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UFC 183
''UFC 183: Silva vs. Diaz'' was a mixed martial arts event held on January 31, 2015, at MGM Grand Garden Arena in Las Vegas, Nevada. Background The event was headlined by a middleweight bout between former UFC Middleweight champion Anderson Silva and former WEC & Strikeforce Welterweight champion Nick Diaz. A flyweight bout between Ian McCall and John Lineker was originally booked for UFC Fight Night: Shogun vs. St. Preux. However, the bout was canceled on the day of the event as McCall was stricken with a blood infection. The fight was later rescheduled for this event. A middleweight bout between Ed Herman and Derek Brunson was originally booked for UFC on Fox: dos Santos vs. Miocic. However, the bout was cancelled on the day of the event as Brunson was stricken with a stomach ailment. The fight was later rescheduled for this event. Both Kelvin Gastelum and John Lineker missed weight on their first attempts at the weigh ins, coming in at 180 lb and 130 lb respectively. ...
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Ultimate Fighting Championship
The Ultimate Fighting Championship (UFC) is an American mixed martial arts (MMA) promoter (entertainment), promotion company based in Las Vegas, Nevada. It is owned and operated by TKO Group Holdings, a majority owned subsidiary of Endeavor (company), Endeavor Group Holdings. The largest MMA promotion in the world, the UFC has over List of current UFC fighters, 578 fighters contracted that fight across 11 Weight class, weight divisions (eight men's and three women's). The organization produces events worldwide and abides by the Unified Rules of Mixed Martial Arts. , it had held List of UFC events, over 700 events. Dana White has been its president since 2001 and CEO since 2023. Under White's stewardship, it has grown into a global multi-billion-dollar enterprise. The UFC was founded by businessman Art Davie and Brazilian martial artist Rorion Gracie, and the UFC 1, first event was held in 1993 at McNichols Sports Arena in Denver, Colorado. The purpose of the UFC's early compet ...
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Dos Santos Vs
DOS (, ) is a family of disk-based operating systems for IBM PC compatible computers. The DOS family primarily consists of IBM PC DOS and a rebranded version, Microsoft's MS-DOS, both of which were introduced in 1981. Later compatible systems from other manufacturers include DR-DOS (1988), ROM-DOS (1989), PTS-DOS (1993), and FreeDOS (1994). MS-DOS dominated the IBM PC compatible market between 1981 and 1995. Although the name has come to be identified specifically with MS-DOS and compatible operating systems, ''DOS'' is a platform-independent acronym for ''disk operating system'', whose use predates the IBM PC. Dozens of other operating systems also use the acronym, beginning with the mainframe DOS/360 from 1966. Others include Apple DOS, Apple ProDOS, Atari DOS, Commodore DOS, TRSDOS, and AmigaDOS. History Origins IBM PC DOS (and the separately sold MS-DOS) and its predecessor, 86-DOS, ran on Intel 8086 16-bit processors. It was developed to be similar to Digit ...
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Tadalafil
Tadalafil, sold under the brand name Cialis among others, is a medication used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. It is taken by mouth. Onset is typically within half an hour and the duration is up to 36 hours. Common side effects include headache, muscle pain, flushing, and nausea. Caution is advised in those with cardiovascular disease. Rare but serious side effects include a prolonged erection that can lead to damage to the penis, vision problems, and hearing loss. Tadalafil is not recommended in people taking nitrovasodilators such as nitroglycerin, as this may result in a serious drop in blood pressure. Tadalafil is a PDE5 inhibitor which increases blood flow to the penis. It also dilates blood vessels in the lungs, which lowers the pulmonary artery pressure. Tadalafil was approved for medical use in the United States in 2003. It is available as a generic medication. In 2022, it was the 172nd most commonl ...
