The Humidifier Disinfectant Case
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The Humidifier Disinfectant Case
The South Korean humidifier disinfectant case was an outbreak of lung diseases in South Korea, caused by chemicals contained in several humidifier disinfectants. Outbreak The outbreak was detected in children between 2006 and 2011, and in adults in the spring of 2011; the mortality rate in children was 58 percent, while among adults, 53 percent died or required lung transplants. Autopsies and epidemiological work, followed up by animal studies, led the South Korean CDC to identify polyhexamethylene guanidine (PHMG) used in humidifier disinfectants as the cause. Investigation The main cause of the lung diseases was the chemicals PHMG, methylchloroisothiazolinone (CMIT), methylisothiazolinone (MIT) and oligo(2-(2-ethoxy)-ethoxyethyl)guanidinium-chloride (PGH). Experiments by the South Korean government found pulmonary toxicity of PHMG and PGH when inhaled as a vapor. PHMG and PGH caused pulmonary fibrosis when experimented on animals. On November 11, 2011, six humidifier dis ...
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Lung Diseases
Respiratory diseases, or lung diseases, are pathological conditions affecting the organs and tissues that make gas exchange difficult in air-breathing animals. They include conditions of the respiratory tract including the trachea, bronchi, bronchioles, alveoli, pleurae, pleural cavity, the nerves and muscles of respiration. Respiratory diseases range from mild and self-limiting, such as the common cold, influenza, and pharyngitis to life-threatening diseases such as bacterial pneumonia, pulmonary embolism, tuberculosis, acute asthma, lung cancer, and severe acute respiratory syndromes, such as COVID-19. Respiratory diseases can be classified in many different ways, including by the organ or tissue involved, by the type and pattern of associated signs and symptoms, or by the cause of the disease. The study of respiratory disease is known as pulmonology. A physician who specializes in respiratory disease is known as a pulmonologist, a chest medicine specialist, a respi ...
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2000s Disease Outbreaks
S, or s, is the nineteenth letter of the Latin alphabet, used in the English alphabet, the alphabets of other western European languages and other latin alphabets worldwide. Its name in English is ''ess'' (pronounced ), plural ''esses''. History Northwest Semitic šîn represented a voiceless postalveolar fricative (as in 'ip'). It originated most likely as a pictogram of a tooth () and represented the phoneme via the acrophonic principle. Ancient Greek did not have a "sh" phoneme, so the derived Greek letter Sigma () came to represent the voiceless alveolar sibilant . While the letter shape Σ continues Phoenician ''šîn'', its name ''sigma'' is taken from the letter ''Samekh'', while the shape and position of ''samekh'' but name of ''šîn'' is continued in the '' xi''. Within Greek, the name of ''sigma'' was influenced by its association with the Greek word (earlier ), "to hiss". The original name of the letter "Sigma" may have been ''san'', but due to the earl ...
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2011 Disasters In South Korea
Eleven or 11 may refer to: *11 (number) * One of the years 11 BC, AD 11, 1911, 2011 Literature * ''Eleven'' (novel), a 2006 novel by British author David Llewellyn *''Eleven'', a 1970 collection of short stories by Patricia Highsmith *''Eleven'', a 2004 children's novel in The Winnie Years by Lauren Myracle *''Eleven'', a 2008 children's novel by Patricia Reilly Giff *''Eleven'', a short story by Sandra Cisneros Music *Eleven (band), an American rock band * Eleven: A Music Company, an Australian record label *Up to eleven, an idiom from popular culture, coined in the movie ''This Is Spinal Tap'' Albums * ''11'' (The Smithereens album), 1989 * ''11'' (Ua album), 1996 * ''11'' (Bryan Adams album), 2008 * ''11'' (Sault album), 2022 * ''Eleven'' (Harry Connick, Jr. album), 1992 * ''Eleven'' (22-Pistepirkko album), 1998 * ''Eleven'' (Sugarcult album), 1999 * ''Eleven'' (B'z album), 2000 * ''Eleven'' (Reamonn album), 2010 * ''Eleven'' (Martina McBride album), 2011 * ''Eleven'' (Mr Fogg ...
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2011 Disease Outbreaks
Eleven or 11 may refer to: *11 (number) * One of the years 11 BC, AD 11, 1911, 2011 Literature * ''Eleven'' (novel), a 2006 novel by British author David Llewellyn *''Eleven'', a 1970 collection of short stories by Patricia Highsmith *''Eleven'', a 2004 children's novel in The Winnie Years by Lauren Myracle *''Eleven'', a 2008 children's novel by Patricia Reilly Giff *''Eleven'', a short story by Sandra Cisneros Music *Eleven (band), an American rock band * Eleven: A Music Company, an Australian record label *Up to eleven, an idiom from popular culture, coined in the movie ''This Is Spinal Tap'' Albums * ''11'' (The Smithereens album), 1989 * ''11'' (Ua album), 1996 * ''11'' (Bryan Adams album), 2008 * ''11'' (Sault album), 2022 * ''Eleven'' (Harry Connick, Jr. album), 1992 * ''Eleven'' (22-Pistepirkko album), 1998 * ''Eleven'' (Sugarcult album), 1999 * ''Eleven'' (B'z album), 2000 * ''Eleven'' (Reamonn album), 2010 * ''Eleven'' (Martina McBride album), 2011 * ''Eleven'' (Mr Fog ...
