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Sexual Aversion And Lack Of Sexual Enjoyment
Sexual anhedonia, also known as pleasure dissociative orgasmic disorder, is a condition in which an individual cannot feel pleasure (see anhedonia) from an orgasm. It is thought to be a variant of hypoactive sexual desire disorder. Overview Normally, humans feel pleasure from an orgasm; upon reaching a climax, chemicals are released in the brain, and motor signals are activated that will cause quick cycles of muscle contraction in the corresponding areas of both males and females. Sometimes these signals can cause other involuntary muscle contractions, such as body movements and vocalization. Finally, during orgasm, upward neural signals go to the cerebral cortex and feelings of intense pleasure are experienced. People with this disorder are aware of reaching an orgasm, as they can feel the physical effects of it, but they experience very limited or no sort of pleasure. Causes It is thought that people with sexual anhedonia have a dysfunction in the release of the chemical dopami ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anhedonia
Anhedonia is a diverse array of deficits in hedonic function, including reduced motivation or ability to experience pleasure. While earlier definitions emphasized the inability to experience pleasure, anhedonia is currently used by researchers to refer to reduced motivation, reduced anticipatory pleasure (wanting), reduced consummatory pleasure (liking), and deficits in reinforcement learning. In the ''Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition'' (DSM-5), anhedonia is a component of depressive disorders, substance-related disorders, psychotic disorders, and personality disorders, where it is defined by either a reduced ability to experience pleasure, or a diminished interest in engaging in previously pleasurable activities. While the ''International Statistical Classification of Diseases and Related Health Problems, Tenth Revision'' (ICD-10) does not explicitly mention anhedonia, the depressive symptom analogous to anhedonia as described in the DSM-5 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxytocin
Oxytocin is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. Present in animals since early stages of evolution, in humans it plays roles in behavior that include Human bonding, social bonding, love, reproduction, childbirth, and the Postpartum period, period after childbirth. Oxytocin is released into the bloodstream as a hormone in response to Human sexual activity, sexual activity and during childbirth. It is also available in Oxytocin (medication), pharmaceutical form. In either form, oxytocin stimulates uterine contractions to speed up the process of childbirth. In its natural form, it also plays a role in maternal bonding and lactation, milk production. Production and secretion of oxytocin is controlled by a positive feedback mechanism, where its initial release stimulates production and release of further oxytocin. For example, when oxytocin is released during a contraction of the uterus at the start of c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dyspareunia
Dyspareunia ( ) is painful sexual intercourse due to somatic or psychological causes. The term ''dyspareunia'' covers both female dyspareunia and male dyspareunia, but many discussions that use the term without further specification concern the female type, which is more common than the male type. In females, the pain can primarily be on the external surface of the genitalia, or deeper in the pelvis upon deep pressure against the cervix. Medically, dyspareunia is a pelvic floor dysfunction and is frequently underdiagnosed. It can affect a small portion of the vulva or vagina or be felt all over the surface. Understanding the duration, location, and nature of the pain is important in identifying the causes of the pain. Numerous physical, psychological, and social or relationship causes can contribute to pain during sexual encounters. Commonly, multiple underlying causes contribute to the pain. The pain can be acquired or Congenital disorder, congenital. Symptoms of dyspareunia may ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dysorgasmia
Dysorgasmia is the experience of a painful orgasm, usually in the abdomen. The condition may be experienced during or after orgasm, sometimes as late as several hours after the orgasm occurred. Both men and women can experience orgasmic pain. The term is sometimes used interchangeably with ''painful ejaculation'' when experienced by a man, but ejaculatory pain is only a subtype of male dysorgasmia as men can experience pain without ejaculating. The phenomenon is poorly understood and underresearched. Dysorgasmia can come as a side effect of surgical interventions such as prostatectomy. See also * Dyspareunia Dyspareunia ( ) is painful sexual intercourse due to somatic or psychological causes. The term ''dyspareunia'' covers both female dyspareunia and male dyspareunia, but many discussions that use the term without further specification concern the f ..., pain during sex References Orgasm Sexual dysfunctions Pain {{Sex-stub} ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anhedonia
Anhedonia is a diverse array of deficits in hedonic function, including reduced motivation or ability to experience pleasure. While earlier definitions emphasized the inability to experience pleasure, anhedonia is currently used by researchers to refer to reduced motivation, reduced anticipatory pleasure (wanting), reduced consummatory pleasure (liking), and deficits in reinforcement learning. In the ''Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition'' (DSM-5), anhedonia is a component of depressive disorders, substance-related disorders, psychotic disorders, and personality disorders, where it is defined by either a reduced ability to experience pleasure, or a diminished interest in engaging in previously pleasurable activities. While the ''International Statistical Classification of Diseases and Related Health Problems, Tenth Revision'' (ICD-10) does not explicitly mention anhedonia, the depressive symptom analogous to anhedonia as described in the DSM-5 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yohimbine