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Temazepam
Temazepam, sold under the brand name Restoril among others, is a medication of the benzodiazepine class which is generally used to treat severe or debilitating insomnia. It is taken by mouth. Temazepam is rapidly absorbed, and significant hypnotic and anxiolytic effects begin in less than 30 minutes and can last for up to eight hours. Prescriptions for hypnotics such as temazepam have seen a dramatic decrease since 2010, while anxiolytics such as alprazolam, clonazepam, and lorazepam have increased or remained stable. Temazepam and similar hypnotics, such as triazolam (Halcion) are generally reserved for severe and debilitating insomnia. They have largely been replaced by z-drugs ( zopiclone, zolpidem) and atypical antidepressants ( trazodone, mirtazapine) as first line treatment for insomnia. Common side effects include drowsiness, motor and cognitive impairment, lethargy, confusion, euphoria, and dizziness. Serious side effects may include hallucinations, hypotension, res ...
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Oxazepam
Oxazepam is a short-to-intermediate-acting benzodiazepine. Oxazepam is used for the treatment of anxiety, insomnia, and to control symptoms of alcohol withdrawal syndrome. It is a metabolite of diazepam, prazepam, and temazepam, and has moderate amnesic, anxiolytic, anticonvulsant, hypnotic, sedative, and skeletal muscle relaxant properties compared to other benzodiazepines. It was patented in 1962 and approved for medical use in 1964. Medical uses Oxazepam is an intermediate-acting benzodiazepine with a slow onset of action, so it is usually prescribed to individuals who have trouble staying asleep, rather than falling asleep. It is commonly prescribed for anxiety disorders with associated tension, irritability, and agitation. It is also prescribed for drug and alcohol Drug withdrawal, withdrawal, and for anxiety associated with clinical depression, depression. Oxazepam is sometimes prescribed off-label to treat social anxiety disorder, social phobia, post-traumatic stress dis ...
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Cannabis (drug)
Cannabis (), commonly known as marijuana (), weed, pot, and ganja, List of slang names for cannabis, among other names, is a non-chemically uniform psychoactive drug from the ''Cannabis'' plant. Native to Central or South Asia, cannabis has been used as a drug for both recreational and Entheogenic use of cannabis, entheogenic purposes and in various traditional medicines for centuries. Tetrahydrocannabinol (THC) is the main psychoactive component of cannabis, which is one of the 483 known compounds in the plant, including at least 65 other cannabinoids, such as cannabidiol (CBD). Cannabis can be used Cannabis smoking, by smoking, Vaporizer (inhalation device), vaporizing, Cannabis edible, within food, or Tincture of cannabis, as an extract. Cannabis has effects of cannabis, various mental and physical effects, which include euphoria, altered states of mind and Cannabis and time perception, sense of time, difficulty concentrating, Cannabis and memory, impaired short-term memo ...
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Androsterone
Androsterone, or 3α-hydroxy-5α-androstan-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. It is a weak androgen with a potency that is approximately 1/7 that of testosterone. Androsterone is a metabolite of testosterone and dihydrotestosterone (DHT). In addition, it can be converted back into DHT via 3α-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase, bypassing conventional intermediates such as androstanedione and testosterone, and as such, can be considered to be a metabolic intermediate in its own right. Androsterone is also known to be an inhibitory androstane neurosteroid, acting as a positive allosteric modulator of the GABAA receptor, and possesses anticonvulsant effects. The unnatural enantiomer of androsterone is more potent as a positive allosteric modulator of GABAA receptors and as an anticonvulsant than the natural form. Androsterone's 3β-isomer is epiandrosterone, and its 5β- epimer is etiocholanol ...
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Anabolic Steroid
Anabolic steroids, also known as anabolic-androgenic steroids (AAS), are a class of drugs that are structurally related to testosterone, the main male sex hormone, and produce effects by binding to the androgen receptor (AR). Anabolism, Anabolic Steroid, steroids have a number of medical uses, but are also used by athletes to increase muscle size, strength, and performance. Health risks can be produced by long-term use or excessive doses of AAS. These effects include harmful changes in cholesterol levels (increased low-density lipoprotein and decreased high-density lipoprotein), acne, high blood pressure, hepatotoxicity, liver damage (mainly with most oral AAS), and left ventricular hypertrophy. These risks are further increased when athletes take steroids alongside other drugs, causing significantly more damage to their bodies. The effect of anabolic steroids on the heart can cause myocardial infarction and strokes. Conditions pertaining to hormonal imbalances such as gynecomas ...
