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Alphaxolone
Alfaxalone, also known as alphaxalone or alphaxolone and sold under the brand name Alfaxan, is a neuroactive steroid and general anesthetic which is used currently in veterinary practice as an induction agent for anesthesia and as an injectable anesthetic. Though it is more expensive than other induction agents, it often preferred due to the lack of depressive effects on the cardiovascular system. The most common side effect seen in current veterinary practice is respiratory depression when Alfaxan is administered concurrently with other sedative and anesthetic drugs; when premedications are not given, veterinary patients also become agitated and hypersensitive when waking up. Alfaxalone works as a positive allosteric modulator on GABAA receptors and, at high concentrations, as a direct agonist of the GABAA receptor. It is cleared quickly by the liver, giving it a relatively short terminal half-life and preventing it from accumulating in the body, lowering the chance of ove ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroactive Steroid
Neurosteroids, also known as neuroactive steroids, are endogenous or exogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors. The term ''neurosteroid'' was coined by the French physiologist Étienne-Émile Baulieu and refers to steroids synthesized in the brain. The term, ''neuroactive steroid'' refers to steroids that can be synthesized in the brain, or are synthesized by an endocrine gland, that then reach the brain through the bloodstream and have effects on brain function. The term neuroactive steroids was first coined in 1992 by Steven Paul and Robert Purdy. In addition to their actions on neuronal membrane receptors, some of these steroids may also exert effects on gene expression via nuclear steroid hormone receptors. Neurosteroids have a wide range of potential clinical applications from sedation to treatment of epilepsy and traumatic brain injury. Ganaxolone, a synthetic analog of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GABA Receptor Agonist
A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects. There are three receptors of the ''gamma''-aminobutyric acid. The two receptors GABA-α and GABA-ρ are ion channels that are permeable to chloride ions which reduces neuronal excitability. The GABA-β receptor belongs to the class of G-Protein coupled receptors that inhibit adenylyl cyclase, therefore leading to decreased cyclic adenosine monophosphate (cAMP). GABA-α and GABA-ρ receptors produce sedative and hypnotic effects and have anti-convulsion properties. GABA-β receptors also produce similar effects. Furthermore, they lead to changes in gene transcription, and are mainly found in autonomic nervous system centers. Types Many commonly used sedative and anxiolytic drugs that affect the GABA receptor complex are not agonists. These drugs act inste ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sheep
Sheep (: sheep) or domestic sheep (''Ovis aries'') are a domesticated, ruminant mammal typically kept as livestock. Although the term ''sheep'' can apply to other species in the genus '' Ovis'', in everyday usage it almost always refers to domesticated sheep. Like all ruminants, sheep are members of the order Artiodactyla, the even-toed ungulates. Numbering a little over one billion, domestic sheep are also the most numerous species of sheep. An adult female is referred to as a ''ewe'' ( ), an intact male as a ''ram'', occasionally a ''tup'', a castrated male as a ''wether'', and a young sheep as a ''lamb''. Sheep are most likely descended from the wild mouflon of Europe and Asia, with Iran being a geographic envelope of the domestication center. One of the earliest animals to be domesticated for agricultural purposes, sheep are raised for fleeces, meat ( lamb, hogget or mutton), and milk. A sheep's wool is the most widely used animal fiber, and is usually harvested by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cats
The cat (''Felis catus''), also referred to as the domestic cat or house cat, is a small domesticated carnivorous mammal. It is the only domesticated species of the family Felidae. Advances in archaeology and genetics have shown that the domestication of the cat occurred in the Near East around 7500 BC. It is commonly kept as a pet and working cat, but also ranges freely as a feral cat avoiding human contact. It is valued by humans for companionship and its ability to kill vermin. Its retractable claws are adapted to killing small prey species such as mice and rats. It has a strong, flexible body, quick reflexes, and sharp teeth, and its night vision and sense of smell are well developed. It is a social species, but a solitary hunter and a crepuscular predator. Cat intelligence is evident in their ability to adapt, learn through observation, and solve problems. Research has shown they possess strong memories, exhibit neuroplasticity, and display cognitive skill ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dogs
The dog (''Canis familiaris'' or ''Canis lupus familiaris'') is a domesticated descendant of the gray wolf. Also called the domestic dog, it was selectively bred from a population of wolves during the Late Pleistocene by hunter-gatherers. The dog was the first species to be domesticated by humans, over 14,000 years ago and before the development of agriculture. Due to their long association with humans, dogs have gained the ability to thrive on a starch-rich diet that would be inadequate for other canids. Dogs have been bred for desired behaviors, sensory capabilities, and physical attributes. Dog breeds vary widely in shape, size, and color. They have the same number of bones (with the exception of the tail), powerful jaws that house around 42 teeth, and well-developed senses of smell, hearing, and sight. Compared to humans, dogs possess a superior sense of smell and hearing, but inferior visual acuity. Dogs perform many roles for humans, such as hunting, herding, pu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rabbits
