Neophyl Chloride Synthesis
Neophyl can mean: * neophyl group, trivial name of 2-methyl-2-phenylpropyl functional group, PhC(CH3)2CH2- (e.g. in neophyl chloride) * one of trade names of diprophylline Diprophylline (INN) or dyphylline ( USAN) (trade names Dilor, Lufyllin), is a xanthine derivative with bronchodilator and vasodilator effects. It is used in the treatment of respiratory disorders like asthma, cardiac dyspnea, and bronchitis. It a ...

Neophyl Chloride
Neophyl chloride, C6H5C(CH3)2CH2Cl, is a halogenated organic compound with unusual nucleophilic substitution properties. Neophyl chloride is used to form a versatile organolithium reagent, neophyl lithium, by reaction with lithium. Preparation Neophyl chloride was first synthesized by Haller and Ramart by reacting the chlorinating reagent thionyl chloride with neophyl alcohol: :C6H5C(CH3)2CH2OH + SOCl2 → C6H5C(CH3)2CH2Cl + HCl + SO2 It is easily prepared on a large scale by combining benzene and methallyl chloride in the presence of a catalytic quantity of sulfuric acid. The reaction is an example of an electrophilic aromatic substitution. :H2C=C(CH3)CH2Cl + C6H6 → C6H5C(CH3)2CH2Cl Alternatively ''tert''-butylbenzene can be chlorinated with sulfuryl chloride. Reactions and applications Neophyl chloride can be used to form an organolithium reagent, neophyl lithium, by reaction with lithium. Organolithium reagents are useful due to their nucleophilic properties and th ...
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