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New England Compounding Center Meningitis Outbreak
A New England Compounding Center meningitis outbreak that began in September 2012 sickened 798 individuals and resulted in the deaths of 64 people. In September 2012, the Centers for Disease Control and Prevention, in collaboration with state and local health departments and the Food and Drug Administration (FDA), began investigating a multistate outbreak of fungal meningitis and other infections among patients who had received contaminated steroid injections from the New England Compounding Center (NECC) in Framingham, Massachusetts. The NECC was classified as a compounding pharmacy. The traditional role of compounding pharmacies is to make drugs prescribed by doctors for specific patients with needs that can't be met by commercially available drugs. In October 2012, an investigation of the NECC revealed the company had been in violation of its state license because it had been functioning as a drug manufacturer, producing drugs for broad use rather than filling individual pre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steroid
A steroid is an organic compound with four fused compound, fused rings (designated A, B, C, and D) arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and as signal transduction, signaling molecules. Examples include the lipid cholesterol, sex hormones estradiol and testosterone, anabolic steroids, and the anti-inflammatory corticosteroid drug dexamethasone. Hundreds of steroids are found in Fungus, fungi, plants, and animals. All steroids are manufactured in cells from a sterols, sterol: Cholesterol, cholesterol (animals), lanosterol (opisthokonts), or cycloartenol (plants). All three of these molecules are produced via Cyclic compound, cyclization of the triterpene squalene. Structure The steroid nucleus (parent structure, core structure) is called gonane (cyclopentanoperhydrophenanthrene). It is typically composed of seventeen carbon atoms, bonded in fou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Racketeer Influenced And Corrupt Organizations Act
The Racketeer Influenced and Corrupt Organizations (RICO) Act is a United States federal law that provides for extended criminal penalties and a civil cause of action for acts performed as part of an ongoing criminal organization. RICO was enacted by Title IX of the Organized Crime Control Act, Organized Crime Control Act of 1970 (), and is codified at as . This article primarily covers the federal criminal statute, but since 1972, 33 U.S. states and territories have adopted state RICO laws, which although similar, cover additional state crimes and may differ from the federal law and each other in several respects. History G. Robert Blakey, an adviser to the United States Senate Committee on Homeland Security and Governmental Affairs, United States Senate Government Operations Committee, drafted the law under the close supervision of Senator John L. McClellan, the Chairman of the Criminal Law and Procedures Subcommittee of the Senate Judiciary Committee. It was signed i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aspergillus Fumigatus
''Aspergillus fumigatus'' is a species of fungus in the genus ''Aspergillus'', and is one of the most common ''Aspergillus'' species to cause disease in individuals with an immunodeficiency. ''Aspergillus fumigatus'', a saprotroph widespread in nature, is typically found in soil and decaying organic matter, such as compost heaps, where it plays an essential role in carbon and nitrogen recycling. Colonies of the fungus produce from conidiophores; thousands of minute grey-green conidia (2–3 μm) which readily become airborne. For many years, ''A. fumigatus'' was thought to only reproduce asexually, as neither mating nor meiosis had ever been observed. In 2008, ''A. fumigatus'' was shown to possess a fully functional sexual reproductive cycle, 145 years after its original description by Fresenius. Although ''A. fumigatus'' occurs in areas with widely different climates and environments, it displays low genetic variation and a lack of population genetic differentiation on a global s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Exserohilum Rostratum
''Setosphaeria rostrata'' is a heat tolerant fungus with an asexual reproductive form (anamorph) known as '' Exserohilum rostratum''. This fungus is a common plant pathogen, causing leaf spots as well as crown rot and root rot in grasses. It is also found in soils and on textiles in subtropical and tropical regions. ''Exserohilum rostratum'' is one of the 35 ''Exserohilum'' species implicated uncommonly as opportunistic pathogens of humans where it is an etiologic agent of sinusitis, keratitis, skin lesions and an often fatal meningoencephalitis. Infections caused by this species are most often seen in regions with hot climates like Israel, India and the southern USA. Growth ''Setosphaeria rostrata'' produce mature conidia with a distinct protruding hilum. The conidia are either straight, curved or bent and the septum above the hilum is thickened and dark. The walls are typically roughened and brown to olive in colour and there are typically 7–9 septa, however, some have 4–1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Triamcinolone Acetonide
Triamcinolone acetonide, sold under the brand name Kenalog among others, is a synthetic compound, synthetic corticosteroid medication used topical medication, topically to treat various skin conditions, to relieve the discomfort of mouth sores, and by Joint injection, injection into joints to treat various arthropathy, joint conditions. It is also injected into lesion, lesions to treat inflammation in some parts of the body, particularly the skin. In nasal spray form, it is used to treat allergic rhinitis. It is used for the treatment of macular edema associated with uveitis. It is a more potency (pharmacology), potent derivative of triamcinolone, and is about eight times as potent as prednisone. Most forms of triamcinolone acetonide are Prescription drug, prescription drugs. In 2014, the U.S. Food and Drug Administration (FDA) made triamcinolone acetonide an over-the-counter drug in the United States in nasal spray form under the brand name Nasacort. It is available as a gener ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Associated Press
