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Secobarbital
Secobarbital, sold under the brand name Seconal among others, is a short-acting barbiturate drug originally used for the treatment of insomnia. It was patented by Eli Lilly and Company in 1934 in the United States. It possesses anesthetic, anticonvulsant, anxiolytic, sedative, and hypnotic properties. In the United Kingdom, it was known as quinalbarbitone. Secobarbital is considered to be an obsolete sedative-hypnotic (sleeping pill) and has largely been replaced by the benzodiazepine family. It was widely abused, known on the street as "red devils" or "reds." Among barbiturates, secobarbital carries a particularly high risk of abuse and addiction, which is largely responsible for it falling out of use. Uses Medical Secobarbital is used for managing symptoms of epilepsy and for short-term treatment of insomnia. It is also used as a preoperative medication to produce anesthesia and anxiolysis for short surgical, diagnostic, or therapeutic procedures which are minimally painful. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eli Lilly And Company
Eli Lilly and Company, Trade name, doing business as Lilly, is an American multinational Medication, pharmaceutical company headquartered in Indianapolis, Indiana, with offices in 18 countries. Its products are sold in approximately 125 countries. The company was founded in 1876 by Eli Lilly, a pharmaceutical chemist and Union army veteran during the American Civil War for whom the company was later named. As of October 2024, Lilly is the most valuable drug company in the world with a $842 billion market capitalization, the highest valuation ever achieved to date by a drug company. The company is ranked 127th on the Fortune 500, ''Fortune'' 500 with revenue of $34.12 billion. It is ranked 221st on the Forbes Global 2000, ''Forbes'' Global 2000 list of the world's largest publicly traded companies and 252nd on ''Forbes'' list of "America's Best Employers". Lilly is known for its Major depressive disorder, clinical depression drugs Prozac (fluoxetine) (1986), Cymbalta (duloxet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carole Landis
Carole Landis (born Frances Lillian Mary Ridste; January 1, 1919 – July 5, 1948) was an American actress and singer. She worked as a contract player for Twentieth Century-Fox in the 1940s. Her breakout role was as the female lead in the 1940 film '' One Million B.C.'' from United Artists. She was known as "The Ping Girl" and "The Chest" because of her curvy figure. Early life Landis was born on January 1, 1919, in Fairchild, Wisconsin, the youngest of five children of Clara (née Sentek), a Polish farmer's daughter, and Norwegian-American Alfred Ridste, a drifting railroad mechanic who abandoned the family after Landis's birth. According to Landis's biographer E. J. Fleming, circumstantial evidence supports that Landis was likely the biological child of her mother's second husband, Charles Fenner. Fenner left Landis's mother in April 1921 and remarried a few months later. In 1923, Landis's family moved to San Bernardino, California, where her mother worked menial jobs to s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sedative
A sedative or tranquilliser is a substance that induces sedation by reducing irritability or Psychomotor agitation, excitement. They are central nervous system (CNS) Depressant, depressants and interact with brain activity, causing its deceleration. Various kinds of sedatives can be distinguished, but the majority of them affect the neurotransmitter Gamma-Aminobutyric acid, gamma-aminobutyric acid (GABA). Most sedatives produce relaxing effects by increasing GABA activity. This group is related to hypnotics. The term ''sedative'' describes drugs that serve to calm or Anxiolytic, relieve anxiety, whereas the term ''hypnotic'' describes drugs whose main purpose is to initiate, sustain, or lengthen sleep. Because these two functions frequently overlap, and because drugs in this class generally produce dose-dependent effects (ranging from anxiolysis to loss of consciousness), they are often referred to collectively as ''sedative–hypnotic'' drugs. Terminology There is some overlap ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barbiturate
Barbiturates are a class of depressant, depressant drugs that are chemically derived from barbituric acid. They are effective when used medication, medically as anxiolytics, hypnotics, and anticonvulsants, but have physical and psychological addiction potential as well as overdose potential among other possible adverse effects. They have been recreational drug use, used recreationally for their anti-anxiety and sedative effects, and are thus prohibition of drugs, controlled in most countries due to the risks associated with such use. Barbiturates have largely been replaced by benzodiazepines and nonbenzodiazepines ("Z-drugs") in routine medical practice, particularly in the treatment of anxiety disorders and insomnia, because of the significantly lower risk of overdose, and the lack of an antidote for barbiturate overdose. Despite this, barbiturates are still in use for various purposes: in general anesthesia, epilepsy, treatment of acute migraines or cluster headaches, acute t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anesthesia
Anesthesia (American English) or anaesthesia (British English) is a state of controlled, temporary loss of sensation or awareness that is induced for medical or veterinary purposes. It may include some or all of analgesia (relief from or prevention of pain), paralysis (muscle relaxation), amnesia (loss of memory), and unconsciousness. An individual under the effects of anesthetic drugs is referred to as being anesthetized. Anesthesia enables the painless performance of procedures that would otherwise require physical restraint in a non-anesthetized individual, or would otherwise be technically unfeasible. Three broad categories of anesthesia exist: * ''General anesthesia'' suppresses central nervous system activity and results in unconsciousness and total lack of Sensation (psychology), sensation, using either injected or inhaled drugs. * ''Sedation'' suppresses the central nervous system to a lesser degree, inhibiting both anxiolysis, anxiety and creation of long-term memory, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chlorpromazine
