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Uncouple (other)
Uncoupling or uncouple may refer to: * Uncoupling (neuropsychopharmacology), changes in neurochemical binding sites as a consequence of drug tolerance. * An uncoupling protein in cell biology. * An uncoupling agent in cell biology. * Un coupling (or decoupling) rail vehicles. See also * Decoupling (other) * Coupling (other) * Coupler (other) * Couple (other) Couple or couples may refer to: *Couple, a set of two of items of a type *Couple (mechanics), a pair of force which are equal in magnitude but opposite in direction and separated by a perpendicular distance so that their line of action do not co ... * '' Uncoupled'', a Netflix romantic comedy series starring Neil Patrick Harris {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uncoupling (neuropsychopharmacology)
In neuropsychopharmacology, uncoupling, also known as decoupling, refers to the separation, shifting, or internalization of the brain's receptors (signal receivers) or ligands (signal senders) due to long-term exposure to mind-altering drugs or toxins, as the brain adapts through drug tolerance. For example, prolonged use of opioids like morphine can lead to uncoupling of opioid receptor Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. The opioid receptors are ~40% identical to somatostati ...s, reducing their responsiveness over time. References Neuropharmacology Molecular neuroscience {{psych-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uncoupling Protein
An uncoupling protein (UCP) is a mitochondrial inner membrane protein that is a regulated proton channel or transporter. An uncoupling protein is thus capable of dissipating the proton gradient generated by NADH-powered pumping of protons from the mitochondrial matrix to the mitochondrial intermembrane space. The energy lost in dissipating the proton gradient via UCPs is not used to do biochemical work. Instead, heat is generated. This is what links UCP to thermogenesis. However, not every type of UCPs are related to thermogenesis. Although UCP2 and UCP3 are closely related to UCP1, UCP2 and UCP3 do not affect thermoregulatory abilities of vertebrates. UCPs are positioned in the same membrane as the ATP synthase, which is also a proton channel. The two proteins thus work in parallel with one generating heat and the other generating ATP from ADP and inorganic phosphate, the last step in oxidative phosphorylation. Mitochondria respiration is coupled to ATP synthesis (ADP phosphorylati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uncoupling Agent
An uncoupler or uncoupling agent is a molecule that disrupts oxidative phosphorylation in prokaryotes and mitochondria or photophosphorylation in chloroplasts and cyanobacteria by dissociating the reactions of ATP synthesis from the electron transport chain. The result is that the cell or mitochondrion expends energy to generate a proton-motive force, but the proton-motive force is dissipated before the ATP synthase can recapture this energy and use it to make Adenosine triphosphate, ATP. Because the intracellular supply of protons is replenished, uncouplers actually stimulate cellular metabolism and oxygen consumption (despite their inhibitory effects on oxidative phosphorylation) and increase the energy cost of generating ATP. Uncouplers are capable of transporting protons through mitochondrial and lipid membranes. Description Classical uncouplers have five properties: # the complete release of respiratory control # the substitution of all coupled processes (ATP synthesis, trans ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Railway Coupling
A coupling or coupler is a mechanism, typically located at each end of a rolling stock, rail vehicle, that connects them together to form a train. The equipment that connects the couplers to the vehicles is the draft gear or draw gear, which must absorb the stresses of the coupling and the acceleration of the train. Throughout the history of rail vehicles, a variety of coupler designs and types have been developed worldwide. Key design considerations include strength, reliability, easy and efficient handling, and operator safety. Automatic couplers engage automatically when the cars are pushed together. Modern versions not only provide a mechanical connection, but can also couple brake lines and data lines. Different countries use different types of couplers. While North American railroads and China use Janney couplers, railroads in the former Soviet Union use SA3 couplers and the European countries use Scharfenberg coupler, Scharfenberg and Buffers and chain coupler, screw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Decoupling (other)
__NOTOC__ Decoupling usually refers to the ending, removal or reverse of coupling. Decoupling may also refer to: Economics * Decoupling (advertising), the purchase of services directly from suppliers rather than via an advertising agency * Decoupling (utility regulation), the disassociation of a utility's profits from its sales * Decoupling and re-coupling in economics, where country's economies are no longer impacted by each other * Decoupling (organizational studies), creating and maintaining separation between policy, implementation and/or practice * Decoupling of wages from productivity, sometimes known as the Great Decoupling * Eco-economic decoupling, economic growth without increase in environmental costs Science * Decoupling (cosmology), transition from close interactions between particles to their effective independence * Decoupling (meteorology), change in the interaction between atmospheric layers at night * Decoupling (neuropsychopharmacology), changes in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coupling (other)
Coupling is a connection or joint between two things. Coupling may also refer to: *Coupling (physics), when two systems are interacting with each other ** Rotational–vibrational coupling, occurring when rotation frequency of an object is close to or identical to a natural internal vibration frequency **Angular momentum coupling, the combining of quantized angular momentum (e.g., the interaction between two nuclei in nuclear magnetic resonance) ** Quantum coupling, when quantum states in one of the systems will cause an instantaneous change in all of the bound systems *Coupling (computer programming), the degree to which each program module relies on each one of the other modules * Coupling (electronics), the transfer of a signal from one medium or circuit block to another *Coupling (genetics), a type of genetic linkage * Coupling (piping), a short length of pipe or tube to connect two pipes or tubes together * Coupling (probability), a proof technique in probability theory *Rail ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coupler (other)
Coupler may refer to: Engineering Mechanical * Railway coupler, a mechanism for connecting rolling stock on a train ** Janney coupler ** SA3 coupler ** Scharfenberg coupler for multiple unit passenger cars * Quick coupler, used in construction machines to allow the rapid change of buckets * Coupling, a device used to connect two shafts together at their ends for the purpose of transmitting power ** Universal coupling, a joint or coupling in a rigid rod that allows the rod to 'bend' in any direction Electronics * Acoustic coupler, for coupling electrical signals by acoustical means * Directional coupler, a passive device used in radio technology * Antenna coupler, a device connected between a radio transmitter or receiver and its antenna * Output coupler, a partially reflective mirror used in lasers * Optocoupler, an electronic component that transfers electrical signals between two isolated circuits by using light Other uses * Coupler (piping), also called a (joist) sh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Couple (other)
Couple or couples may refer to: *Couple, a set of two of items of a type *Couple (mechanics), a pair of force which are equal in magnitude but opposite in direction and separated by a perpendicular distance so that their line of action do not coincide that cause a turning effect *Couple (relationship), two people in an intimate relationship Arts and entertainment *Couples (novel), ''Couples'' (novel), by John Updike, 1968 *Couples (Duty Free), "Couples" (''Duty Free''), a 1984 television episode Films *Couples (2011 film), ''Couples'' (2011 film), a South Korean film *Couples (1999 film), ''Couples'' (1999 film), a Spanish comedy film *''Couples'', a 1994 American television film directed by Betty Thomas *''The Aryan Couple'', a 2004 drama film released in the U.S. as ''The Couple'' *''A Couple'', 2022 French film Music *''Couple'', a 2004 album by Kim Yeon-woo *Couples (Pizzicato Five album), ''Couples'' (Pizzicato Five album), 1987 *Couples (The Long Blondes album), ''Coup ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
