fibroblasts have a branched cytoplasm surrounding an elliptical, speckled nucleus having two or more nucleoli. Active fibroblasts can be recognized by their abundant rough endoplasmic reticulum (RER). Inactive fibroblasts, called ' fibrocytes', are smaller, spindle-shaped, and have less RER. Although disjointed and scattered when covering large spaces, fibroblasts often locally align in parallel clusters when crowded together. Unlike the epithelial cells lining the body structures, fibroblasts do not form flat monolayers and are not restricted by a polarizing attachment to a basal lamina on one side, although they may contribute to basal lamina components in s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
Congenital Generalized Fibromatosis
A birth defect is an abnormal condition that is present at birth, regardless of its cause. Birth defects may result in disabilities that may be physical, intellectual, or developmental. The disabilities can range from mild to severe. Birth defects are divided into two main types: structural disorders in which problems are seen with the shape of a body part and functional disorders in which problems exist with how a body part works. Functional disorders include metabolic and degenerative disorders. Some birth defects include both structural and functional disorders. Birth defects may result from genetic or chromosomal disorders, exposure to certain medications or chemicals, or certain infections during pregnancy. Risk factors include folate deficiency, drinking alcohol or smoking during pregnancy, poorly controlled diabetes, and a mother over the age of 35 years old. Many birth defects are believed to involve multiple factors. Birth defects may be visible at birth or diagno ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
Arthur Purdy Stout
Arthur Purdy Stout (1885–1967) was an American surgeon and pathologist. Early years and education Arthur Purdy Stout was the fourth son of Joseph and Julia Frances (née Purdy) Stout. He attended the Pomfret School and Yale University, where he earned an A.B. degree in 1907. After spending a year abroad, Arthur entered the College of Physicians & Surgeons (CPS) of Columbia University. He completed his M.D. degree in 1912.Stout AP: Notes on the education of an "oncological" surgical pathologist: the autobiography of Arthur Purdy Stout. IN: ''Guiding the Surgeon's Hand'' (Rosai J, Ed), American Registry of Pathology, Washington, D.C., 1997; pp. 197-274. Career at Columbia-Presbyterian Medical Center in New York Stout was a surgical house-officer at Roosevelt Hospital in New York City; he then joined the staff of CPS in 1914 as an instructor in surgery. During World War I, Dr. Stout was a field surgeon in the U.S. Army in France (see image at right). Returning to CPS thereafter, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
EMedicine
eMedicine is an online clinical medical knowledge base founded in 1996 by doctors Scott Plantz and Jonathan Adler, and computer engineers Joanne Berezin and Jeffrey Berezin. The eMedicine website consists of approximately 6,800 medical topic review articles, each of which is associated with a clinical subspecialty "textbook". The knowledge base includes over 25,000 clinically multimedia files. Each article is authored by board certified specialists in the subspecialty to which the article belongs and undergoes three levels of physician peer-review, plus review by a Doctor of Pharmacy. The article's authors are identified with their current faculty appointments. Each article is updated yearly, or more frequently as changes in practice occur, and the date is published on the article. eMedicine.com was sold to WebMD in January, 2006 and is available as the Medscape Reference. History Plantz, Adler and Berezin evolved the concept for eMedicine.com in 1996 and deployed the initia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
Georg Ledderhose
Georg Otto Ledderhose (15 December 1855 – 1 February 1925) was a German surgeon, professor and pioneering traumatologist. Born in Bockenheim, Frankfurt am Main, he studied medicine at the University of Strasbourg and the University of Göttingen. Ledderhose is best known for identifying and describing Ledderhose's disease, a condition affecting the plantar fascia of the foot. He made significant contributions to the fields of surgery, traumatology, and orthopedics throughout his career. Biography Early life He was born in the Bockenheim (Frankfurt am Main), Bockenheim district of Frankfurt am Main. His father was the politician and university Rector (academia), rector Karl Ledderhose (26 March 1821 - 1 January 1899) and his mother was Wilhelmine ''Justine Charlotte'' (nee Pfeiffer; 21 October 1826 - 29 June 1892). Wilhelmine's father was ''Johann'' Georg ''Heinrich'' Pfeiffer (14 December 1781 - 27 January 1859), the third son of Johann Jakob Pfeiffer, and brother of Burkhard Wil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
Archives Of Surgery
