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Pulmonary Surfactant (medication)
Pulmonary surfactant is used as a medication to treat and prevent respiratory distress syndrome in newborn babies. Prevention is generally done in babies born at a gestational age of less than 32 weeks. It is given by the endotracheal tube. Onset of effects is rapid. A number of doses may be needed. Side effects may include slow heart rate and low oxygen levels. Its use is also linked with intracranial bleeding. Pulmonary surfactant may be isolated from the lungs of cows or pigs or made artificially. Pulmonary surfactant was discovered in the 1950s and a manufactured version was approved for medical use in the United States in 1990. It is on the World Health Organization's List of Essential Medicines. Medical uses Pulmonary surfactant is used to treat and prevent respiratory distress syndrome in newborn babies. Prevention is generally done in babies born less than 32 weeks gestational age. Tentative evidence supports use in drowning. Surfactant administration can al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beractant
Beractant, also known by the trade name of Survanta, is a modified bovine pulmonary surfactant containing bovine lung extract (phospholipids, neutral lipids, fatty acids, and bovine surfactant proteins), to which synthetic DPPC, tripalmitin and palmitic acid are added. The composition provides 25 mg/mL phospholipids, 0.5 to 1.75 mg/mL triglycerides, 1.4 to 3.5 mg/mL free fatty acids, and <1.0 mg/mL total surfactant proteins. As an intratracheal suspension, it can be used for the prevention and treatment of neonatal syndrome. Survanta is manufactured by Abbvie
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Colfosceril Palmitate
Colfosceril palmitate (trade name Exosurf) is a drug used as a pulmonary surfactant. It is a drug that is used in surfactant deficient conditions such as infant respiratory distress syndrome in newborns. See also *Dipalmitoylphosphatidylcholine Dipalmitoylphosphatidylcholine (DPPC) is a phospholipid (and a lecithin) consisting of two C16 palmitic acid groups attached to a phosphatidylcholine head-group. It is the main constituent of pulmonary surfactants, which reduces the work of breath ... References Palmitate esters Phosphate esters {{respiratory-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Allen Clements
John Allen Clements (March 16, 1923 – September 3, 2024) was an American physician and physiologist known for his role in the discovery of pulmonary surfactant, a crucial factor in the development of life-saving treatments for neonatal respiratory distress syndrome. His research revolutionized the care of premature infants, greatly reducing infant mortality. Early life and education Clements was born on March 16, 1923, in Auburn, New York. He developed an early interest in medicine, completing his undergraduate studies at Princeton University. He graduated from Weill Cornell Medical College in 1947. Career Clements began his career as a physiologist focused on cardiovascular research but later shifted to pulmonary medicine. In 1957, while working at the University of California, San Francisco (UCSF), he made his seminal discovery of pulmonary surfactant, a lipid-protein mixture that reduces surface tension in the lungs and prevents the collapse of alveoli during exhalation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boehringer Ingelheim
C.H. Boehringer Sohn AG & Co. is the parent company of the Boehringer Ingelheim group, which was founded in 1885 by Albert Boehringer (1861–1939) in Ingelheim am Rhein, Germany. As of 2018, Boehringer Ingelheim is one of the world's List of largest pharmaceutical companies by revenue, largest pharmaceutical companies, and the largest private one. Headquartered in Ingelheim, it operates globally with more than 54,000 employees in 78 countries. Unlike most large pharmaceutical companies which are listed, the company is private and fully owned by the Boehringer, Liebrecht and von Baumbach families. The company's key areas of interest are: respiratory diseases, metabolism, immunology, oncology and diseases of the central nervous system. Boehringer Ingelheim is a full member of the European Federation of Pharmaceutical Industries and Associations (EFPIA). The corporate logo of Boehringer Ingelheim depicts a stylized rendition of the central section of Imperial Palace, Ingelheim, the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Poractant Alfa
Poractant alfa is a pulmonary surfactant sold under the brand name Curosurf by Chiesi Farmaceutici. Poractant alfa is an extract of natural porcine lung surfactant. As with other surfactants, marked improvement on oxygenation may occur within minutes of the administration of poractant alfa. The new generic form of surfactant is Varasurf (Sheep Lung Surfactant) developed in PersisGen Co. and commercialized by ArnaGen Pharmad. It has fully comparable quality profile with Curosurf. Pharmacology Each milliliter of poractant alfa contains 80 mg of surfactant (extract) that includes 76 mg of phospholipids and 1 mg of protein of which 0.2 mg is surfactant protein B (SP-B). Depending on local country registration, CUROSURF is available in 1.5 mL vials, 3.0 mL vials, and/or twin packs containing two 1.5 mL vials. The amount of phospholipids is calculated from the content of phosphorus and contains 55 mg of phosphatidylcholine of which 30 mg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calfactant
