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Reflex Neurovascular Dystrophy
Complex regional pain syndrome (CRPS type 1 and type 2), sometimes referred to by the hyponyms reflex sympathetic dystrophy (RSD) or reflex neurovascular dystrophy (RND), is a rare and severe form of neuroinflammatory and dysautonomic disorder causing chronic pain, neurovascular, and neuropathic symptoms. Although it can vary widely, the classic presentation occurs when severe pain from a physical trauma or neurotropic viral infection outlasts the expected recovery time, and may subsequently spread to uninjured areas. The symptoms of types 1 and 2 are the same, except type 2 is associated with nerve injury. Usually starting in a single limb, CRPS often first manifests as pain, swelling, limited range of motion, or partial paralysis, and/or changes to the skin and bones. It may initially affect one limb and then spread throughout the body; 35% of affected individuals report symptoms throughout the body. Two types are thought to exist: CRPS type 1 (previously referred to as ' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tibial Fracture
The leg is the entire lower limb of the human body, including the foot, thigh or sometimes even the hip or buttock region. The major bones of the leg are the femur (thigh bone), tibia (shin bone), and adjacent fibula. There are 30 bones in each leg. The thigh is located in between the hip and knee. The calf (rear) and shin (front), or shank, are located between the knee and ankle. Legs are used for standing, many forms of human movement, recreation such as dancing, and constitute a significant portion of a person's mass. Evolution has led to the human leg's development into a mechanism specifically adapted for efficient bipedal gait. While the capacity to walk upright is not unique to humans, other primates can only achieve this for short periods and at a great expenditure of energy. In humans, female legs generally have greater hip anteversion and tibiofemoral angles, while male legs have longer femur and tibial lengths. In humans, each lower limb is divided into the hip ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gabapentin
Gabapentin, sold under the brand name Neurontin among others, is an anticonvulsant medication primarily used to treat neuropathic pain and also for partial seizures of epilepsy. It is a commonly used medication for the treatment of neuropathic pain caused by diabetic neuropathy, postherpetic neuralgia, and central pain. It is moderately effective: about 30–40% of those given gabapentin for diabetic neuropathy or postherpetic neuralgia have a meaningful benefit. Gabapentin, like other gabapentinoid drugs, acts by decreasing activity of the α2δ-1 protein, coded by the CACNA2D1 gene, first known as an auxiliary subunit of voltage gated calcium channels. However, see Pharmacodynamics, below. By binding to α2δ-1, gabapentin reduces the release of excitatory neurotransmitters (primarily glutamate) and as a result, reduces excess excitation of neuronal networks in the spinal cord and brain. Sleepiness and dizziness are the most common side effects. Serious side effects in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rheumatology
Rheumatology () is a branch of medicine devoted to the diagnosis and management of disorders whose common feature is inflammation in the bones, muscles, joints, and internal organs. Rheumatology covers more than 100 different complex diseases, collectively known as rheumatic diseases, which includes many forms of arthritis as well as lupus and Sjögren syndrome, Sjögren's syndrome. Physician, Doctors who have undergone formal training in rheumatology are called rheumatologists. Many of these diseases are now known to be disorders of the immune system, and rheumatology has significant overlap with immunology, the branch of medicine that studies the immune system. Rheumatologist A rheumatologist is a physician who specializes in the field of medical sub-specialty called rheumatology. A rheumatologist holds a board certification after specialized training. In the United States, training in this field requires four years of undergraduate school, four years of medical school, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amplified Musculoskeletal Pain Syndrome
Amplified musculoskeletal pain syndrome (AMPS) is an illness characterized by notable pain intensity without an identifiable physical cause. Characteristic symptoms include skin sensitivity to light touch, also known as allodynia. Associated symptoms may include changes associated with disuse including changes in skin texture, color, and temperature, and changes in hair and nail growth. In up to 80% of cases, symptoms are associated with psychological trauma or psychological stress. AMPS may also follow physical injury or disease, illness. Other associations with AMPS include Ehlers-Danlos syndromes, Ehlers-danlos syndrome, myositis, arthritis, and other Rheumatism, rheumatologic diseases. Treatment for notable pain intensity without identifiable pathophysiology can include psychotherapy to alleviate psychological stress. Physical therapists, psychologically informed physical therapists in particular, can coach people on exercises they can do everyday at home. Clinicians who u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Range Of Motion
Range of motion (or ROM) is the linear or angular distance that a moving object may normally travel while properly attached to another. In biomechanics and strength training, ROM refers to the angular distance and direction a joint can move between the flexed position and the extended position. The act of attempting to increase this distance through therapeutic exercises (range of motion therapy— stretching from flexion to extension for physiological gain) is also sometimes called range of motion. In mechanical engineering, it is (also called ''range of travel'' or ''ROT'') used particularly when talking about mechanical devices, such as a sound volume control knob. In biomechanics Measuring range of motion Each specific joint has a normal range of motion that is expressed in degrees. The reference values for the normal ROM in individuals differ slightly depending on age and sex. For example, as an individual ages, they typically lose a small amount of ROM. Analog and trad ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edema
