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Methuselah Prize
The Methuselah Foundation is an American-based global non-profit organization based in Springfield, Virginia, with a declared mission to "make 90 the new 50 by 2030" by supporting tissue engineering and regenerative medicine therapies. The organization was originally incorporated by David Gobel in 2001 as the Performance Prize Society, a name inspired by the British government’s Longitude Act, which offered monetary rewards for anyone who could devise a portable, practical solution for determining a ship's longitude. Founding In 2003, David Gobel, Aubrey de Grey, and Dane Gobel rebranded the organization Methuselah Foundation, named after Methuselah, the grandfather of Noah in the Hebrew Bible, whose lifespan was recorded as 969 years. The new name was introduced at the 32nd Annual Meeting of the American Aging Association, where they awarded the first Methuselah Mouse Prize to Andrej Bartke for his work on mice that lived the equivalent of 180 human years. The Foundation's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methuselah Foundation New Logo
Methuselah (; ''Məṯūšélaḥ'', in pausa ''Məṯūšālaḥ'', "His death shall send" or "Man of the javelin" or "Death of sword"; ''Mathousalas'') was a biblical patriarch and a figure in Judaism, Christianity, and Islam. He is claimed to have lived the longest life, dying at 969 years of age. According to the Book of Genesis, Methuselah was the son of Enoch, the father of Lamech, and the grandfather of Noah. Elsewhere in the Bible, Methuselah is mentioned in genealogies in 1 Chronicles and the Gospel of Luke. His life is described in further detail in other texts such as the Book of Enoch, Second Book of Enoch, Slavonic Enoch, and the Book of Moses. Bible commentators have offered various explanations as to why the Book of Genesis describes him as having died at such an advanced age; some believe that Methuselah's age is the result of a mistranslation, while others believe that his age is used to give the impression that part of Genesis takes place in a very distant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bible
The Bible is a collection of religious texts that are central to Christianity and Judaism, and esteemed in other Abrahamic religions such as Islam. The Bible is an anthology (a compilation of texts of a variety of forms) originally written in Hebrew, Aramaic, and Koine Greek. The texts include instructions, stories, poetry, prophecies, and other genres. The collection of materials accepted as part of the Bible by a particular religious tradition or community is called a biblical canon. Believers generally consider it to be a product of divine inspiration, but the way they understand what that means and interpret the text varies. The religious texts were compiled by different religious communities into various official collections. The earliest contained the first five books of the Bible, called the Torah in Hebrew and the Pentateuch (meaning 'five books') in Greek. The second-oldest part was a collection of narrative histories and prophecies (the Nevi'im). The third co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cellular Senescence
Cellular senescence is a phenomenon characterized by the cessation of cell division. In their experiments during the early 1960s, Leonard Hayflick and Paul Moorhead found that normal human fetal fibroblasts in culture reach a maximum of approximately 50 cell population doublings before becoming senescent. This process called the Hayflick limit is also known as "replicative senescence", since it is brought about through replication. Hayflick's discovery of mortal cells paved the path for the discovery and understanding of cellular aging molecular pathways. Cellular senescence can be initiated by a wide variety of stress inducing factors. These stress factors include both environmental and internal damaging events, abnormal cellular growth, oxidative stress, autophagy factors, among many other things. The physiological importance for cell senescence has been attributed to prevention of carcinogenesis, and more recently, aging, development, and tissue repair. Senescent cells c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organ Donation
Organ donation is the process when a person authorizes an organ (anatomy), organ of their own to be removed and organ transplantation, transplanted to another person, #Legislation and global perspectives, legally, either by consent while the donor is alive, through a Authorization, legal authorization for deceased donation made prior to death, or for deceased donations through the authorization by the De jure, legal next of Kinship, kin. Donation may be for research or, more commonly, healthy transplantable organs and tissues may be donated to be transplanted into another person. Common transplantations include kidney transplantation, kidneys, heart transplantation, heart, liver transplantation, liver, pancreas transplantation, pancreas, intestine transplantation, intestines, lung transplantation, lungs, bone transplantation, bones, bone marrow transplantation, bone marrow, skin transplantation, skin, and cornea transplantation, corneas. Some organs and tissues can be donated ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3D Bioprinting
Three dimensional (3D) bioprinting is the use of 3D printing–like techniques to combine cells, growth factors, bio-inks, and biomaterials to fabricate functional structures that were traditionally used for tissue engineering applications but in recent times have seen increased interest in other applications such as biosensing, and environmental remediation. Generally, 3D bioprinting uses a layer-by-layer method to deposit materials known as bio-inks to create tissue-like structures that are later used in various medical and tissue engineering fields. 3D bioprinting covers a broad range of bioprinting techniques and biomaterials. Currently, bioprinting can be used to print tissue and organ models to help research drugs and potential treatments. Nonetheless, translation of bioprinted living cellular constructs into clinical application is met with several issues due to the complexity and cell number necessary to create functional organs. However, innovations span from bioprint ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organovo