Rabbits are small mammals in the family Leporidae (which also includes the hares), which is in the order Lagomorpha (which also includes pikas). They are familiar throughout the world as a small herbivore, a prey animal, a domesticated form of livestock, and a pet, having a widespread effect on ecologies and cultures. The most widespread rabbit genera are '' Oryctolagus'' and ''Sylvilagus''. The former, ''Oryctolagus'', includes the European rabbit, ''Oryctolagus cuniculus'', which is the ancestor of the hundreds of breeds of domestic rabbit and has been introduced on every continent except Antarctica. The latter, ''Sylvilagus'', includes over 13 wild rabbit species, among them the cottontails and tapetis. Wild rabbits not included in ''Oryctolagus'' and ''Sylvilagus'' include several species of limited distribution, including the pygmy rabbit, volcano rabbit, and Sumatran striped rabbit. Rabbits are a paraphyletic grouping, and do not constitute a clade, as hares (bel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Horses
The horse (''Equus ferus caballus'') is a domesticated, one-toed, hoofed mammal. It belongs to the taxonomic family Equidae and is one of two extant subspecies of ''Equus ferus''. The horse has evolved over the past 45 to 55 million years from a small multi-toed creature, '' Eohippus'', into the large, single-toed animal of today. Humans began domesticating horses around 4000 BCE in Central Asia, and their domestication is believed to have been widespread by 3000 BCE. Horses in the subspecies ''caballus'' are domesticated, although some domesticated populations live in the wild as feral horses. These feral populations are not true wild horses, which are horses that have never been domesticated. There is an extensive, specialized vocabulary used to describe equine-related concepts, covering everything from anatomy to life stages, size, colors, markings, breeds, locomotion, and behavior. Horses are adapted to run, allowing them to quickly escape predators, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Renal
In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blood exits into the paired renal veins. Each kidney is attached to a ureter, a tube that carries excreted urine to the bladder. The kidney participates in the control of the volume of various body fluids, fluid osmolality, acid-base balance, various electrolyte concentrations, and removal of toxins. Filtration occurs in the glomerulus: one-fifth of the blood volume that enters the kidneys is filtered. Examples of substances reabsorbed are solute-free water, sodium, bicarbonate, glucose, and amino acids. Examples of substances secreted are hydrogen, ammonium, potassium and uric acid. The nephron is the structural and functiona ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pigs
The pig (''Sus domesticus''), also called swine (: swine) or hog, is an omnivorous, domesticated, even-toed, hoofed mammal. It is named the domestic pig when distinguishing it from other members of the genus '' Sus''. Some authorities consider it a subspecies of ''Sus scrofa'' (the wild boar or Eurasian boar); other authorities consider it a distinct species. Pigs were domesticated in the Neolithic, both in China and in the Near East (around the Tigris Basin). When domesticated pigs arrived in Europe, they extensively interbred with wild boar but retained their domesticated features. Pigs are farmed primarily for meat, called pork. The animal's skin or hide is used for leather. China is the world's largest pork producer, followed by the European Union and then the United States. Around 1.5 billion pigs are raised each year, producing some 120 million tonnes of meat, often cured as bacon. Some are kept as pets. Pigs have featured in human culture since Neolithic time ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sedative
A sedative or tranquilliser is a substance that induces sedation by reducing irritability or Psychomotor agitation, excitement. They are central nervous system (CNS) Depressant, depressants and interact with brain activity, causing its deceleration. Various kinds of sedatives can be distinguished, but the majority of them affect the neurotransmitter Gamma-Aminobutyric acid, gamma-aminobutyric acid (GABA). Most sedatives produce relaxing effects by increasing GABA activity. This group is related to hypnotics. The term ''sedative'' describes drugs that serve to calm or Anxiolytic, relieve anxiety, whereas the term ''hypnotic'' describes drugs whose main purpose is to initiate, sustain, or lengthen sleep. Because these two functions frequently overlap, and because drugs in this class generally produce dose-dependent effects (ranging from anxiolysis to loss of consciousness), they are often referred to collectively as ''sedative–hypnotic'' drugs. Terminology There is some overlap ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Axolotl
The axolotl (; from ) (''Ambystoma mexicanum'') is a neoteny, paedomorphic salamander, one that Sexual maturity, matures without undergoing metamorphosis into the terrestrial adult form; adults remain Aquatic animal, fully aquatic with obvious external gills. This trait is somewhat unusual among amphibians, though this trait is not unique to axolotls, and this is apparent as they may be confused with the Tadpole, larval stage or Ambystoma#Species, other neotenic adult mole salamanders (''Ambystoma spp.''), such as the occasionally paedomorphic tiger salamander (''Ambystoma tigrinum, A. tigrinum'') widespread in North America; or with mudpuppies (''Necturus spp.''), which bear a superficial resemblance but are from a different Family (biology), family of salamanders. Axolotls originally inhabited a system of interconnected wetlands and lakes in the Mexican highlands; they were known to inhabit the smaller lakes of Lake Xochimilco, Xochimilco and Lake Chalco, Chalco, and are al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
