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Basophilic
Basophilic is a technical term used by pathologists. It describes the appearance of cells, tissues and cellular structures as seen through the microscope after a histological section has been stained with a basic dye. The most common such dye is haematoxylin. The name basophilic refers to the characteristic of these structures to be stained very well by basic dyes. This can be explained by their charges. Basic dyes are cationic, i.e. contain positive charges, and thus they stain anionic structures (i.e. structures containing negative charges), such as the phosphate backbone of DNA in the cell nucleus and ribosomes. "Basophils" are cells that "love" (from greek "-phil") basic dyes, for example haematoxylin, azure and methylene blue. Specifically, this term refers to: * basophil granulocytes * anterior pituitary basophils An abnormal increase in basophil granulocytes is therefore also described as basophilia."Basophilia" ''Collins Online Dictionary'' 2024 https://www.colli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acidophile (histology)
Acidophile (or acidophil, or, as an adjectival form, acidophilic) is a term used by histologists to describe a particular staining pattern of cells and tissues when using haematoxylin and eosin stains. Specifically, the name refers to structures which "love" acid, and take it up readily. More specifically, acidophilia can be described by cationic groups of most often proteins in the cell readily reacting with acidic stains.Ross MH, Pawlina W. Histology : a text and atlas. 5. ed. Philadelphia, Pa.: Lippincott Williams & Wilkins; 2005. It describes the microscopic appearance of cells and tissues, as seen through a microscope, after a histological section has been stained with an acidic dye. The most common such dye is eosin, which stains acidophilic substances red and is the source of the related term eosinophilic. Note that a single cell can have both acidophilic substances/organelles and basophilic substances/organelles, albeit some have historically had so much of one stain th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
H&E Stain
Hematoxylin and eosin stain ( or haematoxylin and eosin stain or hematoxylin–eosin stain; often abbreviated as H&E stain or HE stain) is one of the principal tissue stains used in histology. It is the most widely used stain in medical diagnosis and is often the ''gold standard.'' For example, when a pathologist looks at a biopsy of a suspected cancer, the histological section is likely to be stained with H&E. H&E is the combination of two histological stains: hematoxylin and eosin. The hematoxylin stains cell nuclei a purplish blue, and eosin stains the extracellular matrix and cytoplasm pink, with other structures taking on different shades, hues, and combinations of these colors. Hence a pathologist can easily differentiate between the nuclear and cytoplasmic parts of a cell, and additionally, the overall patterns of coloration from the stain show the general layout and distribution of cells and provides a general overview of a tissue sample's structure. Thus, patte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Haematoxylin
Haematoxylin American and British English spelling differences#ae and oe, or hematoxylin (), also called natural black 1 or Colour Index International, C.I. 75290, is a chemical compound, compound extracted from wood#Heartwood and sapwood, heartwood of the logwood tree (''Haematoxylum campechianum'') with a chemical formula of . This Natural dye, naturally derived dye has been used as a staining, histologic stain, as an ink and as a dye in the textile and leather industry. As a dye, haematoxylin has been called palo de Campeche, logwood extract, bluewood and blackwood. In histology, haematoxylin staining is commonly followed by counterstain, counterstaining with eosin. When paired, this staining procedure is known as H&E staining and is one of the most commonly used combinations in histology. In addition to its use in the H&E stain, haematoxylin is also a component of the Papanicolaou stain (or Pap stain) which is widely used in the study of cytology specimens. Although the stain ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basophil Cell
An anterior pituitary basophil is a type of cell in the anterior pituitary which manufactures hormones. It is called a basophil because it is basophilic (readily takes up bases), and typically stains a relatively deep blue or purple. These basophils are further classified by the hormones they produce. (It is usually not possible to distinguish between these cell types using standard staining techniques.) *Produced only in pregnancy by the developing embryo. See also * Chromophobe cell :* Melanotroph * Chromophil :* Acidophil cell * Oxyphil cell * Oxyphil cell (parathyroid) * Pituitary gland * Neuroendocrine cell * Basophilic Basophilic is a technical term used by pathologists. It describes the appearance of cells, tissues and cellular structures as seen through the microscope after a histological section has been stained with a basic dye. The most common such dye ... References External links * {{Authority control Histology ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basophil
Basophils are a type of white blood cell White blood cells (scientific name leukocytes), also called immune cells or immunocytes, are cells of the immune system that are involved in protecting the body against both infectious disease and foreign entities. White blood cells are genera .... Basophils are the least common type of granulocyte, representing about 0.5% to 1% of circulating white blood cells. They are the largest type of granulocyte. They are responsible for inflammatory reactions during immune response, as well as in the formation of acute and chronic allergic diseases, including anaphylaxis, asthma, atopic dermatitis and Hay Fever, hay fever. They also produce compounds that coordinate immune responses, including histamine and serotonin that induce inflammation, and heparin that prevents Coagulation, blood clotting, although there are less than that found in mast cell granules. Mast cells were once thought to be basophils that migrated from the blood into their r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eosinophilic