''JAMA Surgery'' is an international peer-reviewed journal, which began publication in 1920.Kibbe, MD, Melina R. and Howard Bauchner, MD (2020)"Announcing the 100th Anniversary of JAMA Surgery, 1920 to 2020" editorial, JAMA Network, January 8, 2020. Retrieved 2020-05-31. It is the official publication of the Association of VA Surgeons, the Pacific Coast Surgical Association, and the Surgical Outcomes Club.Kibbe, MD, Melina R. (2022)"About ''JAMA Surgery''" JAMA Network, American Medical Association, Chicago, Illinois. Retrieved 2022-12-22. It is a member of the JAMA Network, a consortium of peer-reviewed, general medicine and specialty publications. Its current (2022) editor-in-chief is Melina Kibbe at the University of North Carolina at Chapel Hill. Published online weekly, every Wednesday, ''JAMA Surgery'' is also published in print/online issues 12 times a year. In 2021, the journal logged over 3.8 million web sessions and more than 4.7 million article views and downloads. W ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
Johannes Peter Müller
Johannes Peter Müller (14 July 1801 – 28 April 1858) was a German physiologist, comparative anatomist, ichthyologist, and herpetologist, known not only for his discoveries but also for his ability to synthesize knowledge. The paramesonephric duct (Müllerian duct) was named in his honor. Life Early years and education Müller was born in Coblenz. He was the son of a poor shoemaker, and was about to be apprenticed to a saddler when his talents attracted the attention of his teacher, and he prepared himself to become a Roman Catholic Priest. During his college course in Koblenz, he devoted himself to the classics and made his own translations of Aristotle. At first, his intention was to become a priest. When he was eighteen, his love for natural science became dominant, and he turned to medicine, entering the University of Bonn in 1819. There he received his M.D. in 1822. He then studied at the University of Berlin. There, under the influence of G. W. F. Hegel and Kar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
John MacFarlane (New South Wales Politician)
John MacFarlane (31 July 1813 – 6 July 1873) was a Scottish-born Australian physician and politician. He was born in Glasgow and studied medicine at Glasgow University, qualifying in 1837. MacFarlane was the first to describe desmoid tumours. He worked as a ship's doctor until 1840, when he settled in Sydney and opened a practice. In 1847 he married Agnes Grace Johnstone. He was honorary physician at Sydney Infirmary from 1847 to 1869 and an examiner for the University of Sydney in 1856; he was also awarded an honorary degree from the University of Melbourne. In 1860 he was president of the Australian Medical Association. He was a member of the New South Wales Legislative Council from 1858 to 1861 and from 1861 to 1870. He died in Sydney Sydney is the capital city of the States and territories of Australia, state of New South Wales and the List of cities in Australia by population, most populous city in Australia. Located on Australia's east coast, the metropolis s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
Chronic Condition
A chronic condition (also known as chronic disease or chronic illness) is a health condition or disease that is persistent or otherwise long-lasting in its effects or a disease that comes with time. The term ''chronic'' is often applied when the course of the disease lasts for more than three months. Common chronic diseases include diabetes, functional gastrointestinal disorder, eczema, arthritis, asthma, chronic obstructive pulmonary disease, autoimmune diseases, genetic disorders and some viral diseases such as hepatitis C and acquired immunodeficiency syndrome. An illness which is lifelong because it ends in death is a terminal illness. It is possible and not unexpected for an illness to change in definition from terminal to chronic as medicine progresses. Diabetes and HIV for example were once terminal yet are now considered chronic, due to the availability of insulin for diabetics and daily drug treatment for individuals with HIV, which allow these individuals to live wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
Fibrosarcoma
Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern. Fibrosarcomas mainly arise in people between the ages of 25 and 79. It originates in fibrous tissues of the bone and invades long or flat bones such as the femur, tibia, and mandible. It also involves the periosteum and overlying muscle. Presentation Adult-type Individuals presenting with fibrosarcoma are usually adults thirty to fifty-five years old, often presenting with pain. Among adults, fibrosarcomas develop equally in men and women. Infantile-type In infants, fibrosarcoma (often termed congenital infantile fibrosarcoma) is usually congenital. Infants presenting with this fibrosarcoma usually do so in the first two years of their life. Cytogenetically, congenital infantile fibrosarcoma is characterized by the majority of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
