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Behavioural Despair Test
The behavioural despair test (or Porsolt forced swimming test) is a test, centered on a rodent's response to the threat of drowning, whose result has been interpreted as measuring susceptibility to negative mood. It is commonly used to measure the effectiveness of antidepressants, although significant criticisms of its interpretation have been made. Method Animals are subjected to two trials during which they are forced to swim in an acrylic glass cylinder filled with water, and from which they cannot escape. The first trial lasts 15 minutes. Then, after 24-hours, a second trial is performed that lasts 5 minutes. The time that the test animal spends in the second trial without making any movements beyond those required to keep its head above water is measured. This immobility time is decreased by various types of antidepressants and also by electroconvulsive shock. Another common variant of this behavioural test specifically used for mice is conducted only for one trial and la ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anthropomorphism
Anthropomorphism is the attribution of human traits, emotions, or intentions to non-human entities. It is considered to be an innate tendency of human psychology. Personification is the related attribution of human form and characteristics to abstract concepts such as nations, emotions, and natural forces, such as seasons and weather. Both have ancient roots as storytelling and artistic devices, and most cultures have traditional fables with anthropomorphized animals as characters. People have also routinely attributed human emotions and behavioral traits to wild as well as domesticated animals. Etymology Anthropomorphism and anthropomorphization derive from the verb form ''anthropomorphize'', itself derived from the Greek ''ánthrōpos'' (, "human") and ''morphē'' (, "form"). It is first attested in 1753, originally in reference to the heresy of applying a human form to the Christian God.''Oxford English Dictionary'', 1st ed. "anthropomorphism, ''n.''" Oxford University ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tail Suspension Test
The tail suspension test (TST) is an experimental method used in scientific research to measure stress in rodents. It is based on the observation that if a mouse is subjected to short term inescapable stress then the mouse will become immobile. It is used to measure the effectiveness of antidepressant-like agents but there is significant controversy over its interpretation and usefulness. History The TST was introduced in 1985 due to the popularity of a similar test called the forced swim test (FST). However this test only recently became popular in the 2000s where data has shown that animals do show a change in behavior when injected with antidepressants. TST is more reliable when done in conjunction with other depression models such as FST, learned helplessness, anhedonia models and olfactory bulbectomy. Modeling depression Depression is a complex multi-faceted disorder with symptoms that can have multiple causes such as psychological, behavioral, and genetics. Sinc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Learned Helplessness
Learned helplessness is the behavior exhibited by a subject after enduring repeated aversive stimuli beyond their control. It was initially thought to be caused by the subject's acceptance of their powerlessness, by way of their discontinuing attempts to escape or avoid the aversive stimulus, even when such alternatives are unambiguously presented. Upon exhibiting such behavior, the subject was said to have acquired learned helplessness. Over the past few decades, neuroscience has provided insight into learned helplessness and shown that the original theory was the wrong way about—the brain's default state is to assume that control is not present. The presence of control is therefore learned. However, it is unlearned when a subject is faced with prolonged aversive stimulation. In humans, learned helplessness is related to the concept of self-efficacy, the individual's belief in their innate ability to achieve goals. Learned helplessness theory is the view that clinical depress ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Curt Richter
Curt Paul Richter (February 20, 1894 – December 21, 1988) was an American biologist, psychobiologist and geneticist who made important contributions in the field of circadian rhythms. Notably, Richter identified the hypothalamus as a "biological pacemaker" involved in sleeping and wakefulness. In particular, this region suspected by Richter was later identified as the suprachiasmatic nucleus. Early life, family and education Richter was born on February 20, 1894, in Denver, Colorado, to German immigrants from Saxony, Germany. Richter's father was an engineer who owned a steel and iron firm in Denver. In 1912, Richter studied engineering at a Technische Hochschule in Germany, but he left after the outbreak of World War I in 1914, switching to Harvard University where he studied biology under William E. Castle. Due to Richter's lack of experience with biology, Castle advised that he drop the course, so he switched to psychology instead, studying under E. B. Holt and Robert ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Animal Models Of Depression
