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Outer Hair Cell
Hair cells are the sensory receptors of both the auditory system and the vestibular system in the ears of all vertebrates, and in the lateral line organ of fishes. Through mechanotransduction, hair cells detect movement in their environment. In mammals, the auditory hair cells are located within the spiral organ of Corti on the thin basilar membrane in the cochlea of the inner ear. They derive their name from the tufts of stereocilia called ''hair bundles'' that protrude from the apical surface of the cell into the fluid-filled cochlear duct. The stereocilia number from fifty to a hundred in each cell while being tightly packed together and decrease in size the further away they are located from the kinocilium. Mammalian cochlear hair cells are of two anatomically and functionally distinct types, known as outer, and inner hair cells. Damage to these hair cells results in decreased hearing sensitivity, and because the inner ear hair cells cannot regenerate, this damage ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spiral Organ Of Corti
The organ of Corti, or spiral organ, is the receptor organ for hearing and is located in the mammalian cochlea. This highly varied strip of epithelium, epithelial cells allows for transduction of auditory signals into nerve impulses' action potential. Transduction occurs through vibrations of structures in the inner ear causing displacement of cochlear fluid and movement of hair cells at the organ of Corti to produce electrochemical signals.The Ear Pujol, R., Irving, S., 2013 Italian anatomist Alfonso Giacomo Gaspare Corti (1822–1876) discovered the organ of Corti in 1851. The structure evolved from the basilar papilla and is crucial for mechanotransduction in mammals. Structure [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basilar Membrane
The basilar membrane is a stiff structural element within the cochlea of the inner ear which separates two liquid-filled tubes that run along the coil of the cochlea, the scala media and the scala tympani. The basilar membrane moves up and down in response to incoming sound waves, which are converted to traveling waves on the basilar membrane. Structure The basilar membrane is a pseudo-resonant structure that, like the strings on an instrument, varies in width and stiffness. But unlike the parallel strings of a guitar, the basilar membrane is not a discrete set of resonant structures, but a single structure with varying width, stiffness, mass, damping, and duct dimensions along its length. The motion of the basilar membrane is generally described as a traveling wave. The properties of the membrane at a given point along its length determine its characteristic frequency (CF), the frequency at which it is most sensitive to sound vibrations. The basilar membrane is widest (0.42 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Physiological Reviews
''Physiological Reviews'' is a journal published quarterly by the American Physiological Society which has been published since 1921. The editor in chief of the journal is Sadis Matalon (University of Alabama at Birmingham). The journal's first managing editor, who served to his death in 1946, was Dr. Donald R. Hooker. Among the cadre of editors at the journal's inception were William Henry Howell, Lafayette Mendel, and John Macleod. From 1932 to 1950, the chairman of the board of editors of the journal was Anton J. Carlson. Other notable people who have served on the journal's editorial board include John Jacob Abel (c. 1935), Ernest William Goodpasture (c.1938). According to the Journal Citation Reports, the journal has a 2020 impact factor of 37.312Internet Archive page set(values in table linked to specific pages) References Further reading * ResearchGate journal ranking: * SCImago Journal Rank The SCImago Journal Rank (SJR) indicator is a measure of the pres ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Journal Of Physiology
''The Journal of Physiology'' is a semi-monthly peer-reviewed scientific journal that was established in 1878 and is published by Wiley-Blackwell on behalf of The Physiological Society. It covers research on all aspects of physiology, with an emphasis on human and mammalian physiology, including work at the molecular level, at the level of the cell membrane, single cells, tissues or organs, and systems physiology. The full archive back to 1878 up to issues published 12 months from the current date is freely available online. The editor-in-chief is Kim Barrett (University of California, Davis). According to the ''Journal Citation Reports'', the journal has a 2022 impact factor of 5.5. History The journal was first published in 1878 and edited by Michael Foster. In 1893–1894 Foster's colleague John Newport Langley took over as editor. Langley remained the proprietor and editor until his death in 1925, when The Physiological Society bought the journal from his widow. Charles ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mechanical Amplifier
A mechanical amplifier or a mechanical amplifying element is a linkage mechanism that amplifies the magnitude of mechanical quantities such as force, displacement, velocity, acceleration and torque in linear and rotational systems.B.C. Nakra and K.K. Chaudhry, (1985), Instrumentation, Measurement and Analysis, Tata McGraw-Hill Publishing, , page 153. In some applications, mechanical amplification induced by nature or unintentional oversights in man-made designs can be disastrous, causing situations such as the 1940 Tacoma Narrows Bridge collapse. When employed appropriately, it can help to magnify small mechanical signals for practical applications. No additional energy can be created from any given mechanical amplifier due to conservation of energy. Claims of using mechanical amplifiers for perpetual motion machines are false, due to either a lack of understanding of the working mechanism or a simple hoax. Generic mechanical amplifiers Amplifiers, in the most general sense, are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bird
Birds are a group of warm-blooded vertebrates constituting the class (biology), class Aves (), characterised by feathers, toothless beaked jaws, the Oviparity, laying of Eggshell, hard-shelled eggs, a high Metabolism, metabolic rate, a four-chambered heart, and a strong yet lightweight Bird skeleton, skeleton. Birds live worldwide and range in size from the bee hummingbird to the common ostrich. There are over 11,000 living species and they are split into 44 Order (biology), orders. More than half are passerine or "perching" birds. Birds have Bird wing, wings whose development varies according to species; the only known groups without wings are the extinct moa and elephant birds. Wings, which are modified forelimbs, gave birds the ability to fly, although further evolution has led to the Flightless bird, loss of flight in some birds, including ratites, penguins, and diverse endemism, endemic island species. The digestive and respiratory systems of birds are also uniquely a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zebrafish
