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Bronchopulmonary Dysplasia
Bronchopulmonary dysplasia (BPD; part of the spectrum of chronic lung disease of infancy) is a chronic lung disease which affects premature infants. Premature (preterm) infants who require treatment with supplemental oxygen or require long-term oxygen are at a higher risk. The alveoli that are present tend to not be mature enough to function normally. It is also more common in infants with low birth weight (LBW) and those who receive prolonged mechanical ventilation to treat respiratory distress syndrome. It results in significant morbidity and mortality. The definition of bronchopulmonary dysplasia has continued to evolve primarily due to changes in the population, such as more survivors at earlier gestational ages, and improved neonatal management including surfactant, antenatal glucocorticoid therapy, and less aggressive mechanical ventilation. Currently the description of bronchopulmonary dysplasia includes the grading of its severity into mild, moderate and severe. This corr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lung
The lungs are the primary Organ (biology), organs of the respiratory system in many animals, including humans. In mammals and most other tetrapods, two lungs are located near the Vertebral column, backbone on either side of the heart. Their function in the respiratory system is to extract oxygen from the atmosphere and transfer it into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere, in a process of gas exchange. Respiration is driven by different muscular systems in different species. Mammals, reptiles and birds use their musculoskeletal systems to support and foster breathing. In early tetrapods, air was driven into the lungs by the pharyngeal muscles via buccal pumping, a mechanism still seen in amphibians. In humans, the primary muscle that drives breathing is the Thoracic diaphragm, diaphragm. The lungs also provide airflow that makes Animal communication#Auditory, vocalisation including speech possible. Humans have two lungs, a ri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chest X-ray
A chest radiograph, chest X-ray (CXR), or chest film is a Projectional radiography, projection radiograph of the chest used to diagnose conditions affecting the chest, its contents, and nearby structures. Chest radiographs are the most common film taken in medicine. Like all methods of radiography, chest radiography employs ionizing radiation in the form of X-rays to generate images of the chest. The mean radiation dose to an adult from a chest radiograph is around 0.02 Sievert, mSv (2 Roentgen equivalent man, mrem) for a front view (PA, or posteroanterior) and 0.08 mSv (8 mrem) for a side view (LL, or latero-lateral). Together, this corresponds to a background radiation equivalent time of about 10 days. Medical uses Conditions commonly identified by chest radiography * Pneumonia * Pneumothorax * Interstitial lung disease * Heart failure * Fracture (bone), Bone fracture * Hiatal hernia * Pulmonary tuberculosis Chest radiographs are used to diagnose many conditions involving th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypocapnia
Hypocapnia (from the Greek words meaning ''below normal'' and ''kapnós'' meaning ''smoke''), also known as hypocarbia, sometimes incorrectly called acapnia, is a state of reduced carbon dioxide in the blood. Hypocapnia usually results from deep or rapid breathing, known as hyperventilation. Hypocapnia is the opposite of hypercapnia. Short term hypocapnia does not usually have any adverse effects. It is sometimes used as lifesaving treatment for conditions such as neonatal pulmonary-artery hypertension and for people with severe intracranial hypertension. If the state of hypocapnia persists or is prolonged, adverse outcomes may occur. Effects Even when marked, hypocapnia is normally well tolerated. Symptoms include tingling sensation (usually in the limbs), abnormal heartbeat, painful muscle cramps, and seizures. Acute hypocapnia causes hypocapnic alkalosis, which causes cerebral vasoconstriction leading to cerebral hypoxia, and this can cause transient dizziness, fainting, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypercarbia
Hypercapnia (from the Greek ''hyper'', "above" or "too much" and ''kapnos'', "smoke"), also known as hypercarbia and CO2 retention, is a condition of abnormally elevated carbon dioxide (CO2) levels in the blood. Carbon dioxide is a gaseous product of the body's metabolism and is normally expelled through the lungs. Carbon dioxide may accumulate in any condition that causes hypoventilation, a reduction of alveolar ventilation (the clearance of air from the small sacs of the lung where gas exchange takes place) as well as resulting from inhalation of CO2. Inability of the lungs to clear carbon dioxide, or inhalation of elevated levels of CO2, leads to respiratory acidosis. Eventually the body compensates for the raised acidity by retaining alkali in the kidneys, a process known as "metabolic compensation". Acute hypercapnia is called acute hypercapnic respiratory failure (AHRF) and is a medical emergency as it generally occurs in the context of acute illness. Chronic hypercapnia, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxygen Therapy
Oxygen therapy, also referred to as supplemental oxygen, is the use of oxygen as medical treatment. Supplemental oxygen can also refer to the use of oxygen enriched air at altitude. Acute indications for therapy include hypoxemia (low blood oxygen levels), carbon monoxide toxicity and cluster headache. It may also be prophylactically given to maintain blood oxygen levels during the induction of anesthesia. Oxygen therapy is often useful in chronic hypoxemia caused by conditions such as severe COPD or cystic fibrosis. Oxygen can be delivered via nasal cannula, face mask, or endotracheal intubation at normal atmospheric pressure, or in a hyperbaric chamber. It can also be given through bypassing the airway, such as in ECMO therapy. Oxygen is required for normal cellular metabolism. However, excessively high concentrations can result in oxygen toxicity, leading to lung damage and respiratory failure. Higher oxygen concentrations can also increase the risk of airway fire ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Signal Transduction And Targeted Therapy
