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MicroRNA And MicroRNA Target Database
This microRNA database and microRNA targets databases is a compilation of databases and web portals and servers used for microRNAs and their targets. MicroRNAs MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides. Found in plants, animals and some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. miR ... (miRNAs) represent an important class of small non-coding RNAs (ncRNAs) that regulate gene expression by targeting messenger RNAs. microRNA target gene databases microRNA databases References Further reading * * External links starBase databaseStarScan toolCupid: simultaneous reconstruction of microRNA-target and ceRNA networksmiRBase databasedeepBase databaseTargetScanpicTarmiRecords databaseTarBase databaseTarget ID LibrarymiRTarBase database {{DEFAULTSORT:MicroRNA RNA MicroRNA Genetics databases ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MicroRNA
MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides. Found in plants, animals and some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. miRNAs base-pair to complementary sequences in mRNA molecules, then gene silence said mRNA molecules by one or more of the following processes: (1) cleavage of mRNA strand into two pieces, (2) destabilization of mRNA by shortening its poly(A) tail, or (3) translation of mRNA into proteins. This last method of gene silencing is the least efficient of the three, and requires the aid of ribosomes. miRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins, whereas siRNAs derive from longer regions of double-stranded RNA. The human genome may encode over 1900 miRNAs, although more recent analysis s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pien Chien Huang
Pien-Chien Huang (; 13 July 1931 – 3 August 2020) was a Chinese-American molecular biologist. Huang was born in Shanghai on 13 July 1931. He graduated from National Taiwan University in 1952, with a bachelor's degree in agriculture. Huang earned a master's degree at Virginia Tech in 1956, followed by a doctorate from Ohio State University in 1960. He was elected to the Academia Sinica in 1986, and taught at National Tsing Hua University in Taiwan from 1993 to 1996, concurrently serving as dean of the College of Life Sciences at NTHU. Huang taught at Johns Hopkins University's Bloomberg School of Public Health Bloomberg may refer to: People * Daniel J. Bloomberg (1905–1984), audio engineer * Georgina Bloomberg (born 1983), professional equestrian * Michael Bloomberg (born 1942), American businessman and founder of Bloomberg L.P.; politician and ma ... for five decades, where he was professor of biochemistry and molecular biology. Huang was also a correspondence research ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Footnotes
A note is a string of text placed at the bottom of a page in a book or document or at the end of a chapter, volume, or the whole text. The note can provide an author's comments on the main text or citations of a reference work in support of the text. Footnotes are notes at the foot of the page while endnotes are collected under a separate heading at the end of a chapter, volume, or entire work. Unlike footnotes, endnotes have the advantage of not affecting the layout of the main text, but may cause inconvenience to readers who have to move back and forth between the main text and the endnotes. In some editions of the Bible, notes are placed in a narrow column in the middle of each page between two columns of biblical text. Numbering and symbols In English, a footnote or endnote is normally flagged by a superscripted number immediately following that portion of the text the note references, each such footnote being numbered sequentially. Occasionally, a number between bracke ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TargetScan
In bioinformatics, TargetScan is a web server that predicts biological targets of microRNAs (miRNAs) by searching for the presence of sites that match the seed region of each miRNA. For many species, other types of sites, known as 3'-compensatory sites are also identified. These miRNA target predictions are regularly updated and improved by the laboratory of David Bartel in conjunction with the Whitehead Institute Bioinformatics and Research Computing Group. TargetScan includes TargetScanHuman, TargetScanMouse, TargetScanFish, TargetScanFly, and TargetScanWorm. which provide predictions for mammals, zebrafish, insects, and nematodes centered on the genes of human, mouse, zebrafish, ''Drosophila melanogaster'', and ''Caenorhabditis elegans'', respectively. Compared to other target-prediction tools TargetScan provides accurate rankings of the predicted targets for each miRNA. These rankings are based on either the probability of evolutionarily conserved targeting (PCT scores.) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MiRBase
In bioinformatics, miRBase is a biological database that acts as an archive of microRNA sequences and annotations. As of September 2010 it contained information about 15,172 microRNAs. This number has risen to 38,589 by March 2018. The miRBase registry provides a centralised system for assigning new names to microRNA genes. miRBase grew from the microRNA registry resource set up by Sam Griffiths-Jones in 2003. According to Ana Kozomara and Sam Griffiths-Jones miRBase has five aims: # To provide a consistent naming system for microRNAs # To provide a central place collecting all known microRNA sequences # To provide human and computer readable information for each microRNA # To provide primary evidence for each microRNA # To aggregate and link to microRNA target information MiRBase contains miRNAs belonging of various species belonging to Alveolata, Chromalveolata, Metazoa, Mycetozoa, Viridiplantae and Viruses. For the Viridiplantae, in release 21 (2014) data is available ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Database
In computing, a database is an organized collection of data stored and accessed electronically. Small databases can be stored on a file system, while large databases are hosted on computer clusters or cloud storage. The design of databases spans formal techniques and practical considerations, including data modeling, efficient data representation and storage, query languages, security and privacy of sensitive data, and distributed computing issues, including supporting concurrent access and fault tolerance. A database management system (DBMS) is the software that interacts with end users, applications, and the database itself to capture and analyze the data. The DBMS software additionally encompasses the core facilities provided to administer the database. The sum total of the database, the DBMS and the associated applications can be referred to as a database system. Often the term "database" is also used loosely to refer to any of the DBMS, the database system or an appli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deep Sequencing
Coverage (or depth) in DNA sequencing is the number of unique reads that include a given nucleotide in the reconstructed sequence. Deep sequencing refers to the general concept of aiming for high number of unique reads of each region of a sequence. Rationale Even though the sequencing accuracy for each individual nucleotide is very high, the very large number of nucleotides in the genome means that if an individual genome is only sequenced once, there will be a significant number of sequencing errors. Furthermore, many positions in a genome contain rare single-nucleotide polymorphisms (SNPs). Hence to distinguish between sequencing errors and true SNPs, it is necessary to increase the sequencing accuracy even further by sequencing individual genomes a large number of times. Ultra-deep sequencing The term "ultra-deep" can sometimes also refer to higher coverage (>100-fold), which allows for detection of sequence variants in mixed populations. In the extreme, error-corrected seq ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
