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Late-onset Hypogonadism
Late-onset hypogonadism (LOH) or testosterone deficiency syndrome (TDS) is a condition in older men characterized by measurably low testosterone levels and clinical symptoms mostly of a sexual nature, including decreased desire for mating, fewer spontaneous erections, and erectile dysfunction. It is the result of a gradual drop in testosterone; a steady decline in testosterone levels of about 1% per year can happen and is well documented in both men and women. Signs and symptoms Some men present with symptoms, but they have normal testosterone levels, while others with low testosterone levels have no symptoms. The reasons for this phenomenon are currently unknown. In their late 40s and early 50s, some men may experience depression, loss of libido, erectile dysfunction, and other physical and emotional symptoms. These symptoms include irritability, loss of muscle mass and reduced ability to exercise, weight gain, lack of energy, difficulty sleeping, and poor concentration. It is im ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
An Irishman Abroad
Jarlath Regan (born 1980) is an Irish stand-up comedian, television performer, and host of the ''An Irishman Abroad'' podcast. Stand-up shows While attending University College Dublin, he was auditor of the Literary and Historical Society. Regan began his stand-up comedy career in 2003 and by the end of 2004 was a finalist for three major UK comedy newcomer awards: So You Think You're Funny, BBC New Comedy Awards and the Chortle Student Comedian of the Year. In 2006, he performed as part of the first ever Irish gala at the Just for Laughs festival in Montreal, Canada. Regan's shows have included 2007's Edinburgh Fringe show "Nobody Knows... Jarlath Regan", 2018/19's "Organ Freeman", which chronicled his experience as a live-organ donor, and 2019/2020's "Notion's Eleven", which was recorded in Vicar Street for online release in late 2020. Television work Regan wrote and performed sketches on Scope, an Irish science television programme for teenagers and was a regular ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York Times
''The New York Times'' (''NYT'') is an American daily newspaper based in New York City. ''The New York Times'' covers domestic, national, and international news, and publishes opinion pieces, investigative reports, and reviews. As one of the longest-running newspapers in the United States, the ''Times'' serves as one of the country's Newspaper of record, newspapers of record. , ''The New York Times'' had 9.13 million total and 8.83 million online subscribers, both by significant margins the List of newspapers in the United States, highest numbers for any newspaper in the United States; the total also included 296,330 print subscribers, making the ''Times'' the second-largest newspaper by print circulation in the United States, following ''The Wall Street Journal'', also based in New York City. ''The New York Times'' is published by the New York Times Company; since 1896, the company has been chaired by the Ochs-Sulzberger family, whose current chairman and the paper's publ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frailty Syndrome
Frailty or frailty syndrome refers to a state of health in which older adults gradually lose their bodies' in-built reserves and functioning. This makes them more vulnerable, less able to recover and even apparently minor events (infections, environmental changes) can have drastic impacts on their physical and mental health. Frailty can have various symptoms including muscle weakness (reduced grip strength), slower walking speed, exhaustion, unintentional weight loss, and frequent falls. Older people with certain medical conditions such as diabetes, heart disease and dementia, are also more likely to have frailty. In addition, adults living with frailty face more symptoms of anxiety and depression than those who do not. Frailty is not an inevitable part of aging. Its development can be prevented, delayed and its progress slowed. The most effective ways of preventing or improving frailty are regular physical activity and a healthy diet. The prevalence of frailty varies based on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spermatogenesis
Spermatogenesis is the process by which haploid spermatozoa develop from germ cells in the seminiferous tubules of the testicle. This process starts with the Mitosis, mitotic division of the stem cells located close to the basement membrane of the tubules. These cells are called Spermatogonial Stem Cells, spermatogonial stem cells. The mitotic division of these produces two types of cells. Type A cells replenish the stem cells, and type B cells differentiate into primary spermatocytes. The primary spermatocyte divides meiotically (Meiosis I) into two secondary spermatocytes; each secondary spermatocyte divides into two equal haploid spermatids by Meiosis II. The spermatids are transformed into spermatozoa (sperm) by the process of spermiogenesis. These develop into mature spermatozoa, also known as sperm, sperm cells. Thus, the primary spermatocyte gives rise to two cells, the secondary spermatocytes, and the two secondary spermatocytes by their subdivision produce four spermatoz ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dutasteride
Dutasteride, sold under the brand name Avodart among others, is a medication primarily used to treat the symptoms of a benign prostatic hyperplasia (BPH), an enlarged prostate not associated with cancer. A few months may be required before benefits occur. It is also used for pattern hair loss, scalp hair loss in men and as a part of transgender hormone therapy (male-to-female), hormone therapy in transgender women. It is usually taken by mouth. The most commonly reported side effects of dutasteride, although rare, include sexual dysfunction and depression (mood), depression. In the largest available study of 6,729 men with BPH, 9% experienced erectile dysfunction (compared to 5.7% treated with a placebo), 3.3% experienced decreased libido, sex drive (vs 1.6% of placebo), and 1.9% had gynecomastia, enlarged breasts (vs 1% of placebo). Exposure during pregnancy is specifically contraindicated because antiandrogens such as dutasteride have been shown to interfere with the sexual d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Finasteride