Organovo Holdings, Inc. is an early-stage medical laboratory and research company which designs and develops functional, three dimensional human tissue (also known as 3D bioprinting technology) for medical research and therapeutic applications. Organovo was established in 2007 and is headquartered in San Diego, California. The company uses its internally developed NovoGen MMX Bioprinter for 3D bioprinting. Operations The company bioprints and markets human tissues as a means of accelerating the preclinical drug testing and discovery process, enabling treatments to be created more quickly and at lower cost, and without immediate risks to living test subjects. Organovo has long-term expectations that this technology could be suitable for surgical therapy and transplantation. Organovo also partners with biopharmaceutical companies and academic medical centers to design, build, and validate more predictive ''in vitro'' tissues for disease modeling and toxicology. The living test t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Subsidiary
A subsidiary, subsidiary company, or daughter company is a company (law), company completely or partially owned or controlled by another company, called the parent company or holding company, which has legal and financial control over the subsidiary company. Unlike regional branches or divisions, subsidiaries are considered to be distinct entities from their parent companies; they are required to follow the laws of where they are incorporated, and they maintain their own executive leadership. Two or more subsidiaries primarily controlled by same entity/group are considered to be sister companies of each other. Subsidiaries are a common feature of modern business, and most multinational corporations organize their operations via the creation and purchase of subsidiary companies. Examples of holding companies are Berkshire Hathaway, Jefferies Financial Group, The Walt Disney Company, Warner Bros. Discovery, and Citigroup, which have subsidiaries involved in many different Industry (e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Limited Liability Company
A limited liability company (LLC) is the United States-specific form of a private limited company. It is a business structure that can combine the pass-through taxation of a partnership or sole proprietorship with the limited liability of a corporation. An LLC is not a corporation under the laws of every state; it is a legal form of a company that provides limited liability to its owners in many jurisdictions. LLCs are well known for the flexibility that they provide to business owners; depending on the situation, an LLC may elect to use corporate tax rules instead of being treated as a partnership, and, under certain circumstances, LLCs may be organized as not-for-profit. In certain U.S. states (for example, Texas), businesses that provide professional services requiring a state professional license, such as legal or medical services, may not be allowed to form an LLC but may be required to form a similar entity called a professional limited liability company (PLLC). An ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inducement Prize Contest
An inducement prize contest (IPC) is a competition that awards a cash prize for the accomplishment of a feat, usually of engineering. IPCs are typically designed to extend the limits of human ability. Some of the most famous IPCs include the Longitude prize (1714–1765), the Orteig Prize (1919–1927) and prizes from enterprises such aChallenge Worksand the X Prize Foundation. IPCs are distinct from recognition prizes, such as the Nobel Prize, in that IPCs have prospectively defined criteria for what feat is to be achieved for winning the prize, while recognition prizes may be based on the beneficial effects of the feat. History Throughout history, there have been instances where IPCs were successfully utilized to push the boundaries of what would have been considered state-of-the-art at the time. The Longitude Prize was a reward offered by the British government for a simple and practical method for the precise determination of a ship's longitude. The prize, established t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fiscal Sponsorship
Fiscal sponsorship refers to the practice of non-profit organizations offering their legal and tax-exempt status to groups—typically projects—engaged in activities related to the sponsoring organization's mission. It typically involves a fee-based contractual arrangement between a project and an established non-profit. Originally, this concept was developed at the request of the Department of Housing and Urban Development to enable distribution of funds to local charitable groups in the 1950s and has been a practice ever since. Advantages of fiscal sponsorship Fiscal sponsorship can enable projects to share a common administrative platform with a larger organization, thus increasing efficiency. In addition to legal status, sponsors can provide payroll, employee benefits, office space, publicity, fundraising assistance, and training services, sparing projects the necessity of developing these resources and allowing them to focus on programmatic activities. Projects may seek f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific Research
The scientific method is an empirical method for acquiring knowledge that has been referred to while doing science since at least the 17th century. Historically, it was developed through the centuries from the ancient and medieval world. The scientific method involves careful observation coupled with rigorous skepticism, because cognitive assumptions can distort the interpretation of the observation. Scientific inquiry includes creating a testable hypothesis through inductive reasoning, testing it through experiments and statistical analysis, and adjusting or discarding the hypothesis based on the results. Although procedures vary across fields, the underlying process is often similar. In more detail: the scientific method involves making conjectures (hypothetical explanations), predicting the logical consequences of hypothesis, then carrying out experiments or empirical observations based on those predictions. with added notes. Reprinted with previously unpublished part, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Life Science
Life, also known as biota, refers to matter that has biological processes, such as signaling and self-sustaining processes. It is defined descriptively by the capacity for homeostasis, organisation, metabolism, growth, adaptation, response to stimuli, and reproduction. All life over time eventually reaches a state of death, and none is immortal. Many philosophical definitions of living systems have been proposed, such as self-organizing systems. Viruses in particular make definition difficult as they replicate only in host cells. Life exists all over the Earth in air, water, and soil, with many ecosystems forming the biosphere. Some of these are harsh environments occupied only by extremophiles. Life has been studied since ancient times, with theories such as Empedocles's materialism asserting that it was composed of four eternal elements, and Aristotle's hylomorphism asserting that living things have souls and embody both form and matter. Life originated at least ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
