Francisella Tularensis
''Francisella tularensis'' is a pathogenic species of Gram-negative coccobacillus, an aerobic bacterium. It is nonspore-forming, nonmotile, and the causative agent of tularemia, the pneumonic form of which is often lethal without treatment. It is a fastidious, facultative intracellular bacterium, which requires cysteine for growth. Due to its low infectious dose, ease of spread by aerosol, and high virulence, ''F. tularensis'' is classified as a Tier 1 Select Agent by the U.S. government, along with other potential agents of bioterrorism such as ''Yersinia pestis, Bacillus anthracis'', and Ebola virus. When found in nature, ''Francisella tularensis'' can survive for several weeks at low temperatures in animal carcasses, soil, and water. In the laboratory, ''F. tularensis'' appears as small rods (0.2 by 0.2 μm), and is grown best at 35–37 °C. History This species was discovered in ground squirrels in Tulare County, California in 1911. ''Bacterium tularense'' was so ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Macrophage
Macrophages (; abbreviated MPhi, φ, MΦ or MP) are a type of white blood cell of the innate immune system that engulf and digest pathogens, such as cancer cells, microbes, cellular debris and foreign substances, which do not have proteins that are specific to healthy body cells on their surface. This self-protection method can be contrasted with that employed by Natural killer cell, Natural Killer cells. This process of engulfment and digestion is called phagocytosis; it acts to defend the host against infection and injury. Macrophages are found in essentially all tissues, where they patrol for potential pathogens by amoeboid movement. They take various forms (with various names) throughout the body (e.g., histiocytes, Kupffer cells, alveolar macrophages, microglia, and others), but all are part of the mononuclear phagocyte system. Besides phagocytosis, they play a critical role in nonspecific defense (innate immunity) and also help initiate specific defense mechanisms (adapti ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Biovar
A biovar is a variant prokaryotic Strain (biology), strain that differs physiologically or biochemically from other strains in a particular species. Morphovars (or morphotypes) are those strains that differ morphologically. Serovars (or serotypes) are those strains that have antigenic properties that differ from other strains. __FORCETOC__ List of biovars This is a list of biovars and strains of biovars listed at the NCBI Taxonomy database:Schoch CL, et al. NCBI Taxonomy: a comprehensive update on curation, resources and tools. Database (Oxford). 2020: baaa062. PubMed: 32761142 PMC: PMC7408187 *Acinetobacter calcoaceticus biovar anitratus, ''Acinetobacter calcoaceticus'' biovar ''anitratus'', a homotypic synonym for Acinetobacter calcoaceticus subsp. anitratus, ''Acinetobacter calcoaceticus'' subsp. ''anitratus'' *Actinobacillus anseriformium biovar 1, ''Actinobacillus anseriformium'' biovar 1 *Actinobacillus anseriformium biovar 2, ''Actinobacillus anseriformium'' biovar 2 *Aerom ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Horse-fly
Horse flies and deer flies are true flies in the family Tabanidae in the insect Order (biology), order Diptera. The adults are often large and agile in flight. Only females bite land vertebrates, including humans, to hematophagy, obtain blood. They prefer to fly in sunlight, avoiding dark and shady areas, and are inactive at night. They are found all over the world except for some islands and the polar regions (Hawaii, Greenland, Iceland). Both horse flies and botflies (Oestridae) are sometimes referred to as gadflies. Adult horse flies feed on nectar and plant exudates; males have weak insect mouthparts, mouthparts, but females have mouthparts strong enough to puncture the skin of large animals. This is for the purpose of obtaining enough protein from blood to produce eggs. The mouthparts of females are formed into a stout stabbing organ with two pairs of sharp cutting blades, and a spongelike part used to lap up the blood that flows from the wound. The larvae are predaceous ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Deer Fly
Chrysopsinae is an insect subfamily in the family Tabanidae commonly known as deer flies or sheep flies and are bloodsucking insects considered pests to humans and cattle. They are large flies with large brightly-coloured compound eyes, and large clear wings with dark bands. They are larger than the common housefly and smaller than the horse-fly. Deer flies lay between 100 and 800 eggs on vegetation near water or dampness in batches. During the larval stage, which lasts one to three weeks, they feed on small creatures or rotting organic matter near or in the water. After a pupal stage, they emerge as adults in late spring and summer. While male deer flies collect pollen, female deer flies feed on blood, which they require to produce eggs. Females feed primarily on mammals. They are attracted to prey by sight, smell, or the carbon dioxide detection. Other attractants are body heat, movement, dark colours, and lights in the night. They are active under direct sunshine and hours whe ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Mosquito
Mosquitoes, the Culicidae, are a Family (biology), family of small Diptera, flies consisting of 3,600 species. The word ''mosquito'' (formed by ''Musca (fly), mosca'' and diminutive ''-ito'') is Spanish and Portuguese for ''little fly''. Mosquitoes have a slender segmented body, one pair of wings, three pairs of long hair-like legs, and specialized, highly elongated, piercing-sucking mouthparts. All mosquitoes drink nectar from flowers; females of some species have in addition adapted to drink blood. The group diversified during the Cretaceous period. Evolutionary biology, Evolutionary biologists view mosquitoes as micropredators, small animals that Parasitism, parasitise larger ones by drinking their blood without immediately killing them. Parasitology, Medical parasitologists view mosquitoes instead as Disease vector, vectors of disease, carrying protozoan parasites or bacterial or virus, viral pathogens from one Host (biology), host to another. The mosquito life cycle cons ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Vector (epidemiology)
