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Bioamplifier
A Bioamplifier is an electrophysiological device, a variation of the instrumentation amplifier, used to gather and increase the signal integrity of physiologic electrical activity for output to various sources. It may be an independent unit, or integrated into the electrodes. History Efforts to amplify biosignals started with the development of electrocardiography. In 1887, Augustus Waller, a British physiologist, successfully measured the electrocardiograph of his dog using two buckets of saline, in which he submerged each of the front and the hind paws.Webster, John G. (2006) Encyclopedia of Medical Devices and Instrumentation Volume I. New Jersey: Wiley-Interscience. . A few months later, Waller successfully recorded the first human electrocardiography using the capillary electrometer. However, at the time of invention, Waller did not envision that electrocardiography would be used extensively in healthcare. The electrocardiograph was impractical to use until Willem Einthove ...
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Instrumentation Amplifier
An instrumentation amplifier (sometimes shorthanded as in-amp or InAmp) is a type of differential amplifier that has been outfitted with input buffer amplifiers, which eliminate the need for input impedance matching and thus make the amplifier particularly suitable for use in measurement and test equipment. Additional characteristics include very low DC offset, low drift, low noise, very high open-loop gain, very high common-mode rejection ratio, and very high input impedances. Instrumentation amplifiers are used where great accuracy and stability of the circuit both short- and long-term are required. Although the instrumentation amplifier is usually shown schematically identical to a standard operational amplifier (op-amp), the electronic instrumentation amplifier is almost always internally composed of 3 op-amps. These are arranged so that there is one op-amp to buffer each input (+, −), and one to produce the desired output with adequate impedance matching for th ...
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Indium Tin Oxide
Indium tin oxide (ITO) is a ternary composition of indium, tin and oxygen in varying proportions. Depending on the oxygen content, it can be described as either a ceramic or an alloy. Indium tin oxide is typically encountered as an oxygen-saturated composition with a formulation of 74% In, 18% Sn, and 8% O by weight. Oxygen-saturated compositions are so typical that unsaturated compositions are termed ''oxygen-deficient ITO''. It is transparent and colorless in thin layers, while in bulk form it is yellowish to gray. In the infrared region of the spectrum it acts as a metal-like mirror. Indium tin oxide is one of the most widely used transparent conducting oxides because of its electrical conductivity and optical transparency, the ease with which it can be deposited as a thin film, and its chemical resistance to moisture. As with all transparent conducting films, a compromise must be made between conductivity and transparency, since increasing the thickness and increasing the co ...
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Neurophysiology
Neurophysiology is a branch of physiology and neuroscience that studies nervous system function rather than nervous system architecture. This area aids in the diagnosis and monitoring of neurological diseases. Historically, it has been dominated by electrophysiology—the electrical recording of neural activity ranging from the molar (the electroencephalogram, EEG) to the cellular (intracellular recording of the properties of single neurons), such as patch clamp, voltage clamp, extracellular single-unit recording and recording of local field potentials. However, since the neurone is an electrochemical machine, it is difficult to isolate electrical events from the metabolic and molecular processes that cause them. Thus, neurophysiologists currently utilise tools from chemistry (calcium imaging), physics (functional magnetic resonance imaging, fMRI), and molecular biology (site directed mutations) to examine brain activity. The word originates from the Greek word meaning "nerve" and ...
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Operational Amplifier Applications
This article illustrates some typical operational amplifier applications. A non-ideal operational amplifier's equivalent circuit has a finite input impedance, a non-zero output impedance, and a finite gain. A real op-amp has a number of non-ideal features as shown in the diagram, but here a simplified schematic notation is used, many details such as device selection and power supply connections are not shown. Operational amplifiers are optimised for use with negative feedback, and this article discusses only negative-feedback applications. When positive feedback is required, a comparator is usually more appropriate. See Comparator applications for further information. Practical considerations Operational amplifiers parameter requirements In order for a particular device to be used in an application, it must satisfy certain requirements. The operational amplifier must * have large open-loop signal gain (voltage gain of 200,000 is obtained in early integrated circuit exemplars) ...
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Biosignal
A biosignal is any signal in living beings that can be continually measured and monitored. The term biosignal is often used to refer to bioelectrical signals, but it may refer to both electrical and non-electrical signals. The usual understanding is to refer only to time-varying signals, although spatial parameter variations (e.g. the nucleotide sequence determining the genetic code) are sometimes subsumed as well. Electrical biosignals Electrical biosignals, or bioelectrical time signals, usually refers to the change in electric current produced by the sum of an electrical potential difference across a specialized tissue, organ or cell system like the nervous system. Thus, among the best-known bioelectrical signals are: * Electroencephalogram (EEG) * Electrocardiogram (ECG) * Electromyogram (EMG) * Electrooculogram (EOG) * Electroretinogram (ERG) * Electrogastrogram (EGG) * Galvanic skin response (GSR) or electrodermal activity (EDA) EEG, ECG, EOG and EMG are measured with ...
