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Amatoxins
Amatoxin is the collective name of a subgroup of at least nine related toxic compounds found in three genera of poisonous mushrooms (''Amanita'', ''Galerina'' and ''Lepiota'') and one species (Conocybe filaris) of the genus ''Conocybe''. Amatoxins are lethal in even small doses, as little as half a mushroom, including the immature 'egg' form which appears quite different from the fully-grown mushroom. Although laboratory analysis has found that the spores contain as little as 3% the toxin concentration of the main mushroom body, anecdotes have been repeated in field guides that claim foragers have fallen ill from spores alone after collecting but then discarding toxic Amanitas, unknowingly leaving their spore dust on the remaining harvest. Unlike many ingested poisons, they cannot be destroyed by heat without destroying the mushrooms beyond edibility first, so cooking the poisonous mushrooms does not diminish their lethality. Structure The compounds have a similar structure, tha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amanullinic Acid
Amanullinic acid is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the mushroom genus '' Amanita''. Amanullinic acid is relatively non-toxic( oral >20 mg/kg in mice). Toxicology Like other amatoxins, amanullinic acid is an inhibitor of RNA polymerase II. See also *Mushroom poisoning Mushroom poisoning is poisoning resulting from the ingestion of mushrooms that contain toxic substances. Its symptoms can vary from slight gastrointestinal discomfort to death in about 10 days. Mushroom toxins are secondary metabolites produced by ... References External linksAmatoxins REVISED {{Toxins Peptides Amatoxins Hepatotoxins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proamanullin
Promanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in the mushroom genus '' Amanita''. Toxicology Like other amatoxins, proamanullin is an inhibitor of RNA polymerase II. Promanullin has a specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells). See also *Mushroom poisoning Mushroom poisoning is poisoning resulting from the ingestion of mushrooms that contain toxic substances. Its symptoms can vary from slight gastrointestinal discomfort to death in about 10 days. Mushroom toxins are secondary metabolites produced by ... References External linksAmatoxins REVISED {{Toxins Peptides Amatoxins Hepatotoxins Tryptamines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amanullin
Amanullin is a cyclic peptide. It is an amatoxin, all of which are found in several members of the mushroom genus ''Amanita''. The oral of amanullin is approximately 20 mg/kg in mice; however, it is non-toxic in humans. Toxicology Like other amatoxins, amanullin is an inhibitor of RNA polymerase II. Amanullin has a species dependent and specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells). See also *Mushroom poisoning Mushroom poisoning is poisoning resulting from the ingestion of mushrooms that contain toxic substances. Its symptoms can vary from slight gastrointestinal discomfort to death in about 10 days. Mushroom toxins are secondary metabolites produc ... References External linksAmatoxins REVISED (German) {{Toxins [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amaninamide
Amaninamide is a cyclic peptide. It is one of the amatoxins, all of which are found in several members of the mushroom genera '' Amanita'', '' Lepiota'' and '' Galerina''. It differs from alpha-amanitin in lacking the hydroxyl group on tryptophan. This alters its UV absorption spectrum but not its toxicity. Toxicology Like other amatoxins, amaninamide is an inhibitor of RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme which completely prevents mRNA synthesis, effectively causing cytolysis of hepatocytes (liver cells) and kidney cells. See also *Mushroom poisoning Mushroom poisoning is poisoning resulting from the ingestion of mushrooms that contain toxic substances. Its symptoms can vary from slight gastrointestinal discomfort to death in about 10 days. Mushroom toxins are secondary metabolites produced by ... References External linksAmatoxins REVISED [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Galerina
''Galerina'' is a genus of small brown-spore saprobic fungi (colloquially often ''mushrooms''), with over 300 species found throughout the world from the far north to remote Macquarie Island in the Southern Ocean. The genus is most noted for some extremely poisonous species which are occasionally confused with hallucinogenic species of ''Psilocybe''. Species are typically small and hygrophanous, with a slender and brittle stem. They are often found growing on wood, and when on the ground have a preference for mossy habitats. ''Galerina'' means ''helmet-like''. Taxonomic definition The genus ''Galerina'' is defined as small mushrooms of mycenoid stature, that is, roughly similar in form to '' Mycena'' species: a small conical to bell-shaped cap, and gills attached to a long and slender cartilaginous stem. Species have a pileipellis that is a cutis, and ornamented spores that are brown in deposit, where the spore ornamentation comes from an extra spore covering. Descript ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amanin
Amanin is a cyclic peptide. It is one of the amatoxins, all of which are found in several members of the mushroom genus ''Amanita''. Toxicology Like other amatoxins, amanin is an inhibitor of RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme which completely prevents mRNA synthesis, effectively causing cytolysis of hepatocytes (liver cells) and kidney cells. See also *Mushroom poisoning Mushroom poisoning is poisoning resulting from the ingestion of mushrooms that contain toxic substances. Its symptoms can vary from slight gastrointestinal discomfort to death in about 10 days. Mushroom toxins are secondary metabolites produc ... References {{Toxins Peptides Amatoxins Hepatotoxins Tryptamines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cornell University
Cornell University is a private statutory land-grant research university based in Ithaca, New York. It is a member of the Ivy League. Founded in 1865 by Ezra Cornell and Andrew Dickson White, Cornell was founded with the intention to teach and make contributions in all fields of knowledge—from the classics to the sciences, and from the theoretical to the applied. These ideals, unconventional for the time, are captured in Cornell's founding principle, a popular 1868 quotation from founder Ezra Cornell: "I would found an institution where any person can find instruction in any study." Cornell is ranked among the top global universities. The university is organized into seven undergraduate colleges and seven graduate divisions at its main Ithaca campus, with each college and division defining its specific admission standards and academic programs in near autonomy. The university also administers three satellite campuses, two in New York City and one in Educatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lysis
Lysis ( ) is the breaking down of the membrane of a cell, often by viral, enzymic, or osmotic (that is, "lytic" ) mechanisms that compromise its integrity. A fluid containing the contents of lysed cells is called a ''lysate''. In molecular biology, biochemistry, and cell biology laboratories, cell cultures may be subjected to lysis in the process of purifying their components, as in protein purification, DNA extraction, RNA extraction, or in purifying organelles. Many species of bacteria are subject to lysis by the enzyme lysozyme, found in animal saliva, egg white, and other secretions. Phage lytic enzymes (lysins) produced during bacteriophage infection are responsible for the ability of these viruses to lyse bacterial cells. Penicillin and related β-lactam antibiotics cause the death of bacteria through enzyme-mediated lysis that occurs after the drug causes the bacterium to form a defective cell wall. If the cell wall is completely lost and the penicillin was used on gram ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SnRNA
Small nuclear RNA (snRNA) is a class of small RNA molecules that are found within the splicing speckles and Cajal bodies of the cell nucleus in eukaryotic cells. The length of an average snRNA is approximately 150 nucleotides. They are transcribed by either RNA polymerase II or RNA polymerase III. Their primary function is in the processing of pre- messenger RNA ( hnRNA) in the nucleus. They have also been shown to aid in the regulation of transcription factors ( 7SK RNA) or RNA polymerase II (B2 RNA), and maintaining the telomeres. snRNA are always associated with a set of specific proteins, and the complexes are referred to as small nuclear ribonucleoproteins (snRNP, often pronounced "snurps"). Each snRNP particle is composed of a snRNA component and several snRNP-specific proteins (including Sm proteins, a family of nuclear proteins). The most common human snRNA components of these complexes are known, respectively, as: U1 spliceosomal RNA, U2 spliceosomal RNA, U4 splic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
