|
Experimental System
In scientific research, an experimental system is the physical, technical and procedural basis for an experiment or series of experiments. Historian of science Hans-Jörg Rheinberger defines an experimental system as: "A basic unit of experimental activity combining local, technical, instrumental, institutional, social, and epistemic aspects." Scientists (particularly laboratory biologists) and historians and philosophers of biology have pointed to the development and spread of successful experimental systems, such as those based on popular model organism or scientific apparatus, as key elements in the history of science, particularly since the early 20th century. The choice of an appropriate experimental system is often seen as critical for a scientist's long-term success, as experimental systems can be very productive for some kinds of questions and less productive for others, acquiring a sort of momentum that takes research in unpredicted directions. A successful experimental ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific Research
The scientific method is an empirical method for acquiring knowledge that has been referred to while doing science since at least the 17th century. Historically, it was developed through the centuries from the ancient and medieval world. The scientific method involves careful observation coupled with rigorous skepticism, because cognitive assumptions can distort the interpretation of the observation. Scientific inquiry includes creating a testable hypothesis through inductive reasoning, testing it through experiments and statistical analysis, and adjusting or discarding the hypothesis based on the results. Although procedures vary across fields, the underlying process is often similar. In more detail: the scientific method involves making conjectures (hypothetical explanations), predicting the logical consequences of hypothesis, then carrying out experiments or empirical observations based on those predictions. with added notes. Reprinted with previously unpublished part, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Strain (biology)
In biology, a strain is a genetic variant, a subtype or a culture within a biological species. Strains are often seen as inherently artificial concepts, characterized by a specific intent for genetic isolation. This is most easily observed in microbiology where strains are derived from a single cell colony and are typically quarantined by the physical constraints of a Petri dish. Strains are also commonly referred to within virology, botany, and with rodents used in experimental studies. Microbiology and virology It has been said that "there is no universally accepted definition for the terms 'strain', ' variant', and 'isolate' in the virology community, and most virologists simply copy the usage of terms from others". A strain is a genetic variant or subtype of a microorganism such as a bacterial strain or a specific strain of a virus, or fungus. For example, a "flu strain" is a certain biological form of the influenza or "flu" virus. These flu strains are characterized ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Systems Theory
Systems theory is the Transdisciplinarity, transdisciplinary study of systems, i.e. cohesive groups of interrelated, interdependent components that can be natural or artificial. Every system has causal boundaries, is influenced by its context, defined by its structure, function and role, and expressed through its relations with other systems. A system is "more than the sum of its parts" when it expresses synergy or emergent behavior. Changing one component of a system may affect other components or the whole system. It may be possible to predict these changes in patterns of behavior. For systems that learn and adapt, the growth and the degree of adaptation depend upon how well the system is engaged with its environment and other contexts influencing its organization. Some systems support other systems, maintaining the other system to prevent failure. The goals of systems theory are to model a system's dynamics, Theory of constraints, constraints, conditions, and relations; and to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Historiography Of Science
The historiography of science or the historiography of the history of science is the study of the history and methodology of the sub-discipline of history, known as the history of science, including its disciplinary aspects and practices (methods, theories, schools) and the study of its own historical development ("History of History of Science", i.e., the history of the discipline called History of Science). Historiographical debates regarding the proper method for the study of the history of science are sometimes difficult to demarcate from historical controversies regarding the course of science. Early controversies of the latter kind are considered by some to be the inception of the sub-discipline. Amateur historiography of science Histories of science were originally written by practicing and retired scientists, a notable early example being William Whewell, William Whewell's ''History of the Inductive Sciences'' (1837). Biographies of natural philosophers (early scientists) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Philosophy Of Science
Philosophy of science is the branch of philosophy concerned with the foundations, methods, and implications of science. Amongst its central questions are the difference between science and non-science, the reliability of scientific theories, and the ultimate purpose and meaning of science as a human endeavour. Philosophy of science focuses on metaphysical, epistemic and semantic aspects of scientific practice, and overlaps with metaphysics, ontology, logic, and epistemology, for example, when it explores the relationship between science and the concept of truth. Philosophy of science is both a theoretical and empirical discipline, relying on philosophical theorising as well as meta-studies of scientific practice. Ethical issues such as bioethics and scientific misconduct are often considered ethics or science studies rather than the philosophy of science. Many of the central problems concerned with the philosophy of science lack contemporary consensus, including whether ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul Rabinow
