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Streptomyces Bottropensis
''Streptomyces bottropensis'' is a bacterium species from the genus ''Streptomyces'' which has been isolated from soil.Deutsche Sammlung von Mikroorganismen und Zellkulturenbr>/ref> ''Streptomyces bottropensis'' produces bottromycin, dunaimycin and mensacarcin. ''Streptomyces bottropensis'' can metabolize (+)-carvone Carvone is a member of a family of chemicals called terpenoids. Carvone is found naturally in many essential oils, but is most abundant in the oils from seeds of caraway (''Carum carvi''), spearmint (''Mentha spicata''), and dill. Uses Both carv ... to (+)- bottrospicatol. See also * List of ''Streptomyces'' species References Further reading * * * * * * * * * External linksType strain of ''Streptomyces bottropensis'' at Bac''Dive'' - the Bacterial Diversity Metadatabase bottropensis Bacteria described in 1961 {{Streptomyces-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptomyces
''Streptomyces'' is the largest genus of Actinomycetota and the type genus of the family Streptomycetaceae. Over 500 species of ''Streptomyces'' bacteria have been described. As with the other Actinomycetota, streptomycetes are gram-positive, and have genomes with high GC content. Found predominantly in soil and decaying vegetation, most streptomycetes produce spores, and are noted for their distinct "earthy" odor that results from production of a volatile metabolite, geosmin. Streptomycetes are characterised by a complex secondary metabolism. They produce over two-thirds of the clinically useful antibiotics of natural origin (e.g., neomycin, streptomycin, cypemycin, grisemycin, bottromycins and chloramphenicol). The antibiotic streptomycin takes its name directly from ''Streptomyces''. Streptomycetes are infrequent pathogens, though infections in humans, such as mycetoma, can be caused by '' S. somaliensis'' and '' S. sudanensis'', and in plants can be caused by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deutsche Sammlung Von Mikroorganismen Und Zellkulturen
The Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures GmbH (German: ''Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH''), located in Braunschweig, is a research infrastructure in the Leibniz Association. Also the DSMZ is the world's most diverse collection of bioresources (status 2021: 75,000 bioresources). These include microorganisms (including more than 32,000 bacterial strains, 690 archaeal strains, 7,000 strains of yeasts and fungi) as well as more than 840 human and animal cell cultures, over 1. 500 plant viruses, over 940 bacteriophages, and 250 plasmids (status 2021). Since 2010, the scientific director of the Leibniz Institute DSMZ has been Jörg Overmann, a microbiologist with a PhD. He holds a professorship in microbiology at the Technical University of Braunschweig. Since August 2018, he has led the institute in a dual leadership with Bettina Fischer as administrative director. History Structu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bottromycin
Bottromycin is a macrocyclic peptide with antibiotic activity. It was first discovered in 1957 as a natural product isolated from '' Streptomyces bottropensis''. It has been shown to inhibit methicillin-resistant ''Staphylococcus aureus'' (MRSA) and vancomycin-resistant Enterococci ( VRE) among other Gram-positive bacteria and mycoplasma. Bottromycin is structurally distinct from both vancomycin, a glycopeptide antibiotic, and methicillin, a beta-lactam antibiotic. Bottromycin binds to the A site of the ribosome and blocks the binding of aminoacyl-''t''RNA, therefore inhibiting bacterial protein synthesis. Although bottromycin exhibits antibacterial activity ''in vitro'', it has not yet been developed as a clinical antibiotic, potentially due to its poor stability in blood plasma. To increase its stability ''in vivo'', some bottromycin derivatives have been explored. The structure of bottromycin contains a macrocyclic amidine as well as a thiazole ring. The absolute stereochemi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mensacarcin
Mensacarcin is a highly oxygenated polyketide first isolated from soil-dwelling '' Streptomyces bottropensis'' bacteria. The molecule is a secondary metabolite, and can be obtained in large amounts from its producing organism. Due to its unique properties it is an important model for drug development against melanoma and other cancers. Medical properties In NCI-60 anti-cancer compound screening mensacarcin has a high cytostatic effect against almost all cell lines (mean of 50% growth inhibition) and a relatively selective cytotoxic effect against melanoma cells. Low COMPARE correlation with standard antitumor agents indicate a unique mechanism of action. Further examinations reveal mensacarcin effecting the mitochondria. Potential use in cancer therapy With its unique mechanism, effective also in BRAF V600E mutation cell lines, mensacarcin is a promising model for the development of new anticancer drugs. Existing therapies for melanoma are limited. Mensacarc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Journal Of Biological Chemistry
