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Damage To Reputations.
Damage is any change in a thing, often a physical object, that degrades it away from its initial state. It can broadly be defined as "changes introduced into a system that adversely affect its current or future performance".Farrar, C.R., Sohn, H., Park, G.,Converting Large Sensor Array Data into Structural Health Information, in Andrew Smyth, Raimondo Betti, ''The 4th International Workshop on Structural Control'' (2005), p. 67. Damage "does not necessarily imply total loss of system functionality, but rather that the system is no longer operating in its optimal manner". Damage to physical objects is "the progressive physical process by which they break",Jean Lemaitre, ''A Course on Damage Mechanics'' (2013). and includes mechanical stress that weakens a structure, even if this is not visible. Physical damage All physical damage begins on the atomic level, with the shifting or breaking of atomic bonds, and the rate at which damage to any physical thing occurs is therefore lar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Change (philosophy)
Impermanence, also known as the philosophical problem of change, is a philosophical concept addressed in a variety of religions and philosophies. In Eastern philosophy it is notable for its role in the Buddhist three marks of existence. It is also an important element of Hinduism. In Western philosophy it is most famously known through its first appearance in Greek philosophy in the writings of Heraclitus and in his doctrine of ''panta rhei'' (everything flows). In Western philosophy the concept is also referred to as '' ''becoming''. Indian religions The Pali word for impermanence, ''anicca'', is a compound word consisting of ''"a"'' meaning non-, and ''"nicca"'' meaning "constant, continuous, permanent". While 'nicca' is the concept of continuity and permanence, 'anicca' refers to its exact opposite; the absence of permanence and continuity. The term is synonymous with the Sanskrit term ''anitya'' (a + nitya). The concept of impermanence is prominent in Buddhism, and it i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Foreign Object Damage
In aviation and aerospace, the term foreign object damage (FOD) refers to any damage to an aircraft attributed to foreign object debris (also referred to as "FOD"), which is any particle or substance, alien to an aircraft or system which could potentially cause damage to it. External FOD hazards include bird strikes, hail, ice, sandstorms, ash-clouds or objects left on a runway or flight deck. Internal FOD hazards include items left in the cockpit that interfere with flight safety by getting tangled in control cables, jam moving parts or short-out electrical connections. To jet engines Jet engines can suffer major damage from even small objects being sucked into the engine. In the United States, the Federal Aviation Administration (FAA) requires that all engine types pass a test which includes firing a fresh chicken (dead, but not frozen) into a running jet engine from a small cannon. The engine does not have to remain functional after the test, but it must not cause signifi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Unintended Consequence
In the social sciences, unintended consequences (sometimes unanticipated consequences or unforeseen consequences, more colloquially called knock-on effects) are outcomes of a purposeful action that are not intended or foreseen. The term was popularized in the 20th century by American sociologist Robert K. Merton. and later used to prevent erosion in earthworks, has become a major problem in the Southeastern United States. Kudzu has displaced native plants and has effectively taken over significant portions of land. The protection of the steel industry in the United States reduced production of steel in the United States, increased costs to users, and increased unemployment in associated industries. Perverse results In 2003, Barbra Streisand unsuccessfully sued Kenneth Adelman and Pictopia.com for posting a photograph of her home online. Before the lawsuit had been filed, only 6 people had downloaded the file, two of them Streisand's attorneys. The lawsuit drew attention to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ageing
Ageing (or aging in American English) is the process of becoming older until death. The term refers mainly to humans, many other animals, and fungi; whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal. In a broader sense, ageing can refer to single cells within an organism which have ceased dividing, or to the population of a species. In humans, ageing represents the accumulation of changes in a human being over time and can encompass physical, psychological, and social changes. Reaction time, for example, may slow with age, while memories and general knowledge typically increase. Of the roughly 150,000 people who die each day across the globe, about two-thirds die from age-related causes. Current ageing theories are assigned to the damage concept, whereby the accumulation of damage (such as DNA oxidation) may cause biological systems to fail, or to the programmed ageing concept, whereby the internal processes (e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trauma (medicine)
Injury is physiological damage to the living tissue of any organism, whether in humans, in other animals, or in plants. Injuries can be caused in many ways, including mechanically with penetration by sharp objects such as teeth or with blunt objects, by heat or cold, or by venoms and biotoxins. Injury prompts an inflammatory response in many taxa of animals; this prompts wound healing. In both plants and animals, substances are often released to help to occlude the wound, limiting loss of fluids and the entry of pathogens such as bacteria. Many organisms secrete antimicrobial chemicals which limit wound infection; in addition, animals have a variety of immune responses for the same purpose. Both plants and animals have regrowth mechanisms which may result in complete or partial healing over the injury. Cells too can repair damage to a certain degree. Taxonomic range Animals Injury in animals is sometimes defined as mechanical damage to anatomical struct ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Articular Cartilage Damage
