|
Alphacoronavirus 1
''Alphacoronavirus suis'', also called Alphacoronavirus 1, is a species of coronavirus that infects cats, dogs and pigs. It includes the virus strains feline coronavirus, canine coronavirus, and transmissible gastroenteritis virus. It is an enveloped, positive-strand RNA virus which is able to enter its host cell by binding to the APN receptor. Member viruses were first recognised as viruses that caused transmissible gastroenteritis in pigs in 1965. It was originally named ''porcine transmissible gastroenteritis virus'' in 1976. After subsequent discovery of ''canine coronavirus'' in dogs and ''feline coronavirus'' in cats, the three virus species were merged into a single species in 2009. The strain canine coronavirus-HuPn-2018 has been identified in a small number of human cases. Discovery In the mid-1940s there was an outbreak of pig disease in US, called transmissible gastroenteritis, which was characterised mainly by diarrhoea and vomiting. It was suspected to be a vi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electron Micrograph
A micrograph is an image, captured photographically or digitally, taken through a microscope or similar device to show a magnify, magnified image of an object. This is opposed to a macrograph or photomacrograph, an image which is also taken on a microscope but is only slightly magnified, usually less than 10 times. Micrography is the practice or art of using microscopes to make photographs. A photographic micrograph is a photomicrograph, and one taken with an electron microscope is an electron micrograph. A micrograph contains extensive details of microstructure. A wealth of information can be obtained from a simple micrograph like behavior of the material under different conditions, the phases found in the system, failure analysis, grain size estimation, elemental analysis and so on. Micrographs are widely used in all fields of microscopy. Types Photomicrograph A light micrograph or photomicrograph is a micrograph prepared using an optical microscope, a process referred to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Positive-strand RNA Virus
Positive-strand RNA viruses (+ssRNA viruses) are a group of related viruses that have Sense (molecular biology), positive-sense, single-stranded genomes made of ribonucleic acid. The positive-sense genome can act as messenger RNA (mRNA) and can be directly translation (biology), translated into viral proteins by the host cell, host cell's ribosomes. Positive-strand RNA viruses encode an RNA-dependent RNA polymerase (RdRp) which is used during replication of the genome to synthesize a negative-sense antigenome that is then used as a template to create a new positive-sense viral genome. Positive-strand RNA viruses are divided between the phyla ''Kitrinoviricota'', ''Lenarviricota'', and ''Pisuviricota'' (specifically classes ''Pisoniviricetes'' and ''Stelpaviricetes, Stelpavirictes'') all of which are in the kingdom ''Orthornavirae'' and Realm (virology), realm ''Riboviria''. They are Monophyly, monophyletic and descended from a common RNA virus ancestor. In the Baltimore classi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dog Diseases
This list of dog diseases is a selection of diseases and other conditions found in the dog. Some of these diseases are unique to dogs or closely related species, while others are found in other animals, including humans. Not all of the articles listed here contain information specific to dogs. Articles with non-dog information are marked with an asterisk (*). Infectious diseases Viral infections *Rabies (hydrophobia) is a fatal viral disease that can affect any mammal, although the close relationship of dogs with humans makes canine rabies a zoonotic concern. Vaccination of dogs for rabies is commonly required by law. Please see the article dog health for information on this disease in dogs. *Canine parvovirus is a sometimes fatal gastrointestinal infection that mainly affects puppies. It occurs worldwide. *Canine coronavirus is a gastrointestinal disease that is usually asymptomatic or with mild clinical signs. The signs are worse in puppies. * Canine distemper is an often fata ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Animal Viral Diseases
Animals are multicellular, eukaryotic organisms in the biological kingdom Animalia (). With few exceptions, animals consume organic material, breathe oxygen, have myocytes and are able to move, can reproduce sexually, and grow from a hollow sphere of cells, the blastula, during embryonic development. Animals form a clade, meaning that they arose from a single common ancestor. Over 1.5 million living animal species have been described, of which around 1.05 million are insects, over 85,000 are molluscs, and around 65,000 are vertebrates. It has been estimated there are as many as 7.77 million animal species on Earth. Animal body lengths range from to . They have complex ecologies and interactions with each other and their environments, forming intricate food webs. The scientific study of animals is known as zoology, and the study of animal behaviour is known as ethology. The animal kingdom is divided into five major clades, namely Porifera, Ctenophora, Placozoa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Committee On Taxonomy Of Viruses
The International Committee on Taxonomy of Viruses (ICTV) authorizes and organizes the taxonomic classification of and the nomenclature for viruses. The ICTV develops a universal taxonomic scheme for viruses, and thus has the means to appropriately describe, name, and classify every virus taxon. The members of the International Committee on Taxonomy of Viruses are considered expert virologists. The ICTV was formed from and is governed by the Virology Division of the International Union of Microbiological Societies. Detailed work, such as identifying new taxa and delimiting the boundaries of species, genera, families, etc. typically is performed by study groups of experts in the families. History The International Committee on Nomenclature of Viruses (ICNV) was established in 1966, at the International Congress for Microbiology in Moscow, to standardize the naming of virus taxa. The ICVN published its first report in 1971. For viruses infecting vertebrates, the first report i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canine Coronavirus HuPn-2018
