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Bexicaserin
Bexicaserin (; developmental code names LP352 and AN352) is a binding selectivity, selective serotonin 5-HT2C receptor, 5-HT2C receptor agonist which is under development for the treatment of seizures in developmental disability, developmental disabilities such as Dravet syndrome and Lennox-Gastaut syndrome. It is taken oral administration, by mouth. The drug is highly selective for the serotonin 5-HT2C receptor, with negligible affinity (pharmacology), affinity for the serotonin 5-HT2A receptor, 5-HT2A and 5-HT2B receptor, 5-HT2B receptors. Because it does not activate the serotonin 5-HT2B receptor, bexicaserin is not expected to pose a risk of cardiac valvulopathy, unlike the existing agent fenfluramine. As of October 2024, bexicaserin is in Phases of clinical research#Phase III, phase 3 clinical trials for treatment of developmental disabilities. It is being developed by Longboard Pharmaceuticals. The activation of 5HT2c receptors has been shown to reduce epileptic seizure ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5-HT2C Agonists
Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, memory, and physiological processes such as vomiting and vasoconstriction. In the CNS, serotonin regulates mood, appetite, and sleep. Most of the body's serotonin—about 90%—is synthesized in the gastrointestinal tract by enterochromaffin cells, where it regulates intestinal movements. It is also produced in smaller amounts in the brainstem's raphe nuclei, the skin's Merkel cells, pulmonary neuroendocrine cells, and taste receptor cells of the tongue. Once secreted, serotonin is taken up by platelets in the blood, which release it during clotting to promote vasoconstriction and platelet aggregation. Around 8% of the body's serotonin is stored in platelets, and 1–2% is found in the CNS. Serotonin acts as both a vasoconstrictor and v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