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Amplifier
An amplifier, electronic amplifier or (informally) amp is an electronic device that can increase the magnitude of a signal (a time-varying voltage or current). It may increase the power significantly, or its main effect may be to boost the voltage or current ( power, voltage or current amplifier). It is a two-port electronic circuit that uses electric power from a power supply to increase the amplitude of a signal applied to its input terminals, producing a greater amplitude signal at its output. The ratio of output to input voltage, current, or power is termed gain (voltage, current, or power gain). An amplifier, by definition has gain greater than unity (if the gain is less than unity, the device is an attenuator). An amplifier can either be a separate piece of equipment or an electrical circuit contained within another device. Amplification is fundamental to modern electronics, and amplifiers are widely used in almost all electronic equipment. Amplifiers can be cat ...
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Vapor-compression Refrigeration
Vapour-compression refrigeration or vapor-compression refrigeration system (VCRS), in which the refrigerant undergoes phase changes, is one of the many refrigeration cycles and is the most widely used method for air conditioning of buildings and automobiles. It is also used in domestic and commercial refrigerators, large-scale warehouses for chilled or frozen storage of foods and meats, refrigerated trucks and railroad cars, and a host of other commercial and industrial services. Oil refineries, petrochemical and chemical processing plants, and natural gas processing plants are among the many types of industrial plants that often utilize large vapor-compression refrigeration systems. Cascade refrigeration systems may also be implemented using two compressors. Refrigeration may be defined as lowering the temperature of an enclosed space by removing heat from that space and transferring it elsewhere. A device that performs this function may also be called an air conditioner, re ...
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Thermoelectric Effect
The thermoelectric effect is the direct conversion of temperature differences to electric voltage and vice versa via a thermocouple. A thermoelectric device creates a voltage when there is a different temperature on each side. Conversely, when a voltage is applied to it, heat is transferred from one side to the other, creating a temperature difference. At the atomic scale, an applied temperature gradient causes charge carriers in the material to diffuse from the hot side to the cold side. This effect can be used to generate electricity, measure temperature or change the temperature of objects. Because the direction of heating and cooling is affected by the applied voltage, thermoelectric devices can be used as temperature controllers. The term "thermoelectric effect" encompasses three separately identified effects: the Seebeck effect, Peltier effect, and Thomson effect. The Seebeck and Peltier effects are different manifestations of the same physical process; textbooks may re ...
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Thermoelectric Cooling
Thermoelectric cooling uses the Peltier effect to create a heat flux at the junction of two different types of materials. A Peltier cooler, heater, or thermoelectric heat pump is a solid-state active heat pump which transfers heat from one side of the device to the other, with consumption of electrical energy, depending on the direction of the current. Such an instrument is also called a Peltier device, Peltier heat pump, solid state refrigerator, or thermoelectric cooler (TEC) and occasionally a thermoelectric battery. It can be used either for heating or for cooling, although in practice the main application is cooling. It can also be used as a temperature controller that either heats or cools. This technology is far less commonly applied to refrigeration than vapor-compression refrigeration is. The primary advantages of a Peltier cooler compared to a vapor-compression refrigerator are its lack of moving parts or circulating liquid, very long life, invulnerability to leaks, s ...
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Field-programmable Gate Array
A field-programmable gate array (FPGA) is an integrated circuit designed to be configured by a customer or a designer after manufacturinghence the term '' field-programmable''. The FPGA configuration is generally specified using a hardware description language (HDL), similar to that used for an application-specific integrated circuit (ASIC). Circuit diagrams were previously used to specify the configuration, but this is increasingly rare due to the advent of electronic design automation tools. FPGAs contain an array of programmable logic blocks, and a hierarchy of reconfigurable interconnects allowing blocks to be wired together. Logic blocks can be configured to perform complex combinational functions, or act as simple logic gates like AND and XOR. In most FPGAs, logic blocks also include memory elements, which may be simple flip-flops or more complete blocks of memory. Many FPGAs can be reprogrammed to implement different logic functions, allowing flexible reconfi ...
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Action Potentials
An action potential occurs when the membrane potential of a specific cell location rapidly rises and falls. This depolarization then causes adjacent locations to similarly depolarize. Action potentials occur in several types of animal cells, called excitable cells, which include neurons, muscle cells, and in some plant cells. Certain endocrine cells such as pancreatic beta cells, and certain cells of the anterior pituitary gland are also excitable cells. In neurons, action potentials play a central role in cell-cell communication by providing for—or with regard to saltatory conduction, assisting—the propagation of signals along the neuron's axon toward synaptic boutons situated at the ends of an axon; these signals can then connect with other neurons at synapses, or to motor cells or glands. In other types of cells, their main function is to activate intracellular processes. In muscle cells, for example, an action potential is the first step in the chain of event ...
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