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Yonhap News Agency
Yonhap News Agency (; ) is a major news agency in South Korea. It is based in Seoul, South Korea. Yonhap provides news articles, pictures, and other information to newspapers, TV networks and other media in South Korea. History Yonhap was established on 19 December 1980, through the merger of Hapdong News Agency and Orient Press. The Hapdong News Agency itself emerged in late 1945 out of the short-lived Kukje News, which had operated for two months out of the office of the Domei, the former Japanese news agency that had functioned in Korea during the Japanese Japanese colonial era. In 1999, Yonhap took over the Naewoe News Agency. Naewoe was a South Korea government-affiliated organization, created in the mid 1970s, tasked with publishing information and analysis on North Korea from a South Korean perspective through books and journals. Naewoe was known to have close links with South Korea's intelligence agency, and according to the British academic and historian James Hoar ...
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Reckitt Benckiser
Reckitt Benckiser Group PLC, currently branded as Reckitt, formerly known as Reckitt Benckiser, is a British multinational consumer goods company headquartered in Slough, United Kingdom. It is a producer of health, hygiene and nutrition products. The company was formed in 1999 by the merger of British company Reckitt & Colman plc and Dutch company Benckiser N.V. Reckitt's brands include the antiseptic brand Dettol, the analgesic Disprin, the sore throat medicine Strepsils, the toilet cleaner Harpic, the hair removal brand Veet, the immune support supplement Airborne, the Australian insecticide brand Mortein, the indigestion remedy Gaviscon, the baby food brand Mead Johnson, the air freshener Air Wick, and other brands and products like: Calgon, Clearasil, Cillit Bang, Durex, Lysol, Mycil, Enfamil, and Vanish. History Origins Johann Benckiser founded a business in Pforzheim, Germany, in 1823. Its core business was industrial chemicals. Ludwig Reimann, a c ...
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Korea Centers For Disease Control And Prevention
Korea Disease Control and Prevention Agency (KDCA; ), formerly Korea Centers for Disease Control and Prevention (KCDC, ), is an organization under the South Korean Ministry of Welfare and Health that is responsible for the advancement of public health by managing prevention, survey, quarantine, trial, and research on infectious diseases, chronic and rare illnesses and injuries. It was founded in December 2003 and is located in Osong Health Technology Administration Complex in Cheongju. History * * * * * * November 1981: renamed to National Institute of Health * * * * April 2012: National Central Human Body Resource Bank was founded under KNIH of KCDC * September 12, 2020: restructured into an expanded Korea Disease Control and Prevention Agency (KDCA) under the Ministry with more autonomy and resources Source: Its history is in line with the major infectious disease outbreaks in South Korea. After the SARS outbreak in 2003, the then-National Institute of Health was re ...
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Pulmonary Fibrosis
Pulmonary fibrosis is a condition in which the lungs become scarred over time. Symptoms include shortness of breath, a dry cough, feeling tired, weight loss, and nail clubbing. Complications may include pulmonary hypertension, respiratory failure, pneumothorax, and lung cancer. Causes include environmental pollution, certain medications, connective tissue diseases, infections, and interstitial lung diseases. But in most cases the cause is unknown ( idiopathic pulmonary fibrosis). Diagnosis may be based on symptoms, medical imaging, lung biopsy, and lung function tests. No cure exists and treatment options are limited. Treatment is directed toward improving symptoms and may include oxygen therapy and pulmonary rehabilitation. Certain medications may slow the scarring. Lung transplantation may be an option. At least 5 million people are affected globally. Life expectancy is generally less than five years. Signs and symptoms Symptoms of pulmonary fibrosis are ...
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Oligo(2-(2-ethoxy)-ethoxyethyl)guanidinium-chloride
Oligo may refer to: *Oligomer, as an abbreviation for the general term, or specifically for oligonucleotide, oligopeptide, oligosaccharide, or oligoester An oligoester is an ester oligomer chain containing a small number of repeating ester units (monomers). Oligoesters are short analogs of polymeric polyesters. An example is oligo-(''R'')-3-hydroxybutyrate. See also * Oligopeptide An oligopep .... * OLIGO Primer Analysis Software * Oligo- as a prefix, meaning "few" {{disambiguation ...
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South Korea
South Korea, officially the Republic of Korea (ROK), is a country in East Asia. It constitutes the southern half of the Korea, Korean Peninsula and borders North Korea along the Korean Demilitarized Zone, with the Yellow Sea to the west and the Sea of Japan to the east. Like North Korea, South Korea claims to be the sole legitimate government of the entire peninsula and List of islands of South Korea, adjacent islands. It has Demographics of South Korea, a population of about 52 million, of which half live in the Seoul Metropolitan Area, the List of largest cities, ninth most populous metropolitan area in the world; other major cities include Busan, Daegu, and Incheon. The Korean Peninsula was inhabited as early as the Lower Paleolithic period. Gojoseon, Its first kingdom was noted in Chinese records in the early seventh century BC. From the mid first century BC, various Polity, polities consolidated into the rival Three Kingdoms of Korea, kingdoms of Goguryeo, Baekje, and Sil ...
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Methylisothiazolinone
Methylisothiazolinone (), MIT, or MI, is the organic compound with the formula S(CH)2C(O)NCH3. It is a white solid. Isothiazolinones, a class of heterocycles, are used as biocides in numerous personal care products and other industrial applications. MIT and related compounds have attracted much attention for their allergenic properties, e.g. contact dermatitis. Chemistry It is prepared by cyclization of ''cis''-''N''-methyl-3-thiocyanoacrylamide: : The crystal and molecular structure of methylisothiazolinone, as determined by in situ cryocrystallography, was reported for the first time in 2024. Applications Methylisothiazolinone is used for controlling microbial growth in water-containing solutions. It is typically used in a formulation with 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT), in a 3:1 mixture (CMIT:MIT) sold commercially as ''Kathon''. Kathon is supplied to manufacturers as a concentrated stock solution containing from 1.5 to 15% of CMIT/MIT. Kathon also has bee ...
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