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Hippocampal Formation
The hippocampal formation is a compound structure in the medial temporal lobe of the brain. It forms a c-shaped bulge on the floor of the inferior horn of the lateral ventricle. Typically, the hippocampal formation is said to included the dentate gyrus, the hippocampus, and the subiculum. The presubiculum, parasubiculum, and the entorhinal cortex may also be included. The hippocampal formation is thought to play a role in memory, spatial navigation and control of attention. The neural layout and pathways within the hippocampal formation are very similar in all mammals. History and function During the nineteenth and early twentieth centuries, based largely on the observation that, between species, the size of the olfactory bulb varies with the size of the parahippocampal gyrus, the hippocampal formation was thought to be part of the olfactory system. In 1937, Papez theorized that a circuit (the Papez circuit) including the hippocampal formation constitutes the neural subst ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Santiago Ramon Y Cajal
Santiago (, ; ), also known as Santiago de Chile (), is the capital and largest city of Chile and one of the largest cities in the Americas. It is located in the country's central valley and is the center of the Santiago Metropolitan Region, which has a population of seven million, representing 40% of Chile's total population. Most of the city is situated between above sea level. Founded in 1541 by the Spanish conquistador Pedro de Valdivia, Santiago has served as the capital city of Chile since colonial times. The city features a downtown core characterized by 19th-century neoclassical architecture and winding side streets with a mix of Art Deco, Gothic Revival, and other styles. Santiago's cityscape is defined by several standalone hills and the fast-flowing Mapocho River, which is lined by parks such as Parque Bicentenario, Parque Forestal, and Parque de la Familia. The Andes Mountains are visible from most parts of the city and contribute to a smog problem, particul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amygdala
The amygdala (; : amygdalae or amygdalas; also '; Latin from Greek language, Greek, , ', 'almond', 'tonsil') is a paired nucleus (neuroanatomy), nuclear complex present in the Cerebral hemisphere, cerebral hemispheres of vertebrates. It is considered part of the limbic system. In Primate, primates, it is located lateral and medial, medially within the temporal lobes. It consists of many nuclei, each made up of further subnuclei. The subdivision most commonly made is into the Basolateral amygdala, basolateral, Central nucleus of the amygdala, central, cortical, and medial nuclei together with the intercalated cells of the amygdala, intercalated cell clusters. The amygdala has a primary role in the processing of memory, decision making, decision-making, and emotions, emotional responses (including fear, anxiety, and aggression). The amygdala was first identified and named by Karl Friedrich Burdach in 1822. Structure Thirteen Nucleus (neuroanatomy), nuclei have been identif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
May-Britt Moser
May-Britt Moser (born 1963) is a Norwegian psychologist and neuroscientist, who is a Professor of Psychology and Neuroscience at the Norwegian University of Science and Technology (NTNU). She and her former husband, Edvard Moser, shared half of the 2014 Nobel Prize in Physiology or Medicine, awarded for work concerning the grid cells in the entorhinal cortex, as well as several additional space-representing cell types in the same circuit that make up the positioning system in the brain. Together with Edvard Moser she established the Moser research environment at NTNU, which they lead. Since 2012 she has headed the Centre for Neural Computation. Moser received her education as a psychologist at the Department of Psychology, University of Oslo and obtained a PhD in neurophysiology at the Faculty of Medicine in 1995; in 1996 she was appointed as associate professor in biological psychology at the Department of Psychology at the Norwegian University of Science and Technolog ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grid Cells
A grid cell is a type of neuron within the entorhinal cortex that fires at regular intervals as an animal navigates an open area, allowing it to understand its position in space by storing and integrating information about location, distance, and direction. Grid cells have been found in many animals, including rats, mice, bats, monkeys, and humans. Grid cells were discovered in 2005 by Edvard Moser, May-Britt Moser, and their students Torkel Hafting, Marianne Fyhn, and Sturla Molden at the Centre for the Biology of Memory (CBM) in Norway. They were awarded the 2014 Nobel Prize in Physiology or Medicine together with John O'Keefe for their discoveries of cells that constitute a positioning system in the brain. The arrangement of spatial firing fields, all at equal distances from their neighbors, led to a hypothesis that these cells encode a neural representation of Euclidean space. The discovery also suggested a mechanism for dynamic computation of self-position based on continu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lynn Nadel
Lynn Nadel (born November 12, 1942) is an American psychologist who is the Regents' Professor of psychology at the University of Arizona. Nadel specializes in memory, and has investigated the role of the hippocampus in memory formation. Together with John O'Keefe, he coauthored the influential 1978 book ''The Hippocampus as a Cognitive Map'', which defended the theory that the hippocampus learns and stores cognitive maps of portions of space. With Morris Moscovitch, he advanced the multiple trace theory that the hippocampus is always involved in storage and retrieval of episodic memory, but that semantic memory can be established in the neocortex. Nadel received a Ph.D. from McGill University in 1967, and joined the faculty of the University of Arizona in 1985, where he is now an Emeritus Professor of Psychology and Cognitive Science. Nadel, together with John O'Keefe, received the 2006 Grawemeyer Award for their work in identifying the brain's mapping system. He was named rec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Place Cells
