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Marginal Zone
The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.) A marginal zone also exists in the lymphoid follicles of lymph nodes. Those marginal zones contain naive B cells and memory B cells. In contrast to the marginal zone of the spleen, they are not characterized by containing additional non-recirculating B2 cells. Structure It is composed of cells derived primarily from the myeloid compartment of bone marrow differentiation. More recently, a population of neutrophil-killers has been described to populate peripheral areas of the marginal zone. At least three distinct cellular markers can be used to identify cells of the marginal zone, MOMA-1, ERTR-9 and MARCO. Blood flow The marginal zone (MZ) is a highly transited area that receives large amou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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Red Pulp
The red pulp of the spleen is composed of connective tissue known also as the cords of Billroth and many splenic sinusoids that are engorged with blood, giving it a red color. Its primary function is to filter the blood of antigens, microorganisms, and defective or worn-out red blood cells. The spleen is made of red pulp and white pulp, separated by the marginal zone; 76–79% of a normal spleen is red pulp. Unlike white pulp, which mainly contains lymphocytes such as T cells, red pulp is made up of several different types of blood cells, including platelets, granulocytes, red blood cells, and plasma. The red pulp also acts as a large reservoir for monocytes. These monocytes are found in clusters in the Billroth's cords (red pulp cords). The population of monocytes in this reservoir is greater than the total number of monocytes present in circulation. They can be rapidly mobilised to leave the spleen and assist in tackling ongoing infections. Sinusoids The splenic sinusoids, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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Marginal Sinus
The marginal sinus is a dural venous sinus surrounding the margin of the foramen magnum inside the skull, accommodated by the groove for marginal sinus. It usually drains into either the sigmoid sinus, or the jugular bulb. It communicates with the basilar venous plexus anteriorly, and the occipital sinus posteriorly (the posterior union of the left and the right marginal sinus usually representing the commencement of the occipital sinus); it may form extracranial communications with the internal vertebral venous plexuses The internal vertebral venous plexuses (intraspinal veins) lie within the vertebral canal in the epidural space, embedded within epidural fat. They receive tributaries from bones, red bone marrow, and spinal cord. They are arranged into four interc ..., or deep cervical veins. Clinical significance Arteriovenous fistulas involving the marginal sinus have been described - often following basilar skull fractures. The marginal sinus must be traversed during s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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Immunogenicity
Immunogenicity is the ability of a foreign substance, such as an antigen, to provoke an immune response in the body of a human or other animal. It may be wanted or unwanted: * Wanted immunogenicity typically relates to vaccines, where the injection of an antigen (the vaccine) provokes an immune response against the pathogen, protecting the organism from future exposure. Immunogenicity is a central aspect of vaccine development. * Unwanted immunogenicity is an immune response by an organism against a therapeutic antigen. This reaction leads to production of anti-drug-antibodies (ADAs), inactivating the therapeutic effects of the treatment and potentially inducing adverse effects. A challenge in biotherapy is predicting the immunogenic potential of novel protein therapeutics. For example, immunogenicity data from high-income countries are not always transferable to low-income and middle-income countries. Another challenge is considering how the immunogenicity of vaccines changes wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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Listeria Monocytogenes
''Listeria monocytogenes'' is the species of pathogenic bacteria that causes the infection listeriosis. It is a facultative anaerobic bacterium, capable of surviving in the presence or absence of oxygen. It can grow and reproduce inside the host's cells and is one of the most virulent foodborne pathogens. Twenty to thirty percent of foodborne listeriosis infections in high-risk individuals may be fatal. In the European Union, listeriosis continues an upward trend that began in 2008, causing 2,161 confirmed cases and 210 reported deaths in 2014, 16% more than in 2013. In the EU, listeriosis mortality rates also are higher than those of other foodborne pathogens. Responsible for an estimated 1,600 illnesses and 260 deaths in the United States annually, listeriosis ranks third in total number of deaths among foodborne bacterial pathogens, with fatality rates exceeding even ''Salmonella'' spp. and ''Clostridium botulinum''. Named for Joseph Lister, ''Listeria monocytogenes'' is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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Escherichia Coli
''Escherichia coli'' ( )Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. is a gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus '' Escherichia'' that is commonly found in the lower intestine of warm-blooded organisms. Most ''E. coli'' strains are part of the normal microbiota of the gut, where they constitute about 0.1%, along with other facultative anaerobes. These bacteria are mostly harmless or even beneficial to humans. For example, some strains of ''E. coli'' benefit their hosts by producing vitamin K2 or by preventing the colonization of the intestine by harmful pathogenic bacteria. These mutually beneficial relationships between ''E. coli'' and humans are a type of mutualistic biological relationship—where both the humans and the ''E. coli'' are benefitting each other. ''E. coli'' is expelled into the environment within fecal matter. The bacterium grows massi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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Beads
