Neuropeptide Receptor

	Neuropeptide Receptor A neuropeptide receptor is a type of peptide receptor which binds one or more neuropeptides. An example is the μ-opioid receptor, which binds to and is activated by the neuropeptide β-endorphin. See also * Neurotransmitter receptor A neurotransmitter receptor (also known as a neuroreceptor) is a membrane receptor protein that is activated by a neurotransmitter. Chemicals on the outside of the cell, such as a neurotransmitter, can bump into the cell's membrane, in which the ... References External links * Neuropeptides Receptors {{receptor-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Peptide Receptor Signaling peptide receptor is a type of receptor which binds one or more signaling peptides or signaling proteins. An example is the tropomyosin receptor kinase B (TrkB), which is bound and activated by the neurotrophic protein brain-derived neurotrophic factor (BDNF). Another example is the μ-opioid receptor (MOR), which is bound and activated by the opioid peptide hormone β-endorphin. Adiponectin receptor AdipoR1 * Agonists Peptide * Adiponectin * ADP-355 * ADP-399 Non-peptide * AdipoRon * (–)-Arctigenin * Arctiin * Gramine * Matairesinol * Antagonists Peptide * ADP-400 AdipoR2 * Agonists Peptide * Adiponectin * ADP-355 * ADP-399 Non-peptide * AdipoRon * Deoxyschizandrin * Parthenolide * Syringing * Taxifoliol * Antagonists Peptide * ADP-400 Angiotensin receptor Bradykinin receptor * Agonists Bradykinin Kallidin * Antagonists FR-173657 Icatibant LF22-0542 Calcitonin gene-relat ... [...More Info...] [...Related Items...] OR:** [Wikipedia] [Google] [Baidu]
	Neuropeptide Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues like the gut, muscles, and heart. There are over 100 known neuropeptides, representing the largest and most diverse class of signaling molecules in the nervous system. Neuropeptides are synthesized from large precursor proteins which are cleaved and post-translationally processed then packaged into dense core vesicles. Neuropeptides are often co-released with other neuropeptides and neurotransmitters in a single neuron, yielding a multitude of effects. Once released, neuropeptides can diffuse widely to affect a broad range of targets. Synthesis Neuropeptides are synthesized from large, inactive precursor proteins called prepropeptides. Prepropeptides contain sequences for a family of distinct peptides and often contain repeated copies of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	μ-opioid Receptor The μ-opioid receptors (MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins. They are also referred to as μ(''mu'')-opioid peptide (MOP) receptors. The prototypical μ-opioid receptor agonist is morphine, the primary psychoactive alkaloid in opium. It is an inhibitory G-protein coupled receptor that activates the Gi alpha subunit, inhibiting adenylate cyclase activity, lowering cAMP levels. Structure The structure of the μ-opioid receptor has been determined with the antagonist β-FNA, the agonist BU72, and in a complex with DAMGO and Gi protein. Splice variants Three variants of the μ-opioid receptor are well characterized, though RT-PCR has identified up to 10 total splice variants in humans. Location They can exist either presynaptically or postsynaptically depending upon cell types. The μ-opioid receptors exist mostly presynaptically in the periaqueductal gray region, and in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	β-endorphin ''beta''-Endorphin (β-endorphin) is an endogenous opioid neuropeptide and peptide hormone that is produced in certain neurons within the central nervous system and peripheral nervous system. It is one of three endorphins that are produced in humans, the others of which include α-endorphin and γ-endorphin. The amino acid sequence is: tyrosine, Tyr-Glycine, Gly-Gly-Phenylalanine, Phe-Methionine, Met-Threonine, Thr-Serine, Ser-glutamic acid, Glu-Lysine, Lys-Ser-Glutamine, Gln-Thr-Proline, Pro-Leucine, Leu-Valine, Val-Thr-Leu-Phe-Lys-Asparagine, Asn-Alanine, Ala-Isoleucine, Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu (31 amino acids). The first 16 amino acids are identical to α-endorphin. β-Endorphin is considered to be a part of the endogenous opioid and endorphin classes of neuropeptides; all of the established endogenous opioid peptides contain the same N-terminal amino acid sequence, Tyr-Gly-Gly-Phe, followed by either or . Function of β-endorphin has been known to be assoc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Neurotransmitter Receptor A neurotransmitter receptor (also known as a neuroreceptor) is a membrane receptor protein that is activated by a neurotransmitter. Chemicals on the outside of the cell, such as a neurotransmitter, can bump into the cell's membrane, in which there are receptors. If a neurotransmitter bumps into its corresponding receptor, they will bind and can trigger other events to occur inside the cell. Therefore, a membrane receptor is part of the molecular machinery that allows cells to communicate with one another. A neurotransmitter receptor is a class of receptors that specifically binds with neurotransmitters as opposed to other molecules. In postsynaptic cells, neurotransmitter receptors receive signals that trigger an electrical signal, by regulating the activity of ion channels. The influx of ions through ion channels opened due to the binding of neurotransmitters to specific receptors can change the membrane potential of a neuron. This can result in a signal that runs along the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Neuropeptides Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons. Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues like the gut, muscles, and heart. There are over 100 known neuropeptides, representing the largest and most diverse class of signaling molecules in the nervous system. Neuropeptides are synthesized from large precursor proteins which are cleaved and post-translationally processed then packaged into dense core vesicles. Neuropeptides are often co-released with other neuropeptides and neurotransmitters in a single neuron, yielding a multitude of effects. Once released, neuropeptides can diffuse widely to affect a broad range of targets. Synthesis Neuropeptides are synthesized from large, inactive precursor proteins called prepropeptides. Prepropeptides contain sequences for a family of distinct peptides and often contain repeated copies of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]