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Streptomyces Griseolus
''Streptomyces halstedii'' is a bacterium species from the genus of ''Streptomyces'' which has been isolated from deeper soil layers. ''Streptomyces halstedii'' produces magnamycin B, vicenistatin deltamycin A2, deltamycin A3, bafilomycin B1 and bafilomycin C1. ''Streptomyces halstedii'' also produces complex antifungal antibiotics like oligomycins (oligomycin A, oligomycin B, oligomycin C) and the antibiotics anisomycin and sinefungin. Further reading * * * * * * * * * * * * See also * List of Streptomyces species A ''list'' is any set of items in a row. List or lists may also refer to: People * List (surname) Organizations * List College, an undergraduate division of the Jewish Theological Seminary of America * SC Germania List The SC Germania ... References External linksType strain of ''Streptomyces halstedii'' at Bac''Dive'' - the Bacterial Diversity Metadatabase halstedii Bacteria described in 1948 {{Streptomyces-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deutsche Sammlung Von Mikroorganismen Und Zellkulturen
The Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures GmbH (German: ''Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH''), located in Braunschweig, is a research infrastructure in the Leibniz Association. Also the DSMZ is the world's most diverse collection of bioresources (status 2021: 75,000 bioresources). These include microorganisms (including more than 32,000 bacterial strains, 690 archaeal strains, 7,000 strains of yeasts and fungi) as well as more than 840 human and animal cell cultures, over 1. 500 plant viruses, over 940 bacteriophages, and 250 plasmids (status 2021). Since 2010, the scientific director of the Leibniz Institute DSMZ has been Jörg Overmann, a microbiologist with a PhD. He holds a professorship in microbiology at the Technical University of Braunschweig. Since August 2018, he has led the institute in a dual leadership with Bettina Fischer as administrative director. History Structu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptomyces
''Streptomyces'' is the largest genus of Actinomycetota and the type genus of the family Streptomycetaceae. Over 500 species of ''Streptomyces'' bacteria have been described. As with the other Actinomycetota, streptomycetes are gram-positive, and have genomes with high GC content. Found predominantly in soil and decaying vegetation, most streptomycetes produce spores, and are noted for their distinct "earthy" odor that results from production of a volatile metabolite, geosmin. Streptomycetes are characterised by a complex secondary metabolism. They produce over two-thirds of the clinically useful antibiotics of natural origin (e.g., neomycin, streptomycin, cypemycin, grisemycin, bottromycins and chloramphenicol). The antibiotic streptomycin takes its name directly from ''Streptomyces''. Streptomycetes are infrequent pathogens, though infections in humans, such as mycetoma, can be caused by '' S. somaliensis'' and '' S. sudanensis'', and in plants can be caused by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Magnamycin
Carbomycin, also known as magnamycin, is a colorless, optically active crystalline macrolide antibiotic with the molecular formula C42 H67 N O16. It is derived from the bacterium ''Streptomyces halstedii'' and active in inhibiting the growth of Gram-positive bacteria and "certain Mycoplasma strains." Its structure was first proposed by Robert Woodward in 1957 and was subsequently corrected in 1965. Synthesis The discovery of carbomycin was first reported by Fred W. Tanner Jr. of Pfizer. Carbomycin can be isolated from ''Streptomyces halstedii'' via extraction from a fermentation broth and purified through crystallization from alcohol-water mixtures. Carbomycin can be further purified with the use of preparative thin-layer chromatography. The most efficient solvent is one consisting of ethanol-hexane-water in 90-10-0.15 volume ratio. In the biosynthesis of carbomycin by ''Streptomyces halstedii'', when soybean meal is used to ferment the antibiotic, the addition of several su ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vicenistatin
Vicenistatin is a macrolactam antibiotic synthesized by ''Streptomyces halstedii ''Streptomyces halstedii'' is a bacterium species from the genus of ''Streptomyces'' which has been isolated from deeper soil layers. ''Streptomyces halstedii'' produces magnamycin B, vicenistatin deltamycin A2, deltamycin A3, bafilomycin B1 ...'' HC34. It was originally isolated from this bacterium in 1993. It includes the unusual starter unit methylaspartate. References {{reflist Macrolide antibiotics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bafilomycin
The bafilomycins are a family of macrolide antibiotics produced from a variety of ''Streptomycetes''. Their chemical structure is defined by a 16-membered lactone ring scaffold. Bafilomycins exhibit a wide range of biological activity, including anti-tumor, anti-parasitic, immunosuppressant and anti-fungal activity. The most used bafilomycin is bafilomycin A1, a potent inhibitor of cellular autophagy. Bafilomycins have also been found to act as ionophores, transporting potassium K+ across biological membranes and leading to mitochondrial damage and cell death. Bafilomycin A1 specifically targets the vacuolar-type H+ -ATPase (V-ATPase) enzyme, a membrane-spanning proton pump that acidifies either the extracellular environment or intracellular organelles such as the lysosome. At higher micromolar concentrations, bafilomycin A1 also acts on P-type ATPases, which have a phosphorylated transitional state. Bafilomycin A1 serves as an important tool compound in many ''in vitro'' researc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oligomycins
Oligomycins are macrolides created by ''Streptomyces'' that can be poisonous to other organisms. Function They have use as antibiotics. Oligomycin A is an inhibitor of ATP synthase. In oxidative phosphorylation research, it is used to prevent state 3 (phosphorylating) respiration. Oligomycin A inhibits ATP synthase by blocking its proton channel (FO subunit), which is necessary for oxidative phosphorylation of ADP to ATP (energy production). The inhibition of ATP synthesis by oligomycin A will significantly reduce electron flow through the electron transport chain An electron transport chain (ETC) is a series of protein complexes and other molecules that transfer electrons from electron donors to electron acceptors via redox reactions (both reduction and oxidation occurring simultaneously) and couples th ...; however, electron flow is not stopped completely due to a process known as ''proton leak'' or '' mitochondrial uncoupling''. This process is due to facilitated di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anisomycin
Anisomycin, also known as flagecidin, is an antibiotic produced by ''Streptomyces griseolus'' which inhibits eukaryotic protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis. Anisomycin can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways. Pharmacology Anisomycin interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. Anisomycin is also mentioned as a potential psychiatric drug, as it may inhibit the consolidation of new context-specific long-term memories, as well as long time consolidated memories rendered labile through reactivation. Injection of anisomycin into the hippocampus has been proposed for selective removal of memories. Biosynthesis Because of anisomycin's wide use as a protein synthesis inhibitor, there have been many studies centered on the biosynthesis of anisomycin. One study by B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Streptomyces Species
A ''list'' is any set of items in a row. List or lists may also refer to: People * List (surname) Organizations * List College, an undergraduate division of the Jewish Theological Seminary of America * SC Germania List The SC Germania List is a German rugby union club from the district List of Hanover, currently playing in the Rugby-Bundesliga. Apart from rugby, the club also offers other sports like tennis, gymnastics and handball. The club has three German ..., German rugby union club Other uses * Angle of list, the leaning to either port or starboard of a ship * List (information), an ordered collection of pieces of information ** List (abstract data type), a method to organize data in computer science * List on Sylt, previously called List, the northernmost village in Germany, on the island of Sylt * ''List'', an alternative term for ''roll'' in flight dynamics * To ''list'' a building, etc., in the UK it means to designate it a listed building that may ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
