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HLA B7-DR15-DQ6
HLA B7-DR15-DQ6 is a multigene haplotype that covers a majority of the human major histocompatibility complex on chromosome 6. A multigene haplotype is set of inherited alleles covering several genes, or gene-alleles, common multigene haplotypes are generally the result of descent by common ancestry (share a recent common ancestor for that segment of the chromosome). Chromosomal recombination fragments multigene haplotypes as the distance to that ancestor increases in number of generations. HLA B7-DR15-DQ6 is a representation(by serotype) of a common HLA haplotype found in Western Eurasia. The haplotype can be written in an extended form covering the major histocompatibility loci as follows: HLA Cw : B : DRB1 : DQA1 : DQB1 The older literature may describe this haplotype in two different ways. One B7-DR2-DQ6 derives from the fact that DR15 is a split antigen of the DR2 broad antigen serotype. The other B7-DR2-DQ1 stems from the fact that DQ1 is an alpha chain serotype that is n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HLA DR3-DQ2
HLA DR3-DQ2 is double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype. Certain HLA DR and DQ genes have known involvement in autoimmune diseases. DR3- DQ2, a multigene haplotype, stands out in prominence because it is a factor in several prominent diseases, namely coeliac disease and juvenile diabetes. In coeliac disease, the DR3-DQ2 haplotype is associated with highest risk for disease in first degree relatives, highest risk is conferred by DQA1*0501:DQB1*0201 homozygotes and semihomozygotes of DQ2, and represents the overwhelming majority of risk. HLA DR3-DQ2 encodes DQ2.5cis isoform of HLA-DQ, this isoform is described frequently as 'the DQ2 isoform', but in actuality there are two major DQ2 isoform. The DQ2.5 isoform, however, is many times more frequently associated with autoimmune disease, and as a result to contribution of DQ2.2 is often ignored. The frequency of both diseases changes with respect to both the env ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HLA A1-B8 Haplotype
HLA A1-B8 (Also:''HL A1,8''; ''HL A1,A8''; ''HLA A1-Cw7-B8''; ''HLA A*01-B*08'', ''HLA A*0101-B*0801'', ''HLA A*0101-Cw*0701-B*0801''; ''HLA A*01:01-C*07:01-B*08:01'') is a multigene haplotype that covers the MHC Class I region of the human major histocompatibility complex on chromosome 6. A multigene haplotype is set of inherited alleles covering several genes, or gene-alleles; common multigene haplotypes are generally the result of identity by descent from a common ancestor (share a recent common ancestor for that segment of the chromosome). Chromosomal recombination fragments multigene haplotypes as the distance to that ancestor increases in number of generations. The haplotype can be written in an extended form covering the major histocompatibility loci as follows: HLA A : Cw : B However, there are many other gene-alleles within the haplotype. In Europe A1-B8 is found, generally as part of the HLA A1-B8-DR3-DQ2 haplotype. This haplotype is 4.7 million nucleotides in length ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HLA A3-B7
HLA may refer to: Airports * Hacienda Lipangue Airport, Chile * Huslia Airport (FAA LID: HLA), in Alaska, United States * Lanseria International Airport (IATA: HLA), near Johannesburg, South Africa People * Hla Myint (Brigadier General) (born 1940s), Burmese politician * Hla Myint (1920–2017), Burmese economist * Hla Pe (1913–2007), Burmese linguist * Hla Thaung (died 1949), Burmese soldier * M.T. Hla (U Tun Hla) (1874–1946), Burmese painter * Min Saw Hla (1532–1564), king of Arakan * Sanda Min Hla (died 1363), Chief queen consort of Hanthawaddy * Saw Min Hla (), Chief queen consort of Ava Schools * Heath Lane Academy, in Earl Shilton, Leicestershire, England * Hidden Lake Academy, in Georgia, United States * Hillcrest Lutheran Academy, in Minnesota, United States Science and technology * High Level Architecture, a distributed computer simulation standard * High Level Assembly, an Intel 80x86 Assembly Language * ''HLA'' (journal), a scientific journal * HLA Informatic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HLA-A2-B7
HLA-A is a group of human leukocyte antigens (HLA) that are encoded by the HLA-A locus, which is located at human chromosome 6p21.3. HLA is a major histocompatibility complex (MHC) antigen specific to humans. HLA-A is one of three major types of human MHC class I transmembrane proteins. The others are HLA-B and HLA-C. The protein is a heterodimer, and is composed of a heavy α chain and smaller β chain. The α chain is encoded by a variant HLA-A gene, and the β chain (β2-microglobulin) is an invariant β2 microglobulin molecule. The β2 microglobulin protein is encoded by the B2M gene, which is located at chromosome 15q21.1 in humans. MHC Class I molecules such as HLA-A are part of a process that presents short polypeptides to the immune system. These polypeptides are typically 7-11 amino acids in length and originate from proteins being expressed by the cell. There are two classes of polypeptide that can be presented by an HLA protein: those that are supposed to be expres ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HLA A24-B7
HLA may refer to: Airports * Hacienda Lipangue Airport, Chile * Huslia Airport (FAA LID: HLA), in Alaska, United States * Lanseria International Airport (IATA: HLA), near Johannesburg, South Africa People * Hla Myint (Brigadier General) (born 1940s), Burmese politician * Hla Myint (1920–2017), Burmese economist * Hla Pe (1913–2007), Burmese linguist * Hla Thaung (died 1949), Burmese soldier * M.T. Hla (U Tun Hla) (1874–1946), Burmese painter * Min Saw Hla (1532–1564), king of Arakan * Sanda Min Hla (died 1363), Chief queen consort of Hanthawaddy * Saw Min Hla (), Chief queen consort of Ava Schools * Heath Lane Academy, in Earl Shilton, Leicestershire, England * Hidden Lake Academy, in Georgia, United States * Hillcrest Lutheran Academy, in Minnesota, United States Science and technology * High Level Architecture, a distributed computer simulation standard * High Level Assembly, an Intel 80x86 Assembly Language * ''HLA'' (journal), a scientific journal * HLA Informatic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
