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History Of Penicillin
The history of penicillin follows a number of observations and discoveries of apparent evidence of antibiotic activity of the mould ''Penicillium'' that led to the development of penicillins that became the most widely used antibiotics. Following the identification of ''Penicillium rubens'' as the source of the compound in 1928 and with the production of pure compound in 1942, penicillin became the first naturally derived antibiotic. There are anecdotes about ancient societies using moulds to treat infections, and in the following centuries many people observed the inhibition of bacterial growth by various moulds. However, it is unknown if the species involved were ''Penicillium'' species or if the antimicrobial substances produced were penicillin. While working at St Mary's Hospital in London, Scottish physician Alexander Fleming was the first to experimentally discover that a ''Penicillium'' mould secretes an antibacterial substance, and the first to concentrate the active sub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillin Core
Penicillins (P, PCN or PEN) are a group of β-lactam antibiotics originally obtained from ''Penicillium'' moulds, principally '' P. chrysogenum'' and '' P. rubens''. Most penicillins in clinical use are synthesised by P. chrysogenum using deep tank fermentation and then purified. A number of natural penicillins have been discovered, but only two purified compounds are in clinical use: penicillin G (intramuscular or intravenous use) and penicillin V (given by mouth). Penicillins were among the first medications to be effective against many bacterial infections caused by staphylococci and streptococci. They are still widely used today for different bacterial infections, though many types of bacteria have developed resistance following extensive use. 10% of the population claims penicillin allergies but because the frequency of positive skin test results decreases by 10% with each year of avoidance, 90% of these patients can tolerate penicillin. Additionally, those with p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacteria
Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit soil, water, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria are vital in many stages of the nutrient cycle by recycling nutrients such as the fixation of nitrogen from the atmosphere. The nutrient cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide and methane, to energy. Bacteria also live in symbiotic and parasitic re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microbiological Culture
A microbiological culture, or microbial culture, is a method of multiplying microbial organisms by letting them reproduce in predetermined culture medium under controlled laboratory conditions. Microbial cultures are foundational and basic diagnostic methods used as a research tool in molecular biology. The term ''culture'' can also refer to the microorganisms being grown. Microbial cultures are used to determine the type of organism, its abundance in the sample being tested, or both. It is one of the primary diagnostic methods of microbiology and used as a tool to determine the cause of infectious disease by letting the agent multiply in a predetermined medium. For example, a throat culture is taken by scraping the lining of tissue in the back of the throat and blotting the sample into a medium to be able to screen for harmful microorganisms, such as ''Streptococcus pyogenes'', the causative agent of strep throat. Furthermore, the term culture is more generally used informall ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Scott Burdon-Sanderson
Sir John Scott Burdon-Sanderson, 1st Baronet, FRS, HFRSE D.Sc. (21 December 182823 November 1905) was an English physiologist born near Newcastle upon Tyne, and a member of a well known Northumbrian family. Biography He was born at Jesmond near Newcastle-upon-Tyne on 21 December 1828 the son of Richard Burdon (1791-1865) and his wife Elizabeth Sanderson. His maternal grandfather was Sir James Sanderson, 1st Baronet. His paternal grandfather was Sir Thomas Burdon. He received his medical education at the University of Edinburgh with the thesis ''"On the metamorphoses of the coloured corpuscles in extravasated blood"'' and at Paris. Settling in London, he became Medical Officer of Health for Paddington in 1856 and four years later physician to the Middlesex Hospital and the Brompton Consumption hospitals. When diphtheria appeared in England in 1858 he was sent to investigate the disease at the different points of outbreak, and in subsequent years he carried out a numbe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmacology
Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism (sometimes the word ''pharmacon'' is used as a term to encompass these endogenous and exogenous bioactive species). More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties,functions,sources,synthesis and drug design, molecular and cellular mechanisms, organ/systems mechanisms, signal transduction/cellular communication, molecular diagnostics, interactions, chemical biology, therapy, and medical applications and antipathogenic capabili ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
England
