Hepatitis B Surface Antigen
HBsAg (also known as the Australia antigen) is the surface antigen of the hepatitis B virus (HBV). Its presence in blood indicates existing hepatitis B infection. Structure and function The viral envelope of an enveloped virus has different surface proteins from the rest of the virus which act as antigens. These antigens are recognized by antibody proteins that bind specifically to one of these surface proteins. The full-length HBsAg is called the L (for "large") form. It consists of a preS loop, a first transmembrane helix (TM1), a cytosolic loop (CYL), another TM helix (TM2), an antigenic loop (AGL), followed by two TM helices (TM3 and TM4). The preS loop can either be on the outside (lumen), or be located in the cytosol with the TM1 helix not actually penetrating the membrane. The M ("medium") form has a truncated preS; the part of preS1 unique to L is called preS1, while the part shared by L and M is called preS2. preS2 is always located in the lumen. The S ("small") form h ...
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HBV Genome
HBV may refer to: * Buskerud and Vestfold University College (Norwegian: ') * Hamengkubuwono V, 19th-century ruler of Yogyakarta, Java * ''Handbuch der Vögel Mitteleuropas'' (''Handbook of the Birds of Central Europe'') * HBV hydrology model * Hepatitis B virus * Hepatitis B vaccine * Heterostructure barrier varactor * Trade, Banking and Insurance Union The Trade, Banking and Insurance Union (, HBV) was a trade union representing workers in commerce and finance in Germany. During 1947 and 1948, German trade unionists were regrouping and the majority decided to establish the German Trade Union Co ...

Histopathology
Histopathology (compound of three Greek words: 'tissue', 'suffering', and '' -logia'' 'study of') is the microscopic examination of tissue in order to study the manifestations of disease. Specifically, in clinical medicine, histopathology refers to the examination of a biopsy or surgical specimen by a pathologist, after the specimen has been processed and histological sections have been placed onto glass slides. In contrast, cytopathology examines free cells or tissue micro-fragments (as "cell blocks "). Collection of tissues Histopathological examination of tissues starts with surgery, biopsy, or autopsy. The tissue is removed from the body or plant, and then, often following expert dissection in the fresh state, placed in a fixative which stabilizes the tissues to prevent decay. The most common fixative is 10% neutral buffered formalin (corresponding to 3.7% w/v formaldehyde in neutral buffered water, such as phosphate buffered saline). Preparation for h ...
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Recombinant DNA
Recombinant DNA (rDNA) molecules are DNA molecules formed by laboratory methods of genetic recombination (such as molecular cloning) that bring together genetic material from multiple sources, creating sequences that would not otherwise be found in the genome. Recombinant DNA is the general name for a piece of DNA that has been created by combining two or more fragments from different sources. Recombinant DNA is possible because DNA molecules from all organisms share the same chemical structure, differing only in the nucleotide sequence. Recombinant DNA molecules are sometimes called chimeric DNA because they can be made of material from two different species like the mythical chimera. rDNA technology uses palindromic sequences and leads to the production of sticky and blunt ends. The DNA sequences used in the construction of recombinant DNA molecules can originate from any species. For example, plant DNA can be joined to bacterial DNA, or human DNA can be joined with fun ...
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Blood Plasma
Blood plasma is a light Amber (color), amber-colored liquid component of blood in which blood cells are absent, but which contains Blood protein, proteins and other constituents of whole blood in Suspension (chemistry), suspension. It makes up about 55% of the body's total blood volume. It is the Intravascular compartment, intravascular part of extracellular fluid (all body fluid outside cells). It is mostly water (up to 95% by volume), and contains important dissolved proteins (6–8%; e.g., serum albumins, globulins, and fibrinogen), glucose, clotting factors, electrolytes (, , , , , etc.), hormones, carbon dioxide (plasma being the main medium for excretory product transportation), and oxygen. It plays a vital role in an intravascular osmotic effect that keeps electrolyte concentration balanced and protects the body from infection and other blood-related disorders. Blood plasma can be separated from whole blood through blood fractionation, by adding an anticoagulant to a tube ...
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Indigenous Australians
Indigenous Australians are people with familial heritage from, or recognised membership of, the various ethnic groups living within the territory of contemporary Australia prior to History of Australia (1788–1850), British colonisation. They consist of two distinct groups, which include many ethnic groups: the Aboriginal Australians of the mainland and many islands, including Aboriginal Tasmanians, Tasmania, and the Torres Strait Islanders of the seas between Queensland and Papua New Guinea, located in Melanesia. 812,728 people Aboriginality, self-identified as being of Aboriginal and/or Torres Strait Islander origin in the 2021 Australian Census, representing 3.2% of the total population of Australia. Of these Indigenous Australians, 91.4% identified as Aboriginal, 4.2% identified as Torres Strait Islander, and 4.4% identified with both groups. The term Aboriginal and Torres Strait Islander peoples or the person's specific cultural group, is often preferred, though the term ...
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Australia
Australia, officially the Commonwealth of Australia, is a country comprising mainland Australia, the mainland of the Australia (continent), Australian continent, the island of Tasmania and list of islands of Australia, numerous smaller islands. It has a total area of , making it the list of countries and dependencies by area, sixth-largest country in the world and the largest in Oceania. Australia is the world's flattest and driest inhabited continent. It is a megadiverse countries, megadiverse country, and its size gives it a wide variety of landscapes and Climate of Australia, climates including deserts of Australia, deserts in the Outback, interior and forests of Australia, tropical rainforests along the Eastern states of Australia, coast. The ancestors of Aboriginal Australians began arriving from south-east Asia 50,000 to 65,000 years ago, during the Last Glacial Period, last glacial period. By the time of British settlement, Aboriginal Australians spoke 250 distinct l ...
