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Streptomyces Staurosporeus
''Lentzea aerocolonigenes'' is a bacterium from the genus ''Lentzea'' which has been isolated from soil in Japan. ''Lentzea aerocolonigenes'' produces rebeccamycin Rebeccamycin (NSC 655649) is a weak topoisomerase I inhibitor isolated from ''Nocardia sp.'' It is structurally similar to staurosporine, but does not show any inhibitory activity against protein kinases A protein kinase is a kinase which select .... References Pseudonocardiales Bacteria described in 1986 {{Pseudonocardineae-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LPSN
List of Prokaryotic names with Standing in Nomenclature (LPSN) is an online database that maintains information on the naming and taxonomy of prokaryotes, following the taxonomy requirements and rulings of the International Code of Nomenclature of Prokaryotes. The database was curated from 1997 to June 2013 by Jean P. Euzéby. From July 2013 to January 2020, LPSN was curated by Aidan C. Parte. In February 2020, a new version of LPSN was published as a service of the Leibniz Institute DSMZ, thereby also integrating the Prokaryotic Nomenclature Up-to-date service. References External links List of Prokaryotic names with Standing in Nomenclature [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lentzea
''Lentzea'' is a Gram-positive, mesophilic A mesophile is an organism that grows best in moderate temperature, neither too hot nor too cold, with an optimum growth range from . The optimum growth temperature for these organisms is 37°C. The term is mainly applied to microorganisms. Org ... and aerobic genus from the family Pseudonocardiaceae. References Further reading * Pseudonocardiales Bacteria genera {{Pseudonocardineae-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Japan
Japan ( ja, 日本, or , and formally , ''Nihonkoku'') is an island country in East Asia. It is situated in the northwest Pacific Ocean, and is bordered on the west by the Sea of Japan, while extending from the Sea of Okhotsk in the north toward the East China Sea, Philippine Sea, and Taiwan in the south. Japan is a part of the Ring of Fire, and spans an archipelago of 6852 islands covering ; the five main islands are Hokkaido, Honshu (the "mainland"), Shikoku, Kyushu, and Okinawa. Tokyo is the nation's capital and largest city, followed by Yokohama, Osaka, Nagoya, Sapporo, Fukuoka, Kobe, and Kyoto. Japan is the eleventh most populous country in the world, as well as one of the most densely populated and urbanized. About three-fourths of the country's terrain is mountainous, concentrating its population of 123.2 million on narrow coastal plains. Japan is divided into 47 administrative prefectures and eight traditional regions. The Greater Tokyo Ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rebeccamycin
Rebeccamycin (NSC 655649) is a weak topoisomerase I inhibitor isolated from ''Nocardia sp.'' It is structurally similar to staurosporine, but does not show any inhibitory activity against protein kinases A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. Phosphorylation usually results in a fun .... It shows significant antitumor properties in vitro (IC50=480nM against mouse B16 melanoma cells and IC50=500nM against P388 leukemia cells). It is an antineoplastic antibiotic and an intercalating agent. Becatecarin (BMS-181176) is a synthetic analog of rebeccamycin. Rebeccamycin and becatecarin have been tested in phase II clinical trials for the treatment of lung cancer, liver cancer, breast cancer, lymphoma, retinoblastoma, kidney cancer, and ovarian cancer. References Further reading * * * * * Experimental can ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pseudonocardiales
The Pseudonocardiaceae are a family of bacteria in the order Actinomycetales and the only member of the suborder Pseudonocardineae. Genomics The species within the family Pseudonocardiaceae form a distinct clade in phylogenetic trees based on concatenated protein sequences. Additionally, ''Nakamurella multipartite'', currently part of the order Frankiales, also formed a clade with the Pseudonocardiaceae species in 100% of the bootstrap replications of the phylogenetic trees. A conserved signature indel has been identified which is found in ''N. multipartite'' and all but one of the Pseudonocardiaceae species. This one-amino-acid insertion in UMP kinase serves to both provide a molecular marker for nearly all of the Pseudonocardiaceae and suggests ''N. multipartite'' is closely related to this group. Some evidence also suggests the orders Pseudonocardiales and Corynebacteriales are closely related. Several conserved signature indels have been identified which are found in both ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
