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Cyclosporiasis
Cyclosporiasis is a disease caused by infection with ''Cyclospora cayetanensis'', a pathogenic Apicomplexa, apicomplexan protozoan transmitted by human feces, feces or feces-contaminated food and water. Outbreaks have been reported due to contaminated fruits and vegetables. It is not spread from person to person, but can be a hazard for travelers as a cause of traveler's diarrhea, diarrhea. Cause Cyclosporiasis primarily affects humans and other primates. When an oocyst of ''Cyclospora cayetanensis'' enters the small intestine, it invades the mucosa, where it incubates for about one week. After incubation, the infected person begins to experience severe watery diarrhea, bloating, fever, stomach cramps, and muscle aches. The parasite particularly affects the jejunum of the small intestine. Of nine patients in Nepal who were diagnosed with cyclosporiasis, all had inflammation of the lamina propria along with an increase of Blood plasma, plasma in the lamina propria. Oocysts were als ...
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Cyclospora Cayetanensis
''Cyclospora cayetanensis'' is a coccidian parasite that causes a diarrheal disease called cyclosporiasis in humans and possibly in other primates. Originally reported as a novel pathogen of probable coccidian nature in the 1980s and described in the early 1990s, it was virtually unknown in developed countries until awareness increased due to several outbreaks linked with feces, fecally contaminated imported produce. ''C. cayetanensis'' has since emerged as an endemic cause of diarrheal disease in tropical countries and a cause of traveler's diarrhea and food-borne infections in developed nations. This species was placed in the genus ''Cyclospora'' because of the spherical shape of its sporocysts. The specific name refers to the Cayetano Heredia University in Lima, Peru, where early epidemiological and taxonomic work was done. History As originally recognized by Markus & Frean (1993), the first published report of ''Cyclospora cayetanensis'' in humans appears to be by Ashford (19 ...
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Apicomplexa
The Apicomplexa (also called Apicomplexia; single: apicomplexan) are organisms of a large phylum of mainly parasitic alveolates. Most possess a unique form of organelle structure that comprises a type of non-photosynthetic plastid called an apicoplastwith an apical complex membrane. The organelle's apical shape is an adaptation that the apicomplexan applies in penetrating a host cell. The Apicomplexa are unicellular and spore-forming. Most are obligate endoparasites of animals, except '' Nephromyces'', a symbiont in marine animals, originally classified as a chytrid fungus, and the Chromerida, some of which are photosynthetic partners of corals. Motile structures such as flagella or pseudopods are present only in certain gamete stages. The Apicomplexa are a diverse group that includes organisms such as the coccidia, gregarines, piroplasms, haemogregarines, and plasmodia. Diseases caused by Apicomplexa include: * Babesiosis ('' Babesia'') * Malaria (''Plasmodium'') * Cr ...
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Infectious Disease (medical Speciality)
Infectious diseases (ID), also known as infectiology, is a medical specialty dealing with the diagnosis and treatment of infections. An infectious diseases specialist's practice consists of managing nosocomial ( healthcare-acquired) infections or community-acquired infections. An ID specialist investigates and determines the cause of a disease (bacteria, virus, parasite, fungus or prions). Once the cause is known, an ID specialist can then run various tests to determine the best drug to treat the disease. While infectious diseases have always been around, the infectious disease specialty did not exist until the late 1900s after scientists and physicians in the 19th century paved the way with research on the sources of infectious disease and the development of vaccines. Scope Infectious diseases specialists typically serve as consultants to other physicians in cases of complex infections, and often manage patients with HIV/AIDS and other forms of immunodeficiency. Although many co ...
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Centers For Disease Control And Prevention
The Centers for Disease Control and Prevention (CDC) is the National public health institutes, national public health agency of the United States. It is a Federal agencies of the United States, United States federal agency under the United States Department of Health and Human Services, Department of Health and Human Services (HHS), and is headquartered in Atlanta, Georgia. The CDC's current nominee for director is Susan Monarez. She became acting director on January 23, 2025, but stepped down on March 24, 2025 when nominated for the director position. On May 14, 2025, Robert F. Kennedy Jr. stated that lawyer Matthew Buzzelli is acting CDC director. However, the CDC web site does not state the acting director's name. The agency's main goal is the protection of public health and safety through the control and prevention of disease, injury, and disability in the US and worldwide. The CDC focuses national attention on developing and applying disease control and prevention. It e ...
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Opportunistic Infection
An opportunistic infection is an infection that occurs most commonly in individuals with an immunodeficiency disorder and acts more severe on those with a weakened immune system. These types of infections are considered serious and can be caused by a variety of pathogens including viruses, bacteria, fungi, and parasites. Under normal conditions, such as in humans with uncompromised immune systems, an opportunistic infection would be less likely to cause significant harm and would typically result in a mild infection or no effect at all. These opportunistic infections can stem from a variety of sources, such as a weakened immune system (caused by human immunodeficiency virus and acquired immunodeficiency syndrome), when being treated with immunosuppressive drugs (as in cancer treatment), when a microbiome is altered (such as a disruption in gut microbiota), or when integumentary barriers are breached (as in penetrating trauma). Opportunistic infections can contribute to antimic ...
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Journal Of Nepal Health Research Council
The ''Journal of Nepal Health Research Council'' is a quarterly peer-reviewed open-access medical journal covering all aspects of medicine, medical education, and public health. It was established in 2003 and is published by the Nepal Health Research Council. The editor-in-chief is Rajeev Shrestha ( Kathmandu University School of Medical Sciences). Abstracting and indexing The journal is abstracted and indexed in the Directory of Open Access Journals, EBSCO databases, Index Medicus/MEDLINE/PubMed, and Scopus Scopus is a scientific abstract and citation database, launched by the academic publisher Elsevier as a competitor to older Web of Science in 2004. The ensuing competition between the two databases has been characterized as "intense" and is c .... References External links *{{Official website, https://jnhrc.com.np/index.php/jnhrc General medical journals Quarterly journals English-language journals Creative Commons Attribution-licensed journals Academic jour ...
