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Bopindolol
Bopindolol (INN) is a beta blocker. It is an ester which acts as a prodrug for its active metabolite 4-(3-''t''-butylamino-2-hydroxypropoxy)-2-methylindole. Synthesis The reaction of 4-Hydroxy-2-methylindole 5320-67-3(1) with epichlorohydrin in the presence of lye led to 2-methyl-4-(oxiran-2-ylmethoxy)-1H-indole 2119-47-5(2). Addition of tert-butylamine led to 4-(2-Hydroxy-3-tert-butylaminopropoxy)-2-methylindole 3869-98-9(3). Ester formation with benzoic anhydride 3-97-0(4) in the presence of hexamethylphosphoric acid triamide 80-31-9completed the synthesis of Bopindolol (5). See also * Pindolol Pindolol, sold under the brand name Visken among others, is a non-selective beta blocker which is used in the treatment of hypertension.Drugs.coInternational brand names for pindolol Page accessed Sept 4, 2015 It is also an antagonist of the se ... * mepindolol References Beta blockers Prodrugs Benzoate esters N-tert-butyl-phenoxypropanolamines Indole ethers at the benze ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
Bopindolol Synthesis
Bopindolol (International Nonproprietary Name, INN) is a beta blocker. It is an ester which acts as a prodrug for its active metabolite 4-(3-''t''-butylamino-2-hydroxypropoxy)-2-methylindole. Synthesis The reaction of 4-Hydroxy-2-methylindole [35320-67-3] (1) with epichlorohydrin in the presence of lye led to 2-methyl-4-(oxiran-2-ylmethoxy)-1H-indole [62119-47-5] (2). Addition of tert-butylamine led to 4-(2-Hydroxy-3-tert-butylaminopropoxy)-2-methylindole [23869-98-9] (3). Ester formation with benzoic anhydride [93-97-0] (4) in the presence of hexamethylphosphoric acid triamide [680-31-9] completed the synthesis of Bopindolol (5). See also * Pindolol *mepindolol References Beta blockers Prodrugs Benzoate esters N-tert-butyl-phenoxypropanolamines Indole ethers at the benzene ring {{cardiovascular-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
