|
Laser Speckle Contrast Imaging
Laser speckle contrast imaging (LSCI) which can also be called laser speckle imaging (LSI) is an imaging modality based on the analysis of the blurring effect of the speckle pattern. The operation of LSCI is having a wide-field illumination of a rough surface through a coherent light source. Then using photodetectors such as CCD camera or CMOS sensors imaging the resulting laser speckle pattern caused by the interference of coherent light. In biomedical use, the coherent light is typically in the red or near-infrared region to ensure higher penetration depth. When scattering particles moving during the time, the interference caused by the coherent light will have fluctuations which will lead to the intensity variations detected via the photodetector, and this change of the intensity contain the information of scattering particles' motion. Through image the speckle patterns with finite exposure time, areas with scattering particles will appear blurred. Development The first prac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Speckle Pattern
Speckle, speckle pattern, or speckle noise is a granular noise texture degrading the quality as a consequence of interference among wavefronts in coherent imaging systems, such as radar, synthetic aperture radar (SAR), medical ultrasound and optical coherence tomography. Speckle is not external noise; rather, it is an inherent fluctuation in diffuse reflections, because the scatterers are not identical for each cell, and the coherent illumination wave is highly sensitive to small variations in phase changes. Although scientists have investigated this phenomenon since the time of Newton, speckles have come into prominence since the invention of the laser. Such reflections may occur on materials such as paper, white paint, rough surfaces, or in media with a large number of scattering particles in space, such as airborne dust or in cloudy liquids. They have been used in a variety of applications in microscopy, imaging, and optical manipulation. The vast majority of surfaces, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charge-coupled Device
A charge-coupled device (CCD) is an integrated circuit containing an array of linked, or coupled, capacitors. Under the control of an external circuit, each capacitor can transfer its electric charge to a neighboring capacitor. CCD sensors are a major technology used in digital imaging. In a CCD image sensor, pixels are represented by p-doped metal–oxide–semiconductor (MOS) capacitors. These MOS capacitors, the basic building blocks of a CCD, are biased above the threshold for inversion when image acquisition begins, allowing the conversion of incoming photons into electron charges at the semiconductor-oxide interface; the CCD is then used to read out these charges. Although CCDs are not the only technology to allow for light detection, CCD image sensors are widely used in professional, medical, and scientific applications where high-quality image data are required. In applications with less exacting quality demands, such as consumer and professional digital camera ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Active-pixel Sensor
An active-pixel sensor (APS) is an image sensor where each pixel sensor unit cell has a photodetector (typically a pinned photodiode) and one or more active transistors. In a metal–oxide–semiconductor (MOS) active-pixel sensor, MOS field-effect transistors (MOSFETs) are used as amplifiers. There are different types of APS, including the early NMOS APS and the now much more common complementary MOS (CMOS) APS, also known as the CMOS sensor. CMOS sensors are used in digital camera technologies such as cell phone cameras, web cameras, most modern digital pocket cameras, most digital single-lens reflex cameras (DSLRs), and mirrorless interchangeable-lens cameras (MILCs). CMOS sensors emerged as an alternative to charge-coupled device (CCD) image sensors and eventually outsold them by the mid-2000s decade. The term ''active pixel sensor'' is also used to refer to the individual pixel sensor itself, as opposed to the image sensor. In this case, the image sensor is sometim ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coherence (physics)
In physics, two wave sources are coherent if their frequency and waveform are identical. Coherence is an ideal property of waves that enables stationary (i.e., temporally or spatially constant) interference. It contains several distinct concepts, which are limiting cases that never quite occur in reality but allow an understanding of the physics of waves, and has become a very important concept in quantum physics. More generally, coherence describes all properties of the correlation between physical quantities of a single wave, or between several waves or wave packets. Interference is the addition, in the mathematical sense, of wave functions. A single wave can interfere with itself, but this is still an addition of two waves (see Young's slits experiment). Constructive or destructive interference are limit cases, and two waves always interfere, even if the result of the addition is complicated or not remarkable. When interfering, two waves can add together to create a wave of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biomedicine
Biomedicine (also referred to as Western medicine, mainstream medicine or conventional medicine)Biomedicine " NCI Dictionary of Cancer Medicine. . is a branch of medical science that applies biological and physiological principles to . Biomedicine stresses standardized, evidence-based treatment validated through biological research, with treatment administered via formally trained doctors, nurses, and other ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laser
A laser is a device that emits light through a process of optical amplification based on the stimulated emission of electromagnetic radiation. The word "laser" is an acronym for "light amplification by stimulated emission of radiation". The first laser was built in 1960 by Theodore H. Maiman at Hughes Research Laboratories, based on theoretical work by Charles Hard Townes and Arthur Leonard Schawlow. A laser differs from other sources of light in that it emits light which is coherence (physics), ''coherent''. Spatial coherence allows a laser to be focused to a tight spot, enabling applications such as laser cutting and Photolithography#Light sources, lithography. Spatial coherence also allows a laser beam to stay narrow over great distances (collimated light, collimation), enabling applications such as laser pointers and lidar (light detection and ranging). Lasers can also have high temporal coherence, which allows them to emit light with a very narrow frequency spectrum, spectru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Image Sensors
An image sensor or imager is a sensor that detects and conveys information used to make an image. It does so by converting the variable attenuation of light waves (as they pass through or reflect off objects) into signals, small bursts of current that convey the information. The waves can be light or other electromagnetic radiation. Image sensors are used in electronic imaging devices of both analog and digital types, which include digital cameras, camera modules, camera phones, optical mouse devices, medical imaging equipment, night vision equipment such as thermal imaging devices, radar, sonar, and others. As technology changes, electronic and digital imaging tends to replace chemical and analog imaging. The two main types of electronic image sensors are the charge-coupled device (CCD) and the active-pixel sensor ( CMOS sensor). Both CCD and CMOS sensors are based on metal–oxide–semiconductor (MOS) technology, with CCDs based on MOS capacitors and CMOS sensor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Devices
A medical device is any device intended to be used for medical purposes. Significant potential for hazards are inherent when using a device for medical purposes and thus medical devices must be proved safe and effective with reasonable assurance before regulating governments allow marketing of the device in their country. As a general rule, as the associated risk of the device increases the amount of testing required to establish safety and efficacy also increases. Further, as associated risk increases the potential benefit to the patient must also increase. Discovery of what would be considered a medical device by modern standards dates as far back as c. 7000 BC in Baluchistan where Neolithic dentists used flint-tipped drills and bowstrings. Study of archeology and Roman medical literature also indicate that many types of medical devices were in widespread use during the time of ancient Rome. In the United States it wasn't until the Federal Food, Drug, and Cosmetic Act (F ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
