Darobactin
Darobactin is an experimental antibiotic compound that may be effective against Gram-negative bacteria. If it can be developed into a human-compatible form it would be the first to come from an animal microbiome. History The compound was discovered in ''Photorhabdus'' bacteria in 2019, living in the digestive systems of entomopathogenic nematodes. Researchers identified the nematode as a possible host because they feed on insects by targeting their larvae and releasing bacteria that then confront pathogens similar to those found in humans. In experiments, it cured mice of infections with ''Escherichia coli'' and ''Klebsiella pneumoniae'', both members of the Enterobacteriaceae, without toxic side effects. Gram-negative bacteria Gram-negative bacteria have a characteristic architecture for the cell envelope, with an inner membrane, an outer membrane, and a periplasmic space in between. In this arrangement, the peptidoglycan layer is relatively thin and does not retain the crys ...
[...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]