The ''Journal of Biological Chemistry'' (''JBC'') is a weekly peer-reviewed scientific journal that was established in 1905., jbc.org Since 1925, it is published by the American Society for Biochemistry and Molecular Biology. It covers research in areas of biochemistry and molecular biology. The editor is Alex Toker. As of January 2021, the journal is fully open access. In press articles are available free on its website immediately after acceptance. Editors The following individuals have served as editors of the journal: * 1906–1909: John Jacob Abel and Christian Archibald Herter * 1909–1910: Christian Archibald Herter * 1910–1914: Alfred Newton Richards * 1914–1925: Donald D. Van Slyke * 1925–1936: Stanley R. Benedict. After Benedict died, John T. Edsall served as temporary editor until the next editor was appointed. * 1937–1958: Rudolph J. Anderson * 1958–1967: John T. Edsall * 1968–1971: William Howard Stein * 1971–2011: Herbert Tabor * 2011–2015 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phys
Physics is the natural science that studies matter, its fundamental constituents, its motion and behavior through space and time, and the related entities of energy and force. "Physical science is that department of knowledge which relates to the order of nature, or, in other words, to the regular succession of events." Physics is one of the most fundamental scientific disciplines, with its main goal being to understand how the universe behaves. "Physics is one of the most fundamental of the sciences. Scientists of all disciplines use the ideas of physics, including chemists who study the structure of molecules, paleontologists who try to reconstruct how dinosaurs walked, and climatologists who study how human activities affect the atmosphere and oceans. Physics is also the foundation of all engineering and technology. No engineer could design a flat-screen TV, an interplanetary spacecraft, or even a better mousetrap without first understanding the basic laws of physics. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carvone
Carvone is a member of a family of chemicals called terpenoids. Carvone is found naturally in many essential oils, but is most abundant in the oils from seeds of caraway (''Carum carvi''), spearmint (''Mentha spicata''), and dill. Uses Both carvones are used in the food and flavor industry. ''R''-(−)-Carvone is also used for air freshening products and, like many essential oils, oils containing carvones are used in aromatherapy and alternative medicine. ''S''-(+)-Carvone has shown a suppressant effect against high-fat diet induced weight gain in mice. Food applications As the compound most responsible for the flavor of caraway, dill and spearmint, carvone has been used for millennia in food. Wrigley's Spearmint Gum and spearmint flavored Life Savers are major users of natural spearmint oil from '' Mentha spicata''. Caraway seed is extracted with alcohol to make the European drink Kümmel. Agriculture ''S''-(+)-Carvone is also used to prevent premature sprouting of potato ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Streptomyces Species
A ''list'' is any set of items in a row. List or lists may also refer to: People * List (surname) Organizations * List College, an undergraduate division of the Jewish Theological Seminary of America * SC Germania List The SC Germania List is a German rugby union club from the district List of Hanover, currently playing in the Rugby-Bundesliga. Apart from rugby, the club also offers other sports like tennis, gymnastics and handball. The club has three German ..., German rugby union club Other uses * Angle of list, the leaning to either port or starboard of a ship * List (information), an ordered collection of pieces of information ** List (abstract data type), a method to organize data in computer science * List on Sylt, previously called List, the northernmost village in Germany, on the island of Sylt * ''List'', an alternative term for ''roll'' in flight dynamics * To ''list'' a building, etc., in the UK it means to designate it a listed building that may ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