Animal models of depression are research tools used to investigate Major depressive disorder, depression and action of antidepressant, antidepressants. They are used as a simulation to investigate the symptomatology and pathophysiology of depressive illness and to screen novel antidepressants. These models provide insights into molecular, genetic, and epigenetic factors associated with depression. Criteria for valid animal models include face, construct, and predictive validity. Endophenotypes, such as anhedonia, Behavioural despair test, behavioral despair, changes in appetite, neuroanatomical alterations, neuroendocrine disturbances, alterations in sleep architecture, and anxiety-related behaviors, are evaluated in these models. Antidepressant screening tests are employed to assess the effects of genetic, pharmacological, or environmental manipulations. Stress models including learned Learned helplessness, helplessness, chronic mild stress, and Social defeat, social defeat stress ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PETA
People for the Ethical Treatment of Animals (PETA; ) is an American animal rights nonprofit organization based in Norfolk, Virginia, and led by Ingrid Newkirk, its international president. Founded in March 1980 by Newkirk and animal rights activist Alex Pacheco, the organization first gained attention in the summer of 1981 during what became known as the Silver Spring monkeys case.Schwartz, Jeffrey M. and Begley, Sharon. ''The Mind and the Brain: Neuroplasticity and the Power of Mental Force'', Regan Books, 2002, p. 161ff. * Pacheco, Alex and Francione, AnnaThe Silver Spring Monkeys in Peter Singer (ed.) ''In Defense of Animals'', Basil Blackwell 1985, pp. 135–147. The organization opposes factory farming, fur farming, animal testing, and other activities it considers to be exploitation of animals. The organization's controversial campaigns have been credited with drawing media attention to animal rights issues, but have also been widely criticized for their disrupti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Animal Rights Groups
Animals are multicellular, eukaryotic organisms in the biological kingdom Animalia (). With few exceptions, animals consume organic material, breathe oxygen, have myocytes and are able to move, can reproduce sexually, and grow from a hollow sphere of cells, the blastula, during embryonic development. Animals form a clade, meaning that they arose from a single common ancestor. Over 1.5 million living animal species have been described, of which around 1.05 million are insects, over 85,000 are molluscs, and around 65,000 are vertebrates. It has been estimated there are as many as 7.77 million animal species on Earth. Animal body lengths range from to . They have complex ecologies and interactions with each other and their environments, forming intricate food webs. The scientific study of animals is known as zoology, and the study of animal behaviour is known as ethology. The animal kingdom is divided into five major clades, namely Porifera, Ctenophora, Placozoa, C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Locomotor Activity
Locomotor activity is a measure of animal behavior which is employed in scientific research. Hyperlocomotion, also known as locomotor hyperactivity, hyperactivity, or increased locomotor activity, is an effect of certain drugs in animals in which locomotor activity (locomotion) is increased. It is induced by certain drugs like psychostimulants and NMDA receptor antagonists and is reversed by certain other drugs like antipsychotics and certain antidepressants. Stimulation of locomotor activity is thought to be mediated by increased signaling in the nucleus accumbens, a major brain area involved in behavioral activation and motivated behavior. Hypolocomotion, also known as locomotor hypoactivity, hypoactivity, and decreased locomotor activity, is an effect of certain drugs in animals in which locomotor activity is decreased. It is a characteristic effect of many sedative agents and general anesthetics. Antipsychotics, which are dopamine receptor antagonists, and many serotonerg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antidepressants
Antidepressants are a class of medications used to treat major depressive disorder, anxiety disorders, chronic pain, and addiction. Common side effects of antidepressants include dry mouth, weight gain, dizziness, headaches, akathisia, sexual dysfunction, and emotional blunting. There is an increased risk of suicidal thinking and behavior when taken by children, adolescents, and young adults. Discontinuation syndrome, which resembles recurrent depression in the case of the SSRI class, may occur after stopping the intake of any antidepressant. Research regarding the effectiveness of antidepressants for depression in adults is controversial and has found both benefits and drawbacks. Meanwhile, evidence of benefit in children and adolescents is unclear, even though antidepressant use has considerably increased in children and adolescents in the 2000s. While a 2018 study found that the 21 most commonly prescribed antidepressant medications were slightly more effective than p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adaptation
In biology, adaptation has three related meanings. Firstly, it is the dynamic evolutionary process of natural selection that fits organisms to their environment, enhancing their evolutionary fitness. Secondly, it is a state reached by the population during that process. Thirdly, it is a phenotypic trait or adaptive trait, with a functional role in each individual organism, that is maintained and has evolved through natural selection. Historically, adaptation has been described from the time of the ancient Greek philosophers such as Empedocles and Aristotle. In 18th and 19th-century natural theology, adaptation was taken as evidence for the existence of a deity. Charles Darwin and Alfred Russel Wallace proposed instead that it was explained by natural selection. Adaptation is related to biological fitness, which governs the rate of evolution as measured by changes in allele frequencies. Often, two or more species co-adapt and co-evolve as they develop adaptations tha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