A bead is a small, decorative object that is formed in a variety of shapes and sizes of a material such as stone, bone, shell, glass, plastic, wood, or pearl and with a small hole for threading or stringing. Beads range in size from under 1 mm to over 1 cm in diameter. Beads represent some of the earliest forms of jewellery, with a pair of beads made from '' Nassarius'' sea snail shells dating to approximately years ago thought to be the earliest known example. 2] Beadwork is the art or craft of making things with beads. Beads can be woven together with specialized thread, strung onto thread or soft, flexible wire, or adhered to a surface (e.g. fabric, clay). Etymology The word "bead" derives from Old English ''gebed'', originally meaning "prayer", until transferred to small globular objects. This refers to the use of beads for counting repetitions of prayers, as in Christian Pater Noster cords and rosaries. Types Beads can be divided into several types of overl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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Latex
Latex is an emulsion (stable dispersion) of polymer microparticles in water. Latices are found in nature, but synthetic latices are common as well. In nature, latex is found as a wikt:milky, milky fluid, which is present in 10% of all flowering plants (angiosperms) and in some Mushroom, mushrooms (especially species of ''Lactarius''). It is a complex emulsion that coagulation, coagulates on exposure to air, consisting of proteins, alkaloids, starches, sugars, Vegetable oil, oils, tannins, resins, and Natural gum, gums. It is usually exuded after tissue injury. In most plants, latex is white, but some have yellow, orange, or scarlet latex. Since the 17th century, latex has been used as a term for the fluid substance in plants, deriving from the Latin word for "liquid". It serves mainly as Antipredator adaptation, defense against Herbivore, herbivores and Fungivore, fungivores.Taskirawati, I. and Tuno, N., 2016Fungal defense against mycophagy in milk caps ''Science Report Kanazaw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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Circulatory System
In vertebrates, the circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the body. It includes the cardiovascular system, or vascular system, that consists of the heart and blood vessels (from Greek meaning ''heart'', and Latin meaning ''vessels''). The circulatory system has two divisions, a systemic circulation or circuit, and a pulmonary circulation or circuit. Some sources use the terms ''cardiovascular system'' and ''vascular system'' interchangeably with ''circulatory system''. The network of blood vessels are the great vessels of the heart including large elastic arteries, and large veins; other arteries, smaller arterioles, capillaries that join with venules (small veins), and other veins. The circulatory system is closed in vertebrates, which means that the blood never leaves the network of blood vessels. Many invertebrates such as arthropods have an open circulatory system with a he ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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Antigen
In immunology, an antigen (Ag) is a molecule, moiety, foreign particulate matter, or an allergen, such as pollen, that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune response. Antigens can be proteins, peptides (amino acid chains), polysaccharides (chains of simple sugars), lipids, or nucleic acids. Antigens exist on normal cells, cancer cells, parasites, viruses, fungus, fungi, and bacteria. Antigens are recognized by antigen receptors, including antibodies and T-cell receptors. Diverse antigen receptors are made by cells of the immune system so that each cell has a specificity for a single antigen. Upon exposure to an antigen, only the lymphocytes that recognize that antigen are activated and expanded, a process known as clonal selection. In most cases, antibodies are ''antigen-specific'', meaning that an antibody can only react to and bind one specific antigen; in some instances, however, antibodies may cr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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Particulate
Particulate matter (PM) or particulates are microscopic particles of solid or liquid matter suspended in the air. An ''aerosol'' is a mixture of particulates and air, as opposed to the particulate matter alone, though it is sometimes defined as a subset of aerosol terminology. Sources of particulate matter can be natural or anthropogenic. Particulates have impacts on climate and precipitation that adversely affect human health. Types of atmospheric particles include suspended particulate matter; thoracic and respirable particles; inhalable coarse particles, designated PM, which are coarse particles with a diameter of 10 micrometers (μm) or less; fine particles, designated PM, with a diameter of 2.5 μm or less; ultrafine particles, with a diameter of 100 nm or less; and soot. Airborne particulate matter is a Group 1 carcinogen. Particulates are the most harmful form of air pollution as they can penetrate deep into the lungs and brain from blood streams, cau ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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Venous Sinusoid
Veins () are blood vessels in the circulatory system of humans and most other animals that carry blood towards the heart. Most veins carry deoxygenated blood from the tissues back to the heart; exceptions are those of the pulmonary and fetal circulations which carry oxygenated blood to the heart. In the systemic circulation, arteries carry oxygenated blood away from the heart, and veins return deoxygenated blood to the heart, in the deep veins. There are three sizes of veins: large, medium, and small. Smaller veins are called venules, and the smallest the post-capillary venules are microscopic that make up the veins of the microcirculation. Veins are often closer to the skin than arteries. Veins have less smooth muscle and connective tissue and wider internal diameters than arteries. Because of their thinner walls and wider lumens they are able to expand and hold more blood. This greater capacity gives them the term of ''capacitance vessels''. At any time, nearly 70% of the to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |