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Friedrich Miescher Institute For Biomedical Research
The Friedrich Miescher Institute for Biomedical Research (FMI) is a biomedical research institute founded in 1970. Based in Basel, Switzerland, the FMI is affiliated with the University of Basel and the Novartis Institutes for BioMedical Research (NIBR). It is named after Friedrich Miescher. , the FMI has around 340 collaborators, of which 20 are research group leaders, over 80 are postdoctoral collaborators and over 80 are postgraduate students participating in the FMI International PhD Program. The FMI is directed by Dirk Schübeler. The FMI is member of EU-LIFE, an alliance of leading life sciences research centres in Europe. Scientific activities The FMI is devoted to the pursuit of fundamental biomedical research. Areas of research are neurobiology, genome regulation, and multicellular systems. Research is carried out in 20 independent but highly interactive research groups. In addition, several cutting-edge technology platforms – including microscopy & imaging, comp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Basic Research
Basic research, also called pure research, fundamental research, basic science, or pure science, is a type of scientific research with the aim of improving scientific theories for better understanding and prediction of natural or other phenomena. In contrast, applied research uses scientific theories to develop technology or techniques, which can be used to intervene and ''alter'' natural or other phenomena. Though often driven simply by curiosity,"Curiosity creates cures: The value and impact of basic research , National Institute of General Medical Sciences, |
HER2/neu
Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ''ERBB2'' gene. ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 ( cluster of differentiation 340). HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. But contrary to other members of the ERBB family, HER2 does not directly bind ligand. HER2 activation results from heterodimerization with another ERBB member or by homodimerization when HER2 concentration are high, for instance in cancer. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Silvia Arber
Silvia Arber (born 1968 in Geneva) is a Swiss neurobiologist. She teaches and researches at both the Biozentrum of the University of Basel and the Friedrich Miescher Institute for Biomedical Research in Basel Switzerland. Education Silvia Arber studied biology at the Biozentrum of the University of Basel and completed her doctorate in 1995 at the Friedrich Miescher Institute (FMI) in Basel. Career and research Arber subsequently worked as a postdoctoral fellow at the Columbia University in New York City. In 2000, she returned to Basel as a Professor of Neurobiology and Cell Biology continuing her research work and teaching at the Biozentrum as well as at the FMI. Arber's research investigates the mechanisms involved in the function and assembly of neuronal circuits controlling motor behavior. She has shown that premotor interneuron groups differ from each other in their functionality and distribution in the spinal cord and that this property depends on the timing of their ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Susan M
Susan is a feminine given name, the usual English version of Susanna or Susannah. All are versions of the Hebrew name Shoshana, which is derived from the Hebrew ''shoshan'', meaning ''lotus flower'' in Egyptian, original derivation, and several other languages. Variations * Susana, Susanna (or Suzanna), Susannah, Suzana, Suzannah * Susann, Sussan, Suzan, Suzann * Susanne, Suzanne * Susanne * Suzan * Suzanne * Suzette * Susie, Suzy Nicknames Common nicknames for Susan include: * Sue, Susie, Susi (German), Suzi, Suzy, Suzie, Suze, Sanna, Suzie, Sookie, Sukie Sukie are an English four piece indie band from Kettering, Northamptonshire, England, who formed in March 2006. They had a number one on the UK Indie Chart in 2008 with the double a-side "Pink-A-Pade" / "Fairies". Following the split of the band, ..., Sukey, Subo, Suus (Dutch), Shanti In other languages * Albanian and * * , or * * , or * * , or * Catalan, Estonian and * ** * Czech and * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ISREC
The Swiss Institute for Experimental Cancer Research (ISREC, ) is a not-for-profit institution founded in 1964 and located in Épalinges, Switzerland. Since 1 January 2008, it is organized into two distinct entities: * The ISREC Foundation whose mission is to continue to seek and provide resources for the support of translational cancer research projects and the training of young scientists. * The Swiss Institute for Experimental Cancer Research (ISREC), at the School of Life Sciences of the EPFL, whose research projects are oriented towards fundamental cancer research. History The ISREC has its origins in the history of the (CACR), which was founded in 1924 in Lausanne. Initially, the CACR was composed of three main departments: pathology, experimental research and a therapeutic service. The appointment of Alfredo Vannotti (1907–2002) as Head of the experimental research service in 1947 and the appointment one year later of Serge Neukomm (born 1917), led to the developmen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Scientist (magazine)
''The Scientist'' is a professional magazine intended for life scientists. ''The Scientist'' covers recently published research papers, current research, techniques, and other columns and reports of interest to its readers. The magazine is published monthly and is available in print and digital formats. Overview The main purpose of the magazine is to provide print and online coverage of the latest developments in life sciences research, technology, careers, and business. Subject matters covered by the magazine include groundbreaking research, industry innovations, careers, financial topics, the economics of science, scientific ethics, profiles of scientists, lab tools, scientific publishing, techniques, product spotlight, and guides. History ''The Scientist'' was founded in 1986 by American businessman Eugene Garfield as part of his academic publishing service ''Institute for Scientific Information.'' The publishing house was sold two years later to ''JPT Publishing'', but Eug ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biozentrum, University Of Basel