Edema (American English), also spelled oedema (British English), and also known as fluid retention, swelling, dropsy and hydropsy, is the build-up of fluid in the body's tissue (biology), tissue. Most commonly, the legs or arms are affected. Symptoms may include skin that feels tight, the area feeling heavy, and joint stiffness. Other symptoms depend on the underlying cause. Causes may include Chronic venous insufficiency, venous insufficiency, heart failure, kidney problems, hypoalbuminemia, low protein levels, liver problems, deep vein thrombosis, infections, kwashiorkor, angioedema, certain medications, and lymphedema. It may also occur in immobile patients (stroke, spinal cord injury, aging), or with temporary immobility such as prolonged sitting or standing, and during menstruation or pregnancy. The condition is more concerning if it starts suddenly, or pain or shortness of breath is present. Treatment depends on the underlying cause. If the underlying mechanism involve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pain
Pain is a distressing feeling often caused by intense or damaging Stimulus (physiology), stimuli. The International Association for the Study of Pain defines pain as "an unpleasant sense, sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage." Pain motivates organisms to withdraw from damaging situations, to protect a damaged body part while it heals, and to avoid similar experiences in the future. Congenital insensitivity to pain may result in reduced life expectancy. Most pain resolves once the noxious stimulus is removed and the body has healed, but it may persist despite removal of the stimulus and apparent healing of the body. Sometimes pain arises in the absence of any detectable stimulus, damage or disease. Pain is the most common reason for physician consultation in most developed countries. It is a major symptom in many medical conditions, and can interfere with a person's quality of life and general fun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurotropic Virus
A neurotropic virus is a virus that is capable of infecting nerve tissue. Terminology A neurotropic virus is said to be neuroinvasive if it is capable of accessing or entering the nervous system and neurovirulent if it is capable of causing disease within the nervous system. Both terms are often applied to central nervous system infections, although some neurotropic viruses are highly neuroinvasive for the peripheral nervous system (e.g. herpes simplex virus). Important neuroinvasive viruses include poliovirus, which is highly neurovirulent but weakly neuroinvasive, and rabies virus, which is highly neurovirulent but requires tissue trauma (often resulting from an animal bite) to become neuroinvasive. Using these definitions, herpes simplex virus is highly neuroinvasive for the peripheral nervous system and rarely neuroinvasive for the central nervous system, but in the latter case may cause herpesviral encephalitis and is therefore considered highly neurovirulent. Many arthropo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Physical Trauma
Injury is physiology, physiological damage to the living tissue of any organism, whether Injury in humans, in humans, Injury in animals, in other animals, or Injury in plants, in plants. Injuries can be caused in many ways, including mechanically with penetrating trauma, penetration by sharp objects such as Tooth, teeth or blunt trauma, with blunt objects, by heat or cold, or by venoms and biotoxins. Injury prompts an Inflammation, inflammatory response in many taxa of animals; this prompts wound healing. In both plants and animals, substances are often released to help to occlude the wound, limiting loss of fluids and the entry of pathogens such as bacteria. Many organisms secrete antimicrobial chemicals which limit wound infection; in addition, animals have a variety of immune responses for the same purpose. Both plants and animals have regrowth mechanisms which may result in complete or partial healing over the injury. Cells too can Cell damage, repair damage to a certain de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuropathic Pain
Neuropathic pain is pain caused by a lesion or disease of the somatosensory nervous system. Neuropathic pain may be associated with abnormal sensations called dysesthesia or pain from normally non-painful stimuli (allodynia). It may have continuous and/or episodic (paroxysmal) components. The latter resemble stabbings or electric shocks. Common qualities include burning or coldness, "pins and needles" sensations, numbness and itching. Up to 7–8% of the European population is affected by neuropathic pain, and in 5% of persons it may be severe. The pain may result from disorders of the peripheral nervous system or the central nervous system (brain and spinal cord). Neuropathic pain may occur in isolation or in combination with other forms of pain. Medical treatments focus on identifying the underlying cause and relieving pain. In cases of peripheral neuropathy, the pain may progress to insensitivity. Diagnosis Diagnosis of pain conditions relies on the character of the pain w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurovascular
A neurovascular bundle is a structure that binds nerves and veins (and in some cases arteries and lymphatics) with connective tissue so that they travel in tandem through the body. Structure There are two types of neurovascular bundles: superficial bundles and deep bundles. As arteries do not travel within the superficial fascia, the loose connective tissue under the skin, superficial neurovascular bundles differ from deep neurovascular bundles in both composition and function. Superficial bundles Superficial neurovascular bundles do not include arteries, and consist primarily of capillaries and nerves. Because capillaries function as the sites for substance exchange between interstitial fluid and blood, they tend to have large surface area and short diffusion path. Normally, capillaries consist of a central lumen lined with an endothelium, a single layer of smooth epithelial cells. Deep bundles Deep neurovascular bundles, which often include arteries, have a more compli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chronic Pain
Chronic pain is pain that persists or recurs for longer than 3 months.https://icd.who.int/browse/2025-01/mms/en#1581976053 It is also known as gradual burning pain, electrical pain, throbbing pain, and nauseating pain. This type of pain is in contrast to acute pain, which is pain associated with a cause that can be relieved by treating the cause, and decreases or stops when the cause improves. Chronic pain can last for years. Persistent pain often serves no apparent useful purpose. The most common types of chronic pain are back pain, severe headache, migraine, and facial pain. Chronic pain can cause very severe psychological and physical effects that sometimes continue until the end of life. Analysis of the grey matter (damage to brain neurons), insomnia and sleep deprivation, metabolic problems, chronic stress, obesity, and heart attack are examples of physical disorders; and Depression (mood), depression, and neurocognitive disorders are examples of mental disorders. A wide ra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
