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Stria Terminalis
The stria terminalis (or terminal stria) is a structure in the brain consisting of a band of fibers running along the lateral margin of the ventricular surface of the thalamus. Serving as a major output pathway of the amygdala, the stria terminalis runs from its centromedial division to the ventromedial nucleus of the hypothalamus. Anatomy The stria terminalis covers the superior thalamostriate vein, marking a line of separation between the thalamus and the caudate nucleus as seen upon gross dissection of the ventricles of the brain, viewed from the superior aspect. The stria terminalis extends from the region of the interventricular foramina to the temporal horn of the lateral ventricle, carrying fibers from the amygdala to the septal nuclei, hypothalamic, and thalamic areas of the brain. It also carries fibers projecting from these areas back to the amygdala. Bed nucleus of the stria terminalis The bed nucleus of the stria terminalis (BNST) is a collection of nuclei ...
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Mouse Brain
A mouse (: mice) is a small rodent. Characteristically, mice are known to have a pointed snout, small rounded ears, a body-length scaly tail, and a high breeding rate. The best known mouse species is the common house mouse (''Mus musculus''). Mice are also popular as pets. In some places, certain kinds of Apodemus, field mice are locally common. They are known to invade homes for food and shelter. Mice are typically distinguished from rats by their size. Generally, when a muroid rodent is discovered, its common name includes the term ''mouse'' if it is smaller, or ''rat'' if it is larger. The common terms ''rat'' and ''mouse'' are not Taxonomy (biology), taxonomically specific. Typical mice are classified in the genus ''Mus (genus), Mus'', but the term ''mouse'' is not confined to members of ''Mus'' and can also apply to species from other genera such as the deer mouse, deer mouse (''Peromyscus''). Fancy mouse, Domestic mice sold as pets often differ substantially in size f ...
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Optogenetics
Optogenetics is a biological technique to control the activity of neurons or other cell types with light. This is achieved by Gene expression, expression of Channelrhodopsin, light-sensitive ion channels, Halorhodopsin, pumps or Photoactivated adenylyl cyclase, enzymes specifically in the target cells. On the level of individual Cell (biology), cells, Photoactivated adenylyl cyclase, light-activated enzymes and transcription factors allow precise control of biochemical signaling pathways. In Neuroscience, systems neuroscience, the ability to control the activity of a genetically defined set of neurons has been used to understand their contribution to decision making, learning, fear memory, mating, addiction, feeding, and locomotion. In a first medical application of optogenetic technology, vision was partially restored in a blind patient with Retinitis pigmentosa. Optogenetic techniques have also been introduced to map the Brain connectivity estimators, functional connectivity of t ...
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University Of Pennsylvania
The University of Pennsylvania (Penn or UPenn) is a Private university, private Ivy League research university in Philadelphia, Pennsylvania, United States. One of nine colonial colleges, it was chartered in 1755 through the efforts of founder and first president Benjamin Franklin, who had advocated for an educational institution that trained leaders in academia, commerce, and public service. The university has four undergraduate schools and 12 graduate and professional schools. Schools enrolling undergraduates include the College of Arts and Sciences, the University of Pennsylvania School of Engineering and Applied Science, School of Engineering and Applied Science, the Wharton School, and the University of Pennsylvania School of Nursing, School of Nursing. Among its graduate schools are its University of Pennsylvania Law School, law school, whose first professor, James Wilson (Founding Father), James Wilson, helped write the Constitution of the United States, U.S. Cons ...
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Paedophilia
Pedophilia ( alternatively spelled paedophilia) is a psychiatric disorder in which an adult or older adolescent experiences a primary or exclusive sexual attraction to prepubescent children. Although girls typically begin the process of puberty at age 10 or 11, and boys at age 11 or 12, psychiatric diagnostic criteria for pedophilia extend the cut-off point for prepubescence to age 13. People with the disorder are often referred to as pedophiles (or paedophiles). Pedophilia is a paraphilia. In recent versions of formal diagnostic coding systems such as the DSM-5 and ICD-11, "pedophilia" is distinguished from "pedophilic disorder". Pedophilic disorder is defined as a pattern of pedophilic arousal accompanied by either subjective distress or interpersonal difficulty, or having acted on that arousal. The DSM-5 requires that a person must be at least 16 years old, and at least five years older than the prepubescent child or children they are aroused by, for the attraction to be d ...
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Startle Response
In animals, including humans, the startle response is a largely unconscious defensive response to sudden or threatening Stimulus (physiology), stimuli, such as sudden noise or sharp movement, and is associated with negative Affect (psychology), affect.Rammirez-Moreno, David. "A computational model for the modulation of the prepulse inhibition of the acoustic startle reflex". ''Biological Cybernetics'', 2012, p. 169 Usually the onset of the startle response is a startle reflex reaction. The startle reflex is a brainstem reflectory reaction (reflex) that serves to protect vulnerable parts, such as the back of the neck (whole-body startle) and the eyes (eyeblink) and Fight-or-flight response, facilitates escape from sudden stimuli. It is found across many different species, throughout all stages of life. A variety of responses may occur depending on the affected individual's emotional state, body posture, preparation for execution of a motor task, or other activities. The startle respo ...