Research at the Biozentrum of the University of Basel is dedicated to the central question of how molecules and cells create life − from atom to organism, and from the physics of life to the dynamics of multicellular systems. Accordingly, the scientists at the Biozentrum are active in a wide range of research fields. These disciplines are not strictly separated from each other, but often overlap, thus leading to new questions and collaborations. With 550 employees, the Biozentrum is the largest department at the University of Basel's Faculty of Science. It is home to 31 research groups with scientists from more than 40 nations who investigate how molecules and cells create life. History In 1971, at the time when the Biozentrum was founded, the concept of developing an interdisciplinary biological research facility was unique in Europe. Scientists from academy and industry as well as representatives of the Canton of Basel-Stadt promoted the Biozentrum's development. In the win ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Retinitis Pigmentosa
Retinitis pigmentosa (RP) is a member of a group of genetic disorders called inherited retinal dystrophy (IRD) that cause loss of vision. Symptoms include trouble seeing at night and decreasing peripheral vision (side and upper or lower visual field). As peripheral vision worsens, people may experience " tunnel vision". Complete blindness is uncommon. Onset of symptoms is generally gradual and often begins in childhood. Retinitis pigmentosa is generally inherited from one or both parents. It is caused by genetic variants in nearly 100 genes. The underlying mechanism involves the progressive loss of rod photoreceptor cells that line the retina of the eyeball. The rod cells secrete a neuroprotective substance (rod-derived cone viability factor, RdCVF) that protects the cone cells from apoptosis. When these rod cells die, this substance is no longer provided. This is generally followed by the loss of cone photoreceptor cells. Diagnosis is through eye examination of the retina ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Methylation
DNA methylation is a biological process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene promoter (genetics), promoter, DNA methylation typically acts to repress gene Transcription (genetics), transcription. In mammals, DNA methylation is essential for normal development and is associated with a number of key processes including genomic imprinting, X-chromosome inactivation, repression of transposable elements, aging, and carcinogenesis. As of 2016, two nucleobases have been found on which natural, enzymatic DNA methylation takes place: adenine and cytosine. The modified bases are N6-methyladenine,D. B. Dunn, J. D. Smith: "The occurrence of 6-methylaminopurine in deoxyribonucleic acids". In: ''Biochem J.'' 68(4), Apr 1958, S. 627–636. [//www.ncbi.nlm.nih.gov/pubmed/13522672?dopt=Abstract PMID 13522672]. . 5-methylcytosineB. F. Vanyushin, S. G. Tkacheva, A. N. Belozers ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MeDIP
Methylated DNA immunoprecipitation (MeDIP or mDIP) is a large-scale (chromosome- or genome-wide) purification technique in molecular biology that is used to enrich for methylated DNA sequences. It consists of isolating methylated DNA fragments via an antibody raised against 5-methylcytosine (5mC). This technique was first described by Weber M. ''et al.'' in 2005 and has helped pave the way for viable methylome-level assessment efforts, as the purified fraction of methylated DNA can be input to high-throughput DNA detection methods such as high-resolution DNA microarrays ( MeDIP-chip) or next-generation sequencing (MeDIP-seq). Nonetheless, understanding of the methylome remains rudimentary; its study is complicated by the fact that, like other epigenetic properties, patterns vary from cell-type to cell-type. Background DNA methylation, referring to the reversible methylation of the 5 position of cytosine by methyltransferases, is a major epigenetic modification in multicellu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MiRNA
Micro ribonucleic acid (microRNA, miRNA, μRNA) are small, single-stranded, non-coding RNA molecules containing 21–23 nucleotides. Found in plants, animals, and even some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. miRNAs base-pair to complementary sequences in messenger RNA (mRNA) molecules, then Gene silencing, silence said mRNA molecules by one or more of the following processes: * Cleaving the mRNA strand into two pieces. * Destabilizing the mRNA by shortening its polyadenylation, poly(A) tail. * Reducing translation (biology), translation of the mRNA into proteins. In cells of humans and other animals, miRNAs primarily act by destabilizing the mRNA. miRNAs resemble the small interfering RNA, small interfering RNAs (siRNAs) of the RNA interference, RNA interference (RNAi) pathway, except miRNAs derive from regions of RNA transcripts that fold back on themselves to form short stem-loops (hairpins), whereas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RNA Interference
RNA interference (RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene expression by double-stranded RNA, through translational or transcriptional repression. Historically, RNAi was known by other names, including ''co-suppression'', ''post-transcriptional gene silencing'' (PTGS), and ''quelling''. The detailed study of each of these seemingly different processes elucidated that the identity of these phenomena were all actually RNAi. Andrew Fire and Craig Mello shared the 2006 Nobel Prize in Physiology or Medicine for their work on RNAi in the nematode worm ''Caenorhabditis elegans'', which they published in 1998. Since the discovery of RNAi and its regulatory potentials, it has become evident that RNAi has immense potential in suppression of desired genes. RNAi is now known as precise, efficient, stable and better than antisense therapy for gene suppression. Antisense RNA produced intracellularly by an expression vector may be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
