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Cyclopia
Cyclopia (named after the Greek mythology characters cyclopes), also known as alobar holoprosencephaly, is the most extreme form of holoprosencephaly and is a congenital disorder (birth defect) characterized by the failure of the embryonic prosencephalon to properly divide the Orbit (anatomy), orbits of the eye into two cavities. Its incidence is 1 in 16,000 in born animals and 1 in 200 in miscarriage, miscarried fetuses. Signs and symptoms Typically, the nose is either missing or not functional. This deformity (called Proboscis (anomaly), proboscis) forms above the center eye and is characteristic of a form of cyclopia called rhinencephaly or rhinocephaly. Most such embryos are either naturally miscarriage, miscarried or are stillbirth, stillborn upon childbirth, delivery. Although cyclopia is rare, several cyclopic human babies are preserved in medical museums (e.g. The University of Amsterdam, Vrolik Museum, Amsterdam, Trivandrum Medical College). Some extreme cases of cycl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Holoprosencephaly
Holoprosencephaly (HPE) is a cephalic disorder in which the prosencephalon (the forebrain of the embryo) fails to Prenatal development, develop into two Cerebral hemisphere, hemispheres, typically occurring between the 18th and 28th day of gestation. Normally, the forebrain is formed and the face begins to develop in the fifth and sixth weeks of human pregnancy. The condition also occurs in other species. Holoprosencephaly is estimated to occur in approximately 1 in every 250 conceptions; most cases are not compatible with life and result in fetal death Uterus, in utero due to deformities to the skull and brain. However, holoprosencephaly is still estimated to occur in approximately 1 in every 8,000 live births. When the embryo's forebrain does not divide to form bilateral cerebral hemispheres (the left and right halves of the brain), it causes Congenital abnormality, defects in the development of the face and in brain structure and function. The severity of holoprosencephaly is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclopes
In Greek mythology and later Roman mythology, the Cyclopes ( ; , ''Kýklōpes'', "Circle-eyes" or "Round-eyes"; singular Cyclops ; , ''Kýklōps'') are giant one-eyed creatures. Three groups of Cyclopes can be distinguished. In Hesiod's ''Theogony'', the Cyclopes are the three brothers, Brontes, Steropes, and Arges (Cyclops), Arges, who made Zeus's weapon, the thunderbolt. In Homer's ''Odyssey'', they are an uncivilized group of shepherds, the brethren of Polyphemus encountered by Odysseus. Cyclopes were also famous for being the builders of the Cyclopean masonry, Cyclopean walls of Mycenae and Tiryns. In ''Cyclops (play), Cyclops'', the fifth-century BC play by Euripides, a satyr play, chorus of satyrs offers comic relief based on the encounter of Odysseus and Polyphemus. The third-century BC poet Callimachus makes the Hesiodic Cyclopes the assistants of smith-god Hephaestus, as does Virgil in the Latin epic ''Aeneid'', where he seems to equate the Hesiodic and Homeric Cyclop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclopamine
Cyclopamine (11-deoxojervine) is a naturally occurring steroidal alkaloid. It is a teratogenic component of corn lily ('' Veratrum californicum''), which when consumed during gestation has been demonstrated to induce birth defects, including the development of a single eye (cyclopia) in offspring. The molecule was named after this effect, which was originally observed by Idaho lamb farmers in 1957 after their herds gave birth to cycloptic lambs. It then took more than a decade to identify corn lily as the culprit. Later work suggested that differing rain patterns had changed grazing behaviours, which led to a greater quantity of corn lily to be ingested by pregnant sheep. Cyclopamine interrupts the sonic hedgehog signalling pathway, instrumental in early development, ultimately causing birth defects. Discovery and naming In 1957, Idaho sheep ranchers contacted the US Department of Agriculture (USDA) after their sheep gave birth to lambs with a fatal singular eye deformity. Aft ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Holoprosencephaly
Holoprosencephaly (HPE) is a cephalic disorder in which the prosencephalon (the forebrain of the embryo) fails to Prenatal development, develop into two Cerebral hemisphere, hemispheres, typically occurring between the 18th and 28th day of gestation. Normally, the forebrain is formed and the face begins to develop in the fifth and sixth weeks of human pregnancy. The condition also occurs in other species. Holoprosencephaly is estimated to occur in approximately 1 in every 250 conceptions; most cases are not compatible with life and result in fetal death Uterus, in utero due to deformities to the skull and brain. However, holoprosencephaly is still estimated to occur in approximately 1 in every 8,000 live births. When the embryo's forebrain does not divide to form bilateral cerebral hemispheres (the left and right halves of the brain), it causes Congenital abnormality, defects in the development of the face and in brain structure and function. The severity of holoprosencephaly is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sonic Hedgehog Protein
Sonic hedgehog protein (SHH) is a major signaling molecule of embryonic development in humans and animals, encoded by the ''SHH'' gene. This signaling molecule is key in regulating embryonic morphogenesis in all animals. SHH controls organogenesis and the organization of the central nervous system, limbs, digits and many other parts of the body. Sonic hedgehog is a morphogen that patterns the developing embryo using a concentration gradient characterized by the French flag model. This model has a non-uniform distribution of SHH molecules which governs different cell fates according to concentration. Mutations in this gene can cause holoprosencephaly, a failure of splitting in the cerebral hemispheres, as demonstrated in an experiment using SHH knock-out mice in which the forebrain midline failed to develop and instead only a single fused telencephalic vesicle resulted. Sonic hedgehog still plays a role in differentiation, proliferation, and maintenance of adult tissues. Abn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proboscis (anomaly)