In epidemiology, a disease vector is any living agent that carries and transmits an infectious pathogen such as a parasite or microbe, to another living organism. Agents regarded as vectors are mostly blood-sucking (Hematophagy, hematophagous) arthropods such as mosquitoes. The first major discovery of a disease vector came from Ronald Ross in 1897, who discovered the malaria pathogen when he dissected the stomach tissue of a mosquito. Arthropods Arthropods form a major group of pathogen vectors with mosquitoes, Fly, flies, Sandfly, sand flies, lice, fleas, ticks, and mites transmitting a huge number of pathogens. Many such vectors are haematophagous, which feed on blood at some or all stages of their lives. When the insects and ticks feed on blood, the pathogen enters the blood stream of the host. This can happen in different ways. The ''Anopheles'' mosquito, a vector for malaria, filariasis, and various arthropod-borne-viruses (arboviruses), inserts its delicate mouthpart under ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Immunocompromised
Immunodeficiency, also known as immunocompromise, is a state in which the immune system's ability to fight infectious diseases and cancer is compromised or entirely absent. Most cases are acquired ("secondary") due to extrinsic factors that affect the patient's immune system. Examples of these extrinsic factors include HIV infection and environmental factors, such as nutrition. Immunocompromisation may also be due to genetic diseases/flaws such as SCID. In clinical settings, immunosuppression by some drugs, such as steroids, can either be an adverse effect or the intended purpose of the treatment. Examples of such use is in organ transplant surgery as an anti- rejection measure and in patients with an overactive immune system, as in autoimmune diseases. Some people are born with intrinsic defects in their immune system, or primary immunodeficiency. A person who has an immunodeficiency of any kind is said to be immunocompromised. An immunocompromised individual may part ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Francisella Novicida
''Francisella novicida'' is a bacterium of the Francisellaceae family, which consist of Gram-negative pathogenic bacteria. These bacteria vary from small Coccus, cocci to rod-shaped, and are most known for their intracellular parasitic capabilities. In this family, six species have been identified; however, the species ''F. novicida'' is under intense scrutiny. Though some believe it should be classified with its own species designation, others argue it should be reclassified as a subspecies under ''F. tularensis''. If it were to be classified as a subspecies, ''F. novicida'' would join the other known subspecies including ''F. t. tularensis'' (type A) and ''F. t. holarctica'' (type B). Biochemical assays for identifying ''F. tularensis'' subtypes and strains are not ideal because the results are often non-definitive and subject to variation, therefore these assays should only be considered as supplementary tests for identification of ''Francisella'' species and subspecies. Several ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Central Asia
Central Asia is a region of Asia consisting of Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan. The countries as a group are also colloquially referred to as the "-stans" as all have names ending with the Persian language, Persian suffix "-stan" (meaning ) in both respective native languages and most other languages. The region is bounded by the Caspian Sea to the southwest, European Russia to the northwest, China and Mongolia to the east, Afghanistan and Iran to the south, and Siberia to the north. Together, the five Central Asian countries have a total population of around million. In the pre-Islamic and early Islamic eras ( and earlier) Central Asia was inhabited predominantly by Iranian peoples, populated by Eastern Iranian-speaking Bactrians, Sogdians, Khwarezmian language, Chorasmians, and the semi-nomadic Scythians and Dahae. As the result of Turkic migration, Central Asia also became the homeland for the Kazakhs, Kyrgyzs, Volga Tatars, Tatars, Turkmens, ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Food And Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, Prescription drug, prescription and Over-the-counter drug, over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, Animal feed, animal foods & feed and Veterinary medicine, veterinary products. The FDA's primary focus is enforcement of the Federal Food, Drug, and Cosmetic Act (FD&C). However, the agency also enforces other laws, notably Section 361 of the Public Health Service Act as well as associated regulations. Much of this regulatory-enforcement work is ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Vaccine
A vaccine is a biological Dosage form, preparation that provides active acquired immunity to a particular infectious disease, infectious or cancer, malignant disease. The safety and effectiveness of vaccines has been widely studied and verified. A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and recognize further and destroy any of the microorganisms associated with that agent that it may encounter in the future. Vaccines can be prophylaxis, prophylactic (to prevent or alleviate the effects of a future infection by a natural or "wild" pathogen), or therapeutic vaccines, therapeutic (to fight a disease that has already occurred, such as cancer vaccine, cancer). Some vaccines offer full sterilizing immunity, in which infection is prevented. T ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Asia
Asia ( , ) is the largest continent in the world by both land area and population. It covers an area of more than 44 million square kilometres, about 30% of Earth's total land area and 8% of Earth's total surface area. The continent, which has long been home to the majority of the human population, was the site of many of the first civilisations. Its 4.7 billion people constitute roughly 60% of the world's population. Asia shares the landmass of Eurasia with Europe, and of Afro-Eurasia with both Europe and Africa. In general terms, it is bounded on the east by the Pacific Ocean, on the south by the Indian Ocean, and on the north by the Arctic Ocean. The border of Asia with Europe is a social constructionism, historical and cultural construct, as there is no clear physical and geographical separation between them. A commonly accepted division places Asia to the east of the Suez Canal separating it from Africa; and to the east of the Turkish straits, the Ural Mountains an ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |