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Cocaine Hydrochloride
Cocaine is a tropane alkaloid and central nervous system stimulant, derived primarily from the leaves of two South American coca plants, ''Erythroxylum coca'' and '' E. novogranatense'', which are cultivated almost exclusively in the Andes. Indigenous South Americans have traditionally used coca leaves for over a thousand years. Notably, there is no evidence that habitual coca leaf use causes addiction or withdrawal, unlike cocaine. Medically, cocaine is rarely employed, mainly as a topical medication under controlled settings, due to its high abuse potential, adverse effects, and expensive cost. Despite this, recreational use is widespread, driven by its euphoric and aphrodisiac properties. Levamisole induced necrosis syndrome (LINES)-a complication of the common cocaine cutting agent levamisole-and prenatal cocaine exposure is particularly harmful. Street cocaine is typically snorted, injected, or smoked as crack cocaine, with effects beginning within seconds to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tusi (drug)
Tusi (also written as tussi, tuci, or tucibi) is a Recreational drug use, recreational drug that contains a Combination drug, mixture of different Psychoactive drug, psychoactive substances, most commonly found in a pink-dyed powder known as pink cocaine. It is believed to have originated in Latin America, specifically Colombia around 2018. Ketamine and MDMA are the most common ingredients, although cocaine, methamphetamine, oxycodone, caffeine, cathinones, and other designer drugs are found as well. There are no standard proportions of the constituent drugs. The inclusion of pink colorants is an element that seeks to attract consumers, especially young people, by offering a striking visual aspect that resembles something "attractive" or "festive." Though the name "tusi" is phonetically similar to "2C", tusi is not the same psychoactive substance as 2C-B or more broadly, the 2C (psychedelics), 2C family. Tusi, according to the United Nations Office on Drugs and Crime, UN Offic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cocaethylene
Cocaethylene (ethylbenzoylecgonine) is the ethyl ester of benzoylecgonine. It is structurally similar to cocaine, which is the methyl ester of benzoylecgonine. Cocaethylene is formed by the liver in small amounts when cocaine and ethanol coexist in the blood. In 1885, cocaethylene was first synthesized (according to edition 13 of the ''Merck Index''), and in 1979, cocaethylene's side effects were discovered. Metabolic production from cocaine Cocaethylene is the byproduct of concurrent consumption of alcohol and cocaine as metabolized by the liver. Normally, metabolism of cocaine produces two primarily biologically inactive metabolites— benzoylecgonine and ecgonine methyl ester. The hepatic enzyme carboxylesterase is an important part of cocaine's metabolism because it acts as a catalyst for the hydrolysis of cocaine in the liver, which produces these inactive metabolites. If ethanol is present during the metabolism of cocaine, a portion of the cocaine undergoes transes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Euphoric
Euphoria ( ) is the experience (or affect) of pleasure or excitement and intense feelings of well-being and happiness. Certain natural rewards and social activities, such as aerobic exercise, laughter, listening to or making music and dancing, can induce a state of euphoria. Euphoria is also a symptom of certain neurological or neuropsychiatric disorders, such as mania. Romantic love and components of the human sexual response cycle are also associated with the induction of euphoria. Certain drugs, many of which are addictive, can cause euphoria, which at least partially motivates their recreational use. Hedonic hotspots – i.e., the pleasure centers of the brain – are functionally linked. Activation of one hotspot results in the recruitment of the others. Inhibition of one hotspot results in the blunting of the effects of activating another hotspot. Therefore, the simultaneous activation of every hedonic hotspot within the reward system is believed to be ne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Recreational Drug Use
Recreational drug use is the use of one or more psychoactive drugs to induce an altered state of consciousness, either for pleasure or for some other casual purpose or pastime. When a psychoactive drug enters the user's body, it induces an Substance intoxication, intoxicating effect. Recreational drugs are commonly divided into three categories: depressants (drugs that induce a feeling of relaxation and calmness), stimulants (drugs that induce a sense of energy and alertness), and hallucinogens (drugs that induce perceptual distortions such as hallucination). In popular practice, recreational drug use is generally tolerated as a social behaviour, rather than perceived as the medical condition of self-medication. However, drug use and drug addiction are Social stigma, severely stigmatized everywhere in the world. Many people also use prescribed and controlled depressants such as opioids, opiates, and benzodiazepines. What controlled substances are considered generally unlawful t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Topical Medication
A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surface area, body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including Cream (pharmaceutical), creams, foams, gels, lotions, and ointments. Many topical medications are epicutaneous, meaning that they are applied directly to the skin. Topical medications may also be insufflation (medicine), inhalational, such as asthma medications, or applied to the surface of tissues other than the skin, such as eye drops applied to the conjunctiva, or ear drops placed in the ear, or medications applied to the surface of a Human tooth, tooth. The word ''topical'' derives from Ancient Greek, Greek wikt:τοπικός, τοπικός ''topikos'', "of a place". Justification Topical drug delivery is a route of administering drugs via the Human skin, skin to provide topical therapeutic effects. As sk ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indigenous Peoples Of South America
In South America, Indigenous peoples comprise the Pre-Columbian peoples and their descendants, as contrasted with people of European ancestry and those of African descent. In Spanish, Indigenous peoples are referred to as (), or (). The term () is used in Argentina, and () is commonly used in Colombia. The English term ''Amerindian'' (short for "Indians of the Americas") is often used in the Guianas. Latin Americans of mixed European and Indigenous descent are usually referred to as (Spanish) and (Portuguese), while those of mixed African and Indigenous ancestry are referred to as . It is believed that the first human populations of South America either arrived from Asia into North America via the Bering Land Bridge and migrated southwards or alternatively from Polynesia across the Pacific. The earliest generally accepted archaeological evidence for human habitation in South America dates to 14,000 years ago, and is located at the Monte Verde site in southern Chile. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Andes