Chlorpromazine (CPZ), marketed under the brand names Thorazine and Largactil among others, is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia. Other uses include the treatment of bipolar disorder, severe behavioral problems in children including those with attention deficit hyperactivity disorder, nausea and vomiting, anxiety before surgery, and hiccups that do not improve following other measures. It can be given orally (by mouth), by intramuscular injection (injection into a muscle), or intravenously (injection into a vein). Chlorpromazine is in the typical antipsychotic class, and, chemically, is one of the phenothiazines. Its mechanism of action is not entirely clear but is believed to be related to its ability as a dopamine antagonist. It has antiserotonergic and antihistaminergic properties. Common side effects include movement problems, sleepiness, dry mouth, low blood pressure upon standing, and incr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diazepam
Diazepam, sold under the brand name Valium among others, is a medicine of the benzodiazepine family that acts as an anxiolytic. It is used to treat a range of conditions, including anxiety disorder, anxiety, seizures, alcohol withdrawal syndrome, muscle spasms, insomnia, and restless legs syndrome. It may also be used to cause amnesia, memory loss during certain medical procedures. It can be taken Oral administration, orally (by mouth), as a suppository inserted into the rectum, Intramuscular injection, intramuscularly (injected into muscle), Intravenous therapy, intravenously (injection into a vein) or used as a nasal spray. When injected intravenously, effects begin in one to five minutes and last up to an hour. When taken by mouth, effects begin after 15 to 60 minutes. Common side effects include sleepiness and trouble with coordination. Serious side effects are rare. They include increased risk of suicide, decreased breathing, and a paradoxical increased risk of seizures ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jonestown
The Peoples Temple Agricultural Project, better known by its informal name "Jonestown", was a remote settlement in Guyana established by the Peoples Temple, an American religious movement under the leadership of Jim Jones. Jonestown became internationally infamous when, on November 18, 1978, a total of 918 people died at the settlement; at the nearby Port Kaituma Airport, airstrip in Port Kaituma; and at a Temple-run building in Georgetown, Guyana, Georgetown, Guyana's capital city. The name of the settlement became synonymous with the incidents at those locations. A total of 909 individuals died in Jonestown itself, all but two from apparent cyanide poisoning, a significant number of whom were injected against their will. Jones and some Peoples Temple members referred to the act as a "revolutionary suicide" on an audio tape of the event, and in prior recorded discussions. The poisonings in Jonestown followed the murder of five others, including Member of Congress#United State ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fred Hampton
Fredrick Allen Hampton Sr. (August 30, 1948 – December 4, 1969) was an American activist and revolutionary socialist. He came to prominence in his late teens and early 20s in Chicago as deputy chairman of the national Black Panther Party and chair of the Illinois chapter. He founded the anti-racist, anti-classist Rainbow Coalition, a prominent multicultural political organization that initially included the Black Panthers, Young Patriots (which organized poor whites), and the Young Lords (which organized Puerto Ricans), and an alliance among major Chicago street gangs to help them end infighting and work for social change. As a Marxist-Leninist, Hampton considered fascism the greatest threat, saying "nothing is more important than stopping fascism, because fascism will stop us all." In 1967, the Federal Bureau of Investigation (FBI) identified Hampton as a radical threat. It tried to subvert his activities in Chicago, sowing disinformation among black progressive groups an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dorothy Kilgallen
Dorothy Mae Kilgallen (July 3, 1913 – November 8, 1965) was an American columnist, journalist, and television game show panelist. After spending two semesters at the College of New Rochelle, she started her career shortly before her 18th birthday as a reporter for the Hearst Corporation's '' New York Evening Journal''. In 1938, she began her newspaper column "The Voice of Broadway", which was eventually syndicated to more than 140 papers. In 1950, she became a regular panelist on the television game show ''What's My Line?'', continuing in the role until her death. Kilgallen's columns featured mostly show-business news and gossip, but also ventured into other topics, such as politics and organized crime. She wrote front-page articles for multiple newspapers on the Sam Sheppard trial and, years later, events related to the John F. Kennedy assassination, such as testimony by Jack Ruby. Early life Kilgallen was born in Chicago, Illinois, the daughter of newspaper reporter Ja ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tennessee Williams
Thomas Lanier Williams III (March 26, 1911 – February 25, 1983), known by his pen name Tennessee Williams, was an American playwright and screenwriter. Along with contemporaries Eugene O'Neill and Arthur Miller, he is considered among the three foremost playwrights of 20th-century American drama. At age 33, after years of obscurity, Williams suddenly became famous with the success of ''The Glass Menagerie'' (1944) in New York City. It was the first of a string of successes, including ''A Streetcar Named Desire'' (1947), ''Cat on a Hot Tin Roof'' (1955), ''Sweet Bird of Youth'' (1959), and ''The Night of the Iguana'' (1961). With his later work, Williams attempted a new style that did not appeal as widely to audiences. His drama ''A Streetcar Named Desire'' is often numbered on short lists of the finest American plays of the 20th century alongside Eugene O'Neill's ''Long Day's Journey into Night'' and Arthur Miller's ''Death of a Salesman''. Much of Williams's most acclaimed wor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Judy Garland
Judy Garland (born Frances Ethel Gumm; June 10, 1922June 22, 1969) was an American actress and singer. Possessing a strong contralto voice, she was celebrated for her emotional depth and versatility across film, stage, and concert performance. Garland achieved international recognition for her portrayal of Dorothy Gale in ''The Wizard of Oz'' (1939). Her recording of "Over the Rainbow" became an enduring song in American popular music. Over a career spanning more than forty-five years, she recorded Judy Garland discography#Studio albums, eleven studio albums, and several of her recordings were later inducted into the Grammy Hall of Fame. At the age of two, Garland began her career by performing with her two sisters as a vaudeville act, The Gumm Sisters. In 1935, she signed a contract with Metro-Goldwyn-Mayer at thirteen and appeared in supporting roles in ensemble musicals such as Broadway Melody of 1938, ''Broadway Melody of 1938'' (1937) and Thoroughbreds Don't Cry, ''Thorough ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
