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Clinical Efficacy
Efficacy is the ability to perform a task to a satisfactory or expected degree. The word comes from the same roots as ''effectiveness'', and it has often been used synonymously, although in pharmacology a pragmatic clinical trial#Efficacy versus effectiveness, distinction is now often made between efficacy and effectiveness. The word ''efficacy'' is used in pharmacology and medicine to refer both to the maximum response achievable from a pharmaceutical drug in research settings, and to the capacity for sufficient therapeutic effect or beneficial change in clinical settings. Pharmacology In pharmacology, efficacy () is the maximum response achievable from an applied or dosed agent, for instance, a small molecule drug. Intrinsic activity is a relative term for a drug's efficacy relative to a drug with the highest observed efficacy. It is a purely descriptive term that has little or no mechanistic interpretation. In order for a drug to have an effect, it needs to bind to its t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmacology
Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties, functions, sources, synthesis and drug design, molecular and cellular mechanisms, organ/systems mechanisms, signal transduction/cellular communication, molecular diagnostics, interactions, chemical biology, therapy, and medical applications and antipathogenic capabilities. The two main areas of pharmacology are pharmacodynamics and pharmacokinetics. Pharmacodynamics studies the effects of a drug on biological systems, and pharmacokinetics studies the effects of biological systems on a drug. In broad terms, pharmacod ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lutheran
Lutheranism is a major branch of Protestantism that emerged under the work of Martin Luther, the 16th-century German friar and Protestant Reformers, reformer whose efforts to reform the theology and practices of the Catholic Church launched the Reformation in 1517. The Lutheran Churches adhere to the Bible and the Ecumenical Creeds, with Lutheran doctrine being explicated in the Book of Concord. Lutherans hold themselves to be in continuity with the apostolic church and affirm the writings of the Church Fathers and the first four ecumenical councils. The schism between Roman Catholicism and Lutheranism, which was formalized in the Diet of Worms, Edict of Worms of 1521, centered around two points: the proper source of s:Augsburg Confession#Article XXVIII: Of Ecclesiastical Power., authority in the church, often called the formal principle of the Reformation, and the doctrine of s:Augsburg Confession#Article IV: Of Justification., justification, the material principle of Luther ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Efficiency (other)
Efficiency is the extent to which time or effort is well used for the intended task or purpose. Efficiency may also refer to: * Efficiency (aerodynamics), the amount of lift divided by the aerodynamic drag * Efficiency (apartment), a one-room apartment * Efficiency (basketball), a statistical benchmark to compare the overall value of players * Efficiency (computer science), related to the amount of computational resources used by the algorithm * Efficiency (economics), a situation in which nothing can be improved without something else being hurt ** Efficiency (fair division), any changes made to assist one person would harm another * Efficiency (finance), non-mean-variance portfolio analysis, a way of showing that a portfolio is not efficient * Efficiency (mechanical) * Efficiency (network science), a measure of how efficiently a network exchanges information * Efficiency (statistics), a measure of quality of an estimator, experiment, or test * Energy efficiency (physics), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Average Treatment Effect
The average treatment effect (ATE) is a measure used to compare treatments (or interventions) in randomized experiments, evaluation of policy interventions, and medical trials. The ATE measures the difference in mean (average) outcomes between units assigned to the treatment and units assigned to the control. In a randomized trial (i.e., an experimental study), the average treatment effect can be estimated from a sample using a comparison in mean outcomes for treated and untreated units. However, the ATE is generally understood as a causal parameter (i.e., an estimate or property of a population) that a researcher desires to know, defined without reference to the study design or estimation procedure. Both observational studies and experimental study designs with random assignment may enable one to estimate an ATE in a variety of ways. The average treatment effect is under some conditions directly related to the partial dependence plot. General definition Originating from e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Law And Gospel
Law is a set of rules that are created and are enforceable by social or governmental institutions to regulate behavior, with its precise definition a matter of longstanding debate. It has been variously described as a science and as the art of justice. State-enforced laws can be made by a legislature, resulting in statutes; by the executive through decrees and regulations; or by judges' decisions, which form precedent in common law jurisdictions. An autocrat may exercise those functions within their realm. The creation of laws themselves may be influenced by a constitution, written or tacit, and the rights encoded therein. The law shapes politics, economics, history and society in various ways and also serves as a mediator of relations between people. Legal systems vary between jurisdictions, with their differences analysed in comparative law. In civil law jurisdictions, a legislature or other central body codifies and consolidates the law. In common law systems, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Good News (Christianity)