The Andes ( ), Andes Mountains or Andean Mountain Range (; ) are the List of longest mountain chains on Earth, longest continental mountain range in the world, forming a continuous highland along the western edge of South America. The range is long and wide (widest between 18th parallel south, 18°S and 20th parallel south, 20°S latitude) and has an average height of about . The Andes extend from south to north through seven South American countries: Argentina, Chile, Bolivia, Peru, Ecuador, Colombia, and Venezuela. Along their length, the Andes are split into several ranges, separated by intermediate depression (geology), depressions. The Andes are the location of several high plateaus—some of which host major cities such as Quito, Bogotá, Cali, Arequipa, Medellín, Bucaramanga, Sucre, Mérida, Mérida, Mérida, El Alto, and La Paz. The Altiplano, Altiplano Plateau is the world's second highest after the Tibetan Plateau. These ranges are in turn grouped into three majo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erythroxylum Novogranatense
''Erythroxylum novogranatense'' is a neotropical species of ''Erythroxylum'' ( Erythroxylaceae). Cocaine is produced from the leaves. Name "Novogranatense" is derived from Latin: ''novo'' (new) and ''granatense'' (Granada). It was named by William Turner Thiselton-Dyer, the third director of Royal Botanic Gardens, Kew, because its country of origin was the Spanish colonial Viceroyalty of New Granada—present day Colombia. Subspecies ''Erythroxylum novogranatense'' contains 2 subspecies: *''Erythroxylum novogranatense'' var. ''novogranatense'' (D.Morris) Hieron *''Erythroxylum novogranatense'' var. ''truxillense'' (Rusby) Plowman These two subspecies are phenotypically similar, but morphologically distinguishable. Taxonomy Among the genus ''Erythroxylum'', cocaine-rich leaves are obtained from 4 taxa: *'' Erythroxylum coca'' var. ''coca'' *''Erythroxylum coca'' var. '' ipadu'' *''Erythroxylum novogranatense'' var. ''novogranatense'' *''Erythroxylum novogranatense'' var. ''t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erythroxylum Coca
''Erythroxylum coca'' is one of two species of cultivated coca. Description The coca plant resembles a blackthorn bush, and grows to a height of . The branches are straight, and the leaves, which have a green tint, are thin, opaque, oval, and taper at the extremities. A marked characteristic of the leaf is an areolated portion bounded by two longitudinal curved lines, one line on each side of the midrib, and more conspicuous on the underside of the leaf. Coca plants are mainly found in Colombia. The flowers are small, and disposed in little clusters on short stalks; the corolla is composed of five yellowish-white petals, the anthers are heart-shaped, and the pistil consists of three carpels united to form a three-chambered ovary. The flowers mature into red berries. Unlike ''Erythroxylum novogranatense'', ''Erythroxylum coca'' requires very acidic soil conditions. Soil acidity and water acidity need to be below pH 5.5, with the optimal value being pH 3.5, similar to that of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coca
Coca is any of the four cultivated plants in the family Erythroxylaceae, native to western South America. Coca is known worldwide for its psychoactive alkaloid, cocaine. Coca leaves contain cocaine which acts as a mild stimulant when chewed or consumed as tea, with slower absorption than purified cocaine and no evidence of addiction or withdrawal symptoms from natural use. The coca plant is a shrub-like bush with curved branches, oval leaves featuring distinct curved lines, small yellowish-white flowers that develop into red berries. Genomic analysis reveals that coca, a culturally and economically important plant, was domesticated two or three separate times from the wild species ''Erythroxylum gracilipes'' by different South American groups during the Holocene. Chewing coca in South America began at least 8,000 years ago, as evidenced by coca leaves and calcite found in house floors in Peru’s Nanchoc Valley, suggesting early communal use alongside the rise of farming. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stimulant
Stimulants (also known as central nervous system stimulants, or psychostimulants, or colloquially as uppers) are a class of drugs that increase alertness. They are used for various purposes, such as enhancing attention, motivation, cognition, Mood disorder, mood, and physical activity, physical performance. Some stimulants occur naturally, while others are exclusively synthetic. Common stimulants include caffeine, nicotine, amphetamines, cocaine, methylphenidate, and modafinil. Stimulants may be subject to varying forms of regulation, or outright prohibition, depending on jurisdiction. Stimulants increase activity in the sympathetic nervous system, either directly or indirectly. Prototypical stimulants increase synaptic concentrations of neurotransmitter, excitatory neurotransmitters, particularly norepinephrine and dopamine (e.g., methylphenidate). Other stimulants work by binding to the Receptor (biochemistry), receptors of excitatory neurotransmitters (e.g., nicotine) or by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tropane Alkaloid
Tropane alkaloids are a class of bicyclic .2.1alkaloids and secondary metabolites that contain a tropane ring in their chemical structure. Tropane alkaloids occur naturally in many members of the plant family Solanaceae. Certain tropane alkaloids such as cocaine and scopolamine are notorious for their psychoactive effects, related usage and cultural associations. Particular tropane alkaloids such as these have pharmacological properties and can act as anticholinergics or stimulants. Classification Anticholinergics Anticholinergic drugs and deliriants: * Atropine, racemic hyoscyamine, from the deadly nightshade (''Atropa belladonna'') * Hyoscyamine, the ''levo''-isomer of atropine, from henbane (''Hyoscyamus niger''), mandrake ('' Mandragora officinarum'') and the sorcerers' tree ('' Latua pubiflora''). * Scopolamine, from henbane and ''Datura'' species (Jimson weed) All three acetylcholine-inhibiting chemicals can also be found in the leaves, stems, and flowers in varyi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