The Associated Press (AP) is an American not-for-profit organization, not-for-profit news agency headquartered in New York City. Founded in 1846, it operates as a cooperative, unincorporated association, and produces news reports that are distributed to its members, major U.S. daily newspapers and radio and television broadcasters. Since the award was established in 1917, the AP has earned 59 Pulitzer Prizes, including 36 for photography. The AP is also known for its widely used ''AP Stylebook'', its AP polls tracking National Collegiate Athletic Association, NCAA sports, sponsoring the National Football League's annual awards, and its election polls and results during Elections in the United States, US elections. By 2016, news collected by the AP was published and republished by more than 1,300 newspapers and broadcasters. The AP operates 235 news bureaus in 94 countries, and publishes in English, Spanish, and Arabic. It also operates the AP Radio Network, which provides twice ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yahoo! News
Yahoo News (stylized as Yahoo! News) is a news website that originated as an internet-based news aggregator by Yahoo. The site was created by Yahoo software engineer Brad Clawsie in August 1996. Articles originally came from news services such as the Associated Press, Reuters, Fox News, Al Jazeera, ABC News, ''USA Today'', CNN and BBC News. In 2000, Yahoo News launched pages tracking the content on the site that was most viewed and most shared by email. The "most emailed" page in particular was noted as an innovation in online news aggregation. Yahoo News allows users to comment on articles. Between late 2006 and early 2010, comments were disabled in part due to moderation challenges. By 2011, Yahoo had expanded its focus to include original content, as part of its plans to become a major media organization. Veteran journalists (including Walter Shapiro and Virginia Heffernan) were hired, while the website had a correspondent in the White House press corps for the first ti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Product Recall
"Product Recall" is the twenty-first episode of the third season of the American comedy television series '' The Office'' and the show's forty-ninth episode overall. The series depicts the everyday lives of office employees in the Scranton branch of the fictional Dunder Mifflin Paper Company. In this episode, the company deals with the consequences of an offending watermark that appeared on several reams of paper. Michael Scott ( Steve Carell) holds a poorly attended press conference, Jim Halpert ( John Krasinski) and Andy Bernard ( Ed Helms) head to a high school that printed their prom invitations on the paper to apologize, and Creed Bratton ( Creed Bratton) frames an employee at the paper mill to keep his job. The episode was written by Justin Spitzer and Brent Forrester, and was directed by Randall Einhorn, the series director of photography. The cast found the scene in which Jim impersonates Dwight Schrute ( Rainn Wilson) to be hilarious and had trouble keeping ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Wall Street Journal
''The Wall Street Journal'' (''WSJ''), also referred to simply as the ''Journal,'' is an American newspaper based in New York City. The newspaper provides extensive coverage of news, especially business and finance. It operates on a subscription model, requiring readers to pay for access to most of its articles and content. The ''Journal'' is published six days a week by Dow Jones & Company, a division of News Corp. As of 2023, ''The'' ''Wall Street Journal'' is the List of newspapers in the United States, largest newspaper in the United States by print circulation, with 609,650 print subscribers. It has 3.17 million digital subscribers, the second-most in the nation after ''The New York Times''. The newspaper is one of the United States' Newspaper of record, newspapers of record. The first issue of the newspaper was published on July 8, 1889. The Editorial board at The Wall Street Journal, editorial page of the ''Journal'' is typically center-right in its positio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epidural
Epidural administration (from Ancient Greek ἐπί, "upon" + '' dura mater'') is a method of medication administration in which a medicine is injected into the epidural space around the spinal cord. The epidural route is used by physicians and nurse anesthetists to administer local anesthetic agents, analgesics, diagnostic medicines such as radiocontrast agent Radiocontrast agents are substances used to enhance the visibility of internal structures in X-ray-based imaging techniques such as computed tomography (contrast CT), projectional radiography, and fluoroscopy. Radiocontrast agents are typically iod ...s, and other medicines such as glucocorticoids. Epidural administration involves the placement of a catheter into the epidural space, which may remain in place for the duration of the treatment. The technique of intentional epidural administration of medication was first described in 1921 by the Spanish Aragonese people, Aragonese military surgeon Fidel Pagés. Epidural ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Back Pain
Back pain (Latin: ''dorsalgia'') is pain felt in the back. It may be classified as neck pain (cervical), middle back pain (thoracic), lower back pain (lumbar) or coccydynia (tailbone or sacral pain) based on the segment affected. The lumbar area is the most common area affected. An episode of back pain may be Acute (medicine), acute, subacute or Chronic condition, chronic depending on the duration. The pain may be characterized as a dull ache, shooting or piercing pain or a burning sensation. Discomfort can radiate to the arms and hands as well as the Human leg, legs or Human foot, feet, and may include Paresthesia, numbness or weakness in the legs and arms. The majority of back pain is nonspecific and Idiopathic disease, idiopathic. Common underlying mechanisms include degenerative or traumatic changes to the Intervertebral disc, discs and facet joints, which can then cause secondary pain in the muscles and nerves and referred pain to the bones, joints and extremities. Diseases ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
