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Love And Other Drugs
''Love & Other Drugs'' is a 2010 American romantic comedy drama film directed, produced and co-written by Edward Zwick and based on Jamie Reidy's 2005 non-fiction book ''Hard Sell: The Evolution of a Viagra Salesman''. Starring Jake Gyllenhaal, Anne Hathaway, Oliver Platt, Hank Azaria, Josh Gad and Gabriel Macht, the film tells the story of a medicine peddler in 1990s Pittsburgh who starts a relationship with a young woman suffering from Parkinson's disease. ''Love & Other Drugs'' was released in theaters on November 24, 2010, by 20th Century Fox. It grossed $105 million against a $30 million budget, and received mixed reviews from critics. Plot In 1996, womanizer Jamie Randall is fired from a Pittsburgh electronics store for having sex with his manager's girlfriend. His wealthy brother Josh refers him for a job as a pharmaceutical sales representative. After attending a Pfizer training program, Jamie goes to work for them, attempting to get doctors to prescribe Zoloft ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edward Zwick
Edward M. Zwick (born October 8, 1952) is an American filmmaker. He has worked primarily in the comedy drama and historical drama, epic historical film genres and was awarded an Academy Awards, Academy Award, as well as a British Academy Film Awards, BAFTA Award, for his work producing ''Shakespeare in Love'' (1998). He made his film debut with the comedy ''About Last Night (1986 film), About Last Night'' (1986), followed by ''Glory (1989 film), Glory'' (1989), ''Legends of the Fall'' (1994), ''Courage Under Fire'' (1996), ''The Siege'' (1998), ''The Last Samurai'' (2003), ''Blood Diamond'' (2006), and ''Defiance (2008 film), Defiance'' (2008). His later films include ''Love & Other Drugs'' (2010), ''Pawn Sacrifice'' (2014), and ''Jack Reacher: Never Go Back'' (2016). He is also the co-creator of the ABC family drama series ''thirtysomething'' from 1987 to 1991 and ''Once and Again'' from 1999 to 2002. Early life and education Zwick was born on October 8, 1952, into a American ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dune Entertainment
RatPac Entertainment, LLC was an American media and entertainment company that financed and produced motion pictures, television, documentaries, live theater, and podcasts. The company was owned by Brett Ratner and James Packer. History Dune Entertainment was a company founded by Steven Mnuchin in 2004. Mnuchin founded Dune Entertainment as a side business. It financed a number of large-budget films, mostly for 20th Century Fox, including the ''X-Men'' film franchise and ''Avatar''. In 2012, after Dune's deal with 20th Century Fox ended, Mnuchin worked with the filmmaker Brett Ratner and the Australian businessman James Packer to merge his Dune Entertainment company with Ratner and Packer's newly founded RatPac Entertainment joint venture which would be formed into RatPac-Dune Entertainment in 2013; the following year. Between 2013 and 2018, RatPac-Dune financed many films for Warner Bros., including ''American Sniper'' and '' Mad Max: Fury Road''. Mnuchin was co-chairman ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chicago
Chicago is the List of municipalities in Illinois, most populous city in the U.S. state of Illinois and in the Midwestern United States. With a population of 2,746,388, as of the 2020 United States census, 2020 census, it is the List of United States cities by population, third-most populous city in the United States after New York City and Los Angeles. As the county seat, seat of Cook County, Illinois, Cook County, the List of the most populous counties in the United States, second-most populous county in the U.S., Chicago is the center of the Chicago metropolitan area, often colloquially called "Chicagoland" and home to 9.6 million residents. Located on the shore of Lake Michigan, Chicago was incorporated as a city in 1837 near a Chicago Portage, portage between the Great Lakes and the Mississippi River, Mississippi River watershed. It grew rapidly in the mid-19th century. In 1871, the Great Chicago Fire destroyed several square miles and left more than 100,000 homeless, but ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zoloft
Sertraline, sold under the brand name Zoloft among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder. Although also having approval for post-traumatic stress disorder (PTSD), findings indicate it leads to only modest improvements in symptoms associated with this condition. The drug shares the common side effects and contraindications of other SSRIs, with high rates of nausea, diarrhea, headache, insomnia, mild sedation, dry mouth, and sexual dysfunction, but it appears not to lead to much weight gain, and its effects on cognitive performance are mild. Similar to other antidepressants, the use of sertraline for depression may be associated with a mildly elevated rate of suicidal thoughts in people under the age of 25 years old. It should not b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pfizer
Pfizer Inc. ( ) is an American Multinational corporation, multinational Pharmaceutical industry, pharmaceutical and biotechnology corporation headquartered at The Spiral (New York City), The Spiral in Manhattan, New York City. Founded in 1849 in New York by German entrepreneurs Charles Pfizer (1824–1906) and Charles F. Erhart (1821–1891), Pfizer is one of the oldest pharmaceutical companies in North America. Pfizer develops and produces medicines and vaccines for immunology, oncology, cardiology, endocrinology, and neurology. The company's largest products by sales are the Pfizer–BioNTech COVID-19 vaccine ($11 billion in 2023 revenues), apixaban ($6 billion in 2023 revenues), a pneumococcal conjugate vaccine ($6 billion in 2023 revenues), palbociclib ($4 billion in 2023 revenues), and tafamidis ($3 billion in 2023 revenues). In 2023, 46% of the company's revenues came from the United States, 6% came from Japan, and 48% came from other countries. Pfizer has been a publi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmaceutical Sales Representative
Pharmaceutical sales representatives or Medical sales respresentatives are salespeople employed by pharmaceutical companies to persuade doctors to prescribe their drugs to patients. Drug companies in the United States spend ~$5 billion annually sending representatives to doctors, to provide product information, answer questions on product use, and deliver product samples. These interactions are governed according to limits established by the Code on Interactions with Health Care Professionals, created by the Pharmaceutical Research and Manufacturers of America (PhRMA). This code came into practice in 2002 and has since been updated to help define ethical interactions between health care professionals and the pharmaceutical companies Companies maintain this provides an educational service by keeping doctors updated on the latest changes in medical science. Critics point to a systematic use of gifts and personal information to befriend doctors to influence their drug prescript ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Promiscuity
