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West Caucasian Bat Virus
West Caucasian bat virus (WCBV) is a member of genus ''Lyssavirus'', family ''Rhabdoviridae'' and order ''Mononegavirales''. This virus was first isolated from ''Miniopterus schreibersii,'' in the western Caucasus Mountains of southeastern Europe in 2002. WCBV is the most divergent form of ''Lyssavirus'', and is found in '' Miniopterus'' bats (insectivorous), '' Rousettus aegyptiacus'', and ''Eidolon helvum''. The latter two are both fruit bats. The virus is fragile as it can be inactivated by UV light and chemicals, such as ether, chloroform, and bleach. WCBV has not been known to infect humans thus far. Classification The lyssavirus genus can be divided into four phylogroups based upon DNA sequence homology. Phylogroup I includes viruses, such as Rabies virus, Duvenhage virus, European bat lyssavirus types 1 and 2, Australian bat lyssavirus, Khujand virus, Bokeloh bat lyssavirus, Irkut virus, and Aravan virus. Phylogroup II contains Lagos bat virus, Mokola virus, and Shimoni ...
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Lyssavirus
''Lyssavirus'' (from the Greek ''lyssa'' "rage, fury, rabies" and the Latin '' vīrus'') is a genus of RNA viruses in the family ''Rhabdoviridae'', order '' Mononegavirales''. Mammals, including humans, can serve as natural hosts. The genus ''Lyssavirus'' includes the causative agent (rabies virus) of rabies. Taxonomy The genus contains the following species, listed by scientific name and followed by the exemplar virus of the species: * ''Lyssavirus aravan'', Aravan virus * ''Lyssavirus australis'', Australian bat lyssavirus * ''Lyssavirus bokeloh'', Bokeloh bat lyssavirus * ''Lyssavirus caucasicus'', West Caucasian bat virus * ''Lyssavirus duvenhage'', Duvenhage virus * ''Lyssavirus formosa'', Taiwan bat lyssavirus * ''Lyssavirus gannoruwa'', Gannoruwa bat lyssavirus * ''Lyssavirus hamburg'', European bat lyssavirus 1 * ''Lyssavirus helsinki'', European bat lyssavirus 2 * ''Lyssavirus ikoma'', Ikoma lyssavirus * ''Lyssavirus irkut'', Irkut virus * ''Lyssavirus ...
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Rhabdoviridae
''Rhabdoviridae'' is a family of negative-strand RNA viruses in the order ''Mononegavirales''. Vertebrates (including mammals and humans), invertebrates, plants, fungi and protozoans serve as natural hosts. Diseases associated with member viruses include Rabies, rabies encephalitis caused by the rabies virus, and flu-like symptoms in humans caused by vesiculoviruses. The name is derived from Ancient Greek , meaning rod, referring to the shape of the viral particles. The family has 62 genera, most assigned to four subfamilies. Structure The individual virus particles (virions) of rhabdoviruses are composed of RNA, protein, carbohydrate and lipid. They have complex bacilliform or bullet-like shapes. All these viruses have structural similarities and have been classified as a single family. The virions are about 75 nm wide and 180 nm long. Rhabdoviruses are Viral envelope, enveloped and have helical Capsid, nucleocapsids and their genomes are linear, around 11–15 kb ...
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Mononegavirales
''Mononegavirales'' is an order of negative-strand RNA viruses which have nonsegmented genomes. Some members that cause human disease in this order include Ebola virus, human respiratory syncytial virus, measles virus, mumps virus, Nipah virus, and rabies virus. Important pathogens of nonhuman animals and plants are also in the group. The order includes eleven virus families: '' Artoviridae'', '' Bornaviridae'', ''Filoviridae'', '' Lispiviridae'', '' Mymonaviridae'', '' Nyamiviridae'', ''Paramyxoviridae'', '' Pneumoviridae'', ''Rhabdoviridae'', '' Sunviridae'', and '' Xinmoviridae''. Use of term The order ''Mononegavirales'' (pronounced: ) According to the rules for taxon naming established by the International Committee on Taxonomy of Viruses (ICTV), the name ''Mononegavirales'' is always to be capitalized, italicized, and never abbreviated. The names of the order's physical members ("mononegaviruses" or "mononegavirads") are to be written in lower case, are not italicized, ...
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Caucasus Mountains
The Caucasus Mountains * * Azerbaijani: , * * * * * * * * * * * is a mountain range at the intersection of Asia and Europe. Stretching between the Black Sea and the Caspian Sea, they are surrounded by the Caucasus region and are home to Mount Elbrus, the highest peak in Europe at above sea level. The Caucasus Mountains include the Greater Caucasus in the north and the Lesser Caucasus in the south. The Greater Caucasus runs west-northwest to east-southeast, from the Western Caucasus on the northeastern shore of the Black Sea to close to Baku on the Caspian Sea, in Azerbaijan. The Lesser Caucasus runs parallel to the Greater about south. The Greater and Lesser Caucasus ranges are connected by the Likhi Range, and to the west and east of the Likhi Range lie the Colchis Plain and the Kur-Araz Lowland respectively. The Meskheti Range is a part of the Lesser Caucasus system. In the southeast, the Aras River separates the Lesser Caucasus from the Tal ...