Calfactant, also known as Infasurf, is an intratracheal suspension derived from the natural surfactant in calf lungs. It is used in premature infants with lung surfactant deficiency that causes infant respiratory distress syndrome Infant respiratory distress syndrome (IRDS), also known as surfactant deficiency disorder (SDD), and previously called hyaline membrane disease (HMD), is a syndrome in premature infants caused by developmental insufficiency of pulmonary surfacta ... (IRDS).Drugs.com: Mechanism of action Lung surfactant is essential for effective ventilation as it modifies alveolar surface tension. IRDS is caused by a lung surfactant deficiency. Calfactant serves as a substitute for the natural surfactant. References Surfactants {{respiratory-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abbvie
AbbVie Inc. is an American pharmaceutical company headquartered in North Chicago, Illinois. It is ranked sixth on the list of largest biomedical companies by revenue. In 2023, the company's seat in Forbes Global 2000 was 74, and rank 89 on the 2024 list. The company's primary product is Humira (adalimumab) ($14billion in 2023 revenues, 27percent of total), administered via injection. It is approved to treat autoimmune diseases including rheumatoid arthritis, Crohn's disease, plaque psoriasis, and ulcerative colitis. It developed Skyrizi ($7.8billion in 2023 revenues), an interleukin-23 (IL-23) inhibitor also used to treat autoimmune diseases. Its other major products include Botox ($5.7billion in 2023 revenues), Imbruvica to treat cancer ($3.6billion in 2023 revenues), Rinvoq to treat arthritis ($4billion in 2023 revenues), Venclexta to treat leukemia and lymphoma ($2.3billion in 2023 revenues), Vraylar to treat schizophrenia and bipolar disorder ($2.7billion in 2023 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beractant
Beractant, also known by the trade name of Survanta, is a modified bovine pulmonary surfactant containing bovine lung extract (phospholipids, neutral lipids, fatty acids, and bovine surfactant proteins), to which synthetic DPPC, tripalmitin and palmitic acid are added. The composition provides 25 mg/mL phospholipids, 0.5 to 1.75 mg/mL triglycerides, 1.4 to 3.5 mg/mL free fatty acids, and <1.0 mg/mL total surfactant proteins. As an intratracheal suspension, it can be used for the prevention and treatment of neonatal syndrome. Survanta is manufactured by Abbvie
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Venticute
Pulmonary surfactant is used as a medication to treat and prevent respiratory distress syndrome in newborn babies. Prevention is generally done in babies born at a gestational age of less than 32 weeks. It is given by the endotracheal tube. Onset of effects is rapid. A number of doses may be needed. Side effects may include slow heart rate and low oxygen levels. Its use is also linked with intracranial bleeding. Pulmonary surfactant may be isolated from the lungs of cows or pigs or made artificially. Pulmonary surfactant was discovered in the 1950s and a manufactured version was approved for medical use in the United States in 1990. It is on the World Health Organization's List of Essential Medicines. Medical uses Pulmonary surfactant is used to treat and prevent respiratory distress syndrome in newborn babies. Prevention is generally done in babies born less than 32 weeks gestational age. Tentative evidence supports use in drowning. Surfactant administration can also ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Windtree Therapeutics
Windtree Therapeutics, Inc. (formerly Discovery Laboratories) is an American company which was set up in 1992 and now is based in Warrington, Pennsylvania, developing drug products (pulmonary medicine) for patients with respiratory disease. The company joined an alliance with Laboratorios del Dr. Esteve, S.A. In 2016, Discovery Laboratories changed name to Windtree Therapeutics, Inc. Products and services The major products of the company are Surfaxin (based on its capillary aerosol-generating technology) and Aerosurf. Surfaxin is a synthetic, peptide-containing (KL4) surfactant, similar to pulmonary surfactant, which is naturally in the lung for normal respiratory function. The drug is delivered by its capillary aerosol-generating technology to the lung. Aerosurf is a drug-device combination to prevent respiratory distress syndrome (RDS) in premature infants. In addition, the company also provides Afectair devices (disposable aerosol-conducting airway connectors). Research ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
