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Haplogroup U4 (mtDNA)
Haplogroup U is a human mitochondrial DNA haplogroup (mtDNA). The clade arose from haplogroup R, likely during the early Upper Paleolithic. Its various subclades (labelled U1–U9, diverging over the course of the Upper Paleolithic) are found widely distributed across Northern and Eastern Europe, Central, Western and South Asia, as well as North Africa, the Horn of Africa, and the Canary Islands. Origins Haplogroup U descends from the haplogroup R mtDNA branch of the phylogenetic tree. The defining mutations (A11467G, A12308G, G12372A) are estimated to have arisen between 43,000 and 50,000 years ago, in the early Upper Paleolithic (around 46,530 ± 3,290 years before present, with a 95% confidence interval per Behar et al., 2012). Ancient DNA classified as belonging to the U* mitochondrial haplogroup has been recovered from human skeletal remains found in Western Siberia, which have been dated to c. 45,000 years ago. The mitogenome (33-fold coverage) of the Peştera Muie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
U4 Spliceosomal RNA
The U4 small nuclear Ribo-Nucleic Acid (U4 snRNA) is a non-coding RNA component of the major or U2-dependent spliceosome – a eukaryotic molecular machine involved in the splicing of pre-messenger RNA (pre-mRNA). It forms a duplex with U6 spliceosomal RNA, U6, and with each splicing round, it is displaced from the U6 snRNA (and the spliceosome) in an ATP-dependent manner, allowing U6 to re-fold and create the active site for RNA splicing, splicing catalysis. A recycling process involving protein Brr2 releases U4 from U6, while protein Prp24 re-anneals U4 and U6. The crystal structure of a 5′ stem-loop of U4 in complex with a binding protein has been solved. Biological role The U4 snRNA has been shown to exist in a number of different formats including: bound to proteins as a small nuclear Ribo-Nuclear Protein snRNP, involved with the U6 snRNA in the di-snRNP, as well as involved with both the U6 snRNA and the U5 snRNA in the tri-snRNP. The different formats have been propose ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
U4 (Munich U-Bahn)
The Munich U-Bahn () is an Railway electrification system, electric rail Rapid transit, rapid transit network in Munich, Germany. The system began operation in 1971, and is operated by the municipally owned Münchner Verkehrsgesellschaft (MVG; Munich Transport Company). The network is integrated into the Münchner Verkehrs- und Tarifverbund (MVV; Munich Transport and Tariff Association) and interconnected with the Munich S-Bahn. The U-Bahn currently comprises eight lines, serving 96 stations (100 stations if four interchange stations with separate levels for different lines are counted twice), and encompassing of routes. Alongside the S-Bahn, the Munich subway is the most important means of local public transport in Munich. Since the opening of the first line on October 19, 1971, a network with 95 km of track and 96 stops has been built, to which the neighboring town of Garching near Munich is also connected and in future also the Planegg district of Martinsried (both in the dist ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
U4 (Frankfurt U-Bahn)
The B Line is the second line in the network of the Frankfurt U-Bahn, running in a west–east direction from the central railway station (''Hauptbahnhof'') through the old town to Konstablerwache, where it splits into two branches to Bornheim (served by the U4) and Preungesheim (served by the U5). Originally planned as an independent main line, part of the D Line forms an extension of U4 to Bockenheimer Warte from the central railway station. Route The B line can be divided into three sections: the trunk line used by the U4 and U5 between the central railway station (Frankfurt Hauptbahnhof) and Konstablerwache and the two branches which the line splits into at its eastern end. Konstablerwache - Hauptbahnhof Below the subterranean shopping arcade under the station forecourt is the four-track underground station at Hauptbahnhof, which was built as a shared station for the B and D lines. It has two island platforms, which according to long-term planning are to be used for cross ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
U4 (Hamburg U-Bahn)
The U4 is a line of the Hamburg U-Bahn, which opened in 2012, serving 12 stations. It is the shortest line of the network, with a length of and from Jungfernstieg to Billstedt it shares tracks with the U2. Its identifying colour, as seen on route maps, trains, and station signs is . Route The U4 is the newest line of the Hamburg U-Bahn and the first line that is to form as a branch of an older, existing line. It shares the U2's tracks from Billstedt to the major transfer station Jungfernstieg, located in the city center, branching off before the station and stopping at the outer tracks of the four-platform station. It then traverses under the Neustadt in a far-swinging 180° bend and reaches the newly built Überseequartier station in HafenCity after about . The following station, HafenCity Universität lies about to the east in the Elbtorquartier. On 7 December 2018 the line was extended eastward, to a new terminus at Elbbrücken, allowing for a future S-Bahn connection ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
U4 (Berlin U-Bahn)
The U4 is a line of the Berlin U-Bahn in Germany that is the shortest in Berlin's U-Bahn system, with a length of . Opened in 1910, the U4 serves five stations, all of which are step-free: it is also the only subway line in Berlin to have never been extended and the only one to have no night service on weekends. In 1903, Schöneberg, an independent city that as south-west of the municipal limits of Berlin, planned to develop an underground railway line to improve public transportation. As the line promised less profit for private investors (all Berlin U-Bahn lines had until then been built with private capital), negotiations with the (Berlin Elevated Railway Company, the operator of Berlin U-Bahn) were unsuccessful. That made Schöneberg start to build the line itself on 8 December 1908. Two years later, the construction was finished, and on 1 December 1910, the line was put into operation. Although Schöneberg owned the track, upon the line's opening, the city handed operation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