Finasteride, sold under the brand names Proscar and Propecia among others, is a medication used to treat pattern hair loss and benign prostatic hyperplasia (BPH) in men. It can also be used to treat hirsutism, excessive hair growth in women. It is usually taken oral administration, orally but there are Topical medication, topical formulations for patients with hair loss, designed to minimize systemic exposure by acting specifically on hair follicles. Finasteride is a 5α-reductase inhibitor and therefore an antiandrogen. It works by enzyme inhibitor, decreasing the biosynthesis, production of dihydrotestosterone (DHT) by about 70%. In addition to DHT, finasteride also inhibits the production of several anticonvulsant neurosteroids including allopregnanolone, androstanediol, and tetrahydrodeoxycorticosterone. Adverse effects from finasteride are rare in men with already enlarged prostates; however, some men experience sexual dysfunction, depression (mood), depression, and gyne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benign Prostatic Hyperplasia
Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate gland. Symptoms may include frequent urination, trouble starting to urinate, weak stream, urinary retention, inability to urinate, or urinary incontinence, loss of bladder control. Complications can include urinary tract infections, bladder stones, and chronic kidney problems. The cause is unclear. Risk factors include a family history, obesity, type 2 diabetes, not enough exercise, and erectile dysfunction. Medications like pseudoephedrine, anticholinergics, and calcium channel blockers may worsen symptoms. The underlying mechanism involves the prostate pressing on the urethra thereby making it difficult to pass urine out of the bladder. Diagnosis is typically based on symptoms and Physical examination, examination after ruling out other possible causes. Treatment options include lifestyle changes, medications, a number of procedures, and surgery. In th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apnea
Apnea (also spelled apnoea in British English) is the temporary cessation of breathing. During apnea, there is no movement of the muscles of inhalation, and the volume of the lungs initially remains unchanged. Depending on how blocked the airways are ( patency), there may or may not be a flow of gas between the lungs and the environment. If there is sufficient flow, gas exchange within the lungs and cellular respiration would not be severely affected. Voluntarily doing this is called holding one's breath. Apnea may first be diagnosed in childhood, and it is recommended to consult an ENT specialist, allergist or sleep physician to discuss symptoms when noticed; malformation and/or malfunctioning of the upper airways may be observed by an orthodontist. Cause Apnea can be involuntary—for example, drug-induced (such as by opiate toxicity), mechanically / physiologically induced (for example, by strangulation or choking), or a consequence of neurological disease or tra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Venipuncture
In medicine, venipuncture or venepuncture is the process of obtaining intravenous access for the purpose of venous Sampling (medicine)#blood, blood sampling (also called ''phlebotomy'') or intravenous therapy. In healthcare, this procedure is performed by Medical Laboratory Scientist, medical laboratory scientists, physician, medical practitioners, some EMTs, paramedics, phlebotomists, Kidney dialysis, dialysis technicians, and other nursing staff. In veterinary medicine, the procedure is performed by veterinarians and Paraveterinary worker, veterinary technicians. It is essential to follow a standard procedure for the collection of blood specimens to get accurate laboratory results. Any error in collecting the blood or filling the test tubes may lead to erroneous laboratory results. Venipuncture is one of the most routinely performed invasive procedures and is carried out for any of five reasons: # to obtain blood for diagnostic purposes; # to monitor levels of blood component ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hematocrit
The hematocrit () (Ht or HCT), also known by several other names, is the volume percentage (vol%) of red blood cells (RBCs) in blood, measured as part of a blood test. The measurement depends on the number and size of red blood cells. It is normally 40.7–50.3% for males and 36.1–44.3% for females. It is a part of a person's complete blood count results, along with hemoglobin concentration, white blood cell count and platelet count. Because the purpose of red blood cells is to transfer oxygen from the lungs to body tissues, a blood sample's hematocrit—the red blood cell volume percentage—can become a point of reference of its capability of delivering oxygen. Hematocrit levels that are too high or too low can indicate a blood disorder, dehydration, or other medical conditions. An abnormally low hematocrit may suggest anemia, a decrease in the total amount of red blood cells, while an abnormally high hematocrit is called polycythemia. Both are potentially life-threatening d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prostate Cancer
Prostate cancer is the neoplasm, uncontrolled growth of cells in the prostate, a gland in the male reproductive system below the bladder. Abnormal growth of the prostate tissue is usually detected through Screening (medicine), screening tests, typically blood tests that check for prostate-specific antigen (PSA) levels. Those with high levels of PSA in their blood are at increased risk for developing prostate cancer. Diagnosis requires a prostate biopsy, biopsy of the prostate. If cancer is present, the pathologist assigns a Gleason score; a higher score represents a more dangerous tumor. Medical imaging is performed to look for cancer that has spread outside the prostate. Based on the Gleason score, PSA levels, and imaging results, a cancer case is assigned a cancer staging, stage 1 to 4. A higher stage signifies a more advanced, more dangerous disease. Most prostate tumors remain small and cause no health problems. These are managed with active surveillance of prostate cancer, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