Eosinophilic (Greek suffix '' -phil'', meaning ''eosin-loving'') describes the staining of tissues, cells, or organelles after they have been washed with eosin, a dye commonly used in histological staining. Eosin is an acidic dye for staining cell cytoplasm, collagen, and muscle fibers. ''Eosinophilic'' describes the appearance of cells and structures seen in histological sections that take up the staining dye eosin. Such eosinophilic structures are, in general, composed of protein. Eosin is usually combined with a stain called hematoxylin to produce a hematoxylin- and eosin-stained section (also called an H&E stain, HE or H+E section). It is the most widely used histological stain for a medical diagnosis. When a pathologist examines a biopsy of a suspected cancer, they will stain the biopsy with H&E. Some structures seen inside cells are described as being eosinophilic; for example, Lewy and Mallory bodies. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anterior Pituitary Basophil
An anterior pituitary basophil is a type of cell in the anterior pituitary which manufactures hormones. It is called a basophil because it is basophilic (readily takes up Base (chemistry), bases), and typically stains a relatively deep blue or purple. These basophils are further classified by the hormones they produce. (It is usually not possible to distinguish between these cell types using standard staining techniques.) *Produced only in pregnancy by the developing embryo. See also * Chromophobe cell :* Melanotroph * Chromophil :* Acidophil cell * Oxyphil cell (pathology), Oxyphil cell * Oxyphil cell (parathyroid) * Pituitary gland * Neuroendocrine cell * Basophilic References External links * {{Authority control Histology ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basophil Granulocyte
Basophils are a type of white blood cell. Basophils are the least common type of granulocyte, representing about 0.5% to 1% of circulating white blood cells. They are the largest type of granulocyte. They are responsible for inflammatory reactions during immune response, as well as in the formation of acute and chronic allergic diseases, including anaphylaxis, asthma, atopic dermatitis and hay fever. They also produce compounds that coordinate immune responses, including histamine and serotonin that induce inflammation, and heparin that prevents blood clotting, although there are less than that found in mast cell granules. Mast cells were once thought to be basophils that migrated from the blood into their resident tissues (connective tissue), but they are now known to be different types of cells. Basophils were discovered in 1879 by German physician Paul Ehrlich, who one year earlier had found a cell type present in tissues that he termed ''mastzellen'' (now mast cells). Ehrlich ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methylene Blue
Methylthioninium chloride, commonly called methylene blue, is a salt used as a dye and as a medication. As a medication, it is mainly used to treat methemoglobinemia. It has previously been used for treating cyanide poisoning and urinary tract infections, but this use is no longer recommended. Methylene blue is typically given by injection into a vein. Common side effects include headache, nausea, and vomiting. Methylene blue was first prepared in 1876, by Heinrich Caro. It is on the World Health Organization's List of Essential Medicines. Medical uses Methemoglobinemia Methylene blue is used to treat methemoglobinemia by chemically reducing the ferric iron in hemoglobin to ferrous iron. Methemoglobinemia can arise from ingestion of certain pharmaceuticals, toxins, or broad beans in those susceptible. Specifically, it is used to treat methemoglobin levels that are greater than 30% or in which there are symptoms despite oxygen therapy. Normally, through the NADH- or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
-phil-
The Greek root ''-phil-'' originates from the Greek word meaning "love". For example, philosophy (along with the Greek root ''-soph-'' meaning "wisdom") is the study of human customs and the significance of life. One of the most common uses of the root ''-phil-'' is with philias. A philia is the love or obsession with a particular thing or subject. The suffix ''-philia'' is used to specify the love or obsession with something more specific. It is somewhat antonymic to '' -phobia''. Philias can be biological (e.g. rhizophilia, preference for living on roots) or chemical (e.g. chromophilous, materials that stain easily), or can be a hobby/liking (e.g. icthyophilia, love for fish). ' () as a Greek word for love refers to brotherly love, including friendship and affection. This contrasts to the Greek terms Eros, or sexual/romantic love, and agape, or detached, spiritual love. However, English usage differs in some cases from the etymological use, and several of these words ref ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Nucleus
The cell nucleus (; : nuclei) is a membrane-bound organelle found in eukaryote, eukaryotic cell (biology), cells. Eukaryotic cells usually have a single nucleus, but a few cell types, such as mammalian red blood cells, have #Anucleated_cells, no nuclei, and a few others including osteoclasts have Multinucleate, many. The main structures making up the nucleus are the nuclear envelope, a double membrane that encloses the entire organelle and isolates its contents from the cellular cytoplasm; and the nuclear matrix, a network within the nucleus that adds mechanical support. The cell nucleus contains nearly all of the cell's genome. Nuclear DNA is often organized into multiple chromosomes – long strands of DNA dotted with various proteins, such as histones, that protect and organize the DNA. The genes within these chromosomes are Nuclear organization, structured in such a way to promote cell function. The nucleus maintains the integrity of genes and controls the activities of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