England is a country that is part of the United Kingdom. It shares land borders with Wales to its west and Scotland to its north. The Irish Sea lies northwest and the Celtic Sea to the southwest. It is separated from continental Europe by the North Sea to the east and the English Channel to the south. The country covers five-eighths of the island of Great Britain, which lies in the North Atlantic, and includes over 100 smaller islands, such as the Isles of Scilly and the Isle of Wight. The area now called England was first inhabited by modern humans during the Upper Paleolithic period, but takes its name from the Angles, a Germanic tribe deriving its name from the Anglia peninsula, who settled during the 5th and 6th centuries. England became a unified state in the 10th century and has had a significant cultural and legal impact on the wider world since the Age of Discovery, which began during the 15th century. The English language, the Anglican Church, and Eng ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
With Fire And Sword
''With Fire and Sword'' ( pl, Ogniem i mieczem, links=no) is a historical novel by the Polish author Henryk Sienkiewicz, published in 1884. It is the first volume of a series known to Poles as The Trilogy, followed by ''The Deluge'' (''Potop'', 1886) and ''Fire in the Steppe'' (originally published under the Polish title ''Pan Wołodyjowski'', which translates to ''Lord Wolodyjowski''). The novel has been adapted as a film several times, most recently in 1999. ''With Fire and Sword'' is a historical fiction novel, set in the 17th century in the Polish–Lithuanian Commonwealth during the Khmelnytsky Uprising. It was initially serialized in several Polish newspapers, chapters appearing in weekly installments. It gained enormous popularity in Poland, and by the turn of the 20th century had become one of the most popular Polish books ever. It became obligatory reading in Polish schools, and has been translated into English and most European languages. The series was a vehicle fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Henryk Sienkiewicz
Henryk Adam Aleksander Pius Sienkiewicz ( , ; 5 May 1846 – 15 November 1916), also known by the pseudonym Litwos (), was a Polish writer, novelist, journalist and Nobel Prize laureate. He is best remembered for his historical novels, especially for his internationally known best-seller ''Quo Vadis'' (1896). Born into an impoverished Polish noble family in Russian-ruled Congress Poland, in the late 1860s he began publishing journalistic and literary pieces. In the late 1870s he traveled to the United States, sending back travel essays that won him popularity with Polish readers. In the 1880s he began serializing novels that further increased his popularity. He soon became one of the most popular Polish writers of the turn of the 19th and 20th centuries, and numerous translations gained him international renown, culminating in his receipt of the 1905 Nobel Prize in Literature for his "outstanding merits as an epic writer." Many of his novels remain in print. In Poland he ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spore
In biology, a spore is a unit of sexual or asexual reproduction that may be adapted for dispersal and for survival, often for extended periods of time, in unfavourable conditions. Spores form part of the life cycles of many plants, algae, fungi and protozoa. Bacterial spores are not part of a sexual cycle, but are resistant structures used for survival under unfavourable conditions. Myxozoan spores release amoeboid infectious germs ("amoebulae") into their hosts for parasitic infection, but also reproduce within the hosts through the pairing of two nuclei within the plasmodium, which develops from the amoebula. In plants, spores are usually haploid and unicellular and are produced by meiosis in the sporangium of a diploid sporophyte. Under favourable conditions the spore can develop into a new organism using mitotic division, producing a multicellular gametophyte, which eventually goes on to produce gametes. Two gametes fuse to form a zygote which develops into ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Poland
Poland, officially the Republic of Poland, , is a country in Central Europe. Poland is divided into Voivodeships of Poland, sixteen voivodeships and is the fifth most populous member state of the European Union (EU), with over 38 million people, and the List of European countries by area, seventh largest EU country, covering a combined area of . It extends from the Baltic Sea in the north to the Sudetes and Carpathian Mountains in the south, bordering seven countries. The territory is characterised by a varied landscape, diverse ecosystems, and Temperate climate, temperate transitional climate. The capital and List of cities and towns in Poland, largest city is Warsaw; other major cities include Kraków, Wrocław, Łódź, Poznań, and Gdańsk. Prehistory and protohistory of Poland, Humans have been present on Polish soil since the Lower Paleolithic, with continuous settlement since the end of the Last Glacial Period over 12,000 years ago. Culturally diverse throughout ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy, treatment and antibiotic prophylaxis, prevention of such infections. They may either bactericide, kill or bacteriostatic agent, inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the common cold or influenza; drugs which inhibit viruses are termed antiviral drugs or antivirals rather than antibiotics. Sometimes, the term ''antibiotic''—literally "opposing life", from the Greek language, Greek roots ἀντι ''anti'', "against" and βίος ''bios'', "life"—is broadly used to refer to any substance used against microbes, but in the usual medical usage, antibiotics (such as penicillin) are those produced naturally (by one microorgani ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
