L-2-hydroxycarboxylate Dehydrogenase (NAD )
L-2-hydroxycarboxylate dehydrogenase (NAD+) (, ''(R)-sulfolactate:NAD+ oxidoreductase'', ''L-sulfolactate dehydrogenase'', ''(R)-sulfolactate dehydrogenase'', ''L-2-hydroxyacid dehydrogenase (NAD+)'', ''ComC'') is an enzyme with systematic name ''(2S)-2-hydroxycarboxylate:NAD+ oxidoreductase''. This enzyme catalyses the following chemical reaction : (2S)-2-hydroxycarboxylate + NAD+ \rightleftharpoons 2-oxocarboxylate + NADH + H+ The enzyme from the archaeon ''Methanocaldococcus jannaschii ''Methanocaldococcus jannaschii'' (formerly ''Methanococcus jannaschii'') is a thermophilic methanogenic archaean in the class Methanococci. It was the first archaeon to have its complete genome sequenced. The sequencing identified many genes u ...'' uses as a substrate multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)- malate, (S)- lactate, and (S)-2-hydroxyglutarate. References External links * {{Portal bar, Biology, border=no EC 1.1.1 ...
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