In teratology, a proboscis is a blind-ended, tube-like structure, commonly located in the middle of the face. It is commonly seen in severe forms of holoprosencephaly that include cyclopia and is usually the result of abnormal development of the nose. Types Proboscis formation is classified in four general types: holoprosencephalic proboscis, lateral nasal proboscis, supernumerary probosci, and disruptive proboscis. Holoprosencephalic proboscis A holoprosencephalic proboscis is found in holoprosencephaly (a condition in which the forebrain of the embryo fails to develop into two hemispheres as it should). In cyclopia or ethmocephaly, proboscis is an abnormally formed nose. In cyclopia Cyclopia (named after the Greek mythology characters cyclopes), also known as alobar holoprosencephaly, is the most extreme form of holoprosencephaly and is a congenital disorder (birth defect) characterized by the failure of the embryonic prosen ..., a single eye in the middle of the face ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Genetics
Medical genetics is the branch of medicine that involves the diagnosis and management of hereditary disorders. Medical genetics differs from human genetics in that human genetics is a field of scientific research that may or may not apply to medicine, while medical genetics refers to the application of genetics to medical care. For example, research on the causes and inheritance of genetic disorders would be considered within both human genetics and medical genetics, while the diagnosis, management, and counselling people with genetic disorders would be considered part of medical genetics. In contrast, the study of typically non-medical phenotypes such as the genetics of eye color would be considered part of human genetics, but not necessarily relevant to medical genetics (except in situations such as albinism). ''Genetic medicine'' is a newer term for medical genetics and incorporates areas such as gene therapy, personalized medicine, and the rapidly emerging new medical specia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Northwestern Europe, off the coast of European mainland, the continental mainland. It comprises England, Scotland, Wales and Northern Ireland. The UK includes the island of Great Britain, the north-eastern part of the island of Ireland, and most of List of islands of the United Kingdom, the smaller islands within the British Isles, covering . Northern Ireland shares Republic of Ireland–United Kingdom border, a land border with the Republic of Ireland; otherwise, the UK is surrounded by the Atlantic Ocean, the North Sea, the English Channel, the Celtic Sea and the Irish Sea. It maintains sovereignty over the British Overseas Territories, which are located across various oceans and seas globally. The UK had an estimated population of over 68.2 million people in 2023. The capital and largest city of both England and the UK is London. The cities o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Olfactory Bulb
The olfactory bulb (Latin: ''bulbus olfactorius'') is a neural structure of the vertebrate forebrain involved in olfaction, the sense of smell. It sends olfactory information to be further processed in the amygdala, the orbitofrontal cortex (OFC) and the hippocampus where it plays a role in emotion, memory and learning. The bulb is divided into two distinct structures: the main olfactory bulb and the accessory olfactory bulb. The main olfactory bulb connects to the amygdala via the piriform cortex of the primary olfactory cortex and directly projects from the main olfactory bulb to specific amygdala areas. The accessory olfactory bulb resides on the dorsal-posterior region of the main olfactory bulb and forms a parallel pathway. Destruction of the olfactory bulb results in ipsilateral anosmia, while irritative lesions of the uncus can result in olfactory and gustatory hallucinations. Structure In most vertebrates, the olfactory bulb is the most rostral (forward) part ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mercure De France
The () was originally a French gazette and literary magazine first published in the 17th century, but after several incarnations has evolved as a publisher, and is now part of the Éditions Gallimard publishing group. The gazette was published from 1672 to 1724 (with an interruption in 1674–1677) under the title (sometimes spelled ; 1672–1674) and (1677–1724). The title was changed to in 1724. The gazette was briefly suppressed (under Napoleon) from 1811 to 1815 and ceased publication in 1825. The name was revived in 1890 for both a literary review and (in 1894) a publishing house initially linked with the symbolist movement. Since 1995 has been part of the Éditions Gallimard publishing group. The original ''Mercure galant'' and ''Mercure de France'' The ''Mercure galant'' was founded by the writer Jean Donneau de Visé in 1672. He directed the publication until his death in 1710. The name refers to the god Mercury, the messenger of the gods; the title al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Colt (horse)
A colt is a young male horse, usually below the age of four years. Description The term "colt" only describes young male horses and is not to be confused with foal, which is a horse of either sex less than one year of age. Similarly, a yearling is a horse of either sex between the ages of one and two. A young female horse is called a filly, and a mare once she is an adult animal. In horse racing, particularly for Thoroughbreds in the United Kingdom, a colt is defined as an uncastrated male from the age of two up to and including the age of four. The term is derived from Proto-Germanic *''kultaz'' ("lump, bundle, offspring") and is etymologically related to "child." An adult male horse, if left intact, is called either a " stallion" if used for breeding, or a horse (sometimes full horse); if castrated, it is called a gelding. In some cases, particularly informal nomenclature, a gelding under four years is still called a colt. A rig or ridgling is a male equine with a reta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