''Signal Transduction and Targeted Therapy'' is a multidisciplinary peer-reviewed open access scientific journal covering biomedical research with a particular focus on signal transduction and its application to the drug development process. It was established in 2016 and is published by Nature Research. The editors-in-chief are Carlo M. Croce (Ohio State University), Kang Zhang (Macau University of Science and Technology), and Yu-Quan Wei (West China Medical Center). According to the ''Journal Citation Reports'', the journal has a 2023 impact factor of 40.8. Abstract & Indexing * Science Citation Index Expanded * BIOSIS * Open Access Journals (DOAJ) * MEDLINE * PubMed Central (PMC) * Scopus Sponsoring The Journal is sponsored by West China Medical Center The West China Medical Center, Sichuan University ( zh, s=四川大学华西医学中心, labels=no), formerly the West China University of Medical Sciences ( zh, s=华西医科大学, first=t, labels=no), is the medical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pediatric Pulmonology
''Pediatric Pulmonology'' is a monthly peer-reviewed medical journal covering pediatric pulmonology. It was established in 1985; the editor-in-chief is Susanna McColley, MD. According to the ''Journal Citation Reports'', the journal has a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a type of journal ranking. Journals with higher impact factor values are considered more prestigious or important within their field. The Impact Factor of a journa ... of 3.039, ranking it 36th out of 129 journals in the category "Pediatrics" and 36th out of 64 in the category "Respiratory System". References External links * Pediatrics journals Pulmonology journals Wiley (publisher) academic journals Academic journals established in 1985 Monthly journals English-language journals {{pulmonology-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beta-catenin
Catenin beta-1, also known as β-catenin (''beta''-catenin), is a protein that in humans is encoded by the ''CTNNB1'' gene. β-Catenin is a dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the ''CTNNB1'' gene. In ''Drosophila'', the homologous protein is called ''armadillo''. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to Plakoglobin, γ-catenin, also known as plakoglobin. β-Catenin is widely expressed in many tissues. In cardiac muscle, β-catenin localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocytes. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal cance ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wnt Signaling Pathway
In cellular biology, the Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt, pronounced "wint", is a portmanteau created from the names Wingless and Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans. Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the Dishevelled protein inside the cell. The canonical Wnt pathway leads to regulation of gene transcription, and is thought to be negatively regulated in part ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Reviews Disease Primers
''Nature Reviews Disease Primers'' is a peer-reviewed medical journal published by Nature Portfolio. It was established in 2015. The editor-in-chief is Clemens Thoma. The journal publishes broad review articles about disease areas, offering a global overview of the field and outlining "key open research questions". Each "Primer" is accompanied by a "PrimeView" summary poster containing accessible artwork and highlighting key points from the review. The journal's five-year anniversary was celebrated in April 2020, and noted that 225 primers had been published on medical topics. Abstracting and indexing The journal is abstracted and indexed in Index Medicus/MEDLINE/PubMed. According to the ''Journal Citation Reports'', the journal has a 2022 impact factor of 81.5. References External links * General medical journals Nature Research academic journals Academic journals established in 2015 Review journals English-language journals Continuous journals {{General-medical-journ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acini
An acinus (; : acini; adjective, acinar or acinous) refers to any cluster of cells that resembles a many-lobed "berry", such as a raspberry (''acinus'' is Latin for "berry"). The berry-shaped termination of an exocrine gland, where the secretion is produced, is acinar in form, as is the alveolar sac containing multiple alveoli in the lungs. Exocrine glands Acinar exocrine glands are found in many organs, including: * the stomach * the sebaceous gland of the scalp * the salivary glands of the tongue * the liver * the lacrimal glands * the mammary glands * the pancreas * the bulbourethral (Cowper's) glands The thyroid follicles can also be considered of acinar formation but in this case the follicles, being part of an ''endocrine'' gland, act as a hormonal deposit rather than to facilitate secretion. Mucous acini usually stain pale, while serous acini usually stain dark. Lungs The end of the terminal bronchioles in the lungs mark the beginning of a pulmonary acinus that in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
High Frequency Ventilation
Modes of mechanical ventilation are one of the most important aspects of the usage of mechanical ventilation. The mode refers to the method of inspiratory support. In general, mode selection is based on clinician familiarity and institutional preferences, since there is a paucity of evidence indicating that the mode affects clinical outcome. The most frequently used forms of volume-limited mechanical ventilation are intermittent mandatory ventilation (IMV) and continuous mandatory ventilation (CMV). Terminology There have been substantial changes in the nomenclature of mechanical ventilation over the years, but more recently it has become standardized by many respirology and pulmonology groups. Writing a mode is most proper in all capital letters with a dash between the control variable and the strategy (i.e. PC-IMV, or VC-MMV etc.). Taxonomy for mechanical ventilation The taxonomy is a logical classification system based on 10 maxims of ventilator design: 10 maxims ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