The zebrafish (''Danio rerio'') is a species of freshwater ray-finned fish belonging to the family Danionidae of the order Cypriniformes. Native to South Asia, it is a popular aquarium fish, frequently sold under the trade name zebra danio (and thus often called a " tropical fish" although it is both tropical and subtropical). The zebrafish is an important and widely used vertebrate model organism in scientific research, particularly developmental biology, but also gene function, oncology, teratology, and drug development, in particular pre-clinical development. It is also notable for its regenerative abilities, and has been modified by researchers to produce many transgenic strains. Taxonomy The zebrafish is a derived member of the genus '' Brachydanio'', of the family Cyprinidae. It has a sister-group relationship with '' Danio aesculapii''. Zebrafish are also closely related to the genus '' Devario'', as demonstrated by a phylogenetic tree of close species. Distri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Regeneration (biology)
Regeneration in biology is the process of renewal, restoration, and tissue growth that makes genomes, cell (biology), cells, organisms, and ecosystems Resilience (ecology), resilient to natural fluctuations or events that cause disturbance or damage. Every species is capable of regeneration, from bacteria to humans. Regeneration can either be complete where the new tissue is the same as the lost tissue, or incomplete after which the necrotic tissue becomes Fibrosis, fibrotic. At its most elementary level, regeneration is mediated by the molecular processes of gene regulation and involves the cellular processes of cell proliferation, morphogenesis and cell differentiation. Regeneration in biology, however, mainly refers to the Morphogenesis, morphogenic processes that characterize the phenotypic plasticity of Phenotypic trait, traits allowing multi-cellular organisms to repair and maintain the integrity of their physiological and morphological states. Above the genetic level, rege ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sensorineural Hearing Loss
Sensorineural hearing loss (SNHL) is a type of hearing loss in which the root cause lies in the inner ear, sensory organ (cochlea and associated structures), or the vestibulocochlear nerve (Cranial nerves, cranial nerve VIII). SNHL accounts for about 90% of reported hearing loss. SNHL is usually permanent and can be mild, moderate, severe, profound, or total. Various other descriptors can be used depending on the shape of the audiogram, such as high frequency, low frequency, U-shaped, notched, peaked, or flat. ''Sensory'' hearing loss often occurs as a consequence of damaged or deficient cochlear hair cells. Hair cells may be abnormal at birth or damaged during the lifetime of an individual. There are both external causes of damage, including Ear infection, infection, and Ototoxicity, ototoxic drugs, as well as intrinsic causes, including genetic mutations. A common cause or exacerbating factor in SNHL is prolonged exposure to environmental noise, or noise-induced hearing loss. Ex ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mammalian
A mammal () is a vertebrate animal of the Class (biology), class Mammalia (). Mammals are characterised by the presence of milk-producing mammary glands for feeding their young, a broad neocortex region of the brain, fur or hair, and three Evolution of mammalian auditory ossicles, middle ear bones. These characteristics distinguish them from reptiles and birds, from which their ancestors Genetic divergence, diverged in the Carboniferous Period over 300 million years ago. Around 6,640 Neontology#Extant taxon, extant species of mammals have been described and divided into 27 Order (biology), orders. The study of mammals is called mammalogy. The largest orders of mammals, by number of species, are the rodents, bats, and eulipotyphlans (including hedgehogs, Mole (animal), moles and shrews). The next three are the primates (including humans, monkeys and lemurs), the Artiodactyl, even-toed ungulates (including pigs, camels, and whales), and the Carnivora (including Felidae, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kinocilium
A kinocilium is a special type of cilium on the apex of hair cells located in the sensory epithelium of the vertebrate inner ear. Contrasting with stereocilia, which are numerous, there is only one kinocilium on each hair cell. The kinocilium can be identified by its apical position as well as its enlarged tip. Together with stereocilia, the kinocilium regulates depolarization and hyperpolarization of the hair cell, which is a neuron that can generate action potentials. When the stereocilia and kinocilium move further apart, the cell hyperpolarizes. When they move closer together, the cell depolarizes and may fire an action potential. Anatomy in humans Kinocilia are found on the apical surface of hair cells and are involved in both the morphogenesis of the hair bundle and mechanotransduction. Vibrations (either by movement or sound waves) cause displacement of the hair bundle, resulting in depolarization or hyperpolarization of the hair cell. The depolarization of the hair cells ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cochlear Duct
Cochlear, the adjective form of cochlea, may refer to: * Cochlear implant, a sensory aid for the deaf * Cochlear nuclei, the ventral cochlear nucleus and the dorsal (or lateral) cochlear nucleus * Vestibular-cochlear or Vestibulocochlear nerve, the eighth cranial nerve * Cochlear nerve, a division of the eighth cranial nerve * Cochlear aqueduct, or aqueduct of cochlea, a communication between the perilymphatic space and the subarachnoid space * Cochlear artery, a division of the internal auditory artery * Cochlea, part of the Labyrinth (inner ear) * Cochlear duct, also known as the scala media, the endolymph-filled part of the cochlea * Cochlear, an alternate term for the spoon (liturgy) used in the Eastern Orthodox Church in serving the sacramental wine, sometimes with a particle of the sacramental bread * The spoon-like tip of the scape found on the epigyne of some female spiders * Cochlear Limited, manufacturer of Nucleus Cochlear Implant * Cochlear Bone Anchored Solu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