The articular bone is part of the lower jaw of most vertebrates, including most jawed fish, amphibians, birds and various kinds of reptiles, as well as ancestral mammals. Anatomy In most vertebrates, the articular bone is connected to two other lower jaw bones, the suprangular and the angular. Developmentally, it originates from the embryonic mandibular cartilage. The most caudal portion of the mandibular cartilage ossifies to form the articular bone, while the remainder of the mandibular cartilage either remains cartilaginous or disappears. In snakes In snakes, the articular, surangular, and prearticular bones have fused to form the compound bone. The mandible is suspended from the quadrate bone and articulates at this compound bone. Function In amphibians and reptiles In most tetrapods, the articular bone forms the lower portion of the jaw joint. The upper jaw articulates at the quadrate bone. In mammals In mammals, the articular bone evolves to form the mall ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brain Damage
Brain injury (BI) is the destruction or degeneration of brain cells. Brain injuries occur due to a wide range of internal and external factors. In general, brain damage refers to significant, undiscriminating trauma-induced damage. A common category with the greatest number of injuries is traumatic brain injury (TBI) following physical trauma or head injury from an outside source, and the term acquired brain injury (ABI) is used in appropriate circles to differentiate brain injuries occurring after birth from injury, from a genetic disorder (GBI), or from a congenital disorder (CBI). Primary and secondary brain injuries identify the processes involved, while focal and diffuse brain injury describe the severity and localization. Impaired function of affected areas can be compensated through neuroplasticity by forming new neural connections. Signs and symptoms Symptoms of brain injuries vary based on the severity of the injury or how much of the brain is affected. The fou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nerve Damage
Nerve injury is an injury to a nerve. There is no single classification system that can describe all the many variations of nerve injuries. In 1941, Herbert Seddon introduced a classification of nerve injuries based on three main types of nerve fiber injury and whether there is continuity of the nerve. Usually, however, nerve injuries are classified in five stages, based on the extent of damage to both the nerve and the surrounding connective tissue, since supporting glial cells may be involved. Unlike in the central nervous system, neuroregeneration in the peripheral nervous system is possible. The processes that occur in peripheral regeneration can be divided into the following major events: Wallerian degeneration, axon regeneration/growth, and reinnervation of nervous tissue. The events that occur in peripheral regeneration occur with respect to the axis of the nerve injury. The proximal stump refers to the end of the injured neuron that is still attached to the neuron cell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Damage
Cell damage (also known as cell injury) is a variety of changes of stress that a cell suffers due to external as well as internal environmental changes. Amongst other causes, this can be due to physical, chemical, infectious, biological, nutritional or immunological factors. Cell damage can be reversible or irreversible. Depending on the extent of injury, the cellular response may be adaptive and where possible, homeostasis is restored. Cell death occurs when the severity of the injury exceeds the cell's ability to repair itself. Cell death is relative to both the length of exposure to a harmful stimulus and the severity of the damage caused. Cell death may occur by necrosis or apoptosis. Causes * Physical agents such as heat or radiation can damage a cell by literally cooking or coagulating their contents. * Impaired nutrient supply, such as lack of oxygen or glucose, or impaired production of adenosine triphosphate (ATP) may deprive the cell of essential materials needed to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indirect DNA Damage
Indirect DNA damage occurs when a UV-photon is absorbed in the human skin by a chromophore that does not have the ability to convert the energy into harmless heat very quickly. Molecules that do not have this ability have a long-lived excited state. This long lifetime leads to a high probability for reactions with other molecules—so-called bimolecular reactions. Melanin and DNA have extremely short excited state lifetimes in the range of a few femtoseconds (10−15s). The excited state lifetime of compounds used in sunscreens such as menthyl anthranilate, avobenzone or padimate O is 1,000 to 1,000,000 times longer than that of melanin, and therefore they may cause damage to living cells that come in contact with them. The molecule that originally absorbs the UV-photon is called a "chromophore". Bimolecular reactions can occur either between the excited chromophore and DNA or between the excited chromophore and another species, to produce free radicals and reactive ox ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Damage (naturally Occurring)
Natural DNA damage is an alteration in the chemical structure of DNA, such as a break in a strand of DNA, a nucleobase missing from the backbone of DNA, or a chemically changed base such as 8-OHdG. DNA damage can occur naturally or via environmental factors, but is distinctly different from mutation, although both are types of error in DNA. DNA damage is an abnormal chemical structure in DNA, while a mutation is a change in the sequence of base pairs. DNA damages cause changes in the structure of the genetic material and prevents the replication mechanism from functioning and performing properly. The DNA damage response (DDR) is a complex signal transduction pathway which recognizes when DNA is damaged and initiates the cellular response to the damage. DNA damage and mutation have different biological consequences. While most DNA damages can undergo DNA repair, such repair is not 100% efficient. Un-repaired DNA damages accumulate in non-replicating cells, such as cells in the brai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Injury
Injury is physiological damage to the living tissue of any organism, whether in humans, in other animals, or in plants. Injuries can be caused in many ways, including mechanically with penetration by sharp objects such as teeth or with blunt objects, by heat or cold, or by venoms and biotoxins. Injury prompts an inflammatory response in many taxa of animals; this prompts wound healing. In both plants and animals, substances are often released to help to occlude the wound, limiting loss of fluids and the entry of pathogens such as bacteria. Many organisms secrete antimicrobial chemicals which limit wound infection; in addition, animals have a variety of immune responses for the same purpose. Both plants and animals have regrowth mechanisms which may result in complete or partial healing over the injury. Cells too can repair damage to a certain degree. Taxonomic range Animals Injury in animals is sometimes defined as mechanical damage to anatomical struct ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