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Drostanolone
Drostanolone, or dromostanolone, is an anabolic–androgenic steroid (AAS) of the dihydrotestosterone (DHT) group which was never marketed. An androgen ester prodrug of drostanolone, drostanolone propionate, was formerly used in the treatment of breast cancer in women under brand names such as Drolban, Masteril, and Masteron. This has also been used non-medically for physique- or performance-enhancing purposes. Pharmacology Pharmacodynamics Like other AAS, drostanolone is an agonist of the androgen receptor (AR). It is not a substrate for 5α-reductase and is a poor substrate for 3α-hydroxysteroid dehydrogenase (3α-HSD), and therefore shows a high ratio of anabolic to androgenic activity. As a DHT derivative, drostanolone is not a substrate for aromatase and hence cannot be aromatized into estrogenic metabolites. While no data are available on the progestogenic activity of drostanolone, it is thought to have low or no such activity similarly to other DHT derivative ...
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Nevada Athletic Commission
The Nevada State Athletic Commission (also known as the Nevada Athletic Commission or NSAC) regulates all contests and exhibitions of unarmed combat within the state of Nevada, including licensure and supervision of promoters, boxing, boxers, kickboxing, kickboxers, mixed martial arts, mixed martial arts fighters, seconds, ring officials, managers, and matchmakers. The commission is the final authority on licensing matters, having the ability to approve, deny, revoke, or suspend all licenses for unarmed combat. The commission was established in 1941. It has several times been criticized for its conduct and sentences, and has several times been labelled a "kangaroo court". Leadership The Nevada State Athletic Commission is an agency of the Nevada Department of Business & Industry and is made up of five part-time commissioners (known as the "Commission"), an executive director, and seven full-time employees. Each commissioner is appointed by the Governor of Nevada, Governor for a ...
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Diego Brandão
Diego Brandão (born 27 May 1987) is a Brazilian mixed martial artist currently competing in the Lightweight division. A professional since 2005, he formerly competed for the UFC, RIZIN, and Fight Nights Global. He was the winner of Spike TV's The Ultimate Fighter: Team Bisping vs. Team Miller. Mixed martial arts career Early career Brandão made his MMA debut against Michel Bastos, winning via submission. He went 3-1 before fighting against UFC veteran Ronys Torres. He lost the fight by TKO due to punches. He then fought longtime UFC veteran Brian Foster and won via KO in the first round. Following the contest he won 6 and lost four of his next ten fights, with 3 wins by KO, 2 by submission and 1 by decision, before signing with the UFC. Brandão later became a member of Jackson's MMA in Albuquerque, New Mexico. The Ultimate Fighter In 2011, Brandão signed with the UFC to compete on The Ultimate Fighter: Team Bisping vs. Team Miller. In the first episode, Brandão fo ...
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Jimy Hettes
James Michael Hettes (born June 9, 1987) is a retired American mixed martial artist who competed as a Featherweight (MMA), featherweight in the Ultimate Fighting Championship. Background Hettes is a 2-time Keystone State Games Judo Gold Medalist and earned the nickname "Judo Jim" at Greg Jackson's Camp in Albuquerque, NM. Hettes started boxing at age 14 and started training in Brazilian Jiu-Jitsu at the age of 16 and is currently the head instructor at Northeastern Ju-Jitsu in Swoyersville, Pennsylvania. Hettes attended Luzerne County Community College for Criminal Justice. Ultimate Fighting Championship Hettes was originally expected to make his UFC debut in December 2010 as part of The Ultimate Fighter: Team GSP vs. Team Koscheck Finale card; Hettes turned the offer down due to prior engagements with another promotion. On July 16, 2011, Hettes officially signed with the UFC after winning the MMA Melee - MASS Featherweight Championship Belt. As a late replacement to an injured ...
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