U4 (Vienna U-Bahn)
Line U4 is a line on the Vienna U-Bahn metro Metro may refer to: Geography * Metro City (Indonesia), a city in Indonesia * A metropolitan area, the populated region including and surrounding an urban center Public transport * Rapid transit, a passenger railway in an urban area with high ... system. Opened in 1976, it currently has 20 stations and a total length of , from to . It is connected to at and , at , at , at and . Stations Line U4 currently serves the following stations: * (transfer to: - park & ride facility) * * * * * * * (transfer to: ) * * * * (transfer to: ) * * (transfer to: ) * (transfer to: ) * (transfer to: ) * * * (transfer to: - park & ride facility) * (transfer to: ) References External links * {{Metro lines in Vienna U4 Railway lines opened in 1976 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Unemployment
Unemployment, according to the OECD (Organisation for Economic Co-operation and Development), is the proportion of people above a specified age (usually 15) not being in paid employment or self-employment but currently available for work during the reference period. Unemployment is measured by the unemployment rate, which is the number of people who are unemployed as a percentage of the labour force (the total number of people employed added to those unemployed). Unemployment can have many sources, such as the following: * the status of the economy, which can be influenced by a recession * competition caused by globalization and international trade * new technologies and inventions * policies of the government * regulation and market * war, civil disorder, and natural disasters Unemployment and the status of the economy can be influenced by a country through, for example, fiscal policy. Furthermore, the monetary authority of a country, such as the central bank, can in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
U-47700
U-47700, also known as U4, pink heroin, pinky, and pink, is an opioid analgesic drug developed by a team at Upjohn in the 1970s which has around 7.5 times the potency of morphine in animal models. U-47700 is a structural isomer of the earlier opioid AH-7921 and the result of a great deal of work elucidating the quantitative structure–activity relationship of the scaffold. Upjohn looked for the key moiety (chemistry), moieties which gave the greatest activity and posted over a dozen patents on related compounds, each optimizing one moiety until they discovered that U-47700 was the most active. U-47700 became the lead compound of selective kappa-opioid receptor ligands such as U-50488, U-51754 (containing a pyrrolidine rather than a dimethylamine substituent) and U-69,593, which share very similar structures. Although not used medically, the selective kappa ligands are used in research. Pharmacology U-47700 is an agonist of the μ-opioid receptor (Ki ) and possesses significant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PMTair
PMTair (Progress MulTi Air) was a Cambodian airline offering regularly scheduled domestic and international passenger and cargo services out of Phnom Penh International Airport. History PMTair was founded on 14 January 2003 and was owned by Progress Multitrade Co., Ltd. A certificate of airworthiness was issued by the Cambodian Civil Aviation Authority on October 14, 2003. The airline was dissolved in 2008. Destinations Upon closure, PMTair served the following destinations: *Cambodia **Siem Reap - Angkor International Airport base *South Korea, Korea, South **Busan - Gimhae International Airport **Seoul - Incheon International Airport *Vietnam **Hanoi - Noi Bai International Airport Former routes PMTair suspended all domestic flights in the wake of the crash of PMTair Flight U4 241. *U-Tapao International Airport, Pattaya-Siem Reap *Bangkok-Phnom Penh *Hanoi-Phnom Penh *Phnom Penh-Ratanakiri-Siem Reap *Ratanakiri-Phnom Penh *Siem Reap-Phnom Penh *Siem Reap-Sihanoukville ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maple League Of Universities
The Maple League of Universities, previously known as the U4, is an association of four universities in eastern Canada. The four member schools, Acadia University, Bishop's University, Mount Allison University, and St. Francis Xavier University, are all primarily undergraduate liberal arts institutions. Members The four member universities of the Maple League are all primarily undergraduate and located in Eastern Canada: one in Quebec, one in New Brunswick, and two in Nova Scotia. All were established in the early 1800s. History The Maple League was founded in 2013 as the U4, and adopted its current name in 2016. The name "Maple League" was inspired by the Ivy League in the United States. See also *U15 Group of Canadian Research Universities U15 Canada (U15 Group of Canadian Research Universities, ; commonly shortened to U15 Canada) is an association of 15 Canadian public research universities. It is headquartered in Ottawa and was established in 1991 to represent its me ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
London Buses Route U4
This is a list of Transport for London (TfL) contracted bus routes in London, England, as well as commercial services that enter the Greater London area (except coaches). Bus services in London are operated by Arriva London, Go-Ahead London (Blue Triangle, Docklands Buses, London Central and London General), Metroline, First Bus London, Stagecoach London (East London, Selkent and Thameside), Transport UK London Bus and Uno. TfL-sponsored operators run more than 500 services. Examples of non TfL-sponsored operators include, but are not limited to: Arriva Herts & Essex, Arriva Southern Counties, Carousel Buses, Diamond South East, Go-Coach, First Beeline, Metrobus, Stagecoach South, Thames Valley Buses and Reading Buses. Classification of route numbers In Victorian times, people who took the bus would recognise the owner and the route of an only by its livery and its line name, with painted signs on the sides showing the two termini to indicate the route. Then, in 1906, Geo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