Canine coronavirus HuPn-2018, or CCoV-HuPn-2018, is a virus first discovered in a surveillance study in Sarawak, Malaysia, in hospitalized human pneumonia patients. It may be the eighth coronavirus known to cause disease in humans, but no human-to-human transmission has been seen. This is a canine-feline recombinant alphacoronavirus (genotype II) related to the CCoV-II strain of ''Alphacoronavirus suis'' with part of the FCoV in S2 domain and a specific 12 amino acid Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although over 500 amino acids exist in nature, by far the most important are the 22 α-amino acids incorporated into proteins. Only these 22 a ...s deletion in the N protein. CCoV-HuPn-2018 was later seen in a University of Florida researcher who had just returned from Haiti. References {{Coronaviridae Animal virology Alphacoronaviruses Zoonotic viral diseases ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alanine Aminopeptidase
Membrane alanyl aminopeptidase () also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N) is an enzyme that in humans is encoded by the ANPEP gene. Function Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Viral Envelope
A viral envelope is the outermost layer of many types of viruses. It protects the genetic material in their life cycle when traveling between host cells. Not all viruses have envelopes. A viral envelope protein or E protein is a protein in the envelope, which may be acquired by the capsid from an infected host cell. Host cell infection process Numerous human pathogenic viruses in circulation are encased in lipid bilayers, and they infect their target cells by causing the viral envelope and cell membrane to fuse. Although there are effective vaccines against some of these viruses, there is no preventative or curative medicine for the majority of them. In most cases, the known vaccines operate by inducing antibodies that prevent the pathogen from entering cells. This happens in the case of enveloped viruses when the antibodies bind to the viral envelope proteins. The membrane fusion event that triggers viral entrance is caused by the viral membrane fusion protein. Many envelo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Feline Coronavirus
Feline coronavirus (FCoV) is a positive-stranded RNA virus that infects cats worldwide. It is a coronavirus of the species ''Alphacoronavirus suis'', which includes canine coronavirus (CCoV) and porcine transmissible gastroenteritis coronavirus (TGEV). FCoV has two different forms: feline enteric coronavirus (FECV), which infects the intestines, and feline infectious peritonitis virus (FIPV), which causes the disease feline infectious peritonitis (FIP). Feline coronavirus is typically shed in feces by healthy cats, and transmitted by the fecal-oral route to other cats. In environments with multiple cats, the transmission rate is much higher compared to single-cat environments. The virus is insignificant until mutations cause it to be transformed from FECV to FIPV. FIPV causes feline infectious peritonitis, for which treatment is generally symptomatic and palliative only. The drug GS-441524 shows promise as an antiviral treatment for FIP, but at the moment it still require ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transmissible Gastroenteritis Virus
Transmissible gastroenteritis virus or Transmissible gastroenteritis coronavirus (TGEV) is a coronavirus which infects pigs. It is an Viral envelope, enveloped, Sense (molecular biology), positive-sense, RNA, single-stranded RNA virus which enters its host cell by binding to the Alanine aminopeptidase, APN receptor. The virus is a member of the genus ''Alphacoronavirus'', subgenus ''Tegacovirus'', species ''Alphacoronavirus suis''. Proteins that contribute to the overall structure of TGEV include the spike protein, spike (S), envelope protein, envelope (E), membrane protein, membrane (M) and nucleocapsid (N). The genomic size of coronaviruses ranges from approximately 28.6 kilobases. Other coronaviruses that belong to the species ''Alphacoronavirus suis'' are Feline coronavirus, Canine coronavirus and Feline infectious peritonitis virus. Biology TGEV belongs to the family ''Coronaviridae'', genus ''Alphacoronavirus'', species ''Alphacoronavirus suis''. It is an enveloped virus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canine Coronavirus
Canine coronavirus (CCoV) is an enveloped, positive-sense, single-stranded RNA virus which is a member of the species ''Alphacoronavirus suis''. It causes a highly contagious intestinal disease worldwide in dogs. The infecting virus enters its host cell by binding to the APN receptor. It was discovered in 1971 in Germany during an outbreak in sentry dogs. The virus is a member of the genus '' Alphacoronavirus'' and subgenus ''Tegacovirus''. Canine enteric coronavirus Pathology The virus invades and replicates in the villi of the small intestine. Intestinal disease may be related to virus-induced apoptosis (programmed cell death) of cells of the epithelial mucosa of the small intestine. Canine coronavirus was originally thought to cause serious gastrointestinal disease, but now most cases are considered to be very mild or without symptoms. A more serious complication of canine coronavirus occurs when the dog is also infected with canine parvovirus. Coronavirus infection ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