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Open Defecation
Open defecation is the human practice of defecating outside ("in the open") rather than into a toilet. People may choose fields, bushes, forests, ditches, streets, canals, or other open spaces for defecation. They do so either because they do not have a toilet readily accessible or due to archaic traditional cultural practices. The practice is common where sanitation infrastructure and services are not available. Even if toilets are available, behavior change efforts may still be needed to promote the use of toilets. 'Open defecation free' (ODF) is a term used to describe communities that have shifted to using toilets instead of open defecation. This can happen, for example, after community-led total sanitation programs have been implemented. Open defecation can pollute the environment and cause health problems and diseases. High levels of open defecation are linked to high child mortality, poor nutrition, poverty, and large disparities between rich and poor. Ending open de ...
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Kathmandu Valley
The Kathmandu Valley (), also known as the Nepal Valley or Nepa Valley (, Newar language, Nepal Bhasa: đ‘Łđ‘Ÿđ‘„đ‘”đ‘‘… 𑐐𑐔𑑅, à€šà„‡à€Șà€Ÿà€ƒ à€—à€Ÿà€ƒ), National Capital Area, is a bowl-shaped valley located in the Himalayas, Himalayan mountains of Nepal. It lies at the crossroads of ancient civilizations of the Indian subcontinent and the broader Asian continent, and has at least 130 important monuments, including several pilgrimage sites for Hindus and Buddhism, Buddhists. The valley holds seven World Heritage Sites within it. The Kathmandu Valley is the most developed and the largest urban agglomeration in Nepal with a population of about 5 million people. The urban agglomeration of Kathmandu Valley includes the cities of Kathmandu, Lalitpur, Nepal, Lalitpur, Bhaktapur, Changunarayan, Budhanilkantha, Tarakeshwar, Gokarneshwar, Suryabinayak Municipality, Suryabinayak, Tokha, Kirtipur, Madhyapur Thimi, and others. The majority of offices and headquarters are locat ...
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Guillain–BarrĂ© Syndrome
Guillain–BarrĂ© syndrome (GBS) is a rapid-onset Paralysis, muscle weakness caused by the immune system damaging the peripheral nervous system. Typically, both sides of the body are involved, and the initial symptoms are changes in sensation or pain often in the back along with muscle weakness, beginning in the feet and hands, often spreading to the arms and upper body. The symptoms may develop over hours to a few weeks. During the acute phase, the disorder can be life-threatening, with about 15% of people developing respiratory system, respiratory muscle weakness requiring mechanical ventilation. Some are affected by dysautonomia, changes in the function of the autonomic nervous system, which can lead to dangerous abnormalities in heart rate and blood pressure. Although the cause is unknown, the underlying mechanism involves an autoimmune disorder in which the body's immune system mistakenly attacks the peripheral nerves and damages their myelin insulation. Sometimes this im ...
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Bell's Palsy
Bell's palsy is a type of facial paralysis that results in a temporary inability to control the facial muscles on the affected side of the face. In most cases, the weakness is temporary and significantly improves over weeks. Symptoms can vary from mild to severe. They may include muscle twitching, weakness, or total loss of the ability to move one or, in rare cases, both sides of the face. Other symptoms include drooping of the eyebrow, a change in taste, and pain around the ear. Typically symptoms come on over 48 hours. Bell's palsy can trigger an increased sensitivity to sound known as hyperacusis. The cause of Bell's palsy is unknown and it can occur at any age. Risk factors include diabetes, a recent upper respiratory tract infection, and pregnancy. It results from a dysfunction of cranial nerve VII (the facial nerve). Many believe that this is due to a viral infection that results in swelling. Diagnosis is based on a person's appearance and ruling out other possible caus ...
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Spore
In biology, a spore is a unit of sexual reproduction, sexual (in fungi) or asexual reproduction that may be adapted for biological dispersal, dispersal and for survival, often for extended periods of time, in unfavourable conditions. Spores form part of the Biological life cycle, life cycles of many plants, algae, fungus, fungi and protozoa. They were thought to have appeared as early as the mid-late Ordovician period as an adaptation of early land plants. Bacterial spores are not part of a sexual cycle, but are resistant structures used for survival under unfavourable conditions. Myxozoan spores release amoeboid infectious germs ("amoebulae") into their hosts for parasitic infection, but also reproduce within the hosts through the pairing of two nuclei within the plasmodium, which develops from the amoebula. In plants, spores are usually haploid and unicellular and are produced by meiosis in the sporangium of a diploid sporophyte. In some rare cases, a diploid spore is also p ...
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Papua New Guinea
Papua New Guinea, officially the Independent State of Papua New Guinea, is an island country in Oceania that comprises the eastern half of the island of New Guinea and offshore islands in Melanesia, a region of the southwestern Pacific Ocean north of Australia. It has Indonesia–Papua New Guinea border, a land border with Indonesia to the west and neighbours Australia to the south and the Solomon Islands to the east. Its capital, on its southern coast, is Port Moresby. The country is the world's third largest list of island countries, island country, with an area of . The nation was split in the 1880s between German New Guinea in the North and the Territory of Papua, British Territory of Papua in the South, the latter of which was ceded to Australia in 1902. All of present-day Papua New Guinea came under Australian control following World War I, with the legally distinct Territory of New Guinea being established out of the former German colony as a League of Nations mandate. T ...
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