The gospel or good news is a theological concept in several religions. In the historical Roman imperial cult and today in Christianity, the gospel is a message about salvation by a divine figure, a savior, who has brought peace or other benefits to humankind. In Ancient Greek religion, the word designated a type of sacrifice or ritual dedication intended to thank the gods upon receiving good news. The religious concept is found at least as far back as Greece's Classical Greece, Classical era and Roman authors are known to have adopted it toward the end of the 1st century BCE. It is a central message of Christianity today, in which written accounts of the life and teaching of Jesus in Christianity, Jesus Christ are known as Gospels. Etymology ''Gospel'' () is the Old English translation of Koine Greek, Greek , meaning "good news". This may be seen from analysis of ( + + diminutive suffix). The Greek term was Latinisation (literature), Latinized as in the Vulgate, and translat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Original Sin
Original sin () in Christian theology refers to the condition of sinfulness that all humans share, which is inherited from Adam and Eve due to the Fall of man, Fall, involving the loss of original righteousness and the distortion of the Image of God. The biblical basis for the belief is generally found in Fall of man#Genesis 3, Genesis 3 (the story of the expulsion of Adam and Eve from the Garden of Eden), and in texts such as ("I was brought forth in iniquity, and in sin did my mother conceive me") and ("Therefore, just as sin entered the world through one man, and death through sin, and in this way death came to all people, because all sinned"). The specific doctrine of original sin was developed in the 2nd century struggle against Gnosticism by Irenaeus of Lyons, and was shaped significantly by Augustine of Hippo (354–430 AD), who was the first author to use the phrase "original sin". Influenced by Augustine, the Councils of Carthage (411–418 AD) and Council of Orange ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Irresistible Grace
Irresistible grace (also called effectual grace, effectual calling, or efficacious grace) is a doctrine in Christian theology particularly associated with Calvinism, which teaches that the saving grace of God is effectually applied to those whom he has determined to save (the elect) and, in God's timing, overcomes their resistance to obeying the call of the gospel, bringing them to faith in Christ. It is to be distinguished from prevenient grace, particularly associated with Arminianism, which teaches that the offer of salvation through grace does not act irresistibly in a purely cause-effect, deterministic method, but rather in an influence-and-response fashion that can be both freely accepted and freely denied. The doctrine Some claim that fourth-century Church Father Augustine of Hippo taught that God grants those whom he chooses for salvation the gift of persevering grace, and that they could not conceivably fall away. This doctrine gave rise to the doctrine of irresist ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Formula Of Concord
Formula of Concord (1577) (; ; also the "''Bergic Book''" or the "''Bergen Book''") is an authoritative Lutheran statement of faith (called a confession, creed, or "symbol") that, in its two parts (''Epitome'' and ''Solid Declaration''), makes up the final section of the Lutheran ''Corpus Doctrinae'' or Body of Doctrine, known as the Book of Concord (most references to these texts are to the original edition of 1580). The ''Epitome'' is a brief and concise presentation of the ''Formula's'' twelve articles; the ''Solid Declaration'' a detailed exposition. Approved doctrine is presented in "theses"; rejected doctrine in "antitheses." As the original document was written in German, a Latin translation was prepared for the Latin edition of the Book of Concord published in 1584. Significance and composition The promulgation and subscription of this document was a major factor in the unification and preservation of Lutheranism. It was instigated at the behest of the Elector Augu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Means Of Grace
The means of grace in Christian theology are those things (the ''means'') through which God gives grace. Just what this grace entails is interpreted in various ways: generally speaking, some see it as God blessing humankind so as to sustain and empower the Christian life; others see it as forgiveness, life, and salvation. Catholic theology According to the Catholic Church, the means of grace that Christ entrusted to the Church are many.Catholic Bishops' Conferences of England & Wales, Ireland and Scotland, ''One Bread One Body'' , p. 7 They include the entirety of revealed truth, the and the hierarchical ministry. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Smalcald Articles
The Smalcald Articles or Schmalkald Articles () are a summary of Lutheran doctrine, written by Martin Luther in 1537 for a meeting of the Schmalkaldic League in preparation for an intended ecumenical Council of the Church. History The Schmalkaldic League was organized in 1531 as a union of various Lutheran territories and cities, to provide a united military and political front against Roman Catholic politicians and armies, led by Emperor Charles V. Luther's patron, Elector John Frederick of Saxony, asked him to prepare these articles for League's meeting in 1537, held in Schmalkalden. When the Schmalkaldic League met, Luther was taken very ill with a severe case of kidney stones and so was unable to attend the meeting. The league ultimately decided not to adopt the articles Luther had written. They were influenced in this by Philipp Melanchthon, who was concerned that Luther's writing would be regarded as divisive by some. Melanchthon was asked to write a clear statement on the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Faith In Christianity
Faith in Christianity is often discussed in terms of believing God in Christianity, God's promises, trusting in his faithfulness, and relying on God's character and faithfulness to act. Some denominations believe in the New Covenant and in the doctrine of Salvation in Christianity, salvation by justification by faith, faith alone (). According to most Christian traditions and denominations, Christian faith requires a belief in the resurrection of Jesus, and the Agony in the Garden which Jesus states is the plan of God the Father. Since the Protestant Reformation of the 16th century, the meaning of the term ''faith'' has been an object of major Christian theology, theological disagreement in Western Christianity. The differences have been largely overcome in the Joint Declaration on the Doctrine of Justification (1999). The precise understanding of the term "faith" differs among the Christian denomination, various Christian traditions. Despite these differences, Christians generally ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