A place cell is a kind of pyramidal neuron in the hippocampus that becomes active when an animal enters a particular place in its environment, which is known as the place field. Place cells are thought to act collectively as a cognitive representation of a specific location in space, known as a cognitive map. Place cells work with other types of neurons in the hippocampus and surrounding regions to perform this kind of spatial processing. They have been found in a variety of animals, including rodents, bats, monkeys and humans. Place-cell firing patterns are often determined by stimuli in the environment such as visual landmarks, and olfactory and vestibular stimuli. Place cells have the ability to suddenly change their firing pattern from one pattern to another, a phenomenon known as remapping. This remapping may occur in either some of the place cells or in all place cells at once. It may be caused by a number of changes, such as in the odor of the environment. Place cells a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John O'Keefe (neuroscientist)
John O'Keefe (born November 18, 1939) is an American-British neuroscientist, psychologist and a professor at University College London. O'Keefe discovered place cells in the hippocampus, and that they show a specific kind of temporal coding in the form of theta phase precession. He shared the Nobel Prize in Physiology or Medicine in 2014, together with May-Britt Moser and Edvard Moser; he has received several other awards. Early life and education Born in New York City to Irish immigrant parents, O'Keefe attended Regis High School (Manhattan) and received a BA degree from the City College of New York in 1963. Neither of his parents had completed elementary school in Ireland, but his father attained a high school degree in New York. He went on to study at McGill University in Montreal, Quebec, Canada, where he obtained an MA degree in 1964, and a PhD degree in Psychology in 1967, supervised by Ronald Melzack. Career and research O'Keefe went to University College London ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anterior Cingulate Cortex
In human brains, the anterior cingulate cortex (ACC) is the frontal part of the cingulate cortex that resembles a "collar" surrounding the frontal part of the corpus callosum. It consists of Brodmann areas 24, 32, and 33. It is involved in certain higher-level functions, such as attention allocation, reward anticipation, decision-making, impulse control (e.g. performance monitoring and error detection), and emotion. Some research calls it the anterior midcingulate cortex (aMCC). Anatomy The anterior cingulate cortex can be divided anatomically based on cognitive (dorsal), and emotional ( ventral) components. The dorsal part of the ACC is connected with the prefrontal cortex and parietal cortex, as well as the motor system and the frontal eye fields, making it a central station for processing top-down and bottom-up stimuli and assigning appropriate control to other areas in the brain. By contrast, the ventral part of the ACC is connected with the amygdala, nucleu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brenda Milner
Brenda Milner (''née'' Langford; born 15 July 1918) is a British-Canadian neuropsychologist who has contributed extensively to the research literature on various topics in the field of clinical neuropsychology. Milner is a professor in the Department of Neurology and Neurosurgery at McGill University and a professor of Psychology at the Montreal Neurological Institute.Brenda Milner Wins Balzan Prize for Cognitive Neurosciences (2011). Government of Canada. , she holds more than 25 honorary degrees and she continued to work in her nineties. Her work covers many aspects of neuropsychology including her lifelong interest in the involvement of the temporal lobe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William Beecher Scoville
William Beecher Scoville (January 13, 1906 – February 25, 1984) was an American neurosurgeon at Hartford Hospital in Hartford, Connecticut. Scoville established the Department of Neurosurgery at Connecticut's Hartford Hospital in 1939. He performed surgery on Henry Gustav Molaison in 1953 to relieve epilepsy that damaged the hippocampus of both the right and left temporal lobes of Molaison's brain and left him with a memory disorder. Biography Scoville was born in Philadelphia, Pennsylvania, on January 13, 1906. Although he had a strong interest in automobiles throughout his life, his father pushed William toward a career in medicine. After completing his undergraduate degree at Yale (B.A., 1928), he attended and graduated from the University of Pennsylvania School of Medicine in 1932. In 1941, he became board certified in neurosurgery. Also, in 1941 he started the first neurosurgical residency training program in Connecticut. In 1953 Scoville offered Henry Gustav Molaiso ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vladimir Bekhterev
Vladimir Mikhailovich Bekhterev ( rus, Влади́мир Миха́йлович Бе́хтерев, p=ˈbʲextʲɪrʲɪf; 20 January 1857 – 24 December 1927) was a Russian neurologist and the father of objective psychology. He is best known for noting the role of the hippocampus in memory, his study of reflexes, and Bekhterev’s disease. Moreover, he is known for his competition with Ivan Pavlov regarding the study of conditioned reflexes. The sudden circumstances of his death has led to rumours that he died on the orders of Joseph Stalin. This is because Bekhterev performed a medical diagnosis of Stalin shortly before his death which was considered to be politically damaging to the position of the Soviet dictator. This remains disputed among scholars due to the lack of direct evidence. Early life Vladimir Bekhterev was born in Sorali, a village in the Vyatka Governorate of the Russian Empire between the Volga River and the Ural Mountains. V. M. Bekhterev's father – Mi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Axon
An axon (from Greek ἄξων ''áxōn'', axis) or nerve fiber (or nerve fibre: see American and British English spelling differences#-re, -er, spelling differences) is a long, slender cellular extensions, projection of a nerve cell, or neuron, in Vertebrate, vertebrates, that typically conducts electrical impulses known as action potentials away from the Soma (biology), nerve cell body. The function of the axon is to transmit information to different neurons, muscles, and glands. In certain sensory neurons (pseudounipolar neurons), such as those for touch and warmth, the axons are called afferent nerve fibers and the electrical impulse travels along these from the peripheral nervous system, periphery to the cell body and from the cell body to the spinal cord along another branch of the same axon. Axon dysfunction can be the cause of many inherited and acquired neurological disorders that affect both the Peripheral nervous system, peripheral and Central nervous system, central ne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