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Miniopterus
''Miniopterus'', known as the bent-winged or long winged bats, is the sole genus of the family Miniopteridae. They are small flying insectivorous mammals, micro-bats of the order Chiroptera, with wings over twice the length of the body. The genus had been placed in its own subfamily among the vespertilionid bats, as Miniopterinae, but is now classified as its own family. Taxonomy The genus was erected in 1837 by Charles L. Bonaparte. In the first systematic revision of the genus, published in a monograph of ''Miniopterus'' in 1858 by Robert F. Tomes, the author reallocated specimens and described new taxa. A new systematic arrangement was produced in an extensive study of poorly known chiropterans of the Indo-Austral region by James E. Hill in 1985, the greater resolution of the genus being determined by the British Museum of Natural History's acquisition of new series of specimens collected in Fiji, the New Hebrides and New Caledonia and the extensive collection made in New ...
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Rousettus Aegyptiacus
The Egyptian fruit bat or Egyptian rousette (''Rousettus aegyptiacus'') is a species of megabat that occurs in Africa, the Middle East, the Mediterranean and the Indian subcontinent. It is one of three ''Rousettus'' species with an African-Malagasy range, though the only species of its genus found on continental Africa. The common ancestor of the three species colonized the region in the late Pliocene or early Pleistocene. The species is traditionally divided into six subspecies. It is considered a medium-sized megabat, with adults weighing and possessing wingspans of approximately . Individuals are dark brown or grayish brown, with their undersides paler than their backs. The Egyptian fruit bat is a highly social species, usually living in colonies with thousands of other bats. It, along with other members of the genus ''Rousettus'', are some of the only fruit bats to use echolocation, though a more primitive version than used by bats in other families. It has also developed a ...
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Eidolon Helvum
The straw-coloured fruit bat (''Eidolon helvum'') is a large fruit bat that is the most widely distributed of all the African megabats. It is quite common throughout its area ranging from the southwestern Arabian Peninsula, across forest and savanna zones of sub-Saharan Africa. It is listed as Near Threatened on the IUCN Red List due to a decreasing population trend. Straw-coloured fruit bats travel in massive colonies of at least 100,000 bats and sometimes massing up to 1 million. From October to end of December every year, in the largest migration of mammals on the planet, up to 10 million straw-coloured fruit bats congregate in Kasanka National Park, Zambia, roosting in a area of Mushitu forest each day. This migration was only discovered in 1980. Their necks and backs are a yellowish-brown colour, while their undersides are tawny olive or brownish. Description The straw-coloured fruit bat is named for the silky yellowish or straw colour of its fur. The wings are black, and ...
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West Caucasian Bat Lyssavirus Genome
West is one of the four cardinal directions or points of the compass. It is the opposite direction from east and is the direction in which the Sun sets on the Earth. Etymology The word "west" is a Germanic word passed into some Romance languages (''ouest'' in French, ''oest'' in Catalan, ''ovest'' in Italian, ''vest'' in Romanian, ''oeste'' in Spanish and Portuguese). As in other languages, the word formation stems from the fact that west is the direction of the setting sun in the evening: 'west' derives from the Indo-European root ''*wes'' reduced from ''*wes-pero'' 'evening, night', cognate with Ancient Greek ἕσπερος hesperos 'evening; evening star; western' and Latin vesper 'evening; west'. Examples of the same formation in other languages include Latin occidens 'west' from occidō 'to go down, to set' and Hebrew מַעֲרָב (maarav) 'west' from עֶרֶב (erev) 'evening'. West is sometimes abbreviated as W. Navigation To go west using a compass for navigati ...
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Open Reading Frame
In molecular biology, reading frames are defined as spans of DNA sequence between the start and stop codons. Usually, this is considered within a studied region of a prokaryotic DNA sequence, where only one of the six possible reading frames will be "open" (the "reading", however, refers to the RNA produced by transcription of the DNA and its subsequent interaction with the ribosome in translation). Such an open reading frame (ORF) may contain a start codon (usually AUG in terms of RNA) and by definition cannot extend beyond a stop codon (usually UAA, UAG or UGA in RNA). That start codon (not necessarily the first) indicates where translation may start. The transcription termination site is located after the ORF, beyond the translation stop codon. If transcription were to cease before the stop codon, an incomplete protein would be made during translation. In eukaryotic genes with multiple exons, introns are removed and exons are then joined together after transcription to ...
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