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Hormone Replacement Therapy
Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. Effects of menopause can include symptoms such as hot flashes, accelerated skin aging, vaginal dryness, decreased muscle mass, and complications such as osteoporosis (bone loss), sexual dysfunction, and vaginal atrophy. They are mostly caused by low levels of female sex hormones (e.g. estrogens) that occur during menopause. Estrogens and progestogens are the main hormone drugs used in HRT. Progesterone is the main female sex hormone that occurs naturally and is also manufactured into a drug that is used in menopausal hormone therapy. Although both classes of hormones can have symptomatic benefit, progestogen is specifically added to estrogen regimens, unless the uterus has been removed, to avoid the increased risk of endometrial cancer. Unopposed estrogen therapy promotes end ...
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Gender Identity
Gender identity is the personal sense of one's own gender. Gender identity can correlate with a person's assigned sex or can differ from it. In most individuals, the various biological determinants of sex are congruent and consistent with the individual's gender identity. Gender expression typically reflects a person's gender identity, but this is not always the case. While a person may express behaviors, attitudes, and appearances consistent with a particular gender role, such expression may not necessarily reflect their gender identity. The term ''gender identity'' was coined by psychiatry professor Robert J. Stoller in 1964 and popularized by psychologist John Money. In most societies, there is a basic division between gender attributes associated with males and females, a gender binary to which most people adhere and which includes expectations of masculinity and femininity in all aspects of sex and gender: biological sex, gender identity, gender expression, and sexual orient ...
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Transsexual
A transsexual person is someone who experiences a gender identity that is inconsistent with their assigned sex, and desires to permanently transition to the sex or gender with which they identify, usually seeking medical assistance (including gender affirming therapies, such as hormone replacement therapy and gender affirming surgery) to help them align their body with their identified sex or gender. The term ''transsexual'' is a subset of ''transgender'', but some transsexual people reject the label of ''transgender''. A medical diagnosis of gender dysphoria can be made if a person experiences marked and persistent incongruence between their gender identity and their assigned sex. Understanding of transsexual people has rapidly evolved in the 21st century; many 20th century medical beliefs and practices around transsexual people are now considered outdated. Transsexual people were once classified as mentally ill and subject to extensive gatekeeping by the medical esta ...
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Dick Swaab
Dick Frans Swaab (born 17 December 1944) is a Dutch physician and neurobiologist (brain researcher). He is a professor of neurobiology at the University of Amsterdam and was until 2005 Director of the Netherlands Institute for Brain Research (Nederlands Instituut voor Hersenonderzoek) of the Royal Netherlands Academy of Arts and Sciences (Koninklijke Nederlandse Akademie van Wetenschappen). Life Swaab graduated at the Amsterdams Lyceum in 1963. He received his doctorate of medicine at the University of Amsterdam in 1968, and his Ph.D. in 1970 with professor J. Ariëns Kappers on a neuroendocrine thesis, and in 1972 he received his medical degree. He was from 1978 the director of the Netherlands Institute for Brain Research. In 1979 he was appointed professor of neurobiology at the University of Amsterdam. In 1985 he founded the Nederlandse Hersenbank—known in English as The Netherlands Brain Bank—to facilitate international research on brain diseases. Swaab is an atheist. ...
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Trans Man
A trans man or transgender man is a man who was assigned female at birth. Trans men have a male gender identity, and many trans men undergo medical and social transition to alter their appearance in a way that aligns with their gender identity or alleviates gender dysphoria. Transition among trans men can involve a variety of social, medical, and legal steps. Initially, the term referred specifically to those undergoing hormone replacement therapy (HRT) or sex reassignment surgery (SRS), but its meaning has expanded to include psychological development and self-acceptance. While some trans men pursue medical interventions like hormones and surgery, others may opt out due to personal choice or financial constraints. Many who do not undergo top surgery use chest binding, and some employ packing to create a masculine shape. Transitioning can include social changes, such as adopting a new name and pronouns, legal name change or other document updates, and medical transition ...
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Trans Woman
A trans woman or transgender woman is a woman who was assigned male at birth. Trans women have a female gender identity and may experience gender dysphoria (distress brought upon by the discrepancy between a person's gender identity and their sex assigned at birth). Gender dysphoria may be treated with gender-affirming care. Gender-affirming care may include social or medical transition. Social transition may include adopting a new name, hairstyle, clothing style, and/or set of pronouns associated with the individual's affirmed gender identity. A major component of medical transition for trans women is feminizing hormone therapy, which causes the development of female secondary sex characteristics (breasts, redistribution of body fat, lower waist–hip ratio, etc.). Medical transition may also include one or more feminizing surgeries, including vaginoplasty (to create a vagina), feminization laryngoplasty (to raise the vocal pitch), or facial feminization surgery (to f ...
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Hormone Replacement Therapy
Hormone replacement therapy (HRT), also known as menopausal hormone therapy or postmenopausal hormone therapy, is a form of hormone therapy used to treat symptoms associated with female menopause. Effects of menopause can include symptoms such as hot flashes, accelerated skin aging, vaginal dryness, decreased muscle mass, and complications such as osteoporosis (bone loss), sexual dysfunction, and vaginal atrophy. They are mostly caused by low levels of female sex hormones (e.g. estrogens) that occur during menopause. Estrogens and progestogens are the main hormone drugs used in HRT. Progesterone is the main female sex hormone that occurs naturally and is also manufactured into a drug that is used in menopausal hormone therapy. Although both classes of hormones can have symptomatic benefit, progestogen is specifically added to estrogen regimens, unless the uterus has been removed, to avoid the increased risk of endometrial cancer. Unopposed estrogen therapy promotes end ...
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