Promiscuity is the practice of engaging in sexual activity frequently with different partners or being indiscriminate in the choice of sexual partners. The term can carry a moral judgment. A common example of behavior viewed as promiscuous by many cultures is the one-night stand, and its frequency is used by researchers as a marker for promiscuity. What sexual behavior is considered promiscuous varies between cultures, as does the prevalence of promiscuity. Different standards are often applied to different genders and civil statutes. Feminists have traditionally argued a significant double standard exists between how men and women are judged for promiscuity. Historically, stereotypes of the promiscuous woman have tended to be pejorative, such as "the slut" or "the harlot", while male stereotypes have been more varied, some expressing approval, such as "the stud" or "the player", while others imply societal deviance, such as "the womanizer" or "the philanderer". A scientific s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parkinson's Disease
Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor system, motor and non-motor systems. Symptoms typically develop gradually and non-motor issues become more prevalent as the disease progresses. The motor symptoms are collectively called parkinsonism and include tremors, bradykinesia, spasticity, rigidity as well as postural instability (i.e., difficulty maintaining balance). Non-motor symptoms develop later in the disease and include behavior change (individual), behavioral changes or mental disorder, neuropsychiatric problems such as sleep abnormalities, psychosis, anosmia, and mood swings. Most Parkinson's disease cases are idiopathic disease, idiopathic, though contributing factors have been identified. Pathophysiology involves progressive nerve cell death, degeneration of nerve cells in the substantia nigra, a midbrain region that provides dopamine to the basal ganglia, a system invo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pittsburgh
Pittsburgh ( ) is a city in Allegheny County, Pennsylvania, United States, and its county seat. It is the List of municipalities in Pennsylvania#Municipalities, second-most populous city in Pennsylvania (after Philadelphia) and the List of United States cities by population, 67th-most populous city in the U.S., with a population of 302,971 as of the 2020 United States census, 2020 census. The city is located in Western Pennsylvania, southwestern Pennsylvania at the confluence of the Allegheny River and Monongahela River, which combine to form the Ohio River. It anchors the Greater Pittsburgh, Pittsburgh metropolitan area, which had a population of 2.457 million residents and is the largest metro area in both the Ohio Valley and Appalachia, the Pennsylvania metropolitan areas, second-largest in Pennsylvania, and the List of metropolitan statistical areas, 26th-largest in the U.S. Pittsburgh is the principal city of the greater Pittsburgh–New Castle–Weirton combined statistic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Comedy Drama
Comedy drama (also known by the portmanteau dramedy) is a hybrid genre of works that combine elements of comedy and Drama (film and television), drama. In film, as well as scripted television series, serious dramatic subjects (such as death, illness, betrayal, grief, etc.) are handled with realism and subtlety, while preserving a humorous tenor. The term "dramedy" began to be used in the television industry in the 1980s. Modern television comedy dramas tend to have more humour integrated into the story than the comic relief common in drama series, but usually contain a lower joke rate than sitcom, sitcoms. History In Theatre of ancient Greece, Greek theatre, plays were considered comedies or tragedies (i.e. drama): the former being light stories with a happy ending, and the latter serious stories with a sad ending. This concept even influenced Theatre of ancient Rome, Roman theatre and theatre of the Hellenistic period. Theatre of that era is thought to have long-lasting infl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Romance Film
Romance films involve romantic love stories recorded in visual media for broadcast in theatres or on television that focus on passion (emotion), passion, emotion, and the affectionate romantic involvement of the main characters. Typically their journey through dating, courtship or marriage, marriage is featured. These films focus on the search for romantic love as the main plot focus. Occasionally, romance lovers face obstacles such as finances, physical illness, various forms of discrimination, psychological restraints, or family resistance. As in all quite strong, deep, and close romantic relationships, the tensions of day-to-day life, temptations (of infidelity), and differences in compatibility enter into the plots of romantic films. Romantic films often explore the essential themes of love at first sight, young and mature love, unrequited love, obsession, sentimental love, Spirituality, spiritual love, forbidden love, platonic love, sexual and passionate love, sacrificial ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Box Office Mojo
Box Office Mojo is an American website that tracks box-office revenue in a systematic, algorithmic way. The site was founded in 1998 by Brandon Gray, and was bought in 2008 by IMDb, which itself is owned by Amazon. History Brandon Gray began the site on August 7, 1998, making forecasts of the top-10 highest-grossing films in the United States for the following weekend. To compare his forecasts to the actual results, he started posting the weekend grosses and wrote a regular column with box-office analysis. In 1999, he started to post the Friday daily box-office grosses, sourced from Exhibitor Relations, so that they were publicly available online on Saturdays and posted the Sunday weekend estimates on Sundays. Along with the weekend grosses, he was publishing the daily grosses, release schedules and other charts, such as all-time charts, international box office charts, genre charts, and actor and director charts. The site gradually expanded to include weekend charts goin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