Yohimbine, also known as quebrachine, is an indole alkaloid derived from the bark of the African tree '' Pausinystalia johimbe'' (yohimbe); also from the bark of the unrelated South American tree '' Aspidosperma quebracho-blanco''. Yohimbine is an α2-adrenergic receptor antagonist, and has been used in a variety of research projects. It is a veterinary drug used to reverse sedation in dogs and deer. While yohimbine behaves as an aphrodisiac in some mammals, it does not do so in humans. It has been prescribed as a treatment for erectile dysfunction, although its reported clinical benefits were modest and it has largely been superseded by the PDE5 inhibitor class of drugs. Substances that have purported to be extracts from the yohimbe tree have been marketed as dietary supplements for various purposes, but they contain highly variable amounts of yohimbine, if any; no published scientific evidence supports their efficacy. Uses Sexual dysfunction and aphrodisiac Yohimbe extracts, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-2 Blocker
Alpha-2 blockers (or α2 blockers) are a subset of the alpha blocker class of drugs and are antagonists to the α2 adrenergic receptor. They are mainly used in research, having found limited clinical application in human medicine. They are extensively used in veterinary medicine to reverse the effects of alpha-2 agonist drugs used as sedatives, like xylazine, medetomidine and dexmedetomidine. Alpha-2 blockers increase noradrenaline release. Uses Yohimbine, historically used as an aphrodisiac, is sometimes used in veterinary medicine (although now largely replaced by atipamezole) for reversing the effects of α2s such as medetomidine that are used as sedatives during surgery. The tetracyclic antidepressants mianserin and mirtazapine are α2 blockers, although their efficacy as antidepressants may come from their activity at other receptor sites. Mechanistically, α2 blockers increase adrenergic, dopaminergic and serotonergic neurotransmitters and induce insulin secretion, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PDE5 Inhibitor
A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating medication, drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues. These drugs dilate the Corpus cavernosum penis, corpora cavernosa of the Human penis, penis, facilitating erection with sexual stimulation, and are used in the treatment of erectile dysfunction (ED). Sildenafil was the first effective oral treatment available for ED. Because PDE5 is also present in the smooth muscle of the walls of the arterioles within the lungs, two PDE5 inhibitors, sildenafil and tadalafil, are FDA-approved for the treatment of pulmonary hypertension. As of 2019, the wider Circulatory system, cardiovascular benefits of PDE5 inhibitors are being appreciated. Medical uses Phosphodiesterase-5 (PDE5) inhibitors such as sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), and avanafi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dopamine Agonist
A dopamine agonist is a compound that activates dopamine receptors. There are two families of dopamine receptors, D1-like and D2-like. They are all G protein-coupled receptors. D1- and D5-receptors belong to the D1-like family and the D2-like family includes D2, D3 and D4 receptors. Dopamine agonists are primarily used in the treatment of the motor symptoms of Parkinson's disease, and to a lesser extent, in hyperprolactinemia and restless legs syndrome. They are also used off-label in the treatment of clinical depression. Impulse control disorders are associated with the use of dopamine agonists. Medical uses Parkinson's disease Dopamine agonists are mainly used in the treatment of Parkinson's disease. The cause of Parkinson's is not fully known but genetic factors, for example specific genetic mutations, and environmental triggers have been linked to the disease. In Parkinson's disease dopaminergic neurons that produce the neurotransmitter dopamine in the brain slowly ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sex Therapy
Sex therapy is a therapeutic strategy for the improvement of sexual function and treatment of sexual dysfunction. This includes dysfunctions such as premature ejaculation and delayed ejaculation, erectile dysfunction, lack of sexual interest or arousal, and painful sex ( vaginismus and dyspareunia); as well as problems imposed by atypical sexual interests (paraphilias), gender dysphoria (and being transgender), highly overactive libido or hypersexuality, a lack of sexual confidence, and recovering from sexual abuse (such as rape or sexual assault); and also includes sexual issues related to aging, illness, or disability.Binik, Y. M., & Hall, K. S. K. (2014). ''Principles and practice of sex therapy (5th ed.).'' NY: Guildford, Practice Modern sex therapy often integrates psychotherapeutic techniques and medical ones,Bancroft, J. (2009). ''Human Sexuality and Its Problems (3rd ed.).'' Edinburgh: Elsevier. such as Viagra (sildenafil) and Cialis ( tadalafil) to increase erec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Orgasm
Orgasm (from Greek , ; "excitement, swelling"), sexual climax, or simply climax, is the sudden release of accumulated sexual excitement during the sexual response cycle, characterized by intense sexual pleasure resulting in rhythmic, involuntary muscular contractions in the pelvic region.Se133–135 for orgasm information, anpage 76 for G-spot and vaginal nerve ending information. Orgasms are controlled by the involuntary or autonomic nervous system and are experienced by both males and females; the body's response includes muscular spasms (in multiple areas), a general euphoric sensation, and, frequently, body movements and vocalizations. The period after orgasm (known as the resolution phase) is typically a relaxing experience after the release of the neurohormones oxytocin and prolactin, as well as endorphins (or "endogenous morphine"). Human orgasms usually result from physical sexual stimulation of the penis in males (typically accompanied by ejaculation) and of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sensory Neuropathy
Peripheral neuropathy, often shortened to neuropathy, refers to damage or disease affecting the nerves. Damage to nerves may impair sensation, movement, gland function, and/or organ function depending on which nerve fibers are affected. Neuropathies affecting motor, sensory, or autonomic nerve fibers result in different symptoms. More than one type of fiber may be affected simultaneously. Peripheral neuropathy may be acute (with sudden onset, rapid progress) or chronic (symptoms begin subtly and progress slowly), and may be reversible or permanent. Common causes include systemic diseases (such as diabetes or leprosy), hyperglycemia-induced glycation, vitamin deficiency, medication (e.g., chemotherapy, or commonly prescribed antibiotics including metronidazole and the fluoroquinolone class of antibiotics (such as ciprofloxacin, levofloxacin, moxifloxacin)), traumatic injury, ischemia, radiation therapy, excessive alcohol consumption, immune system disease, celiac disease, non- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