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Baruch S
Baruch may refer to: People * Baruch (given name), a given name of Hebrew origin * Baruch Spinoza (1632–1677), Dutch philosopher *Baruch (surname) Other uses * Book of Baruch, also called 1 Baruch, a deuterocanonical book of the Bible * 2 Baruch, also called the ''Syriac Apocalypse of Baruch'' * 3 Baruch, also called the ''Greek Apocalypse of Baruch'' * 4 Baruch, also known as the ''Paraleipomena of Jeremiah'' * Baruch College, part of the City University of New York system, named after Bernard Baruch * Baruch Plan The Baruch Plan was a proposal put forward by the United States government on 14 June 1946 to the United Nations Atomic Energy Commission (UNAEC) during its first meeting. Bernard Baruch wrote the bulk of the proposal, based on the March 1946 Ac ...

Nobel Prize
The Nobel Prizes ( ; ; ) are awards administered by the Nobel Foundation and granted in accordance with the principle of "for the greatest benefit to humankind". The prizes were first awarded in 1901, marking the fifth anniversary of Alfred Nobel, Alfred Nobel's death. The original Nobel Prizes covered five fields: Nobel Prize in Physics, physics, Nobel Prize in Chemistry, chemistry, Nobel Prize in Physiology or Medicine, physiology or medicine, Nobel Prize in Literature, literature, and Nobel Peace Prize, peace, specified in Nobel's will. A sixth prize, the Nobel Memorial Prize in Economic Sciences, Prize in Economic Sciences, was established in 1968 by Sveriges Riksbank (Sweden's central bank) in memory of Alfred Nobel. The Nobel Prizes are widely regarded as the most prestigious awards available in their respective fields.Nobel Prize#Shalev69, Shalev, p. 8. Except in extraordinary circumstances, such as war, all six prizes are given annually. Each recipient, known as a laur ...
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Virus-like Particle
Virus-like particles (VLPs) are molecules that closely resemble viruses, but are non-infectious because they contain no viral genetic material. They can be naturally occurring or synthesized through the individual expression of viral structural proteins, which can then self assemble into the virus-like structure. Combinations of structural capsid proteins from different viruses can be used to create recombinant VLPs. Both in-vivo assembly (i.e., assembly inside E. coli bacteria via recombinant co-expression of multiple proteins) and in-vitro assembly (i.e., protein self-assembly in a reaction vessel using stoichiometric quantities of previously purified proteins) have been successfully shown to form virus-like particles. VLPs derived from the Hepatitis B virus (HBV) and composed of the small HBV derived surface antigen (HBsAg) were described in 1968 from patient sera. VLPs have been produced from components of a wide variety of virus families including Parvoviridae (e.g. adeno-associ ...
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RTS,S
RTS,S/AS01 (trade name Mosquirix) is a recombinant protein-based malaria vaccine. It is one of two malaria vaccines approved (the other is R21/Matrix-M). , the vaccine has been given to 1million children living in areas with moderate-to-high malaria transmission, with millions more doses to be provided as the vaccine's production expands. 18 million doses have been allocated for 2023-2025. It requires at least three doses in infants by age 2, with a fourth dose extending the protection for another 1–2 years. The vaccine reduces hospital admissions from severe malaria by around 30% and reduces toddler deaths by 15%. Medical uses RTS,S/AS01 (commercial name ''Mosquirix'') is the only malaria vaccine approved and in current use. The vaccine's use requires at least three doses in infants by age 2, with a fourth dose extending the protection for another 1–2 years. The vaccine reduces hospital admissions from severe malaria by around 30%. History Potential malaria vaccine ...
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Immunization Action Coalition
The Immunization Action Coalition (IAC) is an organization that distributes information about vaccines and the diseases they prevent. In partnership with the Centers for Disease Control and Prevention (CDC), their headquarters is located in Saint Paul, Minnesota, with member coalitions in the United States and Canada. Paul Offit serves on the Advisory board. Mission Having the goal of providing the public with information about immunization, the IAC has three current functions: # creation and distribution of weekly editions of IAC Express to IAC's email subscribers; # publication of the feature "Ask the Experts," in which CDC and IAC immunization experts answer questions from vaccine providers; and # creation of new immunization education materials designed to respond to the needs of immunization providers, parents, and patients. Activities The coalition's Web site offers "Unprotected People Stories" about the consequences of vaccine avoidance, and "Talking about Vaccin ...
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Hepatitis B Vaccine
Hepatitis B vaccine is a vaccine that prevents hepatitis B. The first dose is recommended within 24 hours of birth with either two or three more doses given after that. This includes those with poor immune function such as from HIV/AIDS and those born premature. It is also recommended that health-care workers be vaccinated. In healthy people, routine immunization results in more than 95% of people being protected. Blood testing to verify that the vaccine has worked is recommended in those at high risk. Additional doses may be needed in people with poor immune function but are not necessary for most people. In those who have been exposed to the hepatitis B virus (HBV) but not immunized, hepatitis B immune globulin should be given in addition to the vaccine. The vaccine is given by injection into a muscle. Serious side effects from the hepatitis B vaccine are very uncommon. Pain may occur at the site of injection. It is safe for use during pregnancy or while breastfeedin ...
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