Paul M. Rabinow (June 21, 1944 – April 6, 2021) was a professor of anthropology at the University of California (Berkeley), director of the Anthropology of the Contemporary Research Collaboratory (ARC), and former director of human practices for the Synthetic Biology Engineering Research Center (SynBERC). He worked with, and wrote extensively about, the French philosopher Michel Foucault. Biographical details Rabinow was born in Florida but raised in New York City from a young age. His grandparents were all Russian Jewish immigrants. He lived in Sunnyside, Queens. He stated that at the time, the neighborhood was a garden city and a socialist and communist 'zone'. He attended Stuyvesant High. School. Rabinow received his B.A. (1965), M.A. (1967), and Ph.D. (1970) in anthropology from the University of Chicago. He studied at the École Pratique des Hautes Études in Paris (1965–66). He received a Guggenheim Fellowship (1980), was a visiting Fulbright Professor at the Nation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Har Gobind Khorana
Har Gobind Khorana (9 January 1922 – 9 November 2011) was an Indian-American biochemist. While on the faculty of the University of Wisconsin–Madison, he shared the 1968 Nobel Prize for Physiology or Medicine with Marshall W. Nirenberg and Robert W. Holley for research that showed the order of nucleotides in nucleic acids, which carry the genetic code of the cell and control the cell's synthesis of proteins. Khorana and Nirenberg were also awarded the Louisa Gross Horwitz Prize from Columbia University in the same year. Born in British India, Khorana served on the faculties of three universities in North America. He became a naturalized citizen of the United States in 1966, and received the National Medal of Science in 1987. Biography Har Gobind Khorana was born to Ganpatrai Khorana and Krishna Devi, in Raipur, a village in Multan, Punjab, British India, in a Punjabi Hindu Khatri family. The exact date of his birth is not certain but he believed that it might have been 9 J ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cetus Corporation
Cetus Corporation was one of the first biotechnology companies. It was established in Berkeley, California, in 1971, but conducted most of its operations in nearby Emeryville. Before merging with Chiron Corporation in 1991 (now a part of Novartis), it developed several significant pharmaceutical drugs as well as a revolutionary DNA amplification technique. History Cetus was founded in 1971 by Ronald E. Cape, Peter Farley, and Nobelist Donald A. Glaser. Its early efforts involved automated methods to select for industrial microorganisms that could produce greater amounts of chemical feedstocks, antibiotics, or vaccine components. By the late 1970s, however, three new revolutionary techniques had been developed: recombinant DNA, monoclonal antibodies, and gene expression, the foundations of the biotechnology industry. In order to enter these new fields, Cetus raised $108 million in an initial public offering (IPO) in 1981, the largest IPO to that date. Its first large devel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kary Mullis
Kary Banks Mullis (December 28, 1944August 7, 2019) was an American biochemist. In recognition of his role in the invention of the polymerase chain reaction (PCR) technique, he shared the 1993 Nobel Prize in Chemistry with Michael Smith and was awarded the Japan Prize in the same year. PCR became a central technique in biochemistry and molecular biology, described by ''The New York Times'' as "highly original and significant, virtually dividing biology into the two epochs of before PCR and after PCR." Mullis downplayed humans' role in climate change, expressed doubt that HIV is the cause of AIDS, and professed a belief in astrology and the paranormal. He also practiced clandestine chemistry by producing LSD. Mullis's unscientific statements about topics outside his area of expertise have been named by '' Skeptical Inquirer'' as an instance of " Nobel disease". Early life and education Mullis was born in Lenoir, North Carolina, near the Blue Ridge Mountains, on December 2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polymerase Chain Reaction
The polymerase chain reaction (PCR) is a method widely used to make millions to billions of copies of a specific DNA sample rapidly, allowing scientists to amplify a very small sample of DNA (or a part of it) sufficiently to enable detailed study. PCR was invented in 1983 by American biochemist Kary Mullis at Cetus Corporation. Mullis and biochemist Michael Smith (chemist), Michael Smith, who had developed other essential ways of manipulating DNA, were jointly awarded the Nobel Prize in Chemistry in 1993. PCR is fundamental to many of the procedures used in genetic testing and research, including analysis of Ancient DNA, ancient samples of DNA and identification of infectious agents. Using PCR, copies of very small amounts of DNA sequences are exponentially amplified in a series of cycles of temperature changes. PCR is now a common and often indispensable technique used in medical laboratory research for a broad variety of applications including biomedical research and forensic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Domestication
Domestication is a multi-generational Mutualism (biology), mutualistic relationship in which an animal species, such as humans or leafcutter ants, takes over control and care of another species, such as sheep or fungi, to obtain from them a steady supply of resources, such as meat, milk, or labor. The process is gradual and geographically diffuse, based on trial and error. Domestication affected genes for behavior in animals, making them less aggressive. In plants, domestication affected genes for morphology, such as increasing seed size and stopping the Shattering (agriculture), shattering of cereal seedheads. Such changes both make domesticated organisms easier to handle and reduce their ability to survive in the wild. The first Domestication of animals, animal to be domesticated by humans was the domestication of the dog, dog, as a Commensalism, commensal, at least 15,000 years ago. Other animals, including goats, sheep, and cows, were domesticated around 11,000 years ago. A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Experiment
An experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs when a particular factor is manipulated. Experiments vary greatly in goal and scale but always rely on repeatable procedure and logical analysis of the results. There also exist natural experimental studies. A child may carry out basic experiments to understand how things fall to the ground, while teams of scientists may take years of systematic investigation to advance their understanding of a phenomenon. Experiments and other types of hands-on activities are very important to student learning in the science classroom. Experiments can raise test scores and help a student become more engaged and interested in the material they are learning, especially when used over time. Experiments can vary from personal and informal natural comparisons ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
